{"count":4,"next":null,"previous":null,"results":[{"gene_data":{"alias":["IFI15","UCRP"],"biotype":"protein_coding","hgnc_id":"HGNC:4053","gene_name":"ISG15 ubiquitin-like modifier","omim_gene":["147571"],"alias_name":null,"gene_symbol":"ISG15","hgnc_symbol":"ISG15","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"1:948803-949920","ensembl_id":"ENSG00000187608"}},"GRch38":{"90":{"location":"1:1001138-1014541","ensembl_id":"ENSG00000187608"}}},"hgnc_date_symbol_changed":"2006-04-28"},"entity_type":"gene","entity_name":"ISG15","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":null,"publications":["22859821","25307056","23579383"],"evidence":["NHS GMS","North West GLH","London North GLH","IUIS Classification February 2018","Victorian Clinical Genetics Services","Expert Review Green","ESID Registry 20171117","GRID V2.0"],"phenotypes":["Immunodeficiency 38, 616126","Defects with susceptibility to mycobacterial infection (MSMD)","idiopathic basal ganglia calcification","Susceptibility to mycobacteria, brain calcifications","Defects in Intrinsic and Innate Immunity"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["IFI15","UCRP"],"biotype":"protein_coding","hgnc_id":"HGNC:4053","gene_name":"ISG15 ubiquitin-like modifier","omim_gene":["147571"],"alias_name":null,"gene_symbol":"ISG15","hgnc_symbol":"ISG15","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"1:948803-949920","ensembl_id":"ENSG00000187608"}},"GRch38":{"90":{"location":"1:1001138-1014541","ensembl_id":"ENSG00000187608"}}},"hgnc_date_symbol_changed":"2006-04-28"},"entity_type":"gene","entity_name":"ISG15","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["25307056","22859821"],"evidence":["Expert Review Green","Other"],"phenotypes":["Immunodeficiency 38 616126"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":180,"hash_id":"56ba024322c1fc5025762b4d","name":"Structural basal ganglia disorders","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Motor Disorders of the CNS","status":"public","version":"1.17","version_created":"2019-09-04T09:40:29.765078Z","relevant_disorders":[],"stats":{"number_of_genes":76,"number_of_strs":1,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["IFI15","UCRP"],"biotype":"protein_coding","hgnc_id":"HGNC:4053","gene_name":"ISG15 ubiquitin-like modifier","omim_gene":["147571"],"alias_name":null,"gene_symbol":"ISG15","hgnc_symbol":"ISG15","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"1:948803-949920","ensembl_id":"ENSG00000187608"}},"GRch38":{"90":{"location":"1:1001138-1014541","ensembl_id":"ENSG00000187608"}}},"hgnc_date_symbol_changed":"2006-04-28"},"entity_type":"gene","entity_name":"ISG15","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["25307056","22859821"],"evidence":["Expert Review Green"],"phenotypes":["Immunodeficiency 38 616126"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":475,"hash_id":null,"name":"Dystonia - childhood onset","disease_group":"","disease_sub_group":"","status":"public","version":"1.8","version_created":"2019-09-09T13:17:58.240159Z","relevant_disorders":[],"stats":{"number_of_genes":176,"number_of_strs":7,"number_of_regions":1},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["IFI15","UCRP"],"biotype":"protein_coding","hgnc_id":"HGNC:4053","gene_name":"ISG15 ubiquitin-like modifier","omim_gene":["147571"],"alias_name":null,"gene_symbol":"ISG15","hgnc_symbol":"ISG15","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"1:948803-949920","ensembl_id":"ENSG00000187608"}},"GRch38":{"90":{"location":"1:1001138-1014541","ensembl_id":"ENSG00000187608"}}},"hgnc_date_symbol_changed":"2006-04-28"},"entity_type":"gene","entity_name":"ISG15","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":["25307056","22859821"],"evidence":["Expert Review Red","NHS GMS","London North GLH"],"phenotypes":["Immunodeficiency 38 616126"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":540,"hash_id":null,"name":"Adult onset movement disorder","disease_group":"","disease_sub_group":"","status":"public","version":"0.125","version_created":"2019-09-29T14:25:05.513850Z","relevant_disorders":["R56"],"stats":{"number_of_genes":202,"number_of_strs":11,"number_of_regions":1},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}}]}