{"count":6,"next":null,"previous":null,"results":[{"gene_data":{"alias":["TRP6"],"biotype":"protein_coding","hgnc_id":"HGNC:12338","gene_name":"transient receptor potential cation channel subfamily C member 6","omim_gene":["603652"],"alias_name":null,"gene_symbol":"TRPC6","hgnc_symbol":"TRPC6","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"11:101322295-101743293","ensembl_id":"ENSG00000137672"}},"GRch38":{"90":{"location":"11:101451564-101872562","ensembl_id":"ENSG00000137672"}}},"hgnc_date_symbol_changed":"1998-08-05"},"entity_type":"gene","entity_name":"TRPC6","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","SFARI"],"phenotypes":[],"mode_of_inheritance":"","tags":[],"panel":{"id":657,"hash_id":null,"name":"Autism","disease_group":"","disease_sub_group":"","status":"public","version":"0.15","version_created":"2019-06-20T15:10:14.437740Z","relevant_disorders":[],"stats":{"number_of_genes":733,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Research","slug":"research","description":"This is a gene panel used for research."}]}},{"gene_data":{"alias":["TRP6"],"biotype":"protein_coding","hgnc_id":"HGNC:12338","gene_name":"transient receptor potential cation channel subfamily C member 6","omim_gene":["603652"],"alias_name":null,"gene_symbol":"TRPC6","hgnc_symbol":"TRPC6","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"11:101322295-101743293","ensembl_id":"ENSG00000137672"}},"GRch38":{"90":{"location":"11:101451564-101872562","ensembl_id":"ENSG00000137672"}}},"hgnc_date_symbol_changed":"1998-08-05"},"entity_type":"gene","entity_name":"TRPC6","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Emory Genetics Laboratory","UKGTN","Radboud University Medical Center, Nijmegen","Illumina TruGenome Clinical Sequencing Services","Eligibility statement prior genetic testing"],"phenotypes":["Glomerulosclerosis, focal segmental, 2 603965"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":156,"hash_id":"5693974122c1fc251660fb1f","name":"Unexplained kidney failure in young people","disease_group":"Renal and urinary tract disorders","disease_sub_group":"Disorders of function","status":"public","version":"1.73","version_created":"2019-07-17T16:13:42.477129Z","relevant_disorders":["Familial IgA nephropathy and IgA vasculitis","End-stage renal disease - childhood onset"],"stats":{"number_of_genes":166,"number_of_strs":0,"number_of_regions":3},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["TRP6"],"biotype":"protein_coding","hgnc_id":"HGNC:12338","gene_name":"transient receptor potential cation channel subfamily C member 6","omim_gene":["603652"],"alias_name":null,"gene_symbol":"TRPC6","hgnc_symbol":"TRPC6","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"11:101322295-101743293","ensembl_id":"ENSG00000137672"}},"GRch38":{"90":{"location":"11:101451564-101872562","ensembl_id":"ENSG00000137672"}}},"hgnc_date_symbol_changed":"1998-08-05"},"entity_type":"gene","entity_name":"TRPC6","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green"],"phenotypes":["Glomerulosclerosis, focal segmental, 2 603965"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":493,"hash_id":null,"name":"Renal and urinary tract disorders","disease_group":"","disease_sub_group":"","status":"public","version":"1.18","version_created":"2019-07-04T13:55:26.963386Z","relevant_disorders":[],"stats":{"number_of_genes":177,"number_of_strs":0,"number_of_regions":3},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["TRP6"],"biotype":"protein_coding","hgnc_id":"HGNC:12338","gene_name":"transient receptor potential cation channel subfamily C member 6","omim_gene":["603652"],"alias_name":null,"gene_symbol":"TRPC6","hgnc_symbol":"TRPC6","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"11:101322295-101743293","ensembl_id":"ENSG00000137672"}},"GRch38":{"90":{"location":"11:101451564-101872562","ensembl_id":"ENSG00000137672"}}},"hgnc_date_symbol_changed":"1998-08-05"},"entity_type":"gene","entity_name":"TRPC6","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green"],"phenotypes":["Glomerulosclerosis, focal segmental, 2 603965"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":678,"hash_id":null,"name":"Unexplained paediatric onset end-stage renal disease","disease_group":"","disease_sub_group":"","status":"public","version":"0.43","version_created":"2019-09-25T12:25:36.245604Z","relevant_disorders":["R257"],"stats":{"number_of_genes":229,"number_of_strs":0,"number_of_regions":3},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["TRP6"],"biotype":"protein_coding","hgnc_id":"HGNC:12338","gene_name":"transient receptor potential cation channel subfamily C member 6","omim_gene":["603652"],"alias_name":null,"gene_symbol":"TRPC6","hgnc_symbol":"TRPC6","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"11:101322295-101743293","ensembl_id":"ENSG00000137672"}},"GRch38":{"90":{"location":"11:101451564-101872562","ensembl_id":"ENSG00000137672"}}},"hgnc_date_symbol_changed":"1998-08-05"},"entity_type":"gene","entity_name":"TRPC6","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["15879175"],"evidence":["NHS GMS","Expert Review Green","Eligibility statement prior genetic testing"],"phenotypes":["Glomerulosclerosis, focal segmental, 2 #603652","Proteinuria","FSGS","kidney failure","Familial and sporadic SRNS (adult)"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":106,"hash_id":"55af787822c1fc78a829f89f","name":"Proteinuric renal disease","disease_group":"Renal and urinary tract disorders","disease_sub_group":"Syndromes with prominent renal abnormalities","status":"public","version":"1.225","version_created":"2019-10-09T10:57:45.692187Z","relevant_disorders":["R195"],"stats":{"number_of_genes":95,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["TRP6"],"biotype":"protein_coding","hgnc_id":"HGNC:12338","gene_name":"transient receptor potential cation channel subfamily C member 6","omim_gene":["603652"],"alias_name":null,"gene_symbol":"TRPC6","hgnc_symbol":"TRPC6","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"11:101322295-101743293","ensembl_id":"ENSG00000137672"}},"GRch38":{"90":{"location":"11:101451564-101872562","ensembl_id":"ENSG00000137672"}}},"hgnc_date_symbol_changed":"1998-08-05"},"entity_type":"gene","entity_name":"TRPC6","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Expert review green","Literature"],"phenotypes":["MIM 603965","Nephropathy of unknown origin","Glomerulopathy","Glomerulosclerosis focal segmental 2"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":720,"hash_id":null,"name":"Groopman et al 2019 - Genes with diagnostic variants","disease_group":"","disease_sub_group":"","status":"public","version":"0.8","version_created":"2019-07-09T15:48:14.145108Z","relevant_disorders":[],"stats":{"number_of_genes":66,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Submitted List","slug":"submitted-list","description":"Original list, ratings, comments submitted to PanelApp- generally used for the creation of reference GMS panels, these panels  should be internal only"}]}}]}