{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["CD283"],"biotype":"protein_coding","hgnc_id":"HGNC:11849","gene_name":"toll like receptor 3","omim_gene":["603029"],"alias_name":null,"gene_symbol":"TLR3","hgnc_symbol":"TLR3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"4:186990306-187009223","ensembl_id":"ENSG00000164342"}},"GRch38":{"90":{"location":"4:186069152-186088069","ensembl_id":"ENSG00000164342"}}},"hgnc_date_symbol_changed":"1998-06-25"},"entity_type":"gene","entity_name":"TLR3","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":null,"publications":["28787010"],"evidence":["Literature"],"phenotypes":[],"mode_of_inheritance":"","tags":[],"panel":{"id":394,"hash_id":null,"name":"Familial Meniere Disease","disease_group":"Hearing and ear disorders","disease_sub_group":"Other hearing and ear disorders","status":"public","version":"1.1","version_created":"2018-01-17T16:26:29.432517Z","relevant_disorders":[],"stats":{"number_of_genes":130,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["CD283"],"biotype":"protein_coding","hgnc_id":"HGNC:11849","gene_name":"toll like receptor 3","omim_gene":["603029"],"alias_name":null,"gene_symbol":"TLR3","hgnc_symbol":"TLR3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"4:186990306-187009223","ensembl_id":"ENSG00000164342"}},"GRch38":{"90":{"location":"4:186069152-186088069","ensembl_id":"ENSG00000164342"}}},"hgnc_date_symbol_changed":"1998-06-25"},"entity_type":"gene","entity_name":"TLR3","confidence_level":"3","penetrance":"Incomplete","mode_of_pathogenicity":"Other - please provide details in the comments","publications":["21911422","25339207","25339207","28368532"],"evidence":["NHS GMS","North West GLH","London North GLH","Expert Review Green","IUIS Classification February 2018","Victorian Clinical Genetics Services","Other"],"phenotypes":["Herpes simplex encephalitis, susceptibility to, 2","Herpetic encephalitis (HSE)","Herpes simplex virus 1 encephalitis (incomplete clinical penetrance for all etiologies listed here)","Defects in Intrinsic and Innate Immunity"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":["missense"],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}}]}