{"count":6,"next":null,"previous":null,"results":[{"gene_data":{"alias":["TIE2","TIE-2","VMCM1","CD202b"],"biotype":"protein_coding","hgnc_id":"HGNC:11724","gene_name":"TEK receptor tyrosine kinase","omim_gene":["600221"],"alias_name":null,"gene_symbol":"TEK","hgnc_symbol":"TEK","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"9:27109139-27230173","ensembl_id":"ENSG00000120156"}},"GRch38":{"90":{"location":"9:27109141-27230175","ensembl_id":"ENSG00000120156"}}},"hgnc_date_symbol_changed":"1994-05-24"},"entity_type":"gene","entity_name":"TEK","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","Illumina TruGenome Clinical Sequencing Services","Radboud University Medical Center, Nijmegen"],"phenotypes":["Venous malformations, multiple cutaneous and mucosal, 600195","Multiple Cutaneous and Mucosal Venous Malformations"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":147,"hash_id":"5819a24f8f6203341de99c89","name":"Cerebral vascular malformations","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Cerebrovascular disorders","status":"public","version":"1.47","version_created":"2019-09-13T13:47:21.970257Z","relevant_disorders":["Cerebrovascular disorders","Vein of Galen malformation","Cerebral arteriovenous malformations","Moyamoya disease"],"stats":{"number_of_genes":95,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["TIE2","TIE-2","VMCM1","CD202b"],"biotype":"protein_coding","hgnc_id":"HGNC:11724","gene_name":"TEK receptor tyrosine kinase","omim_gene":["600221"],"alias_name":null,"gene_symbol":"TEK","hgnc_symbol":"TEK","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"9:27109139-27230173","ensembl_id":"ENSG00000120156"}},"GRch38":{"90":{"location":"9:27109141-27230175","ensembl_id":"ENSG00000120156"}}},"hgnc_date_symbol_changed":"1994-05-24"},"entity_type":"gene","entity_name":"TEK","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["27519652"],"evidence":["Radboud University Medical Center, Nijmegen","Expert Review Red","Illumina TruGenome Clinical Sequencing Services"],"phenotypes":["Venous malformations, multiple cutaneous and mucosal 600195"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":123,"hash_id":"5633857722c1fc582756e3d9","name":"Hereditary haemorrhagic telangiectasia","disease_group":"Respiratory disorders","disease_sub_group":"Vascular lung disorders","status":"public","version":"2.0","version_created":"2019-09-23T17:00:03.179221Z","relevant_disorders":["Familial and multiple pulmonary arteriovenous malformations","R186"],"stats":{"number_of_genes":15,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}},{"gene_data":{"alias":["TIE2","TIE-2","VMCM1","CD202b"],"biotype":"protein_coding","hgnc_id":"HGNC:11724","gene_name":"TEK receptor tyrosine kinase","omim_gene":["600221"],"alias_name":null,"gene_symbol":"TEK","hgnc_symbol":"TEK","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"9:27109139-27230173","ensembl_id":"ENSG00000120156"}},"GRch38":{"90":{"location":"9:27109141-27230175","ensembl_id":"ENSG00000120156"}}},"hgnc_date_symbol_changed":"1994-05-24"},"entity_type":"gene","entity_name":"TEK","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["London North GLH","NHS GMS","Expert Review Green"],"phenotypes":["Venous malformations"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":563,"hash_id":null,"name":"Vascular skin disorders","disease_group":"","disease_sub_group":"","status":"public","version":"0.13","version_created":"2019-09-09T15:38:44.120161Z","relevant_disorders":[],"stats":{"number_of_genes":34,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["TIE2","TIE-2","VMCM1","CD202b"],"biotype":"protein_coding","hgnc_id":"HGNC:11724","gene_name":"TEK receptor tyrosine kinase","omim_gene":["600221"],"alias_name":null,"gene_symbol":"TEK","hgnc_symbol":"TEK","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"9:27109139-27230173","ensembl_id":"ENSG00000120156"}},"GRch38":{"90":{"location":"9:27109141-27230175","ensembl_id":"ENSG00000120156"}}},"hgnc_date_symbol_changed":"1994-05-24"},"entity_type":"gene","entity_name":"TEK","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","PAGE DD-Gene2Phenotype"],"phenotypes":["VENOUS MALFORMATIONS, MULTIPLE CUTANEOUS AND MUCOSAL"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":478,"hash_id":null,"name":"Fetal anomalies","disease_group":"","disease_sub_group":"","status":"public","version":"0.344","version_created":"2019-09-17T09:38:10.568007Z","relevant_disorders":["R21"],"stats":{"number_of_genes":1721,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["TIE2","TIE-2","VMCM1","CD202b"],"biotype":"protein_coding","hgnc_id":"HGNC:11724","gene_name":"TEK receptor tyrosine kinase","omim_gene":["600221"],"alias_name":null,"gene_symbol":"TEK","hgnc_symbol":"TEK","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"9:27109139-27230173","ensembl_id":"ENSG00000120156"}},"GRch38":{"90":{"location":"9:27109141-27230175","ensembl_id":"ENSG00000120156"}}},"hgnc_date_symbol_changed":"1994-05-24"},"entity_type":"gene","entity_name":"TEK","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"Other - please provide details in the comments","publications":["19888299","7833915","10369874"],"evidence":["DD-Gene2Phenotype","Expert Review Green"],"phenotypes":["VENOUS MALFORMATIONS, MULTIPLE CUTANEOUS AND MUCOSAL 600195"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":484,"hash_id":null,"name":"DDG2P","disease_group":"","disease_sub_group":"","status":"public","version":"1.137","version_created":"2019-10-08T15:56:59.220133Z","relevant_disorders":[],"stats":{"number_of_genes":1893,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["TIE2","TIE-2","VMCM1","CD202b"],"biotype":"protein_coding","hgnc_id":"HGNC:11724","gene_name":"TEK receptor tyrosine kinase","omim_gene":["600221"],"alias_name":null,"gene_symbol":"TEK","hgnc_symbol":"TEK","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"9:27109139-27230173","ensembl_id":"ENSG00000120156"}},"GRch38":{"90":{"location":"9:27109141-27230175","ensembl_id":"ENSG00000120156"}}},"hgnc_date_symbol_changed":"1994-05-24"},"entity_type":"gene","entity_name":"TEK","confidence_level":"2","penetrance":"Complete","mode_of_pathogenicity":"Other - please provide details in the comments","publications":[],"evidence":["Expert Review Amber","BRIDGE study SPEED NEURO Tier1 Gene"],"phenotypes":["Venous malformations, multiple cutaneous and mucosal, 600195"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":285,"hash_id":"558aa423bb5a16630e15b63c","name":"Intellectual disability","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Neurodevelopmental disorders","status":"public","version":"2.1065","version_created":"2019-10-07T13:42:16.019766Z","relevant_disorders":["Coarse facial features including Coffin-Siris-like disorders","ID","Moderate","severe or profound intellectual disability","Schizophrenia plus additional features","Intellectual disability - microarray","fragile X and sequencing"],"stats":{"number_of_genes":2253,"number_of_strs":11,"number_of_regions":57},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}}]}