{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["IRAK","pelle"],"biotype":"protein_coding","hgnc_id":"HGNC:6112","gene_name":"interleukin 1 receptor associated kinase 1","omim_gene":["300283"],"alias_name":null,"gene_symbol":"IRAK1","hgnc_symbol":"IRAK1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"X:153275951-153285431","ensembl_id":"ENSG00000184216"}},"GRch38":{"90":{"location":"X:154010500-154019980","ensembl_id":"ENSG00000184216"}}},"hgnc_date_symbol_changed":"1998-06-22"},"entity_type":"gene","entity_name":"IRAK1","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":null,"publications":["28069966"],"evidence":["Expert Review Red","IUIS Classification February 2018"],"phenotypes":["Bacterial infections, X-linked MECP2 deficiency-related syndrome due to a large de novo Xq28 chromosomal deletion encompassing both MECP2 and IRAK1","Defects in Intrinsic and Innate Immunity"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["IRAK","pelle"],"biotype":"protein_coding","hgnc_id":"HGNC:6112","gene_name":"interleukin 1 receptor associated kinase 1","omim_gene":["300283"],"alias_name":null,"gene_symbol":"IRAK1","hgnc_symbol":"IRAK1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"X:153275951-153285431","ensembl_id":"ENSG00000184216"}},"GRch38":{"90":{"location":"X:154010500-154019980","ensembl_id":"ENSG00000184216"}}},"hgnc_date_symbol_changed":"1998-06-22"},"entity_type":"gene","entity_name":"IRAK1","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["21934280","26672597","20236124","27180140","28302064"],"evidence":["Expert Review Red","UKGTN"],"phenotypes":["Lubs X-Linked Mental Retardation Syndrome","MRXSL"],"mode_of_inheritance":"Unknown","tags":[],"panel":{"id":285,"hash_id":"558aa423bb5a16630e15b63c","name":"Intellectual disability","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Neurodevelopmental disorders","status":"public","version":"2.1065","version_created":"2019-10-07T13:42:16.019766Z","relevant_disorders":["Coarse facial features including Coffin-Siris-like disorders","ID","Moderate","severe or profound intellectual disability","Schizophrenia plus additional features","Intellectual disability - microarray","fragile X and sequencing"],"stats":{"number_of_genes":2253,"number_of_strs":11,"number_of_regions":57},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}}]}