{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:9451","gene_name":"protein C, inactivator of coagulation factors Va and VIIIa","omim_gene":["612283"],"alias_name":["prepro-protein C"],"gene_symbol":"PROC","hgnc_symbol":"PROC","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"2:128176003-128186822","ensembl_id":"ENSG00000115718"}},"GRch38":{"90":{"location":"2:127418427-127429246","ensembl_id":"ENSG00000115718"}}},"hgnc_date_symbol_changed":"2001-06-22"},"entity_type":"gene","entity_name":"PROC","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Eligibility statement prior genetic testing","Illumina TruGenome Clinical Sequencing Services","Radboud University Medical Center, Nijmegen","UKGTN","Expert Review Green","BRIDGE Study Tier 1 Gene"],"phenotypes":["Protein C deficiency","Protein C Deficiency","Thrombophilia due to protein C deficiency, autosomal dominant 176860","Thrombophilia due to protein C deficiency, autosomal recessive 612304","Thrombophilia Due To Protein C Deficiency, Autosomal Dominant","Thrombophilia Due To Protein C Deficiency, Autosomal Recessive"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":[],"panel":{"id":175,"hash_id":"5763f32a8f620350a22bccde","name":"Inherited bleeding disorders","disease_group":"Haematological and immunological disorders","disease_sub_group":"Haemostasis disorders","status":"public","version":"1.156","version_created":"2019-08-09T13:55:23.938344Z","relevant_disorders":["Inherited platelet disorders","Monogenic thrombophilia","Inherited bleeding and or platelet disorders","Unprovoked Thrombosis before 40","Monogenic venous thrombosis"],"stats":{"number_of_genes":119,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:9451","gene_name":"protein C, inactivator of coagulation factors Va and VIIIa","omim_gene":["612283"],"alias_name":["prepro-protein C"],"gene_symbol":"PROC","hgnc_symbol":"PROC","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"2:128176003-128186822","ensembl_id":"ENSG00000115718"}},"GRch38":{"90":{"location":"2:127418427-127429246","ensembl_id":"ENSG00000115718"}}},"hgnc_date_symbol_changed":"2001-06-22"},"entity_type":"gene","entity_name":"PROC","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["North West GLH","Yorkshire and North East GLH","London South GLH","NHS GMS","Expert Review Green","Wessex and West Midlands GLH"],"phenotypes":["612304 Thrombophilia due to protein C deficiency, autosomal recessive","176860 Thrombophilia due to protein C deficiency, autosomal dominant"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":[],"panel":{"id":516,"hash_id":null,"name":"Thrombophilia","disease_group":"","disease_sub_group":"","status":"public","version":"1.0","version_created":"2019-09-23T14:53:24.252789Z","relevant_disorders":["R97"],"stats":{"number_of_genes":20,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}}]}