{"count":5,"next":null,"previous":null,"results":[{"gene_data":{"alias":["PGK","PKG"],"biotype":"protein_coding","hgnc_id":"HGNC:9414","gene_name":"protein kinase, cGMP-dependent, type I","omim_gene":["176894"],"alias_name":null,"gene_symbol":"PRKG1","hgnc_symbol":"PRKG1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"10:52750945-54058110","ensembl_id":"ENSG00000185532"}},"GRch38":{"90":{"location":"10:50991358-52298350","ensembl_id":"ENSG00000185532"}}},"hgnc_date_symbol_changed":"1991-07-17"},"entity_type":"gene","entity_name":"PRKG1","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","ClinGen"],"phenotypes":["Familial thoracic aortic aneurysm and aortic dissection"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":210,"hash_id":"594be3878f62037ee3e7e72f","name":"ClinGen_Familial thoracic aortic aneurysm and aortic dissection","disease_group":"","disease_sub_group":"","status":"public","version":"0.10","version_created":"2017-11-05T02:37:20.232365Z","relevant_disorders":[],"stats":{"number_of_genes":53,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"ClinGen Curated genes","slug":"clingen-curated-genes","description":"ClinGen Curated genes"}]}},{"gene_data":{"alias":["PGK","PKG"],"biotype":"protein_coding","hgnc_id":"HGNC:9414","gene_name":"protein kinase, cGMP-dependent, type I","omim_gene":["176894"],"alias_name":null,"gene_symbol":"PRKG1","hgnc_symbol":"PRKG1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"10:52750945-54058110","ensembl_id":"ENSG00000185532"}},"GRch38":{"90":{"location":"10:50991358-52298350","ensembl_id":"ENSG00000185532"}}},"hgnc_date_symbol_changed":"1991-07-17"},"entity_type":"gene","entity_name":"PRKG1","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS"],"phenotypes":[],"mode_of_inheritance":"","tags":[],"panel":{"id":105,"hash_id":"572c908e8f62036eed0a39c8","name":"Pneumothorax - familial","disease_group":"Respiratory disorders","disease_sub_group":"Structural lung disorders","status":"public","version":"1.18","version_created":"2019-09-27T18:57:12.249816Z","relevant_disorders":["Familial Pneumothorax","Familial Primary Spontaneous Pneumothorax","R190"],"stats":{"number_of_genes":35,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["PGK","PKG"],"biotype":"protein_coding","hgnc_id":"HGNC:9414","gene_name":"protein kinase, cGMP-dependent, type I","omim_gene":["176894"],"alias_name":null,"gene_symbol":"PRKG1","hgnc_symbol":"PRKG1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"10:52750945-54058110","ensembl_id":"ENSG00000185532"}},"GRch38":{"90":{"location":"10:50991358-52298350","ensembl_id":"ENSG00000185532"}}},"hgnc_date_symbol_changed":"1991-07-17"},"entity_type":"gene","entity_name":"PRKG1","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","BRIDGE consortium (NIHRBR-RD)"],"phenotypes":["Enzyme Disorder"],"mode_of_inheritance":"Unknown","tags":[],"panel":{"id":159,"hash_id":"58a70e858f62037e8779b2e8","name":"Cytopenias and congenital anaemias","disease_group":"Haematological disorders","disease_sub_group":"Anaemias and red cell disorders","status":"public","version":"1.73","version_created":"2019-09-23T11:25:32.403071Z","relevant_disorders":["Aplastic anaemia with or without paroxysmal nocturnal haemoglobinuria","Apparent aplastic anaemia or paroxysmal nocturnal haemoglobinuria","Congenital anaemias","Early onset pancytopenia and red cell disorders","Anaemias and red cell disorders","Cytopaenias and congenital anaemias","Cytopenia and pancytopenia"],"stats":{"number_of_genes":219,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["PGK","PKG"],"biotype":"protein_coding","hgnc_id":"HGNC:9414","gene_name":"protein kinase, cGMP-dependent, type I","omim_gene":["176894"],"alias_name":null,"gene_symbol":"PRKG1","hgnc_symbol":"PRKG1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"10:52750945-54058110","ensembl_id":"ENSG00000185532"}},"GRch38":{"90":{"location":"10:50991358-52298350","ensembl_id":"ENSG00000185532"}}},"hgnc_date_symbol_changed":"1991-07-17"},"entity_type":"gene","entity_name":"PRKG1","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["South West GLH","London South GLH","Expert Review Amber","South West GLH","London South GLH"],"phenotypes":["Aortic aneurysm, familial thoracic 8, 615436"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":700,"hash_id":null,"name":"Thoracic aortic aneurysm and dissection","disease_group":"","disease_sub_group":"","status":"public","version":"0.32","version_created":"2019-10-02T11:56:22.695639Z","relevant_disorders":["R125"],"stats":{"number_of_genes":62,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["PGK","PKG"],"biotype":"protein_coding","hgnc_id":"HGNC:9414","gene_name":"protein kinase, cGMP-dependent, type I","omim_gene":["176894"],"alias_name":null,"gene_symbol":"PRKG1","hgnc_symbol":"PRKG1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"10:52750945-54058110","ensembl_id":"ENSG00000185532"}},"GRch38":{"90":{"location":"10:50991358-52298350","ensembl_id":"ENSG00000185532"}}},"hgnc_date_symbol_changed":"1991-07-17"},"entity_type":"gene","entity_name":"PRKG1","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["South West GLH","London South GLH","Expert Review Green","Radboud University Medical Center, Nijmegen"],"phenotypes":["Aortic aneurysm, familial thoracic 8, 615436"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":1,"hash_id":"5596735822c1fc4f7d26e96d","name":"Thoracic aortic aneurysm or dissection","disease_group":"Cardiovascular disorders","disease_sub_group":"Connective tissue disorders and aortopathies","status":"public","version":"1.103","version_created":"2019-10-02T10:51:03.815181Z","relevant_disorders":["Familial retinal arteriolar tortuosity","FTAAD","Familial Thoracic Aortic Aneurysm Disease"],"stats":{"number_of_genes":63,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}}]}