{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6161","gene_name":"integrin subunit beta 6","omim_gene":["147558"],"alias_name":null,"gene_symbol":"ITGB6","hgnc_symbol":"ITGB6","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"2:160956177-161128399","ensembl_id":"ENSG00000115221"}},"GRch38":{"90":{"location":"2:160099666-160271888","ensembl_id":"ENSG00000115221"}}},"hgnc_date_symbol_changed":"1992-02-14"},"entity_type":"gene","entity_name":"ITGB6","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["24305999","25431241","24319098","26695873"],"evidence":["Expert Review Green","Radboud University Medical Center, Nijmegen","Other"],"phenotypes":["amelogenesis imperfecta (non-syndromic form)","Amelogenesis imperfecta, type IH,  616221","Amelogenesis imperfecta, type IH, 616221"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":269,"hash_id":"58c7f3c78f620328d77ce70e","name":"Amelogenesis imperfecta","disease_group":"Skeletal disorders","disease_sub_group":"Skeletal dysplasias","status":"public","version":"2.0","version_created":"2019-09-04T13:55:51.137280Z","relevant_disorders":["Amelogenesis Imperfecta","R340"],"stats":{"number_of_genes":39,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6161","gene_name":"integrin subunit beta 6","omim_gene":["147558"],"alias_name":null,"gene_symbol":"ITGB6","hgnc_symbol":"ITGB6","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"2:160956177-161128399","ensembl_id":"ENSG00000115221"}},"GRch38":{"90":{"location":"2:160099666-160271888","ensembl_id":"ENSG00000115221"}}},"hgnc_date_symbol_changed":"1992-02-14"},"entity_type":"gene","entity_name":"ITGB6","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["26695873"],"evidence":["Literature"],"phenotypes":["Alopecia with mental retardation (APMR)","mild-to-moderate intellectual disability, adolescent alopecia and dentogingival abnormalities"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":285,"hash_id":"558aa423bb5a16630e15b63c","name":"Intellectual disability","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Neurodevelopmental disorders","status":"public","version":"2.1065","version_created":"2019-10-07T13:42:16.019766Z","relevant_disorders":["Coarse facial features including Coffin-Siris-like disorders","ID","Moderate","severe or profound intellectual disability","Schizophrenia plus additional features","Intellectual disability - microarray","fragile X and sequencing"],"stats":{"number_of_genes":2253,"number_of_strs":11,"number_of_regions":57},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}}]}