{"count":7,"next":null,"previous":null,"results":[{"gene_data":{"alias":["HEB","HTF4","HsT17266","bHLHb20"],"biotype":"protein_coding","hgnc_id":"HGNC:11623","gene_name":"transcription factor 12","omim_gene":["600480"],"alias_name":["helix-loop-helix transcription factor 4"],"gene_symbol":"TCF12","hgnc_symbol":"TCF12","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"15:57210821-57591479","ensembl_id":"ENSG00000140262"}},"GRch38":{"90":{"location":"15:56918623-57299281","ensembl_id":"ENSG00000140262"}}},"hgnc_date_symbol_changed":"1994-06-17"},"entity_type":"gene","entity_name":"TCF12","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["23354436"],"evidence":["NHS GMS","Expert Review Green","Literature"],"phenotypes":["Craniosynostosis 3  615314"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":179,"hash_id":"5763f35c8f620350a22bccdf","name":"Hydrocephalus","disease_group":"","disease_sub_group":"","status":"public","version":"1.38","version_created":"2019-09-30T12:37:55.307389Z","relevant_disorders":["Hydrocephalus;R86"],"stats":{"number_of_genes":98,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["HEB","HTF4","HsT17266","bHLHb20"],"biotype":"protein_coding","hgnc_id":"HGNC:11623","gene_name":"transcription factor 12","omim_gene":["600480"],"alias_name":["helix-loop-helix transcription factor 4"],"gene_symbol":"TCF12","hgnc_symbol":"TCF12","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"15:57210821-57591479","ensembl_id":"ENSG00000140262"}},"GRch38":{"90":{"location":"15:56918623-57299281","ensembl_id":"ENSG00000140262"}}},"hgnc_date_symbol_changed":"1994-06-17"},"entity_type":"gene","entity_name":"TCF12","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS","Expert list","Expert Review Green"],"phenotypes":["Craniosynostosis 3 615314"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":507,"hash_id":null,"name":"Common craniosynostosis syndromes","disease_group":"","disease_sub_group":"","status":"public","version":"1.0","version_created":"2019-09-04T09:49:37.773020Z","relevant_disorders":["R99"],"stats":{"number_of_genes":7,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}},{"gene_data":{"alias":["HEB","HTF4","HsT17266","bHLHb20"],"biotype":"protein_coding","hgnc_id":"HGNC:11623","gene_name":"transcription factor 12","omim_gene":["600480"],"alias_name":["helix-loop-helix transcription factor 4"],"gene_symbol":"TCF12","hgnc_symbol":"TCF12","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"15:57210821-57591479","ensembl_id":"ENSG00000140262"}},"GRch38":{"90":{"location":"15:56918623-57299281","ensembl_id":"ENSG00000140262"}}},"hgnc_date_symbol_changed":"1994-06-17"},"entity_type":"gene","entity_name":"TCF12","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["23354436"],"evidence":["NHS GMS","Expert Review Green","UKGTN","Radboud University Medical Center, Nijmegen","Expert list"],"phenotypes":["Craniosynostosis 3 615314"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":309,"hash_id":"5693952f22c1fc251660fb1e","name":"Skeletal dysplasia","disease_group":"Skeletal disorders","disease_sub_group":"Skeletal dysplasias","status":"public","version":"1.203","version_created":"2019-10-03T09:38:50.417968Z","relevant_disorders":["Unexplained skeletal dysplasia","Skeletal dysplasia"],"stats":{"number_of_genes":546,"number_of_strs":1,"number_of_regions":6},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["HEB","HTF4","HsT17266","bHLHb20"],"biotype":"protein_coding","hgnc_id":"HGNC:11623","gene_name":"transcription factor 12","omim_gene":["600480"],"alias_name":["helix-loop-helix transcription factor 4"],"gene_symbol":"TCF12","hgnc_symbol":"TCF12","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"15:57210821-57591479","ensembl_id":"ENSG00000140262"}},"GRch38":{"90":{"location":"15:56918623-57299281","ensembl_id":"ENSG00000140262"}}},"hgnc_date_symbol_changed":"1994-06-17"},"entity_type":"gene","entity_name":"TCF12","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["PAGE DD-Gene2Phenotype","Expert Review Green"],"phenotypes":["CORONAL CRANIOSYNOSTOSIS"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":478,"hash_id":null,"name":"Fetal anomalies","disease_group":"","disease_sub_group":"","status":"public","version":"0.344","version_created":"2019-09-17T09:38:10.568007Z","relevant_disorders":["R21"],"stats":{"number_of_genes":1721,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["HEB","HTF4","HsT17266","bHLHb20"],"biotype":"protein_coding","hgnc_id":"HGNC:11623","gene_name":"transcription factor 12","omim_gene":["600480"],"alias_name":["helix-loop-helix transcription factor 4"],"gene_symbol":"TCF12","hgnc_symbol":"TCF12","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"15:57210821-57591479","ensembl_id":"ENSG00000140262"}},"GRch38":{"90":{"location":"15:56918623-57299281","ensembl_id":"ENSG00000140262"}}},"hgnc_date_symbol_changed":"1994-06-17"},"entity_type":"gene","entity_name":"TCF12","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["23354436","25271085","24736737"],"evidence":["NHS GMS","Expert Review Green","Eligibility statement prior genetic testing","Expert list","UKGTN","Radboud University Medical Center, Nijmegen"],"phenotypes":["Craniosynostosis 3, 615314","Craniosynostosis 3"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":168,"hash_id":"55b605f722c1fc05fd2345af","name":"Craniosynostosis","disease_group":"Skeletal disorders","disease_sub_group":"Craniosynostosis syndromes","status":"public","version":"2.0","version_created":"2019-09-17T13:00:09.542482Z","relevant_disorders":["Craniosynostosis syndromes","Craniosynostosis syndromes phenotypes","Rare syndromic craniosynostosis or isolated multisuture synostosis","R100"],"stats":{"number_of_genes":114,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}},{"gene_data":{"alias":["HEB","HTF4","HsT17266","bHLHb20"],"biotype":"protein_coding","hgnc_id":"HGNC:11623","gene_name":"transcription factor 12","omim_gene":["600480"],"alias_name":["helix-loop-helix transcription factor 4"],"gene_symbol":"TCF12","hgnc_symbol":"TCF12","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"15:57210821-57591479","ensembl_id":"ENSG00000140262"}},"GRch38":{"90":{"location":"15:56918623-57299281","ensembl_id":"ENSG00000140262"}}},"hgnc_date_symbol_changed":"1994-06-17"},"entity_type":"gene","entity_name":"TCF12","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["23354436"],"evidence":["DD-Gene2Phenotype","Expert Review Green"],"phenotypes":["CORONAL CRANIOSYNOSTOSIS"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":484,"hash_id":null,"name":"DDG2P","disease_group":"","disease_sub_group":"","status":"public","version":"1.137","version_created":"2019-10-08T15:56:59.220133Z","relevant_disorders":[],"stats":{"number_of_genes":1893,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["HEB","HTF4","HsT17266","bHLHb20"],"biotype":"protein_coding","hgnc_id":"HGNC:11623","gene_name":"transcription factor 12","omim_gene":["600480"],"alias_name":["helix-loop-helix transcription factor 4"],"gene_symbol":"TCF12","hgnc_symbol":"TCF12","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"15:57210821-57591479","ensembl_id":"ENSG00000140262"}},"GRch38":{"90":{"location":"15:56918623-57299281","ensembl_id":"ENSG00000140262"}}},"hgnc_date_symbol_changed":"1994-06-17"},"entity_type":"gene","entity_name":"TCF12","confidence_level":"2","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Amber","BRIDGE study SPEED NEURO Tier1 Gene"],"phenotypes":["Craniosynostosis 3, 615314"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":285,"hash_id":"558aa423bb5a16630e15b63c","name":"Intellectual disability","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Neurodevelopmental disorders","status":"public","version":"2.1065","version_created":"2019-10-07T13:42:16.019766Z","relevant_disorders":["Coarse facial features including Coffin-Siris-like disorders","ID","Moderate","severe or profound intellectual disability","Schizophrenia plus additional features","Intellectual disability - microarray","fragile X and sequencing"],"stats":{"number_of_genes":2253,"number_of_strs":11,"number_of_regions":57},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}}]}
