doc_id	sent_index	relation_id	relation	trigger	trigger_offset	arg_num	arg_base_np	arg_protein	arg_domain	arg_site	arg_sugar	PSource	SiteSource	NProtein	NID	SiteName	sent_text
33819626	4	3	gly	uptake	885:890	arg1	K. marxianus CCT 7735	CCT			uptake	OGER		CCT			Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
34283570	2	84	gly	glycoprotein	380:391	arg1	Lubricin	Lubricin				PUBTATOR		Lubricin	10216		Lubricin (LUB) is an innately biocompatible glycoprotein with impressive antifouling properties.
34817202	3	136	gly	glycoprotein	389:400	arg1	the SARS-CoV-2 S glycoprotein	the SARS-CoV-2 S glycoprotein				PUBTATOR		S glycoprotein	43740568		Approximately 35% of the SARS-CoV-2 S glycoprotein consists of carbohydrate, which can influence virus infectivity and susceptibility to antibody inhibition.
33793546	3	40	gly	glycosylated	427:438	arg1	four full-length, fully glycosylated and palmitoylated S proteins	four full-length, fully glycosylated and palmitoylated S proteins				PUBTATOR		S proteins	43740568		To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
34817202	13	12	gly	glycoprotein	2043:2054	arg1	The viral spike glycoprotein	The viral spike glycoprotein				PUBTATOR		spike glycoprotein	43740568		The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
32612952	9	32	gly	N-GlcNAc	1441:1448	arg1	EGFR	EGFR			N-GlcNAc	PUBTATOR		EGFR	1956		We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32793574	7	36	gly	sialylated	1163:1172	arg1	sialylated IgG4	sialylated IgG4				OGER		IgG4	P01861		All subtypes are equally well amenable to targeted glycosylation, except sialylated IgG4 which frequently accumulates substantial fractions of unusual oligo-mannosidic structures.
33644618	10	90	gly	N-glycosylation	1774:1788	arg1	TSH	TSH				OGER		TSH			During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33376510	7	54	gly	structures	1099:1108	arg1	OCT2	OCT2			structures	PUBTATOR		OCT2	6582		Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
34817202	12	98	gly	glycoprotein	1993:2004	arg1	its spike glycoprotein	its spike glycoprotein				PUBTATOR		spike glycoprotein	43740568		IMPORTANCE The SARS-CoV-2 coronavirus, which causes COVID-19, uses its spike glycoprotein to enter host cells.
33169014	3	49	gly	IgG1	587:590	arg1	afucosylated Fc glycans	IgG1			afucosylated Fc glycans	OGER		IgG1	P01857		Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33925509	4	46	gly	CDM	779:781	arg1	glucose	CDM			glucose	OGER		CDM	Q05682		Increased production of the capsule precursor UDP-glucose has been identified by 31P-NMR in CDM with glucose.
32612952	8	72	gly	GlcNAc	1197:1202	arg1	EGFR	EGFR			GlcNAc	PUBTATOR		EGFR	1956		Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32708305	8	30	gly	glycosylation	1216:1228	arg1	NKp30	NKp30				PUBTATOR		NKp30	259197		Overall, this study provides new insights into the structural basis of NKp30 oligomerization and explains how the stalk region and glycosylation of NKp30 affect its ligand affinity.
34486109	2	50	gly	alpha	447:451	arg1	lipopolysaccharide-induced levels	tumor necrosis factor alpha			lipopolysaccharide-induced levels	PUBTATOR		tumor necrosis factor alpha	21926		Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34955268	10	74	gly	somatotropin	1522:1533	arg1	lower blood glucose	somatotropin			lower blood glucose	PUBTATOR		somatotropin	280804		Feeding LS resulted in lower blood glucose and greater ratio of bovine somatotropin to insulin.
34817202	15	74	gly	glycoprotein	2397:2408	arg1	the SARS-CoV-2 spike glycoprotein	the SARS-CoV-2 spike glycoprotein				PUBTATOR		spike glycoprotein	43740568		Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
33342323	3	6	gly	glycosylated	639:650	arg1	GCS	GCS				OGER		GCS	Q16739		In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33644618	2	43	gly	glycoforms	268:277	arg1	2 different TSH glycoforms	2 different TSH glycoforms				OGER		TSH			The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33712145	6	1	gly	glycoprotein	969:980	arg1	the spike glycoprotein	the spike glycoprotein				PUBTATOR		spike glycoprotein	43740568		Furthermore, we show that the spike glycoprotein of COVID-19 binds 3.5 times stronger to human lung heparan sulfate than bat lung heparan sulfate.
33571209	10	86	gly	cluster	1574:1580	arg1	Dickeya	Dickeya spp			cluster	OGER		Dickeya spp	Q8TCT9		However, comparatively less variation is observed in the putative O-antigen lipopolysaccharide cluster in Dickeya spp.
33376510	1	26	gly	N-glycosylated	203:216	arg1	Organic cation transporter	Organic cation transporter				PUBTATOR		Organic cation transporter member 2	6582		Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
32612952	10	51	gly	N-GlcNAc	1644:1651	arg1	EGFR	EGFR			N-GlcNAc	PUBTATOR		EGFR	1956		Taken together, we conclude that bisecting N-GlcNAc on EGFR inhibits malignant phenotype of breast cancer via down-regulation of EGFR/Erk signaling.
34817202	6	103	gly	glycoproteins	914:926	arg1	soluble or solubilized S glycoproteins	soluble or solubilized S glycoproteins				PUBTATOR		S glycoproteins	43740568		Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
32248230	8	2	gly	sialylated	1548:1557	arg1	sialylated and/or fucosylated HMOs	sialylated and/or fucosylated HMOs				OGER		HMOs	P00540		Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	8	75	gly	fucosylated	1566:1576	arg1	sialylated and/or fucosylated HMOs	sialylated and/or fucosylated HMOs				OGER		HMOs	P00540		Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
31933111	1	28	gly	found	292:296	arg1	PAP AND the lipopolysaccharides	PAP			the lipopolysaccharides	OGER		PAP	P51003		OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
33376510	0	35	gly	transporter	132:142	arg1	N-glycan alteration	organic cation transporter member 2			N-glycan alteration	PUBTATOR		organic cation transporter member 2	6582		Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
32612952	0	73	gly	N-Acetylglucosamine	10:28	arg1	EGFR	EGFR			N-Acetylglucosamine	PUBTATOR		EGFR	1956		Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling.
34817202	4	1	gly	glycoproteins	623:635	arg1	spike glycoproteins	spike glycoproteins				PUBTATOR		spike glycoproteins	43740568		We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	4	123	gly	modified	659:666	arg3	spike glycoproteins AND complex carbohydrates	spike glycoproteins			complex carbohydrates	PUBTATOR		spike glycoproteins	43740568		We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34894199	7	29	gly	Transducer	927:936	arg1	the intestine to regulate glucose metabolite status and ageing in mice	Signal Transducer and Activator of Transcription 3			the intestine to regulate glucose metabolite status and ageing in mice	PUBTATOR		Signal Transducer and Activator of Transcription 3	20848		It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	33	gly	Activator	942:950	arg1	the intestine to regulate glucose metabolite status and ageing in mice	Signal Transducer and Activator of Transcription 3			the intestine to regulate glucose metabolite status and ageing in mice	PUBTATOR		Signal Transducer and Activator of Transcription 3	20848		It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
32475918	4	8	gly	PSP	529:531	arg1	The monosaccharide components	PSP			The monosaccharide components	OGER		PSP	Q96DR5		The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	8	gly	PSP	529:531	arg1	galactose	PSP			galactose	OGER		PSP	Q96DR5		The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
34817202	14	134	gly	glycoprotein	2229:2240	arg1	The SARS-CoV-2 spike glycoprotein	The SARS-CoV-2 spike glycoprotein				PUBTATOR		spike glycoprotein	43740568		The SARS-CoV-2 spike glycoprotein consists of a trimer of two subunits covered with a coat of carbohydrates (sugars).
32217362	4	57	gly	have	614:617	arg1	lactophorin AND several O-glycans	lactophorin			several O-glycans	PUBTATOR		lactophorin	282430		In particular, κ-casein glycomacropeptide and lactophorin, which have several O-glycans, are known to exist in whey protein.
34817202	5	59	gly	glycoprotein	794:805	arg1	a wild-type SARS-CoV-2 S glycoprotein trimer	a wild-type SARS-CoV-2 S glycoprotein trimer				PUBTATOR		S glycoprotein	43740568		We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
32248230	7	4	gly	sialylated	1419:1428	arg1	higher molecular weight sialylated HMOs	higher molecular weight sialylated HMOs				OGER		HMOs	P00540		Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
34817202	11	131	gly	glycoprotein	1843:1854	arg1	the native SARS-CoV-2 S glycoprotein	the native SARS-CoV-2 S glycoprotein				PUBTATOR		S glycoprotein	43740568		These findings enhance our understanding of the Golgi processing of the native SARS-CoV-2 S glycoprotein carbohydrates and could assist the design of interventions.
34817202	2	8	gly	glycoprotein	243:254	arg1	The S glycoprotein	The S glycoprotein				Cterm		S glycoprotein	43740568		The S glycoprotein is the major target for neutralizing antibodies elicited by natural infection and by vaccines.
33169014	5	34	gly	afucosylated	1063:1074	arg1	afucosylated IgG1	afucosylated IgG1				OGER		IgG1	P01857		These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
32248230	5	39	gly	fucosylated	1058:1068	arg1	fucosylated and sialylated HMOs	fucosylated and sialylated HMOs				OGER		HMOs	P00540		This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	5	44	gly	sialylated	1074:1083	arg1	fucosylated and sialylated HMOs	fucosylated and sialylated HMOs				OGER		HMOs	P00540		This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
33063290	2	85	gly	carrying	308:315	arg1	recombinant human lactoferrin AND rhLf-h-glycan	recombinant human lactoferrin			rhLf-h-glycan	PUBTATOR		lactoferrin	280846		In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.