{"count":3,"next":null,"previous":null,"results":[{"gene_data":{"alias":["E1k"],"biotype":"protein_coding","hgnc_id":"HGNC:8124","gene_name":"oxoglutarate dehydrogenase","omim_gene":["613022"],"alias_name":null,"gene_symbol":"OGDH","hgnc_symbol":"OGDH","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"7:44646171-44748665","ensembl_id":"ENSG00000105953"}},"GRch38":{"90":{"location":"7:44606572-44709066","ensembl_id":"ENSG00000105953"}}},"hgnc_date_symbol_changed":"1989-06-30"},"entity_type":"gene","entity_name":"OGDH","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["27604308"],"evidence":["Radboud University Medical Center, Nijmegen","Expert Review Red","Literature"],"phenotypes":["2-Oxoglutarate dehydrogenase deficiency (Disorders of the citric acid cycle)","Alpha-ketoglutarate dehydrogenase deficiency, 203740","(OXOGLUTARIC ACIDURIA)"],"mode_of_inheritance":"Unknown","tags":[],"panel":{"id":302,"hash_id":"5763f1518f620350a22bccdb","name":"Undiagnosed metabolic disorders","disease_group":"Metabolic disorders","disease_sub_group":"Specific metabolic abnormalities","status":"public","version":"1.373","version_created":"2019-10-08T14:47:17.153678Z","relevant_disorders":["Undiagnosed Metabolic Panel"],"stats":{"number_of_genes":744,"number_of_strs":1,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["E1k"],"biotype":"protein_coding","hgnc_id":"HGNC:8124","gene_name":"oxoglutarate dehydrogenase","omim_gene":["613022"],"alias_name":null,"gene_symbol":"OGDH","hgnc_symbol":"OGDH","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"7:44646171-44748665","ensembl_id":"ENSG00000105953"}},"GRch38":{"90":{"location":"7:44606572-44709066","ensembl_id":"ENSG00000105953"}}},"hgnc_date_symbol_changed":"1989-06-30"},"entity_type":"gene","entity_name":"OGDH","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":["27604308"],"evidence":["London North GLH","NHS GMS","Expert Review Red"],"phenotypes":["2-Oxoglutarate dehydrogenase deficiency (Disorders of the citric acid cycle)","Alpha-ketoglutarate dehydrogenase deficiency, 203740 (1)","(OXOGLUTARIC ACIDURIA)","Alpha-ketoglutarate dehydrogenase deficiency, 203740"],"mode_of_inheritance":"Unknown","tags":[],"panel":{"id":467,"hash_id":null,"name":"Inborn errors of metabolism","disease_group":"","disease_sub_group":"","status":"public","version":"1.348","version_created":"2019-10-09T08:19:52.386941Z","relevant_disorders":["Likely inborn error of metabolism - targeted testing not possible"],"stats":{"number_of_genes":877,"number_of_strs":2,"number_of_regions":1},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["E1k"],"biotype":"protein_coding","hgnc_id":"HGNC:8124","gene_name":"oxoglutarate dehydrogenase","omim_gene":["613022"],"alias_name":null,"gene_symbol":"OGDH","hgnc_symbol":"OGDH","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"7:44646171-44748665","ensembl_id":"ENSG00000105953"}},"GRch38":{"90":{"location":"7:44606572-44709066","ensembl_id":"ENSG00000105953"}}},"hgnc_date_symbol_changed":"1989-06-30"},"entity_type":"gene","entity_name":"OGDH","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Radboud University Medical Center, Nijmegen"],"phenotypes":["Alpha-ketoglutarate dehydrogenase deficiency, 203740 (1)"],"mode_of_inheritance":"","tags":[],"panel":{"id":112,"hash_id":"55928cf522c1fc4f7d26e960","name":"Mitochondrial disorders","disease_group":"Metabolic disorders","disease_sub_group":"Mitochondrial","status":"public","version":"2.1","version_created":"2019-10-01T15:59:44.993681Z","relevant_disorders":["Lactic acidosis","All recognised syndromes and those with suggestive features"],"stats":{"number_of_genes":467,"number_of_strs":2,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}}]}