{"count":3,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:11303","gene_name":"signal recognition particle 72","omim_gene":["602122"],"alias_name":null,"gene_symbol":"SRP72","hgnc_symbol":"SRP72","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"4:57333081-57369839","ensembl_id":"ENSG00000174780"}},"GRch38":{"90":{"location":"4:56466915-56503680","ensembl_id":"ENSG00000174780"}}},"hgnc_date_symbol_changed":"1991-12-05"},"entity_type":"gene","entity_name":"SRP72","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":["23926458","28600339"],"evidence":["Expert Review Amber","North West GLH","Yorkshire and North East GLH","NHS GMS","Wessex and West Midlands GLH"],"phenotypes":["602122 (OMIN gene description ID)","602122 Bone marrow failure syndrome 1"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":525,"hash_id":null,"name":"Inherited predisposition to acute myeloid leukaemia (AML)","disease_group":"","disease_sub_group":"","status":"public","version":"1.0","version_created":"2019-09-23T13:06:38.692384Z","relevant_disorders":["R347"],"stats":{"number_of_genes":14,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:11303","gene_name":"signal recognition particle 72","omim_gene":["602122"],"alias_name":null,"gene_symbol":"SRP72","hgnc_symbol":"SRP72","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"4:57333081-57369839","ensembl_id":"ENSG00000174780"}},"GRch38":{"90":{"location":"4:56466915-56503680","ensembl_id":"ENSG00000174780"}}},"hgnc_date_symbol_changed":"1991-12-05"},"entity_type":"gene","entity_name":"SRP72","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","UKGTN","Radboud University Medical Center, Nijmegen","Expert list","Illumina TruGenome Clinical Sequencing Services"],"phenotypes":["Inherited Bone Marrow Failure Syndromes - Aplastic Anaemia","Bone Marrow Failure, Familial","Bone marrow failure, familial, 614675","Familial Bone Marrow Failure","Familial MDS (Myelodysplastic syndromes)","Bone Marrow Failure, Familial"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":["watchlist"],"panel":{"id":159,"hash_id":"58a70e858f62037e8779b2e8","name":"Cytopenias and congenital anaemias","disease_group":"Haematological disorders","disease_sub_group":"Anaemias and red cell disorders","status":"public","version":"1.73","version_created":"2019-09-23T11:25:32.403071Z","relevant_disorders":["Aplastic anaemia with or without paroxysmal nocturnal haemoglobinuria","Apparent aplastic anaemia or paroxysmal nocturnal haemoglobinuria","Congenital anaemias","Early onset pancytopenia and red cell disorders","Anaemias and red cell disorders","Cytopaenias and congenital anaemias","Cytopenia and pancytopenia"],"stats":{"number_of_genes":219,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:11303","gene_name":"signal recognition particle 72","omim_gene":["602122"],"alias_name":null,"gene_symbol":"SRP72","hgnc_symbol":"SRP72","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"4:57333081-57369839","ensembl_id":"ENSG00000174780"}},"GRch38":{"90":{"location":"4:56466915-56503680","ensembl_id":"ENSG00000174780"}}},"hgnc_date_symbol_changed":"1991-12-05"},"entity_type":"gene","entity_name":"SRP72","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":["22541560","29146883"],"evidence":["Expert Review Amber","North West GLH","Yorkshire and North East GLH","London South GLH","NHS GMS","Wessex and West Midlands GLH"],"phenotypes":["Inherited Bone Marrow Failure Syndromes - Aplastic Anaemia","Bone marrow failure, familial, 614675","Familial MDS (Myelodysplastic syndromes)","Bone Marrow Failure, Familial","614675 Bone marrow failure syndrome 1","Familial Bone Marrow Failure"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":519,"hash_id":null,"name":"Cytopenia - NOT Fanconi anaemia","disease_group":"","disease_sub_group":"","status":"public","version":"0.120","version_created":"2019-09-23T10:29:43.892929Z","relevant_disorders":["R91","R258"],"stats":{"number_of_genes":84,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}}]}