{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["CD360"],"biotype":"protein_coding","hgnc_id":"HGNC:6006","gene_name":"interleukin 21 receptor","omim_gene":["605383"],"alias_name":null,"gene_symbol":"IL21R","hgnc_symbol":"IL21R","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"16:27413483-27462115","ensembl_id":"ENSG00000103522"}},"GRch38":{"90":{"location":"16:27402162-27452042","ensembl_id":"ENSG00000103522"}}},"hgnc_date_symbol_changed":"2000-03-29"},"entity_type":"gene","entity_name":"IL21R","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Radboud University Medical Center, Nijmegen"],"phenotypes":["[IgE, elevated level of], 147050Immunodeficiency, primary, autosomal recessive, IL21R-related, 615207"],"mode_of_inheritance":"","tags":[],"panel":{"id":62,"hash_id":"553f95d0bb5a1616e5ed45c1","name":"Severe multi-system atopic disease with high IgE","disease_group":"Dermatological disorders","disease_sub_group":"Atopy","status":"public","version":"1.7","version_created":"2017-11-05T02:37:19.949470Z","relevant_disorders":[],"stats":{"number_of_genes":8,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["CD360"],"biotype":"protein_coding","hgnc_id":"HGNC:6006","gene_name":"interleukin 21 receptor","omim_gene":["605383"],"alias_name":null,"gene_symbol":"IL21R","hgnc_symbol":"IL21R","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"16:27413483-27462115","ensembl_id":"ENSG00000103522"}},"GRch38":{"90":{"location":"16:27402162-27452042","ensembl_id":"ENSG00000103522"}}},"hgnc_date_symbol_changed":"2000-03-29"},"entity_type":"gene","entity_name":"IL21R","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":null,"publications":["23440042","12700598"],"evidence":["NHS GMS","North West GLH","London North GLH","IUIS Classification February 2018","Victorian Clinical Genetics Services","Expert Review Green","ESID Registry 20171117","GRID V2.0"],"phenotypes":["Immunodeficiency 56, 615207","Immunodeficiency, primary, autosomal recessive, IL21R-related","Atypical Severe Combined Immunodeficiency (Atypical SCID)","Combined immunodeficiency","Omenn syndrome","Severe combined immunodeficiency (SCID)","IL-21R deficiency","Recurrent infections, Pneumocystis jiroveci, Cryptosporidium infections and liver disease","Immunodeficiencies affecting cellular and humoral immunity"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}}]}