{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["KIAA0389"],"biotype":"protein_coding","hgnc_id":"HGNC:7605","gene_name":"myosin VI","omim_gene":["600970"],"alias_name":null,"gene_symbol":"MYO6","hgnc_symbol":"MYO6","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"6:76458909-76629254","ensembl_id":"ENSG00000196586"}},"GRch38":{"90":{"location":"6:75749192-75919537","ensembl_id":"ENSG00000196586"}}},"hgnc_date_symbol_changed":"1996-04-04"},"entity_type":"gene","entity_name":"MYO6","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["South West GLH","Radboud University Medical Center, Nijmegen"],"phenotypes":["Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":49,"hash_id":"55a39e2d22c1fc6711b0c6b3","name":"Hypertrophic cardiomyopathy - teen and adult","disease_group":"Cardiovascular disorders","disease_sub_group":"Cardiomyopathy","status":"public","version":"1.77","version_created":"2019-10-02T12:51:19.933333Z","relevant_disorders":["Hypertrophic Cardiomyopathy","HCM","R131"],"stats":{"number_of_genes":70,"number_of_strs":1,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["KIAA0389"],"biotype":"protein_coding","hgnc_id":"HGNC:7605","gene_name":"myosin VI","omim_gene":["600970"],"alias_name":null,"gene_symbol":"MYO6","hgnc_symbol":"MYO6","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"6:76458909-76629254","ensembl_id":"ENSG00000196586"}},"GRch38":{"90":{"location":"6:75749192-75919537","ensembl_id":"ENSG00000196586"}}},"hgnc_date_symbol_changed":"1996-04-04"},"entity_type":"gene","entity_name":"MYO6","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["PMID:10519557","11167014","11468689","11707568","12134162","12687499","12966030","15006355","15060111","15123708","15721263","15944696","16908842","16949370","18212818","18348273","19417007","19744958","7493015","7929586","8884266","9259267"],"evidence":["Expert Review Green","Expert","Radboud University Medical Center, Nijmegen","Emory Genetics Laboratory","UKGTN","Illumina TruGenome Clinical Sequencing Services"],"phenotypes":["Nonsyndromic Hearing Loss, Dominant","Deafness, autosomal dominant 22, 606346","Nonsyndromic Hearing Loss, Recessive","#606346:Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy","#607821:Deafness, autosomal recessive 37"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":[],"panel":{"id":126,"hash_id":"558ac48fbb5a16630dcfeaad","name":"Hearing loss","disease_group":"Hearing and ear disorders","disease_sub_group":"Non-syndromic hearing loss","status":"public","version":"2.2","version_created":"2019-09-03T14:01:56.987667Z","relevant_disorders":["Congenital hearing impairment","Autosomal dominant deafness","Congenital hearing impairment (profound/severe)","R67"],"stats":{"number_of_genes":358,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}}]}