{"count":3,"next":null,"previous":null,"results":[{"gene_data":{"alias":["MGC33727","FLJ11273"],"biotype":"protein_coding","hgnc_id":"HGNC:22407","gene_name":"transmembrane protein 106B","omim_gene":["613413"],"alias_name":null,"gene_symbol":"TMEM106B","hgnc_symbol":"TMEM106B","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"7:12250867-12282993","ensembl_id":"ENSG00000106460"}},"GRch38":{"90":{"location":"7:12211241-12243367","ensembl_id":"ENSG00000106460"}}},"hgnc_date_symbol_changed":"2005-12-19"},"entity_type":"gene","entity_name":"TMEM106B","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":["29186371, 29444210"],"evidence":["Expert Review Red"],"phenotypes":["Leukodystrophy, hypomyelinating 16, MIM#617964"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":476,"hash_id":null,"name":"White matter disorders and cerebral calcification - narrow panel","disease_group":"","disease_sub_group":"","status":"public","version":"1.9","version_created":"2019-08-08T11:56:25.970239Z","relevant_disorders":[],"stats":{"number_of_genes":191,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["MGC33727","FLJ11273"],"biotype":"protein_coding","hgnc_id":"HGNC:22407","gene_name":"transmembrane protein 106B","omim_gene":["613413"],"alias_name":null,"gene_symbol":"TMEM106B","hgnc_symbol":"TMEM106B","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"7:12250867-12282993","ensembl_id":"ENSG00000106460"}},"GRch38":{"90":{"location":"7:12211241-12243367","ensembl_id":"ENSG00000106460"}}},"hgnc_date_symbol_changed":"2005-12-19"},"entity_type":"gene","entity_name":"TMEM106B","confidence_level":"1","penetrance":"unknown","mode_of_pathogenicity":null,"publications":["29186371, 29444210"],"evidence":["Expert Review Red","Expert list"],"phenotypes":["Leukodystrophy, hypomyelinating 16, MIM#617964"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":42,"hash_id":"568f920822c1fc1c79ca177a","name":"Inherited white matter disorders","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"White matter disorders","status":"public","version":"1.71","version_created":"2019-08-08T12:01:29.978699Z","relevant_disorders":["Leukodystrophy - adult onset"],"stats":{"number_of_genes":166,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["MGC33727","FLJ11273"],"biotype":"protein_coding","hgnc_id":"HGNC:22407","gene_name":"transmembrane protein 106B","omim_gene":["613413"],"alias_name":null,"gene_symbol":"TMEM106B","hgnc_symbol":"TMEM106B","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"7:12250867-12282993","ensembl_id":"ENSG00000106460"}},"GRch38":{"90":{"location":"7:12211241-12243367","ensembl_id":"ENSG00000106460"}}},"hgnc_date_symbol_changed":"2005-12-19"},"entity_type":"gene","entity_name":"TMEM106B","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments","publications":[],"evidence":["Expert Review Green","NHS GMS","Wessex and West Midlands GLH"],"phenotypes":["Hypomyelinating leukodystrophy 16, 617964"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":466,"hash_id":null,"name":"Hereditary ataxia - adult onset","disease_group":"","disease_sub_group":"","status":"public","version":"1.211","version_created":"2019-09-20T14:18:40.957460Z","relevant_disorders":["Hereditary ataxia with onset in adulthood","R54"],"stats":{"number_of_genes":236,"number_of_strs":13,"number_of_regions":4},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}}]}
