{"count":3,"next":null,"previous":null,"results":[{"gene_data":{"alias":["hIk-1","LyF-1","Hs.54452","IKAROS","PPP1R92"],"biotype":"protein_coding","hgnc_id":"HGNC:13176","gene_name":"IKAROS family zinc finger 1","omim_gene":["603023"],"alias_name":["protein phosphatase 1, regulatory subunit 92"],"gene_symbol":"IKZF1","hgnc_symbol":"IKZF1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"7:50343720-50472799","ensembl_id":"ENSG00000185811"}},"GRch38":{"90":{"location":"7:50304124-50405101","ensembl_id":"ENSG00000185811"}}},"hgnc_date_symbol_changed":"2006-08-25"},"entity_type":"gene","entity_name":"IKZF1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":null,"publications":["21548011","26981933"],"evidence":["NHS GMS","North West GLH","London North GLH","IUIS Classification February 2018","Victorian Clinical Genetics Services","Expert Review Green","ESID Registry 20171117","GRID V2.0","A- or hypo-gammaglobulinaemia v1.25"],"phenotypes":["Immunodeficiency, common variable, 13, 616873","Immunodeficiency, common variable 13","IKAROS deficiency","Recurrent sinopulmonary infections","Predominantly Antibody Deficiencies"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["hIk-1","LyF-1","Hs.54452","IKAROS","PPP1R92"],"biotype":"protein_coding","hgnc_id":"HGNC:13176","gene_name":"IKAROS family zinc finger 1","omim_gene":["603023"],"alias_name":["protein phosphatase 1, regulatory subunit 92"],"gene_symbol":"IKZF1","hgnc_symbol":"IKZF1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"7:50343720-50472799","ensembl_id":"ENSG00000185811"}},"GRch38":{"90":{"location":"7:50304124-50405101","ensembl_id":"ENSG00000185811"}}},"hgnc_date_symbol_changed":"2006-08-25"},"entity_type":"gene","entity_name":"IKZF1","confidence_level":"2","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Amber","BRIDGE consortium (NIHRBR-RD)"],"phenotypes":["Acute lymphoblastic leukemia (ALL)","Immunodeficiency, common variable, 13 \t616873"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":["somatic"],"panel":{"id":159,"hash_id":"58a70e858f62037e8779b2e8","name":"Cytopenias and congenital anaemias","disease_group":"Haematological disorders","disease_sub_group":"Anaemias and red cell disorders","status":"public","version":"1.73","version_created":"2019-09-23T11:25:32.403071Z","relevant_disorders":["Aplastic anaemia with or without paroxysmal nocturnal haemoglobinuria","Apparent aplastic anaemia or paroxysmal nocturnal haemoglobinuria","Congenital anaemias","Early onset pancytopenia and red cell disorders","Anaemias and red cell disorders","Cytopaenias and congenital anaemias","Cytopenia and pancytopenia"],"stats":{"number_of_genes":219,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["hIk-1","LyF-1","Hs.54452","IKAROS","PPP1R92"],"biotype":"protein_coding","hgnc_id":"HGNC:13176","gene_name":"IKAROS family zinc finger 1","omim_gene":["603023"],"alias_name":["protein phosphatase 1, regulatory subunit 92"],"gene_symbol":"IKZF1","hgnc_symbol":"IKZF1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"7:50343720-50472799","ensembl_id":"ENSG00000185811"}},"GRch38":{"90":{"location":"7:50304124-50405101","ensembl_id":"ENSG00000185811"}}},"hgnc_date_symbol_changed":"2006-08-25"},"entity_type":"gene","entity_name":"IKZF1","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS","Expert Review Amber","Wessex and West Midlands GLH"],"phenotypes":["Acute lymphoblastic leukemia (ALL)","Immunodeficiency, common variable, 13,616873"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":519,"hash_id":null,"name":"Cytopenia - NOT Fanconi anaemia","disease_group":"","disease_sub_group":"","status":"public","version":"0.120","version_created":"2019-09-23T10:29:43.892929Z","relevant_disorders":["R91","R258"],"stats":{"number_of_genes":84,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}}]}