PMID- 10021349
OWN - NLM
STAT- MEDLINE
DCOM- 19990427
LR  - 20131121
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 126
IP  - 6
DP  - 1999 Mar
TI  - Retinoids are produced by glia in the lateral ganglionic eminence and regulate
      striatal neuron differentiation.
PG  - 1317-26
AB  - In order to identify molecular mechanisms involved in striatal development, we
      employed a subtraction cloning strategy to enrich for genes expressed in the
      lateral versus the medial ganglionic eminence. Using this approach, the homeobox 
      gene Meis2 was found highly expressed in the lateral ganglionic eminence and
      developing striatum. Since Meis2 has recently been shown to be upregulated by
      retinoic acid in P19 EC cells (Oulad-Abdelghani, M., Chazaud, C., Bouillet, P.,
      Sapin, V., Chambon, P. and Dolle, P. (1997) Dev. Dyn. 210, 173-183), we examined 
      a potential role for retinoids in striatal development. Our results demonstrate
      that the lateral ganglionic eminence, unlike its medial counterpart or the
      adjacent cerebral cortex, is a localized source of retinoids. Interestingly, glia
      (likely radial glia) in the lateral ganglionic eminence appear to be a major
      source of retinoids. Thus, as lateral ganglionic eminence cells migrate along
      radial glial fibers into the developing striatum, retinoids from these glial
      cells could exert an effect on striatal neuron differentiation. Indeed, the
      treatment of lateral ganglionic eminence cells with retinoic acid or agonists for
      the retinoic acid receptors or retinoid X receptors, specifically enhances their 
      striatal neuron characteristics. These findings, therefore, strongly support the 
      notion that local retinoid signalling within the lateral ganglionic eminence
      regulates striatal neuron differentiation.
FAU - Toresson, H
AU  - Toresson H
AD  - Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of
      Neurobiology, Section for Developmental Neurobiology, Lund University, Solvegatan
      17, S-223 62 Lund, Sweden. hakan.toresson@immuno.lu.se
FAU - Mata de Urquiza, A
AU  - Mata de Urquiza A
FAU - Fagerstrom, C
AU  - Fagerstrom C
FAU - Perlmann, T
AU  - Perlmann T
FAU - Campbell, K
AU  - Campbell K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Mrg1 protein, mouse)
RN  - 0 (Retinoids)
RN  - 0 (Retinol-Binding Proteins)
RN  - 0 (Retinol-Binding Proteins, Cellular)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation
MH  - Cell Differentiation/drug effects
MH  - Corpus Striatum/cytology/*embryology
MH  - Homeodomain Proteins/isolation & purification
MH  - Mice
MH  - Neuroglia/*metabolism
MH  - Neurons/*cytology
MH  - Retinoids/*metabolism
MH  - Retinol-Binding Proteins/isolation & purification
MH  - Retinol-Binding Proteins, Cellular
MH  - Signal Transduction
MH  - Stem Cells
MH  - Tretinoin/pharmacology
EDAT- 1999/02/18 00:00
MHDA- 1999/02/18 00:01
CRDT- 1999/02/18 00:00
PHST- 1999/02/18 00:00 [pubmed]
PHST- 1999/02/18 00:01 [medline]
PHST- 1999/02/18 00:00 [entrez]
PST - ppublish
SO  - Development. 1999 Mar;126(6):1317-26.