{"count":13,"next":null,"previous":null,"results":[{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Emory Genetics Laboratory"],"phenotypes":["Eye Disorders"],"mode_of_inheritance":"","tags":[],"panel":{"id":249,"hash_id":"55507b25bb5a161bf644a3b2","name":"Glaucoma (developmental)","disease_group":"Ophthalmological disorders","disease_sub_group":"Anterior segment abnormalities","status":"public","version":"1.5","version_created":"2019-06-20T15:15:07.662717Z","relevant_disorders":[],"stats":{"number_of_genes":224,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"0","penetrance":null,"mode_of_pathogenicity":null,"publications":["22510444","23692385"],"evidence":["Expert Review Removed","Victorian Clinical Genetics Services"],"phenotypes":["Bardet-Biedl syndrome 17 615994","Polydactyly"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":384,"hash_id":null,"name":"Limb disorders","disease_group":"","disease_sub_group":"","status":"public","version":"1.61","version_created":"2019-10-03T10:01:34.398179Z","relevant_disorders":[],"stats":{"number_of_genes":234,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["22510444"],"evidence":["NHS GMS","Other","Expert Review Green","Expert Review Green"],"phenotypes":["Bardet-Biedl syndrome 17, 615994"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":543,"hash_id":null,"name":"Bardet Biedl syndrome","disease_group":"","disease_sub_group":"","status":"public","version":"1.0","version_created":"2019-10-02T14:32:04.185092Z","relevant_disorders":["R107"],"stats":{"number_of_genes":24,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"2","penetrance":"Complete","mode_of_pathogenicity":"","publications":["22510444","23692385"],"evidence":["Expert Review Amber","UKGTN"],"phenotypes":["Visceral Heterotaxy","Bardet-Biedl Syndrome 17"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":["watchlist"],"panel":{"id":178,"hash_id":"55a76be222c1fc6710839b9f","name":"Primary ciliary disorders","disease_group":"Ciliopathies","disease_sub_group":"Respiratory ciliopathies","status":"public","version":"1.19","version_created":"2019-06-20T15:15:15.426107Z","relevant_disorders":["Primary ciliary dyskinesia"],"stats":{"number_of_genes":140,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Amber","NHS GMS"],"phenotypes":[],"mode_of_inheritance":"","tags":[],"panel":{"id":549,"hash_id":null,"name":"Laterality disorders and isomerism","disease_group":"","disease_sub_group":"","status":"public","version":"0.51","version_created":"2019-09-27T19:31:06.459183Z","relevant_disorders":["R139"],"stats":{"number_of_genes":56,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["27312011","23692385","22510444"],"evidence":["Expert Review Green","NHS GMS"],"phenotypes":["Bardet-Biedl syndrome 17, 615994"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":678,"hash_id":null,"name":"Unexplained paediatric onset end-stage renal disease","disease_group":"","disease_sub_group":"","status":"public","version":"0.43","version_created":"2019-09-25T12:25:36.245604Z","relevant_disorders":["R257"],"stats":{"number_of_genes":229,"number_of_strs":0,"number_of_regions":3},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["PAGE Additional Gene List","Expert Review Green"],"phenotypes":["Bardet-Biedl syndrome 17 615994"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":478,"hash_id":null,"name":"Fetal anomalies","disease_group":"","disease_sub_group":"","status":"public","version":"0.344","version_created":"2019-09-17T09:38:10.568007Z","relevant_disorders":["R21"],"stats":{"number_of_genes":1721,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS","Expert Review Green"],"phenotypes":["Eye Disorders","Bardet-Biedl syndrome 17"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":307,"hash_id":"56e0238b22c1fc09c97a6e46","name":"Retinal disorders","disease_group":"Ophthalmological disorders","disease_sub_group":"Posterior segment abnormalities","status":"public","version":"1.199","version_created":"2019-10-08T09:22:18.436205Z","relevant_disorders":["Posterior segment abnormalities","Cone Dysfunction Syndrome","Developmental macular and foveal dystrophy","Inherited macular dystrophy","Leber Congenital Amaurosis Early-Onset Severe Retinal Dystrophy","Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy","Leber Congenital Amaurosis or Early-Onset Severe Retinal Dystrophy","Rod Dysfunction Syndrome","Rod-cone dystrophy","Familial exudative vitreoretinopathy","Familial exudative retinopathy","R32","R33","R34","R35"],"stats":{"number_of_genes":320,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS","Expert Review Red"],"phenotypes":["Bardet-Biedl syndrome 17, 615994","Eye Disorders"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":509,"hash_id":null,"name":"Structural eye disease","disease_group":"","disease_sub_group":"","status":"public","version":"0.93","version_created":"2019-10-09T13:18:12.923145Z","relevant_disorders":["R36"],"stats":{"number_of_genes":456,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["22510444","23692385","27312011"],"evidence":["Expert Review Green","UKGTN","Emory Genetics Laboratory","Radboud University Medical Center, Nijmegen","Expert list"],"phenotypes":["Bardet-Biedl syndrome 17, 615994"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":150,"hash_id":"568ea01e22c1fc1c78b6715d","name":"Rare multisystem ciliopathy disorders","disease_group":"Ciliopathies","disease_sub_group":"Congenital malformations caused by ciliopathies","status":"public","version":"1.121","version_created":"2019-09-26T13:15:06.802957Z","relevant_disorders":["Joubert syndrome","Bardet-Biedl Syndrome"],"stats":{"number_of_genes":201,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["22510444","27312011","23692385"],"evidence":["Expert Review Green","Radboud University Medical Center, Nijmegen","Expert list","Emory Genetics Laboratory","UKGTN","Expert Review Green"],"phenotypes":["Bardet-Biedl syndrome 17, 615994"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":722,"hash_id":null,"name":"Ophthalmological ciliopathies","disease_group":"","disease_sub_group":"","status":"public","version":"0.11","version_created":"2019-10-02T08:36:04.464711Z","relevant_disorders":[],"stats":{"number_of_genes":89,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["22510444","27312011","23692385"],"evidence":["Expert Review Green","Radboud University Medical Center, Nijmegen","Expert list","Emory Genetics Laboratory","UKGTN","Expert Review Green"],"phenotypes":["Bardet-Biedl syndrome 17, 615994"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":725,"hash_id":null,"name":"Renal ciliopathies","disease_group":"Ciliopathies","disease_sub_group":"Congenital malformations caused by ciliopathies","status":"public","version":"1.0","version_created":"2019-09-03T15:05:56.297619Z","relevant_disorders":[],"stats":{"number_of_genes":91,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}},{"gene_data":{"alias":["BBS17"],"biotype":"protein_coding","hgnc_id":"HGNC:6741","gene_name":"leucine zipper transcription factor like 1","omim_gene":["606568"],"alias_name":null,"gene_symbol":"LZTFL1","hgnc_symbol":"LZTFL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:45864808-45957534","ensembl_id":"ENSG00000163818"}},"GRch38":{"90":{"location":"3:45823316-45916042","ensembl_id":"ENSG00000163818"}}},"hgnc_date_symbol_changed":"2000-06-16"},"entity_type":"gene","entity_name":"LZTFL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["22510444","27312011","23692385"],"evidence":["Expert Review Green","Radboud University Medical Center, Nijmegen","Expert list","Emory Genetics Laboratory","UKGTN","Expert Review Green"],"phenotypes":["Bardet-Biedl syndrome 17, 615994"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":726,"hash_id":null,"name":"Skeletal ciliopathies","disease_group":"Ciliopathies","disease_sub_group":"Congenital malformations caused by ciliopathies","status":"public","version":"0.15","version_created":"2019-10-01T15:09:46.533258Z","relevant_disorders":[],"stats":{"number_of_genes":59,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}}]}