{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["LHR","LCGR","LGR2","ULG5"],"biotype":"protein_coding","hgnc_id":"HGNC:6585","gene_name":"luteinizing hormone/choriogonadotropin receptor","omim_gene":["152790"],"alias_name":null,"gene_symbol":"LHCGR","hgnc_symbol":"LHCGR","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"2:48859428-48982880","ensembl_id":"ENSG00000138039"}},"GRch38":{"90":{"location":"2:48686775-48755730","ensembl_id":"ENSG00000138039"}}},"hgnc_date_symbol_changed":"1990-03-05"},"entity_type":"gene","entity_name":"LHCGR","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","Illumina TruGenome Clinical Sequencing Services","Radboud University Medical Center, Nijmegen","Emory Genetics Laboratory","UKGTN"],"phenotypes":["Leydig cell hypoplasia with hypergonadotropic hypogonadism, Leydig cell hypoplasia with pseudohermaphroditism, Luteinizing hormone resistance,female, 238320","Endocrine Disorders including conditions such as hypogonadotropic hypogonadism (with or without anosmia): Sequencing Panel","Leydig cell adenoma,somatic,with precocious puberty,176410"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":92,"hash_id":"573b204d8f62030defb98057","name":"Hypogonadotropic hypogonadism","disease_group":"Endocrine disorders","disease_sub_group":"Hypothalamic and pituitary disorders","status":"public","version":"1.26","version_created":"2019-06-20T15:11:57.281996Z","relevant_disorders":["Kallmann syndrome","Kallmann syndrom","Idiopathic hypogonadotropic hypogonadism"],"stats":{"number_of_genes":46,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["LHR","LCGR","LGR2","ULG5"],"biotype":"protein_coding","hgnc_id":"HGNC:6585","gene_name":"luteinizing hormone/choriogonadotropin receptor","omim_gene":["152790"],"alias_name":null,"gene_symbol":"LHCGR","hgnc_symbol":"LHCGR","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"2:48859428-48982880","ensembl_id":"ENSG00000138039"}},"GRch38":{"90":{"location":"2:48686775-48755730","ensembl_id":"ENSG00000138039"}}},"hgnc_date_symbol_changed":"1990-03-05"},"entity_type":"gene","entity_name":"LHCGR","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Illumina TruGenome Clinical Sequencing Services","Radboud University Medical Center, Nijmegen","Emory Genetics Laboratory","UKGTN"],"phenotypes":["Gender Assignment Gene Panel (UKGTN)","Endocrine disorders including disorders of sexual development (Emory)","Leydic cell hypoplasia type 1, 238320","Precocious puberty, male, 176410"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":[],"panel":{"id":9,"hash_id":"569380ac22c1fc251660faf8","name":"Disorders of sex development","disease_group":"Endocrine disorders","disease_sub_group":"Gonadal and sex development disorders","status":"public","version":"2.1","version_created":"2019-10-01T10:16:03.440399Z","relevant_disorders":["R146"],"stats":{"number_of_genes":54,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}}]}