{"count":5,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6664","gene_name":"lysyl oxidase","omim_gene":["153455"],"alias_name":null,"gene_symbol":"LOX","hgnc_symbol":"LOX","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"5:121398890-121413980","ensembl_id":"ENSG00000113083"}},"GRch38":{"90":{"location":"5:122063195-122078360","ensembl_id":"ENSG00000113083"}}},"hgnc_date_symbol_changed":"1986-01-01"},"entity_type":"gene","entity_name":"LOX","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["ClinGen","Expert Review Green"],"phenotypes":["Familial thoracic aortic aneurysm and aortic dissection"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":210,"hash_id":"594be3878f62037ee3e7e72f","name":"ClinGen_Familial thoracic aortic aneurysm and aortic dissection","disease_group":"","disease_sub_group":"","status":"public","version":"0.10","version_created":"2017-11-05T02:37:20.232365Z","relevant_disorders":[],"stats":{"number_of_genes":53,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"ClinGen Curated genes","slug":"clingen-curated-genes","description":"ClinGen Curated genes"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6664","gene_name":"lysyl oxidase","omim_gene":["153455"],"alias_name":null,"gene_symbol":"LOX","hgnc_symbol":"LOX","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"5:121398890-121413980","ensembl_id":"ENSG00000113083"}},"GRch38":{"90":{"location":"5:122063195-122078360","ensembl_id":"ENSG00000113083"}}},"hgnc_date_symbol_changed":"1986-01-01"},"entity_type":"gene","entity_name":"LOX","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS"],"phenotypes":[],"mode_of_inheritance":"","tags":[],"panel":{"id":105,"hash_id":"572c908e8f62036eed0a39c8","name":"Pneumothorax - familial","disease_group":"Respiratory disorders","disease_sub_group":"Structural lung disorders","status":"public","version":"1.18","version_created":"2019-09-27T18:57:12.249816Z","relevant_disorders":["Familial Pneumothorax","Familial Primary Spontaneous Pneumothorax","R190"],"stats":{"number_of_genes":35,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6664","gene_name":"lysyl oxidase","omim_gene":["153455"],"alias_name":null,"gene_symbol":"LOX","hgnc_symbol":"LOX","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"5:121398890-121413980","ensembl_id":"ENSG00000113083"}},"GRch38":{"90":{"location":"5:122063195-122078360","ensembl_id":"ENSG00000113083"}}},"hgnc_date_symbol_changed":"1986-01-01"},"entity_type":"gene","entity_name":"LOX","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["South West GLH","London South GLH","Expert Review Amber","South West GLH","London South GLH"],"phenotypes":["Aortic aneurysm, familial thoracic 10, 617168","aortic aneurysm"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":700,"hash_id":null,"name":"Thoracic aortic aneurysm and dissection","disease_group":"","disease_sub_group":"","status":"public","version":"0.32","version_created":"2019-10-02T11:56:22.695639Z","relevant_disorders":["R125"],"stats":{"number_of_genes":62,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6664","gene_name":"lysyl oxidase","omim_gene":["153455"],"alias_name":null,"gene_symbol":"LOX","hgnc_symbol":"LOX","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"5:121398890-121413980","ensembl_id":"ENSG00000113083"}},"GRch38":{"90":{"location":"5:122063195-122078360","ensembl_id":"ENSG00000113083"}}},"hgnc_date_symbol_changed":"1986-01-01"},"entity_type":"gene","entity_name":"LOX","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["26838787","27432961"],"evidence":["South West GLH","London South GLH","Expert Review Green","Literature"],"phenotypes":["aortic aneurysm","Aortic aneurysm, familial thoracic 10, 617168"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":1,"hash_id":"5596735822c1fc4f7d26e96d","name":"Thoracic aortic aneurysm or dissection","disease_group":"Cardiovascular disorders","disease_sub_group":"Connective tissue disorders and aortopathies","status":"public","version":"1.103","version_created":"2019-10-02T10:51:03.815181Z","relevant_disorders":["Familial retinal arteriolar tortuosity","FTAAD","Familial Thoracic Aortic Aneurysm Disease"],"stats":{"number_of_genes":63,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6664","gene_name":"lysyl oxidase","omim_gene":["153455"],"alias_name":null,"gene_symbol":"LOX","hgnc_symbol":"LOX","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"5:121398890-121413980","ensembl_id":"ENSG00000113083"}},"GRch38":{"90":{"location":"5:122063195-122078360","ensembl_id":"ENSG00000113083"}}},"hgnc_date_symbol_changed":"1986-01-01"},"entity_type":"gene","entity_name":"LOX","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["26838787","27432961"],"evidence":["NHS GMS","Expert Review Green","Expert Review","Other"],"phenotypes":["Aortic aneurysm, familial thoracic 10, 617168"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":53,"hash_id":"588728f38f62030cf7152165","name":"Ehlers Danlos syndromes","disease_group":"Rheumatological disorders","disease_sub_group":"Connective tissues disorders","status":"public","version":"2.1","version_created":"2019-10-09T07:04:44.655768Z","relevant_disorders":["Classical Ehlers Danlos Syndrome","Classical Ehlers-Danlos Syndrome","Ehlers-Danlos Syndrome (unusual phenotypes e.g. absent pain sense)","Ehlers-Danlos syndrome type 3","Kyphoscoliotic Ehlers-Danlos syndrome","EDS","Ehlers-Danlos syndromes","R101"],"stats":{"number_of_genes":75,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}}]}