{"count":4,"next":null,"previous":null,"results":[{"gene_data":{"alias":["LAT1"],"biotype":"protein_coding","hgnc_id":"HGNC:18874","gene_name":"linker for activation of T-cells","omim_gene":["602354"],"alias_name":["linker for activation of T cells, transmembrane adaptor"],"gene_symbol":"LAT","hgnc_symbol":"LAT","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"16:28996147-29002104","ensembl_id":"ENSG00000213658"}},"GRch38":{"90":{"location":"16:28984826-28990783","ensembl_id":"ENSG00000213658"}}},"hgnc_date_symbol_changed":"2002-07-12"},"entity_type":"gene","entity_name":"LAT","confidence_level":"2","penetrance":"Complete","mode_of_pathogenicity":"","publications":["27522155","27242165"],"evidence":["Expert Review Amber","Other"],"phenotypes":["Immunodeficiency 52, 617514"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":["watchlist"],"panel":{"id":175,"hash_id":"5763f32a8f620350a22bccde","name":"Inherited bleeding disorders","disease_group":"Haematological and immunological disorders","disease_sub_group":"Haemostasis disorders","status":"public","version":"1.156","version_created":"2019-08-09T13:55:23.938344Z","relevant_disorders":["Inherited platelet disorders","Monogenic thrombophilia","Inherited bleeding and or platelet disorders","Unprovoked Thrombosis before 40","Monogenic venous thrombosis"],"stats":{"number_of_genes":119,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["LAT1"],"biotype":"protein_coding","hgnc_id":"HGNC:18874","gene_name":"linker for activation of T-cells","omim_gene":["602354"],"alias_name":["linker for activation of T cells, transmembrane adaptor"],"gene_symbol":"LAT","hgnc_symbol":"LAT","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"16:28996147-29002104","ensembl_id":"ENSG00000213658"}},"GRch38":{"90":{"location":"16:28984826-28990783","ensembl_id":"ENSG00000213658"}}},"hgnc_date_symbol_changed":"2002-07-12"},"entity_type":"gene","entity_name":"LAT","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":null,"publications":["27522155","27242165"],"evidence":["NHS GMS","North West GLH","London North GLH","Expert Review Green","IUIS Classification February 2018","SCID v1.6","Combined B and T cell defect v1.12","A- or hypo-gammaglobulinaemia v1.25"],"phenotypes":["Immunodeficiency 52, 617514","Adenopathy, splenomegaly, recurrent infections, autoimmunity","Immunodeficiencies affecting cellular and humoral immunity"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["LAT1"],"biotype":"protein_coding","hgnc_id":"HGNC:18874","gene_name":"linker for activation of T-cells","omim_gene":["602354"],"alias_name":["linker for activation of T cells, transmembrane adaptor"],"gene_symbol":"LAT","hgnc_symbol":"LAT","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"16:28996147-29002104","ensembl_id":"ENSG00000213658"}},"GRch38":{"90":{"location":"16:28984826-28990783","ensembl_id":"ENSG00000213658"}}},"hgnc_date_symbol_changed":"2002-07-12"},"entity_type":"gene","entity_name":"LAT","confidence_level":"2","penetrance":"Complete","mode_of_pathogenicity":"","publications":["27522155","27242165"],"evidence":["Expert Review Amber","Other"],"phenotypes":["Immunodeficiency 52, 617514"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":["watchlist"],"panel":{"id":159,"hash_id":"58a70e858f62037e8779b2e8","name":"Cytopenias and congenital anaemias","disease_group":"Haematological disorders","disease_sub_group":"Anaemias and red cell disorders","status":"public","version":"1.73","version_created":"2019-09-23T11:25:32.403071Z","relevant_disorders":["Aplastic anaemia with or without paroxysmal nocturnal haemoglobinuria","Apparent aplastic anaemia or paroxysmal nocturnal haemoglobinuria","Congenital anaemias","Early onset pancytopenia and red cell disorders","Anaemias and red cell disorders","Cytopaenias and congenital anaemias","Cytopenia and pancytopenia"],"stats":{"number_of_genes":219,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["LAT1"],"biotype":"protein_coding","hgnc_id":"HGNC:18874","gene_name":"linker for activation of T-cells","omim_gene":["602354"],"alias_name":["linker for activation of T cells, transmembrane adaptor"],"gene_symbol":"LAT","hgnc_symbol":"LAT","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"16:28996147-29002104","ensembl_id":"ENSG00000213658"}},"GRch38":{"90":{"location":"16:28984826-28990783","ensembl_id":"ENSG00000213658"}}},"hgnc_date_symbol_changed":"2002-07-12"},"entity_type":"gene","entity_name":"LAT","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":["27522155","27242165"],"evidence":["North West GLH","NHS GMS","Expert Review Amber","Wessex and West Midlands GLH"],"phenotypes":["Immunodeficiency 52, 617514"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":519,"hash_id":null,"name":"Cytopenia - NOT Fanconi anaemia","disease_group":"","disease_sub_group":"","status":"public","version":"0.120","version_created":"2019-09-23T10:29:43.892929Z","relevant_disorders":["R91","R258"],"stats":{"number_of_genes":84,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}}]}