{"count":7,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:12010","gene_name":"tropomyosin 1","omim_gene":["191010"],"alias_name":null,"gene_symbol":"TPM1","hgnc_symbol":"TPM1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"15:63334831-63364114","ensembl_id":"ENSG00000140416"}},"GRch38":{"90":{"location":"15:63042632-63071915","ensembl_id":"ENSG00000140416"}}},"hgnc_date_symbol_changed":"1991-07-18"},"entity_type":"gene","entity_name":"TPM1","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Expert list","Radboud University Medical Center, Nijmegen"],"phenotypes":["Left ventricular noncompaction 9,"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":238,"hash_id":"55a38d3a22c1fc64c2942434","name":"Left Ventricular Noncompaction Cardiomyopathy","disease_group":"Cardiovascular disorders","disease_sub_group":"Cardiomyopathy","status":"public","version":"1.3","version_created":"2019-06-20T15:15:12.623782Z","relevant_disorders":[],"stats":{"number_of_genes":16,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:12010","gene_name":"tropomyosin 1","omim_gene":["191010"],"alias_name":null,"gene_symbol":"TPM1","hgnc_symbol":"TPM1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"15:63334831-63364114","ensembl_id":"ENSG00000140416"}},"GRch38":{"90":{"location":"15:63042632-63071915","ensembl_id":"ENSG00000140416"}}},"hgnc_date_symbol_changed":"1991-07-18"},"entity_type":"gene","entity_name":"TPM1","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["27532257","28369730","30681346"],"evidence":["South West GLH","London South GLH","North West GLH","Expert Review Green","Expert list","Illumina TruGenome Clinical Sequencing Services","Radboud University Medical Center, Nijmegen","UKGTN","Emory Genetics Laboratory"],"phenotypes":["Left ventricular noncompaction 9 ( 611878)","Cardiomyopathy, hypertrophic, 3 (115196)","Cardiomyopathy, familial hypertrophic, 3","Cardiomyopathy, dilated, 1Y (611878)"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":49,"hash_id":"55a39e2d22c1fc6711b0c6b3","name":"Hypertrophic cardiomyopathy - teen and adult","disease_group":"Cardiovascular disorders","disease_sub_group":"Cardiomyopathy","status":"public","version":"1.77","version_created":"2019-10-02T12:51:19.933333Z","relevant_disorders":["Hypertrophic Cardiomyopathy","HCM","R131"],"stats":{"number_of_genes":70,"number_of_strs":1,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:12010","gene_name":"tropomyosin 1","omim_gene":["191010"],"alias_name":null,"gene_symbol":"TPM1","hgnc_symbol":"TPM1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"15:63334831-63364114","ensembl_id":"ENSG00000140416"}},"GRch38":{"90":{"location":"15:63042632-63071915","ensembl_id":"ENSG00000140416"}}},"hgnc_date_symbol_changed":"1991-07-18"},"entity_type":"gene","entity_name":"TPM1","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["27532257","20186049"],"evidence":["South West GLH","London South GLH","North West GLH","Expert Review Green","UKGTN","Expert list","Emory Genetics Laboratory","Radboud University Medical Center, Nijmegen","Illumina TruGenome Clinical Sequencing Services"],"phenotypes":["Left ventricular noncompaction 9 ( 611878)","Cardiomyopathy, hypertrophic, 3 (115196)","Cardiomyopathy, dilated, 1Y","Cardiomyopathy, dilated, 1Y (611878)"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":47,"hash_id":"55a4d99022c1fc6710839b84","name":"Dilated Cardiomyopathy and conduction defects","disease_group":"Cardiovascular disorders","disease_sub_group":"Cardiomyopathy","status":"public","version":"1.63","version_created":"2019-09-30T12:02:00.646768Z","relevant_disorders":["Dilated Cardiomyopathy","Dilated Cardiomyopathy (DCM)","Dilated cardiomyopathy - teen and adult"],"stats":{"number_of_genes":84,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:12010","gene_name":"tropomyosin 1","omim_gene":["191010"],"alias_name":null,"gene_symbol":"TPM1","hgnc_symbol":"TPM1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"15:63334831-63364114","ensembl_id":"ENSG00000140416"}},"GRch38":{"90":{"location":"15:63042632-63071915","ensembl_id":"ENSG00000140416"}}},"hgnc_date_symbol_changed":"1991-07-18"},"entity_type":"gene","entity_name":"TPM1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["20186049","27532257"],"evidence":["Expert Review Green","UKGTN","South West GLH","Radboud University Medical Center, Nijmegen","Illumina TruGenome Clinical Sequencing Services","London South GLH","North West GLH","Expert list","Emory Genetics Laboratory","South West GLH","London South GLH","North West GLH"],"phenotypes":["Cardiomyopathy, dilated, 1Y","Cardiomyopathy, dilated, 1Y (611878)","Cardiomyopathy, hypertrophic, 3 (115196)","Left ventricular noncompaction 9 ( 611878)"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":652,"hash_id":null,"name":"Dilated cardiomyopathy - adult and teen","disease_group":"Cardiovascular disorders","disease_sub_group":"Cardiomyopathy","status":"public","version":"0.50","version_created":"2019-10-03T13:24:45.938053Z","relevant_disorders":["R132"],"stats":{"number_of_genes":34,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:12010","gene_name":"tropomyosin 1","omim_gene":["191010"],"alias_name":null,"gene_symbol":"TPM1","hgnc_symbol":"TPM1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"15:63334831-63364114","ensembl_id":"ENSG00000140416"}},"GRch38":{"90":{"location":"15:63042632-63071915","ensembl_id":"ENSG00000140416"}}},"hgnc_date_symbol_changed":"1991-07-18"},"entity_type":"gene","entity_name":"TPM1","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS","South West GLH","Emory Genetics Laboratory"],"phenotypes":["Cardiomyopathy"],"mode_of_inheritance":"","tags":[],"panel":{"id":85,"hash_id":"55ad205422c1fc7041340234","name":"Hereditary neuropathy","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Motor and Sensory Disorders of the PNS","status":"public","version":"1.333","version_created":"2019-07-09T13:10:50.031506Z","relevant_disorders":["Charcot-Marie-Tooth disease"],"stats":{"number_of_genes":276,"number_of_strs":11,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:12010","gene_name":"tropomyosin 1","omim_gene":["191010"],"alias_name":null,"gene_symbol":"TPM1","hgnc_symbol":"TPM1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"15:63334831-63364114","ensembl_id":"ENSG00000140416"}},"GRch38":{"90":{"location":"15:63042632-63071915","ensembl_id":"ENSG00000140416"}}},"hgnc_date_symbol_changed":"1991-07-18"},"entity_type":"gene","entity_name":"TPM1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["South West GLH","London South GLH","Expert Review Green"],"phenotypes":["Cardiomyopathy, familial hypertrophic, 3","Cardiomyopathy, dilated, 1Y","Left ventricular noncompaction 9,"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":749,"hash_id":null,"name":"Cardiomyopathies - including childhood onset","disease_group":"","disease_sub_group":"","status":"public","version":"0.13","version_created":"2019-09-16T12:01:25.928956Z","relevant_disorders":["Paediatric or syndromic cardiomyopathy","R135"],"stats":{"number_of_genes":180,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:12010","gene_name":"tropomyosin 1","omim_gene":["191010"],"alias_name":null,"gene_symbol":"TPM1","hgnc_symbol":"TPM1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"15:63334831-63364114","ensembl_id":"ENSG00000140416"}},"GRch38":{"90":{"location":"15:63042632-63071915","ensembl_id":"ENSG00000140416"}}},"hgnc_date_symbol_changed":"1991-07-18"},"entity_type":"gene","entity_name":"TPM1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["27532257","28369730","20186049"],"evidence":["London South GLH","North West GLH","Expert Review Green","London South GLH","North West GLH","Expert Review Green"],"phenotypes":["Left ventricular noncompaction 9 ( 611878)","Cardiomyopathy, dilated, 1Y","Cardiomyopathy, dilated, 1Y (611878)","Cardiomyopathy, familial hypertrophic, 3","Cardiomyopathy, hypertrophic, 3 (115196)","Left ventricular noncompaction 9,"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":750,"hash_id":null,"name":"Sudden cardiac death","disease_group":"","disease_sub_group":"","status":"public","version":"0.10","version_created":"2019-09-24T10:05:54.784946Z","relevant_disorders":["Molecular autopsy","R138"],"stats":{"number_of_genes":119,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}}]}