{"count":7,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6144","gene_name":"integrin subunit alpha 8","omim_gene":["604063"],"alias_name":null,"gene_symbol":"ITGA8","hgnc_symbol":"ITGA8","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"10:15555948-15762124","ensembl_id":"ENSG00000077943"}},"GRch38":{"90":{"location":"10:15513949-15720125","ensembl_id":"ENSG00000077943"}}},"hgnc_date_symbol_changed":"1998-10-01"},"entity_type":"gene","entity_name":"ITGA8","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Radboud University Medical Center, Nijmegen","Expert list"],"phenotypes":["Renal hypodysplasia/aplasia 1, 191830"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":156,"hash_id":"5693974122c1fc251660fb1f","name":"Unexplained kidney failure in young people","disease_group":"Renal and urinary tract disorders","disease_sub_group":"Disorders of function","status":"public","version":"1.73","version_created":"2019-07-17T16:13:42.477129Z","relevant_disorders":["Familial IgA nephropathy and IgA vasculitis","End-stage renal disease - childhood onset"],"stats":{"number_of_genes":166,"number_of_strs":0,"number_of_regions":3},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6144","gene_name":"integrin subunit alpha 8","omim_gene":["604063"],"alias_name":null,"gene_symbol":"ITGA8","hgnc_symbol":"ITGA8","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"10:15555948-15762124","ensembl_id":"ENSG00000077943"}},"GRch38":{"90":{"location":"10:15513949-15720125","ensembl_id":"ENSG00000077943"}}},"hgnc_date_symbol_changed":"1998-10-01"},"entity_type":"gene","entity_name":"ITGA8","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Expert list","Radboud University Medical Center, Nijmegen"],"phenotypes":["Renal hypodysplasia/aplasia 1, 191830"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":234,"hash_id":"553f9696bb5a1616e5ed45d1","name":"CAKUT","disease_group":"Renal and urinary tract disorders","disease_sub_group":"Structural renal and urinary tract disease","status":"public","version":"1.39","version_created":"2019-06-20T15:14:56.833108Z","relevant_disorders":["Congenital Anomaly of the Kidneys and Urinary Tract (CAKUT)"],"stats":{"number_of_genes":65,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6144","gene_name":"integrin subunit alpha 8","omim_gene":["604063"],"alias_name":null,"gene_symbol":"ITGA8","hgnc_symbol":"ITGA8","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"10:15555948-15762124","ensembl_id":"ENSG00000077943"}},"GRch38":{"90":{"location":"10:15513949-15720125","ensembl_id":"ENSG00000077943"}}},"hgnc_date_symbol_changed":"1998-10-01"},"entity_type":"gene","entity_name":"ITGA8","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green"],"phenotypes":["Renal hypodysplasia/aplasia 1, 191830"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":493,"hash_id":null,"name":"Renal and urinary tract disorders","disease_group":"","disease_sub_group":"","status":"public","version":"1.18","version_created":"2019-07-04T13:55:26.963386Z","relevant_disorders":[],"stats":{"number_of_genes":177,"number_of_strs":0,"number_of_regions":3},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6144","gene_name":"integrin subunit alpha 8","omim_gene":["604063"],"alias_name":null,"gene_symbol":"ITGA8","hgnc_symbol":"ITGA8","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"10:15555948-15762124","ensembl_id":"ENSG00000077943"}},"GRch38":{"90":{"location":"10:15513949-15720125","ensembl_id":"ENSG00000077943"}}},"hgnc_date_symbol_changed":"1998-10-01"},"entity_type":"gene","entity_name":"ITGA8","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Expert Review Green"],"phenotypes":["Renal hypodysplasia/aplasia 1, 191830"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":678,"hash_id":null,"name":"Unexplained paediatric onset end-stage renal disease","disease_group":"","disease_sub_group":"","status":"public","version":"0.43","version_created":"2019-09-25T12:25:36.245604Z","relevant_disorders":["R257"],"stats":{"number_of_genes":229,"number_of_strs":0,"number_of_regions":3},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6144","gene_name":"integrin subunit alpha 8","omim_gene":["604063"],"alias_name":null,"gene_symbol":"ITGA8","hgnc_symbol":"ITGA8","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"10:15555948-15762124","ensembl_id":"ENSG00000077943"}},"GRch38":{"90":{"location":"10:15513949-15720125","ensembl_id":"ENSG00000077943"}}},"hgnc_date_symbol_changed":"1998-10-01"},"entity_type":"gene","entity_name":"ITGA8","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Amber","PAGE DD-Gene2Phenotype"],"phenotypes":["RENAL HYPODYSPLASIA/APLASIA 1"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":478,"hash_id":null,"name":"Fetal anomalies","disease_group":"","disease_sub_group":"","status":"public","version":"0.344","version_created":"2019-09-17T09:38:10.568007Z","relevant_disorders":["R21"],"stats":{"number_of_genes":1721,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6144","gene_name":"integrin subunit alpha 8","omim_gene":["604063"],"alias_name":null,"gene_symbol":"ITGA8","hgnc_symbol":"ITGA8","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"10:15555948-15762124","ensembl_id":"ENSG00000077943"}},"GRch38":{"90":{"location":"10:15513949-15720125","ensembl_id":"ENSG00000077943"}}},"hgnc_date_symbol_changed":"1998-10-01"},"entity_type":"gene","entity_name":"ITGA8","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["DD-Gene2Phenotype","Expert Review Amber"],"phenotypes":["RENAL HYPODYSPLASIA/APLASIA 1 191830"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":484,"hash_id":null,"name":"DDG2P","disease_group":"","disease_sub_group":"","status":"public","version":"1.137","version_created":"2019-10-08T15:56:59.220133Z","relevant_disorders":[],"stats":{"number_of_genes":1893,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:6144","gene_name":"integrin subunit alpha 8","omim_gene":["604063"],"alias_name":null,"gene_symbol":"ITGA8","hgnc_symbol":"ITGA8","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"10:15555948-15762124","ensembl_id":"ENSG00000077943"}},"GRch38":{"90":{"location":"10:15513949-15720125","ensembl_id":"ENSG00000077943"}}},"hgnc_date_symbol_changed":"1998-10-01"},"entity_type":"gene","entity_name":"ITGA8","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert"],"phenotypes":[],"mode_of_inheritance":"","tags":[],"panel":{"id":126,"hash_id":"558ac48fbb5a16630dcfeaad","name":"Hearing loss","disease_group":"Hearing and ear disorders","disease_sub_group":"Non-syndromic hearing loss","status":"public","version":"2.2","version_created":"2019-09-03T14:01:56.987667Z","relevant_disorders":["Congenital hearing impairment","Autosomal dominant deafness","Congenital hearing impairment (profound/severe)","R67"],"stats":{"number_of_genes":358,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}}]}