{"count":4,"next":null,"previous":null,"results":[{"gene_data":{"alias":["FIL1","FIL1(DELTA)","FIL1D","IL1HY1","IL1RP3","IL1L1","IL-1F5","IL36RA","MGC29840"],"biotype":"protein_coding","hgnc_id":"HGNC:15561","gene_name":"interleukin 36 receptor antagonist","omim_gene":["605507"],"alias_name":["family of interleukin 1-delta","interleukin-1 receptor antagonist homolog 1","interleukin-1 HY1","IL-1 related protein 3"],"gene_symbol":"IL36RN","hgnc_symbol":"IL36RN","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"2:113816215-113822959","ensembl_id":"ENSG00000136695"}},"GRch38":{"90":{"location":"2:113058638-113065382","ensembl_id":"ENSG00000136695"}}},"hgnc_date_symbol_changed":"2011-06-06"},"entity_type":"gene","entity_name":"IL36RN","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","Other"],"phenotypes":["Psoriasis 14, pustular,  614204","DITRA","recurrent flares of pustular rash with fever"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":60,"hash_id":"55a6566d22c1fc6710839b9c","name":"Periodic fever syndromes","disease_group":"Rheumatological disorders","disease_sub_group":"Multi-system inflammatory/autoimmune disorders","status":"public","version":"1.12","version_created":"2019-09-26T14:18:15.825616Z","relevant_disorders":["Periodic fever syndromes and amyloidosis"],"stats":{"number_of_genes":30,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["FIL1","FIL1(DELTA)","FIL1D","IL1HY1","IL1RP3","IL1L1","IL-1F5","IL36RA","MGC29840"],"biotype":"protein_coding","hgnc_id":"HGNC:15561","gene_name":"interleukin 36 receptor antagonist","omim_gene":["605507"],"alias_name":["family of interleukin 1-delta","interleukin-1 receptor antagonist homolog 1","interleukin-1 HY1","IL-1 related protein 3"],"gene_symbol":"IL36RN","hgnc_symbol":"IL36RN","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"2:113816215-113822959","ensembl_id":"ENSG00000136695"}},"GRch38":{"90":{"location":"2:113058638-113065382","ensembl_id":"ENSG00000136695"}}},"hgnc_date_symbol_changed":"2011-06-06"},"entity_type":"gene","entity_name":"IL36RN","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["21839423","25458002","27388993"],"evidence":["Expert Review Green","Illumina TruGenome Clinical Sequencing Services","Radboud University Medical Center, Nijmegen"],"phenotypes":["Psoriasis 14, pustular\t614204"],"mode_of_inheritance":"BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal","tags":["monogenic-polygenic"],"panel":{"id":132,"hash_id":"5616435a22c1fc212900fbd1","name":"Generalised pustular psoriasis","disease_group":"Dermatological disorders","disease_sub_group":"Autoimmune skin disorders","status":"public","version":"1.8","version_created":"2017-11-05T02:37:20.087444Z","relevant_disorders":[],"stats":{"number_of_genes":12,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["FIL1","FIL1(DELTA)","FIL1D","IL1HY1","IL1RP3","IL1L1","IL-1F5","IL36RA","MGC29840"],"biotype":"protein_coding","hgnc_id":"HGNC:15561","gene_name":"interleukin 36 receptor antagonist","omim_gene":["605507"],"alias_name":["family of interleukin 1-delta","interleukin-1 receptor antagonist homolog 1","interleukin-1 HY1","IL-1 related protein 3"],"gene_symbol":"IL36RN","hgnc_symbol":"IL36RN","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"2:113816215-113822959","ensembl_id":"ENSG00000136695"}},"GRch38":{"90":{"location":"2:113058638-113065382","ensembl_id":"ENSG00000136695"}}},"hgnc_date_symbol_changed":"2011-06-06"},"entity_type":"gene","entity_name":"IL36RN","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["London North GLH","NHS GMS","Expert Review Green"],"phenotypes":["Recurrent pustular psoriasis"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":565,"hash_id":null,"name":"Rare genetic inflammatory skin disorders","disease_group":"","disease_sub_group":"","status":"public","version":"0.14","version_created":"2019-09-09T15:38:40.627314Z","relevant_disorders":[],"stats":{"number_of_genes":60,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":["FIL1","FIL1(DELTA)","FIL1D","IL1HY1","IL1RP3","IL1L1","IL-1F5","IL36RA","MGC29840"],"biotype":"protein_coding","hgnc_id":"HGNC:15561","gene_name":"interleukin 36 receptor antagonist","omim_gene":["605507"],"alias_name":["family of interleukin 1-delta","interleukin-1 receptor antagonist homolog 1","interleukin-1 HY1","IL-1 related protein 3"],"gene_symbol":"IL36RN","hgnc_symbol":"IL36RN","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"2:113816215-113822959","ensembl_id":"ENSG00000136695"}},"GRch38":{"90":{"location":"2:113058638-113065382","ensembl_id":"ENSG00000136695"}}},"hgnc_date_symbol_changed":"2011-06-06"},"entity_type":"gene","entity_name":"IL36RN","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":null,"publications":["23303454","23698098","22903787"],"evidence":["NHS GMS","North West GLH","London North GLH","Expert Review Green","IUIS Classification February 2018","Victorian Clinical Genetics Services","ESID Registry 20171117","GRID V2.0"],"phenotypes":["Psoriasis 14, generalized pustular 614204","Other autoinflammatory diseases with known genetic defect","Pustular psoriasis","Autoinflammatory Disorders"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}}]}