{"count":8,"next":null,"previous":null,"results":[{"gene_data":{"alias":["TBX3-ISO","XHL"],"biotype":"protein_coding","hgnc_id":"HGNC:11602","gene_name":"T-box 3","omim_gene":["601621"],"alias_name":null,"gene_symbol":"TBX3","hgnc_symbol":"TBX3","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"12:115108059-115121969","ensembl_id":"ENSG00000135111"}},"GRch38":{"90":{"location":"12:114670254-114684164","ensembl_id":"ENSG00000135111"}}},"hgnc_date_symbol_changed":"1997-06-18"},"entity_type":"gene","entity_name":"TBX3","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Expert list","Other"],"phenotypes":["Ulnar-mammary syndrome, 181450","Hypoplastic/absent/deformed radius"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":247,"hash_id":"5763f4588f620350a199604e","name":"Radial dysplasia","disease_group":"Dysmorphic and congenital abnormality syndromes","disease_sub_group":"Dysmorphic disorders","status":"public","version":"1.6","version_created":"2017-11-05T02:37:20.295815Z","relevant_disorders":[],"stats":{"number_of_genes":59,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["TBX3-ISO","XHL"],"biotype":"protein_coding","hgnc_id":"HGNC:11602","gene_name":"T-box 3","omim_gene":["601621"],"alias_name":null,"gene_symbol":"TBX3","hgnc_symbol":"TBX3","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"12:115108059-115121969","ensembl_id":"ENSG00000135111"}},"GRch38":{"90":{"location":"12:114670254-114684164","ensembl_id":"ENSG00000135111"}}},"hgnc_date_symbol_changed":"1997-06-18"},"entity_type":"gene","entity_name":"TBX3","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Emory Genetics Laboratory"],"phenotypes":[],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":101,"hash_id":"553f9598bb5a1616e5ed45ae","name":"VACTERL-like phenotypes","disease_group":"Dysmorphic and congenital abnormality syndromes","disease_sub_group":"Limb disorders","status":"public","version":"1.24","version_created":"2019-06-20T15:15:18.221805Z","relevant_disorders":[],"stats":{"number_of_genes":58,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["TBX3-ISO","XHL"],"biotype":"protein_coding","hgnc_id":"HGNC:11602","gene_name":"T-box 3","omim_gene":["601621"],"alias_name":null,"gene_symbol":"TBX3","hgnc_symbol":"TBX3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"12:115108059-115121969","ensembl_id":"ENSG00000135111"}},"GRch38":{"90":{"location":"12:114670254-114684164","ensembl_id":"ENSG00000135111"}}},"hgnc_date_symbol_changed":"1997-06-18"},"entity_type":"gene","entity_name":"TBX3","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":null,"publications":[],"evidence":["Victorian Clinical Genetics Services","Emory Genetics Laboratory","Expert list","Illumina TruGenome Clinical Sequencing Services","Radboud University Medical Center, Nijmegen","UKGTN","Expert Review Green","London South East RGC GSTT","Viapath"],"phenotypes":["Ulnar-mammary syndrome 181450","Polydactyly","Ulnar-mammary syndrome, 181450","Radial Ray abnormality","Hypoplastic/absent/deformed radius"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":384,"hash_id":null,"name":"Limb disorders","disease_group":"","disease_sub_group":"","status":"public","version":"1.61","version_created":"2019-10-03T10:01:34.398179Z","relevant_disorders":[],"stats":{"number_of_genes":234,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["TBX3-ISO","XHL"],"biotype":"protein_coding","hgnc_id":"HGNC:11602","gene_name":"T-box 3","omim_gene":["601621"],"alias_name":null,"gene_symbol":"TBX3","hgnc_symbol":"TBX3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"12:115108059-115121969","ensembl_id":"ENSG00000135111"}},"GRch38":{"90":{"location":"12:114670254-114684164","ensembl_id":"ENSG00000135111"}}},"hgnc_date_symbol_changed":"1997-06-18"},"entity_type":"gene","entity_name":"TBX3","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","South West GLH"],"phenotypes":[],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":506,"hash_id":null,"name":"Progressive cardiac conduction disease","disease_group":"","disease_sub_group":"","status":"public","version":"0.28","version_created":"2019-09-09T16:10:26.535463Z","relevant_disorders":["R328"],"stats":{"number_of_genes":15,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["TBX3-ISO","XHL"],"biotype":"protein_coding","hgnc_id":"HGNC:11602","gene_name":"T-box 3","omim_gene":["601621"],"alias_name":null,"gene_symbol":"TBX3","hgnc_symbol":"TBX3","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"12:115108059-115121969","ensembl_id":"ENSG00000135111"}},"GRch38":{"90":{"location":"12:114670254-114684164","ensembl_id":"ENSG00000135111"}}},"hgnc_date_symbol_changed":"1997-06-18"},"entity_type":"gene","entity_name":"TBX3","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["28961683","30654152","28145909"],"evidence":["NHS GMS","Expert Review Green","Expert list","UKGTN","Emory Genetics Laboratory","Illumina TruGenome Clinical Sequencing Services","Radboud University Medical Center, Nijmegen",""],"phenotypes":["Ulnar-mammary syndrome 181450"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":309,"hash_id":"5693952f22c1fc251660fb1e","name":"Skeletal dysplasia","disease_group":"Skeletal disorders","disease_sub_group":"Skeletal dysplasias","status":"public","version":"1.203","version_created":"2019-10-03T09:38:50.417968Z","relevant_disorders":["Unexplained skeletal dysplasia","Skeletal dysplasia"],"stats":{"number_of_genes":546,"number_of_strs":1,"number_of_regions":6},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["TBX3-ISO","XHL"],"biotype":"protein_coding","hgnc_id":"HGNC:11602","gene_name":"T-box 3","omim_gene":["601621"],"alias_name":null,"gene_symbol":"TBX3","hgnc_symbol":"TBX3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"12:115108059-115121969","ensembl_id":"ENSG00000135111"}},"GRch38":{"90":{"location":"12:114670254-114684164","ensembl_id":"ENSG00000135111"}}},"hgnc_date_symbol_changed":"1997-06-18"},"entity_type":"gene","entity_name":"TBX3","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["PAGE DD-Gene2Phenotype","Expert Review Green"],"phenotypes":["ULNAR-MAMMARY SYNDROME"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":478,"hash_id":null,"name":"Fetal anomalies","disease_group":"","disease_sub_group":"","status":"public","version":"0.344","version_created":"2019-09-17T09:38:10.568007Z","relevant_disorders":["R21"],"stats":{"number_of_genes":1721,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["TBX3-ISO","XHL"],"biotype":"protein_coding","hgnc_id":"HGNC:11602","gene_name":"T-box 3","omim_gene":["601621"],"alias_name":null,"gene_symbol":"TBX3","hgnc_symbol":"TBX3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"12:115108059-115121969","ensembl_id":"ENSG00000135111"}},"GRch38":{"90":{"location":"12:114670254-114684164","ensembl_id":"ENSG00000135111"}}},"hgnc_date_symbol_changed":"1997-06-18"},"entity_type":"gene","entity_name":"TBX3","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["19938096","9207801","12116211","12668170"],"evidence":["DD-Gene2Phenotype","Expert Review Green"],"phenotypes":["ULNAR-MAMMARY SYNDROME 181450"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":484,"hash_id":null,"name":"DDG2P","disease_group":"","disease_sub_group":"","status":"public","version":"1.137","version_created":"2019-10-08T15:56:59.220133Z","relevant_disorders":[],"stats":{"number_of_genes":1893,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["TBX3-ISO","XHL"],"biotype":"protein_coding","hgnc_id":"HGNC:11602","gene_name":"T-box 3","omim_gene":["601621"],"alias_name":null,"gene_symbol":"TBX3","hgnc_symbol":"TBX3","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"12:115108059-115121969","ensembl_id":"ENSG00000135111"}},"GRch38":{"90":{"location":"12:114670254-114684164","ensembl_id":"ENSG00000135111"}}},"hgnc_date_symbol_changed":"1997-06-18"},"entity_type":"gene","entity_name":"TBX3","confidence_level":"2","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Amber","BRIDGE study SPEED NEURO Tier1 Gene"],"phenotypes":["Ulnar-mammary syndrome, 181450"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":285,"hash_id":"558aa423bb5a16630e15b63c","name":"Intellectual disability","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Neurodevelopmental disorders","status":"public","version":"2.1065","version_created":"2019-10-07T13:42:16.019766Z","relevant_disorders":["Coarse facial features including Coffin-Siris-like disorders","ID","Moderate","severe or profound intellectual disability","Schizophrenia plus additional features","Intellectual disability - microarray","fragile X and sequencing"],"stats":{"number_of_genes":2253,"number_of_strs":11,"number_of_regions":57},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}}]}