{"count":1,"next":null,"previous":null,"results":[{"gene_data":{"alias":["E2A","ITF1","MGC129647","MGC129648","bHLHb21","VDIR","E47"],"biotype":"protein_coding","hgnc_id":"HGNC:11633","gene_name":"transcription factor 3","omim_gene":["147141"],"alias_name":["transcription factor E2-alpha","immunoglobulin transcription factor 1","kappa-E2-binding factor","E2A immunoglobulin enhancer-binding factor E12/E47","VDR interacting repressor"],"gene_symbol":"TCF3","hgnc_symbol":"TCF3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"19:1609291-1652604","ensembl_id":"ENSG00000071564"}},"GRch38":{"90":{"location":"19:1609290-1652605","ensembl_id":"ENSG00000071564"}}},"hgnc_date_symbol_changed":"1990-07-26"},"entity_type":"gene","entity_name":"TCF3","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments","publications":["24216514","28532655","29114388"],"evidence":["NHS GMS","North West GLH","London North GLH","Expert Review Green","IUIS Classification February 2018","Victorian Clinical Genetics Services","ESID Registry 20171117","A- or hypo-gammaglobulinaemia v1.25"],"phenotypes":["Agammaglobulinemia","Agammaglobulinemia 8, autosomal dominant, 616941","Primary immunodeficiency","Recurrent bacterial infections","Predominantly Antibody Deficiencies"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}}]}