{"count":6,"next":null,"previous":null,"results":[{"gene_data":{"alias":["NTH1","OCTS3"],"biotype":"protein_coding","hgnc_id":"HGNC:8028","gene_name":"nth like DNA glycosylase 1","omim_gene":["602656"],"alias_name":null,"gene_symbol":"NTHL1","hgnc_symbol":"NTHL1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"16:2089816-2097867","ensembl_id":"ENSG00000065057"}},"GRch38":{"90":{"location":"16:2039815-2047866","ensembl_id":"ENSG00000065057"}}},"hgnc_date_symbol_changed":"1998-05-27"},"entity_type":"gene","entity_name":"NTHL1","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["25938944"],"evidence":["Expert Review Green","Literature","UKGTN"],"phenotypes":["Familial adenomatous polyposis 3\t616415"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":244,"hash_id":"596f84848f620352d0e3eeba","name":"Colorectal cancer pertinent cancer susceptibility","disease_group":"Cancer Programme","disease_sub_group":"Pertinent cancer susceptibility gene panel","status":"public","version":"1.0","version_created":"2017-11-05T02:37:20.290684Z","relevant_disorders":["Colorectal"],"stats":{"number_of_genes":13,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Cancer Germline 100K","slug":"cancer-germline-100k","description":"Cancer Germline 100K"}]}},{"gene_data":{"alias":["NTH1","OCTS3"],"biotype":"protein_coding","hgnc_id":"HGNC:8028","gene_name":"nth like DNA glycosylase 1","omim_gene":["602656"],"alias_name":null,"gene_symbol":"NTHL1","hgnc_symbol":"NTHL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"16:2089816-2097867","ensembl_id":"ENSG00000065057"}},"GRch38":{"90":{"location":"16:2039815-2047866","ensembl_id":"ENSG00000065057"}}},"hgnc_date_symbol_changed":"1998-05-27"},"entity_type":"gene","entity_name":"NTHL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":null,"publications":[],"evidence":["Expert list","Expert Review Green"],"phenotypes":["Colorectal cancer"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":391,"hash_id":null,"name":"Adult solid tumours for rare disease","disease_group":"Tumour syndromes","disease_sub_group":"Tumour syndromes","status":"public","version":"1.22","version_created":"2019-06-20T15:10:02.142139Z","relevant_disorders":["Young adult onset cancer","Exceptionally young adult onset cancer","Multiple Tumours","Rare tumour predisposition syndromes"],"stats":{"number_of_genes":58,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["NTH1","OCTS3"],"biotype":"protein_coding","hgnc_id":"HGNC:8028","gene_name":"nth like DNA glycosylase 1","omim_gene":["602656"],"alias_name":null,"gene_symbol":"NTHL1","hgnc_symbol":"NTHL1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"16:2089816-2097867","ensembl_id":"ENSG00000065057"}},"GRch38":{"90":{"location":"16:2039815-2047866","ensembl_id":"ENSG00000065057"}}},"hgnc_date_symbol_changed":"1998-05-27"},"entity_type":"gene","entity_name":"NTHL1","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["25938944"],"evidence":["NHS GMS","Expert List","Research","Literature","Expert Review","Expert Review Green"],"phenotypes":["Familial adenomatous polyposis 3\t616415"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":254,"hash_id":"591444928f620348d4b20c16","name":"GI tract tumours","disease_group":"Tumour syndromes","disease_sub_group":"GI tract","status":"public","version":"1.18","version_created":"2019-08-05T14:17:21.117330Z","relevant_disorders":["GI tract tumours","Familial colon cancer","Multiple bowel polyps","Peutz-Jeghers syndrome","GI tract","Inherited colorectal cancer (with or without polyposis)"],"stats":{"number_of_genes":30,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["NTH1","OCTS3"],"biotype":"protein_coding","hgnc_id":"HGNC:8028","gene_name":"nth like DNA glycosylase 1","omim_gene":["602656"],"alias_name":null,"gene_symbol":"NTHL1","hgnc_symbol":"NTHL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"16:2089816-2097867","ensembl_id":"ENSG00000065057"}},"GRch38":{"90":{"location":"16:2039815-2047866","ensembl_id":"ENSG00000065057"}}},"hgnc_date_symbol_changed":"1998-05-27"},"entity_type":"gene","entity_name":"NTHL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Adult solid tumours for rare disease (Version 1.21)"],"phenotypes":["Colorectal cancer"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":470,"hash_id":null,"name":"Tumour predisposition - adult onset","disease_group":"","disease_sub_group":"","status":"public","version":"1.1","version_created":"2019-06-20T15:14:23.703488Z","relevant_disorders":[],"stats":{"number_of_genes":63,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["NTH1","OCTS3"],"biotype":"protein_coding","hgnc_id":"HGNC:8028","gene_name":"nth like DNA glycosylase 1","omim_gene":["602656"],"alias_name":null,"gene_symbol":"NTHL1","hgnc_symbol":"NTHL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"16:2089816-2097867","ensembl_id":"ENSG00000065057"}},"GRch38":{"90":{"location":"16:2039815-2047866","ensembl_id":"ENSG00000065057"}}},"hgnc_date_symbol_changed":"1998-05-27"},"entity_type":"gene","entity_name":"NTHL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","NHS GMS","Expert List"],"phenotypes":["Familial adenomatous polyposis 3\t616415"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":504,"hash_id":null,"name":"Inherited polyposis","disease_group":"","disease_sub_group":"","status":"public","version":"0.55","version_created":"2019-09-03T09:14:02.359574Z","relevant_disorders":["R211","R209"],"stats":{"number_of_genes":17,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["NTH1","OCTS3"],"biotype":"protein_coding","hgnc_id":"HGNC:8028","gene_name":"nth like DNA glycosylase 1","omim_gene":["602656"],"alias_name":null,"gene_symbol":"NTHL1","hgnc_symbol":"NTHL1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"16:2089816-2097867","ensembl_id":"ENSG00000065057"}},"GRch38":{"90":{"location":"16:2039815-2047866","ensembl_id":"ENSG00000065057"}}},"hgnc_date_symbol_changed":"1998-05-27"},"entity_type":"gene","entity_name":"NTHL1","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS","Expert Review Green","Expert list"],"phenotypes":["Colorectal cancer"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":245,"hash_id":"595ce30f8f62036352471f39","name":"Adult solid tumours cancer susceptibility","disease_group":"Cancer Programme","disease_sub_group":"Pertinent cancer susceptibility gene panel","status":"public","version":"1.7","version_created":"2019-08-13T09:55:08.772098Z","relevant_disorders":["Carcinoma of unknown primary","Other","Adult solid tumours pertinent cancer susceptibility"],"stats":{"number_of_genes":103,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Cancer Germline 100K","slug":"cancer-germline-100k","description":"Cancer Germline 100K"},{"name":"GMS Cancer Germline Virtual","slug":"gms-cancer-germline-virtual","description":"This is a panel used for WGS germline analysis for the GMS."}]}}]}