{"count":7,"next":null,"previous":null,"results":[{"gene_data":{"alias":["R51H3","Trad","HsTRAD"],"biotype":"protein_coding","hgnc_id":"HGNC:9823","gene_name":"RAD51 paralog D","omim_gene":["602954"],"alias_name":["recombination repair protein","DNA repair protein RAD51 homolog 4"],"gene_symbol":"RAD51D","hgnc_symbol":"RAD51D","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"17:33426811-33448541","ensembl_id":"ENSG00000185379"}},"GRch38":{"90":{"location":"17:35092208-35121522","ensembl_id":"ENSG00000185379"}}},"hgnc_date_symbol_changed":"2011-07-01"},"entity_type":"gene","entity_name":"RAD51D","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Illumina TruGenome Clinical Sequencing Services","Emory Genetics Laboratory","Radboud University Medical Center, Nijmegen"],"phenotypes":["{Breast-ovarian cancer, familial, susceptibility to, 4}, 614291","Breast and Ovarian Cancer","Breast and Ovarian Cancer Susceptibility"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":158,"hash_id":"55b62bc422c1fc05fc7a1857","name":"Familial breast cancer","disease_group":"Tumour syndromes","disease_sub_group":"Breast and endocrine","status":"public","version":"1.13","version_created":"2017-11-05T02:37:20.139339Z","relevant_disorders":["Familial breast and or ovarian cancer"],"stats":{"number_of_genes":26,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["R51H3","Trad","HsTRAD"],"biotype":"protein_coding","hgnc_id":"HGNC:9823","gene_name":"RAD51 paralog D","omim_gene":["602954"],"alias_name":["recombination repair protein","DNA repair protein RAD51 homolog 4"],"gene_symbol":"RAD51D","hgnc_symbol":"RAD51D","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"17:33426811-33448541","ensembl_id":"ENSG00000185379"}},"GRch38":{"90":{"location":"17:35092208-35121522","ensembl_id":"ENSG00000185379"}}},"hgnc_date_symbol_changed":"2011-07-01"},"entity_type":"gene","entity_name":"RAD51D","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["25445424","21822267","22652533","22415235","10749867","17942895","15781618"],"evidence":["Expert Review Red","ClinGen"],"phenotypes":["Hereditary breast cancer","OrphaNet ORPHA227535","OMIM 614291"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":64,"hash_id":"58ee38f88f62033bda307d54","name":"ClinGen Gene Validity Curations","disease_group":"","disease_sub_group":"","status":"public","version":"0.64","version_created":"2019-06-20T15:10:34.572009Z","relevant_disorders":[],"stats":{"number_of_genes":47,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"ClinGen Curated genes","slug":"clingen-curated-genes","description":"ClinGen Curated genes"}]}},{"gene_data":{"alias":["R51H3","Trad","HsTRAD"],"biotype":"protein_coding","hgnc_id":"HGNC:9823","gene_name":"RAD51 paralog D","omim_gene":["602954"],"alias_name":["recombination repair protein","DNA repair protein RAD51 homolog 4"],"gene_symbol":"RAD51D","hgnc_symbol":"RAD51D","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"17:33426811-33448541","ensembl_id":"ENSG00000185379"}},"GRch38":{"90":{"location":"17:35092208-35121522","ensembl_id":"ENSG00000185379"}}},"hgnc_date_symbol_changed":"2011-07-01"},"entity_type":"gene","entity_name":"RAD51D","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Expert list"],"phenotypes":["Ovarian cancer"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":117,"hash_id":"596f8ca98f620352d1224c1e","name":"Ovarian cancer pertinent cancer susceptibility","disease_group":"Cancer Programme","disease_sub_group":"Pertinent cancer susceptibility gene panel","status":"public","version":"1.0","version_created":"2017-11-05T02:37:20.061451Z","relevant_disorders":["Ovarian"],"stats":{"number_of_genes":8,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Cancer Germline 100K","slug":"cancer-germline-100k","description":"Cancer Germline 100K"}]}},{"gene_data":{"alias":["R51H3","Trad","HsTRAD"],"biotype":"protein_coding","hgnc_id":"HGNC:9823","gene_name":"RAD51 paralog D","omim_gene":["602954"],"alias_name":["recombination repair protein","DNA repair protein RAD51 homolog 4"],"gene_symbol":"RAD51D","hgnc_symbol":"RAD51D","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"17:33426811-33448541","ensembl_id":"ENSG00000185379"}},"GRch38":{"90":{"location":"17:35092208-35121522","ensembl_id":"ENSG00000185379"}}},"hgnc_date_symbol_changed":"2011-07-01"},"entity_type":"gene","entity_name":"RAD51D","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":null,"publications":[],"evidence":["Expert Review Green","Expert list"],"phenotypes":["Ovarian cancer"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":391,"hash_id":null,"name":"Adult solid tumours for rare disease","disease_group":"Tumour syndromes","disease_sub_group":"Tumour syndromes","status":"public","version":"1.22","version_created":"2019-06-20T15:10:02.142139Z","relevant_disorders":["Young adult onset cancer","Exceptionally young adult onset cancer","Multiple Tumours","Rare tumour predisposition syndromes"],"stats":{"number_of_genes":58,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["R51H3","Trad","HsTRAD"],"biotype":"protein_coding","hgnc_id":"HGNC:9823","gene_name":"RAD51 paralog D","omim_gene":["602954"],"alias_name":["recombination repair protein","DNA repair protein RAD51 homolog 4"],"gene_symbol":"RAD51D","hgnc_symbol":"RAD51D","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"17:33426811-33448541","ensembl_id":"ENSG00000185379"}},"GRch38":{"90":{"location":"17:35092208-35121522","ensembl_id":"ENSG00000185379"}}},"hgnc_date_symbol_changed":"2011-07-01"},"entity_type":"gene","entity_name":"RAD51D","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS","Expert List","Expert Review Green","Emory Genetics Laboratory","Radboud University Medical Center, Nijmegen","Illumina TruGenome Clinical Sequencing Services"],"phenotypes":["{Breast-ovarian cancer, familial, susceptibility to, 4}, 614291","Breast and Ovarian Cancer","Breast and Ovarian Cancer Susceptibility"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":143,"hash_id":"592843a08f6203468490fa68","name":"Inherited ovarian cancer (without breast cancer)","disease_group":"Tumour syndromes","disease_sub_group":"Breast and endocrine","status":"public","version":"2.0","version_created":"2019-08-16T09:48:34.583608Z","relevant_disorders":["Familial ovarian cancer","R207"],"stats":{"number_of_genes":26,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}},{"gene_data":{"alias":["R51H3","Trad","HsTRAD"],"biotype":"protein_coding","hgnc_id":"HGNC:9823","gene_name":"RAD51 paralog D","omim_gene":["602954"],"alias_name":["recombination repair protein","DNA repair protein RAD51 homolog 4"],"gene_symbol":"RAD51D","hgnc_symbol":"RAD51D","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"17:33426811-33448541","ensembl_id":"ENSG00000185379"}},"GRch38":{"90":{"location":"17:35092208-35121522","ensembl_id":"ENSG00000185379"}}},"hgnc_date_symbol_changed":"2011-07-01"},"entity_type":"gene","entity_name":"RAD51D","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Adult solid tumours for rare disease (Version 1.21)"],"phenotypes":["Ovarian cancer"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":470,"hash_id":null,"name":"Tumour predisposition - adult onset","disease_group":"","disease_sub_group":"","status":"public","version":"1.1","version_created":"2019-06-20T15:14:23.703488Z","relevant_disorders":[],"stats":{"number_of_genes":63,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["R51H3","Trad","HsTRAD"],"biotype":"protein_coding","hgnc_id":"HGNC:9823","gene_name":"RAD51 paralog D","omim_gene":["602954"],"alias_name":["recombination repair protein","DNA repair protein RAD51 homolog 4"],"gene_symbol":"RAD51D","hgnc_symbol":"RAD51D","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"17:33426811-33448541","ensembl_id":"ENSG00000185379"}},"GRch38":{"90":{"location":"17:35092208-35121522","ensembl_id":"ENSG00000185379"}}},"hgnc_date_symbol_changed":"2011-07-01"},"entity_type":"gene","entity_name":"RAD51D","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS","Expert Review Green","Expert list"],"phenotypes":["Ovarian cancer"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":245,"hash_id":"595ce30f8f62036352471f39","name":"Adult solid tumours cancer susceptibility","disease_group":"Cancer Programme","disease_sub_group":"Pertinent cancer susceptibility gene panel","status":"public","version":"1.7","version_created":"2019-08-13T09:55:08.772098Z","relevant_disorders":["Carcinoma of unknown primary","Other","Adult solid tumours pertinent cancer susceptibility"],"stats":{"number_of_genes":103,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Cancer Germline 100K","slug":"cancer-germline-100k","description":"Cancer Germline 100K"},{"name":"GMS Cancer Germline Virtual","slug":"gms-cancer-germline-virtual","description":"This is a panel used for WGS germline analysis for the GMS."}]}}]}