{"count":5,"next":null,"previous":null,"results":[{"gene_data":{"alias":["MDS1-EVI1","PRDM3","KMT8E"],"biotype":"protein_coding","hgnc_id":"HGNC:3498","gene_name":"MDS1 and EVI1 complex locus","omim_gene":["165215"],"alias_name":["PR domain 3"],"gene_symbol":"MECOM","hgnc_symbol":"MECOM","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"3:168801287-169381406","ensembl_id":"ENSG00000085276"}},"GRch38":{"90":{"location":"3:169083499-169663618","ensembl_id":"ENSG00000085276"}}},"hgnc_date_symbol_changed":"2009-08-07"},"entity_type":"gene","entity_name":"MECOM","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","BRIDGE Study Tier 1 Gene"],"phenotypes":["transcription factor and gives the same pathology (thrombocytopenia with bone defects) as HOXA11","Radioulnar synostosis with amegakaryocytic thrombocytopenia 2"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":175,"hash_id":"5763f32a8f620350a22bccde","name":"Inherited bleeding disorders","disease_group":"Haematological and immunological disorders","disease_sub_group":"Haemostasis disorders","status":"public","version":"1.156","version_created":"2019-08-09T13:55:23.938344Z","relevant_disorders":["Inherited platelet disorders","Monogenic thrombophilia","Inherited bleeding and or platelet disorders","Unprovoked Thrombosis before 40","Monogenic venous thrombosis"],"stats":{"number_of_genes":119,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["MDS1-EVI1","PRDM3","KMT8E"],"biotype":"protein_coding","hgnc_id":"HGNC:3498","gene_name":"MDS1 and EVI1 complex locus","omim_gene":["165215"],"alias_name":["PR domain 3"],"gene_symbol":"MECOM","hgnc_symbol":"MECOM","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:168801287-169381406","ensembl_id":"ENSG00000085276"}},"GRch38":{"90":{"location":"3:169083499-169663618","ensembl_id":"ENSG00000085276"}}},"hgnc_date_symbol_changed":"2009-08-07"},"entity_type":"gene","entity_name":"MECOM","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["26581901","29540340","29519864"],"evidence":["North West GLH","Yorkshire and North East GLH","London South GLH","NHS GMS","Expert Review Green","Wessex and West Midlands GLH"],"phenotypes":["616738 Radioulnar synostosis with amegakaryocytic thrombocytopenia 2"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":545,"hash_id":null,"name":"Bleeding and platelet disorders","disease_group":"","disease_sub_group":"","status":"public","version":"0.78","version_created":"2019-09-23T11:07:54.788299Z","relevant_disorders":["R90"],"stats":{"number_of_genes":111,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["MDS1-EVI1","PRDM3","KMT8E"],"biotype":"protein_coding","hgnc_id":"HGNC:3498","gene_name":"MDS1 and EVI1 complex locus","omim_gene":["165215"],"alias_name":["PR domain 3"],"gene_symbol":"MECOM","hgnc_symbol":"MECOM","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:168801287-169381406","ensembl_id":"ENSG00000085276"}},"GRch38":{"90":{"location":"3:169083499-169663618","ensembl_id":"ENSG00000085276"}}},"hgnc_date_symbol_changed":"2009-08-07"},"entity_type":"gene","entity_name":"MECOM","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["29540340"],"evidence":["Expert Review Green","North West GLH","Yorkshire and North East GLH","NHS GMS","London South GLH"],"phenotypes":["Radioulnar synostosis with amegakaryocytic thrombocytopenia 2, 616738","616738 Radioulnar synostosis with amegakaryocytic thrombocytopenia 2"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":519,"hash_id":null,"name":"Cytopenia - NOT Fanconi anaemia","disease_group":"","disease_sub_group":"","status":"public","version":"0.120","version_created":"2019-09-23T10:29:43.892929Z","relevant_disorders":["R91","R258"],"stats":{"number_of_genes":84,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["MDS1-EVI1","PRDM3","KMT8E"],"biotype":"protein_coding","hgnc_id":"HGNC:3498","gene_name":"MDS1 and EVI1 complex locus","omim_gene":["165215"],"alias_name":["PR domain 3"],"gene_symbol":"MECOM","hgnc_symbol":"MECOM","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:168801287-169381406","ensembl_id":"ENSG00000085276"}},"GRch38":{"90":{"location":"3:169083499-169663618","ensembl_id":"ENSG00000085276"}}},"hgnc_date_symbol_changed":"2009-08-07"},"entity_type":"gene","entity_name":"MECOM","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Amber","PAGE DD-Gene2Phenotype"],"phenotypes":["Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":478,"hash_id":null,"name":"Fetal anomalies","disease_group":"","disease_sub_group":"","status":"public","version":"0.344","version_created":"2019-09-17T09:38:10.568007Z","relevant_disorders":["R21"],"stats":{"number_of_genes":1721,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["MDS1-EVI1","PRDM3","KMT8E"],"biotype":"protein_coding","hgnc_id":"HGNC:3498","gene_name":"MDS1 and EVI1 complex locus","omim_gene":["165215"],"alias_name":["PR domain 3"],"gene_symbol":"MECOM","hgnc_symbol":"MECOM","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:168801287-169381406","ensembl_id":"ENSG00000085276"}},"GRch38":{"90":{"location":"3:169083499-169663618","ensembl_id":"ENSG00000085276"}}},"hgnc_date_symbol_changed":"2009-08-07"},"entity_type":"gene","entity_name":"MECOM","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"Other - please provide details in the comments","publications":["26581901"],"evidence":["DD-Gene2Phenotype","Expert Review Amber"],"phenotypes":["Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":484,"hash_id":null,"name":"DDG2P","disease_group":"","disease_sub_group":"","status":"public","version":"1.137","version_created":"2019-10-08T15:56:59.220133Z","relevant_disorders":[],"stats":{"number_of_genes":1893,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}}]}