{"count":3,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:7562","gene_name":"myeloid differentiation primary response 88","omim_gene":["602170"],"alias_name":null,"gene_symbol":"MYD88","hgnc_symbol":"MYD88","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:38179969-38184513","ensembl_id":"ENSG00000172936"}},"GRch38":{"90":{"location":"3:38138478-38143022","ensembl_id":"ENSG00000172936"}}},"hgnc_date_symbol_changed":"1997-12-23"},"entity_type":"gene","entity_name":"MYD88","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":null,"publications":["28787010"],"evidence":["Literature"],"phenotypes":[],"mode_of_inheritance":"","tags":[],"panel":{"id":394,"hash_id":null,"name":"Familial Meniere Disease","disease_group":"Hearing and ear disorders","disease_sub_group":"Other hearing and ear disorders","status":"public","version":"1.1","version_created":"2018-01-17T16:26:29.432517Z","relevant_disorders":[],"stats":{"number_of_genes":130,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:7562","gene_name":"myeloid differentiation primary response 88","omim_gene":["602170"],"alias_name":null,"gene_symbol":"MYD88","hgnc_symbol":"MYD88","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:38179969-38184513","ensembl_id":"ENSG00000172936"}},"GRch38":{"90":{"location":"3:38138478-38143022","ensembl_id":"ENSG00000172936"}}},"hgnc_date_symbol_changed":"1997-12-23"},"entity_type":"gene","entity_name":"MYD88","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":null,"publications":["18669862","23215570"],"evidence":["NHS GMS","North West GLH","London North GLH","IUIS Classification February 2018","Victorian Clinical Genetics Services","Expert Review Green","ESID Registry 20171117","GRID V2.0","A- or hypo-gammaglobulinaemia v1.25"],"phenotypes":["Pyogenic bacterial infections, recurrent, due to MYD88 deficiency 612260","Defects of TLR/NFkappa-B signalling","recurrent pyogenic bacterial infection","Bacterial infections (pyogens)","Defects in Intrinsic and Innate Immunity"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:7562","gene_name":"myeloid differentiation primary response 88","omim_gene":["602170"],"alias_name":null,"gene_symbol":"MYD88","hgnc_symbol":"MYD88","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"3:38179969-38184513","ensembl_id":"ENSG00000172936"}},"GRch38":{"90":{"location":"3:38138478-38143022","ensembl_id":"ENSG00000172936"}}},"hgnc_date_symbol_changed":"1997-12-23"},"entity_type":"gene","entity_name":"MYD88","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","Radboud University Medical Center, Nijmegen"],"phenotypes":["Pyogenic bacterial infections, recurrent, due to MYD88 deficiency, 612260","Macroglobulinemia, Waldenstrom, somatic, 153600"],"mode_of_inheritance":"","tags":[],"panel":{"id":159,"hash_id":"58a70e858f62037e8779b2e8","name":"Cytopenias and congenital anaemias","disease_group":"Haematological disorders","disease_sub_group":"Anaemias and red cell disorders","status":"public","version":"1.73","version_created":"2019-09-23T11:25:32.403071Z","relevant_disorders":["Aplastic anaemia with or without paroxysmal nocturnal haemoglobinuria","Apparent aplastic anaemia or paroxysmal nocturnal haemoglobinuria","Congenital anaemias","Early onset pancytopenia and red cell disorders","Anaemias and red cell disorders","Cytopaenias and congenital anaemias","Cytopenia and pancytopenia"],"stats":{"number_of_genes":219,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}}]}
