PMID- 10022836
OWN - NLM
STAT- MEDLINE
DCOM- 19990426
LR  - 20181113
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 18
IP  - 4
DP  - 1999 Feb 15
TI  - JunB is essential for mammalian placentation.
PG  - 934-48
AB  - Lack of JunB, an immediate early gene product and member of the AP-1
      transcription factor family causes embryonic lethality between E8.5 and E10.0.
      Although mutant embryos are severely retarded in growth and development, cellular
      proliferation is apparently not impaired. Retardation and embryonic death are
      caused by the inability of JunB-deficient embryos to establish proper vascular
      interactions with the maternal circulation due to multiple defects in
      extra-embryonic tissues. The onset of the phenotypic defects correlates well with
      high expression of junB in wild-type extra-embryonic tissues. In trophoblasts,
      the lack of JunB causes a deregulation of proliferin, matrix metalloproteinase-9 
      (MMP-9) and urokinase plasminogen activator (uPA) gene expression, resulting in a
      defective neovascularization of the decidua. As a result of downregulation of the
      VEGF-receptor 1 (flt-1), blood vessels in the yolk sac mesoderm appeared dilated.
      Mutant embryos which escape these initial defects finally die from a
      non-vascularized placental labyrinth. Injection of junB-/- embryonic stem (ES)
      cells into tetraploid wild-type blastocysts resulted in a partial rescue, in
      which the ES cell-derived fetuses were no longer growth retarded and displayed a 
      normal placental labyrinth. Therefore, JunB appears to be involved in multiple
      signaling pathways regulating genes involved in the establishment of a proper
      feto-maternal circulatory system.
FAU - Schorpp-Kistner, M
AU  - Schorpp-Kistner M
AD  - Deutsches Krebsforschungszentrum Heidelberg, Abteilung fur Signaltransduktion und
      Wachstumskontrolle, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
FAU - Wang, Z Q
AU  - Wang ZQ
FAU - Angel, P
AU  - Angel P
FAU - Wagner, E F
AU  - Wagner EF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Transcription Factor AP-1)
SB  - IM
MH  - Animals
MH  - Cell Division/genetics
MH  - Embryonic and Fetal Development
MH  - Gene Expression Regulation, Developmental
MH  - Gene Targeting
MH  - Genotype
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Knockout
MH  - Mutation/genetics
MH  - Phenotype
MH  - Placenta/blood supply
MH  - *Placentation
MH  - Ploidies
MH  - Proto-Oncogene Proteins c-jun/deficiency/*genetics
MH  - Stem Cells/metabolism
MH  - Transcription Factor AP-1/*genetics
MH  - Yolk Sac/embryology
PMC - PMC1171186
EDAT- 1999/02/18 00:00
MHDA- 1999/02/18 00:01
CRDT- 1999/02/18 00:00
PHST- 1999/02/18 00:00 [pubmed]
PHST- 1999/02/18 00:01 [medline]
PHST- 1999/02/18 00:00 [entrez]
AID - 10.1093/emboj/18.4.934 [doi]
PST - ppublish
SO  - EMBO J. 1999 Feb 15;18(4):934-48. doi: 10.1093/emboj/18.4.934.