{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["TGN","AITD3"],"biotype":"protein_coding","hgnc_id":"HGNC:11764","gene_name":"thyroglobulin","omim_gene":["188450"],"alias_name":null,"gene_symbol":"TG","hgnc_symbol":"TG","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"8:133879203-134147147","ensembl_id":"ENSG00000042832"}},"GRch38":{"90":{"location":"8:132866958-133134903","ensembl_id":"ENSG00000042832"}}},"hgnc_date_symbol_changed":"2001-06-22"},"entity_type":"gene","entity_name":"TG","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["16403815","21476894","28345837"],"evidence":["Expert Review Red","UKGTN","Radboud University Medical Center, Nijmegen","Literature","Illumina TruGenome Clinical Sequencing Services"],"phenotypes":["Thyroid dyshormonogenesis 3 274700"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":171,"hash_id":"576cd7ca8f6203609632be82","name":"Inherited non-medullary thyroid cancer","disease_group":"Tumour syndromes","disease_sub_group":"Breast and endocrine","status":"public","version":"1.4","version_created":"2017-11-05T02:37:20.162547Z","relevant_disorders":[],"stats":{"number_of_genes":30,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["TGN","AITD3"],"biotype":"protein_coding","hgnc_id":"HGNC:11764","gene_name":"thyroglobulin","omim_gene":["188450"],"alias_name":null,"gene_symbol":"TG","hgnc_symbol":"TG","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"8:133879203-134147147","ensembl_id":"ENSG00000042832"}},"GRch38":{"90":{"location":"8:132866958-133134903","ensembl_id":"ENSG00000042832"}}},"hgnc_date_symbol_changed":"2001-06-22"},"entity_type":"gene","entity_name":"TG","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["23164529","27525530 (Nicholas et al.,2016) identify a monogenic and polygenic basis of disease."],"evidence":["Expert Review Green","Eligibility statement prior genetic testing","UKGTN"],"phenotypes":["Congenital hypothyroidism","Thyroid dyshormonogenesis 3,  274700","TDH3","low thyroglobulin, goitre"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":["monogenic-polygenic"],"panel":{"id":31,"hash_id":"5763f2938f620350a1996046","name":"Congenital hypothyroidism","disease_group":"Endocrine disorders","disease_sub_group":"Thyroid disorders","status":"public","version":"2.0","version_created":"2019-07-31T13:52:41.584963Z","relevant_disorders":["Congenital hypothyroidism or thyroid agenesis","R145"],"stats":{"number_of_genes":34,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}}]}