{"count":1,"next":null,"previous":null,"results":[{"gene_data":{"alias":["PY160","IRS-4"],"biotype":"protein_coding","hgnc_id":"HGNC:6128","gene_name":"insulin receptor substrate 4","omim_gene":["300904"],"alias_name":null,"gene_symbol":"IRS4","hgnc_symbol":"IRS4","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"X:107975712-107979651","ensembl_id":"ENSG00000133124"}},"GRch38":{"90":{"location":"X:108732482-108736409","ensembl_id":"ENSG00000133124"}}},"hgnc_date_symbol_changed":"1998-11-24"},"entity_type":"gene","entity_name":"IRS4","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["30061370","10644546"],"evidence":["Expert Review Green","East of England GLH"],"phenotypes":["Congenital central hypothyroidism"],"mode_of_inheritance":"X-LINKED: hemizygous mutation in males, biallelic mutations in females","tags":[],"panel":{"id":31,"hash_id":"5763f2938f620350a1996046","name":"Congenital hypothyroidism","disease_group":"Endocrine disorders","disease_sub_group":"Thyroid disorders","status":"public","version":"2.0","version_created":"2019-07-31T13:52:41.584963Z","relevant_disorders":["Congenital hypothyroidism or thyroid agenesis","R145"],"stats":{"number_of_genes":34,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}}]}