{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:11720","gene_name":"tectorin alpha","omim_gene":["602574"],"alias_name":null,"gene_symbol":"TECTA","hgnc_symbol":"TECTA","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"11:120971882-121062202","ensembl_id":"ENSG00000109927"}},"GRch38":{"90":{"location":"11:121101173-121191493","ensembl_id":"ENSG00000109927"}}},"hgnc_date_symbol_changed":"1997-08-22"},"entity_type":"gene","entity_name":"TECTA","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","SFARI"],"phenotypes":[],"mode_of_inheritance":"","tags":[],"panel":{"id":657,"hash_id":null,"name":"Autism","disease_group":"","disease_sub_group":"","status":"public","version":"0.15","version_created":"2019-06-20T15:10:14.437740Z","relevant_disorders":[],"stats":{"number_of_genes":733,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Research","slug":"research","description":"This is a gene panel used for research."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:11720","gene_name":"tectorin alpha","omim_gene":["602574"],"alias_name":null,"gene_symbol":"TECTA","hgnc_symbol":"TECTA","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"11:120971882-121062202","ensembl_id":"ENSG00000109927"}},"GRch38":{"90":{"location":"11:121101173-121191493","ensembl_id":"ENSG00000109927"}}},"hgnc_date_symbol_changed":"1997-08-22"},"entity_type":"gene","entity_name":"TECTA","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["PMID: 10196713","10987647","11087000","11333869","12162770","12746400","15995703","16718611","17431902","17661817","18575463","6971620","9079715","9503015","9590290","9718342","9949200"],"evidence":["Expert Review Green","Expert","Radboud University Medical Center, Nijmegen","UKGTN","Emory Genetics Laboratory","Illumina TruGenome Clinical Sequencing Services"],"phenotypes":["hearing loss","Nonsyndromic Hearing Loss, Dominant","Deafness, autosomal dominant 8/12, 601543","Nonsyndromic Hearing Loss, Recessive","Nonsyndromic Hearing Loss, Dominant","#603629:Deafness, autosomal recessive 21"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":[],"panel":{"id":126,"hash_id":"558ac48fbb5a16630dcfeaad","name":"Hearing loss","disease_group":"Hearing and ear disorders","disease_sub_group":"Non-syndromic hearing loss","status":"public","version":"2.2","version_created":"2019-09-03T14:01:56.987667Z","relevant_disorders":["Congenital hearing impairment","Autosomal dominant deafness","Congenital hearing impairment (profound/severe)","R67"],"stats":{"number_of_genes":358,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}}]}