{"count":6,"next":null,"previous":null,"results":[{"gene_data":{"alias":["MGC13453","N33","OST3A","MRT7"],"biotype":"protein_coding","hgnc_id":"HGNC:30242","gene_name":"tumor suppressor candidate 3","omim_gene":["601385"],"alias_name":["oligosaccharyltransferase 3 homolog A (S. cerevisiae)","Magnesium uptake/transporter TUSC3"],"gene_symbol":"TUSC3","hgnc_symbol":"TUSC3","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"8:15274724-15624158","ensembl_id":"ENSG00000104723"}},"GRch38":{"90":{"location":"8:15417215-15766649","ensembl_id":"ENSG00000104723"}}},"hgnc_date_symbol_changed":"2004-01-20"},"entity_type":"gene","entity_name":"TUSC3","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["18455129","18452889","26864433","27148795"],"evidence":["Expert Review Green","UKGTN","Radboud University Medical Center, Nijmegen","Literature","Illumina TruGenome Clinical Sequencing Services","Emory Genetics Laboratory"],"phenotypes":["Mental retardation, autosomal recessive 7\t611093","TUSC3-CDG (Disorders of protein N-glycosylation)"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":25,"hash_id":"58346b8b8f62036225ca8a7d","name":"Congenital disorders of glycosylation","disease_group":"Metabolic disorders","disease_sub_group":"Specific metabolic abnormalities","status":"public","version":"1.32","version_created":"2019-10-07T16:15:06.398101Z","relevant_disorders":["Congential disorders of glycosylation"],"stats":{"number_of_genes":100,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["MGC13453","N33","OST3A","MRT7"],"biotype":"protein_coding","hgnc_id":"HGNC:30242","gene_name":"tumor suppressor candidate 3","omim_gene":["601385"],"alias_name":["oligosaccharyltransferase 3 homolog A (S. cerevisiae)","Magnesium uptake/transporter TUSC3"],"gene_symbol":"TUSC3","hgnc_symbol":"TUSC3","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"8:15274724-15624158","ensembl_id":"ENSG00000104723"}},"GRch38":{"90":{"location":"8:15417215-15766649","ensembl_id":"ENSG00000104723"}}},"hgnc_date_symbol_changed":"2004-01-20"},"entity_type":"gene","entity_name":"TUSC3","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["27604308"],"evidence":["Expert Review Green","Literature"],"phenotypes":["TUSC3-CDG (Disorders of protein N-glycosylation)","Mental retardation, autosomal recessive 7"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":302,"hash_id":"5763f1518f620350a22bccdb","name":"Undiagnosed metabolic disorders","disease_group":"Metabolic disorders","disease_sub_group":"Specific metabolic abnormalities","status":"public","version":"1.373","version_created":"2019-10-08T14:47:17.153678Z","relevant_disorders":["Undiagnosed Metabolic Panel"],"stats":{"number_of_genes":744,"number_of_strs":1,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["MGC13453","N33","OST3A","MRT7"],"biotype":"protein_coding","hgnc_id":"HGNC:30242","gene_name":"tumor suppressor candidate 3","omim_gene":["601385"],"alias_name":["oligosaccharyltransferase 3 homolog A (S. cerevisiae)","Magnesium uptake/transporter TUSC3"],"gene_symbol":"TUSC3","hgnc_symbol":"TUSC3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"8:15274724-15624158","ensembl_id":"ENSG00000104723"}},"GRch38":{"90":{"location":"8:15417215-15766649","ensembl_id":"ENSG00000104723"}}},"hgnc_date_symbol_changed":"2004-01-20"},"entity_type":"gene","entity_name":"TUSC3","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["27604308"],"evidence":["London North GLH","NHS GMS","Expert Review Green"],"phenotypes":["TUSC3-CDG (Disorders of protein N-glycosylation)","Mental retardation, autosomal recessive 7"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":467,"hash_id":null,"name":"Inborn errors of metabolism","disease_group":"","disease_sub_group":"","status":"public","version":"1.348","version_created":"2019-10-09T08:19:52.386941Z","relevant_disorders":["Likely inborn error of metabolism - targeted testing not possible"],"stats":{"number_of_genes":877,"number_of_strs":2,"number_of_regions":1},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["MGC13453","N33","OST3A","MRT7"],"biotype":"protein_coding","hgnc_id":"HGNC:30242","gene_name":"tumor suppressor candidate 3","omim_gene":["601385"],"alias_name":["oligosaccharyltransferase 3 homolog A (S. cerevisiae)","Magnesium uptake/transporter TUSC3"],"gene_symbol":"TUSC3","hgnc_symbol":"TUSC3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"8:15274724-15624158","ensembl_id":"ENSG00000104723"}},"GRch38":{"90":{"location":"8:15417215-15766649","ensembl_id":"ENSG00000104723"}}},"hgnc_date_symbol_changed":"2004-01-20"},"entity_type":"gene","entity_name":"TUSC3","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","PAGE DD-Gene2Phenotype"],"phenotypes":["MENTAL RETARDATION AUTOSOMAL RECESSIVE TYPE 7"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":478,"hash_id":null,"name":"Fetal anomalies","disease_group":"","disease_sub_group":"","status":"public","version":"0.344","version_created":"2019-09-17T09:38:10.568007Z","relevant_disorders":["R21"],"stats":{"number_of_genes":1721,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["MGC13453","N33","OST3A","MRT7"],"biotype":"protein_coding","hgnc_id":"HGNC:30242","gene_name":"tumor suppressor candidate 3","omim_gene":["601385"],"alias_name":["oligosaccharyltransferase 3 homolog A (S. cerevisiae)","Magnesium uptake/transporter TUSC3"],"gene_symbol":"TUSC3","hgnc_symbol":"TUSC3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"8:15274724-15624158","ensembl_id":"ENSG00000104723"}},"GRch38":{"90":{"location":"8:15417215-15766649","ensembl_id":"ENSG00000104723"}}},"hgnc_date_symbol_changed":"2004-01-20"},"entity_type":"gene","entity_name":"TUSC3","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["18455129","21739581"],"evidence":["DD-Gene2Phenotype","Expert Review Green"],"phenotypes":["MENTAL RETARDATION AUTOSOMAL RECESSIVE TYPE 7 611093"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":484,"hash_id":null,"name":"DDG2P","disease_group":"","disease_sub_group":"","status":"public","version":"1.137","version_created":"2019-10-08T15:56:59.220133Z","relevant_disorders":[],"stats":{"number_of_genes":1893,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["MGC13453","N33","OST3A","MRT7"],"biotype":"protein_coding","hgnc_id":"HGNC:30242","gene_name":"tumor suppressor candidate 3","omim_gene":["601385"],"alias_name":["oligosaccharyltransferase 3 homolog A (S. cerevisiae)","Magnesium uptake/transporter TUSC3"],"gene_symbol":"TUSC3","hgnc_symbol":"TUSC3","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"8:15274724-15624158","ensembl_id":"ENSG00000104723"}},"GRch38":{"90":{"location":"8:15417215-15766649","ensembl_id":"ENSG00000104723"}}},"hgnc_date_symbol_changed":"2004-01-20"},"entity_type":"gene","entity_name":"TUSC3","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Victorian Clinical Genetics Services","Expert Review Green","Radboud University Medical Center, Nijmegen"],"phenotypes":["Mental retardation, autosomal recessive 7, 611093","MENTAL RETARDATION AUTOSOMAL RECESSIVE TYPE 7 (MRT7)"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":285,"hash_id":"558aa423bb5a16630e15b63c","name":"Intellectual disability","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Neurodevelopmental disorders","status":"public","version":"2.1065","version_created":"2019-10-07T13:42:16.019766Z","relevant_disorders":["Coarse facial features including Coffin-Siris-like disorders","ID","Moderate","severe or profound intellectual disability","Schizophrenia plus additional features","Intellectual disability - microarray","fragile X and sequencing"],"stats":{"number_of_genes":2253,"number_of_strs":11,"number_of_regions":57},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}}]}
