{"count":6,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:5101","gene_name":"homeobox A11","omim_gene":["142958"],"alias_name":null,"gene_symbol":"HOXA11","hgnc_symbol":"HOXA11","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"7:27221129-27224842","ensembl_id":"ENSG00000005073"}},"GRch38":{"90":{"location":"7:27181510-27185223","ensembl_id":"ENSG00000005073"}}},"hgnc_date_symbol_changed":"1990-07-05"},"entity_type":"gene","entity_name":"HOXA11","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","BRIDGE Study Tier 1 Gene"],"phenotypes":["Amegakaryocytic thrombocytopenia with radioulnar synostosis"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":175,"hash_id":"5763f32a8f620350a22bccde","name":"Inherited bleeding disorders","disease_group":"Haematological and immunological disorders","disease_sub_group":"Haemostasis disorders","status":"public","version":"1.156","version_created":"2019-08-09T13:55:23.938344Z","relevant_disorders":["Inherited platelet disorders","Monogenic thrombophilia","Inherited bleeding and or platelet disorders","Unprovoked Thrombosis before 40","Monogenic venous thrombosis"],"stats":{"number_of_genes":119,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:5101","gene_name":"homeobox A11","omim_gene":["142958"],"alias_name":null,"gene_symbol":"HOXA11","hgnc_symbol":"HOXA11","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"7:27221129-27224842","ensembl_id":"ENSG00000005073"}},"GRch38":{"90":{"location":"7:27181510-27185223","ensembl_id":"ENSG00000005073"}}},"hgnc_date_symbol_changed":"1990-07-05"},"entity_type":"gene","entity_name":"HOXA11","confidence_level":"2","penetrance":"Complete","mode_of_pathogenicity":"","publications":["11101832"],"evidence":["Expert Review Amber","Radboud University Medical Center, Nijmegen","Expert list"],"phenotypes":["Congenital amegkaryocytic thrombocytopenia","Radioulnar synostosis with amegakaryocytic thrombocytopenia, 605432"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":159,"hash_id":"58a70e858f62037e8779b2e8","name":"Cytopenias and congenital anaemias","disease_group":"Haematological disorders","disease_sub_group":"Anaemias and red cell disorders","status":"public","version":"1.73","version_created":"2019-09-23T11:25:32.403071Z","relevant_disorders":["Aplastic anaemia with or without paroxysmal nocturnal haemoglobinuria","Apparent aplastic anaemia or paroxysmal nocturnal haemoglobinuria","Congenital anaemias","Early onset pancytopenia and red cell disorders","Anaemias and red cell disorders","Cytopaenias and congenital anaemias","Cytopenia and pancytopenia"],"stats":{"number_of_genes":219,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:5101","gene_name":"homeobox A11","omim_gene":["142958"],"alias_name":null,"gene_symbol":"HOXA11","hgnc_symbol":"HOXA11","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"7:27221129-27224842","ensembl_id":"ENSG00000005073"}},"GRch38":{"90":{"location":"7:27181510-27185223","ensembl_id":"ENSG00000005073"}}},"hgnc_date_symbol_changed":"1990-07-05"},"entity_type":"gene","entity_name":"HOXA11","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["11101832"],"evidence":["NHS GMS","Expert Review Red","Expert list","UKGTN","Radboud University Medical Center, Nijmegen",""],"phenotypes":["Radioulnar synostosis with amegakaryocytic thrombocytopenia 1 605432"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":309,"hash_id":"5693952f22c1fc251660fb1e","name":"Skeletal dysplasia","disease_group":"Skeletal disorders","disease_sub_group":"Skeletal dysplasias","status":"public","version":"1.203","version_created":"2019-10-03T09:38:50.417968Z","relevant_disorders":["Unexplained skeletal dysplasia","Skeletal dysplasia"],"stats":{"number_of_genes":546,"number_of_strs":1,"number_of_regions":6},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:5101","gene_name":"homeobox A11","omim_gene":["142958"],"alias_name":null,"gene_symbol":"HOXA11","hgnc_symbol":"HOXA11","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"7:27221129-27224842","ensembl_id":"ENSG00000005073"}},"GRch38":{"90":{"location":"7:27181510-27185223","ensembl_id":"ENSG00000005073"}}},"hgnc_date_symbol_changed":"1990-07-05"},"entity_type":"gene","entity_name":"HOXA11","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["16765069","11101832"],"evidence":["Expert Review Green","North West GLH","Yorkshire and North East GLH","London South GLH","NHS GMS","Wessex and West Midlands GLH"],"phenotypes":["605432 Radioulnar synostosis with amegakaryocytic thrombocytopenia 1"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":545,"hash_id":null,"name":"Bleeding and platelet disorders","disease_group":"","disease_sub_group":"","status":"public","version":"0.78","version_created":"2019-09-23T11:07:54.788299Z","relevant_disorders":["R90"],"stats":{"number_of_genes":111,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:5101","gene_name":"homeobox A11","omim_gene":["142958"],"alias_name":null,"gene_symbol":"HOXA11","hgnc_symbol":"HOXA11","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"7:27221129-27224842","ensembl_id":"ENSG00000005073"}},"GRch38":{"90":{"location":"7:27181510-27185223","ensembl_id":"ENSG00000005073"}}},"hgnc_date_symbol_changed":"1990-07-05"},"entity_type":"gene","entity_name":"HOXA11","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":["20091385","11101832"],"evidence":["Expert Review Amber","Yorkshire and North East GLH","NHS GMS","London South GLH"],"phenotypes":["605432 Radioulnar synostosis with amegakaryocytic thrombocytopenia 1"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":519,"hash_id":null,"name":"Cytopenia - NOT Fanconi anaemia","disease_group":"","disease_sub_group":"","status":"public","version":"0.120","version_created":"2019-09-23T10:29:43.892929Z","relevant_disorders":["R91","R258"],"stats":{"number_of_genes":84,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:5101","gene_name":"homeobox A11","omim_gene":["142958"],"alias_name":null,"gene_symbol":"HOXA11","hgnc_symbol":"HOXA11","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"7:27221129-27224842","ensembl_id":"ENSG00000005073"}},"GRch38":{"90":{"location":"7:27181510-27185223","ensembl_id":"ENSG00000005073"}}},"hgnc_date_symbol_changed":"1990-07-05"},"entity_type":"gene","entity_name":"HOXA11","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":["26581901"],"evidence":["DD-Gene2Phenotype","Expert Review Red"],"phenotypes":["Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":484,"hash_id":null,"name":"DDG2P","disease_group":"","disease_sub_group":"","status":"public","version":"1.137","version_created":"2019-10-08T15:56:59.220133Z","relevant_disorders":[],"stats":{"number_of_genes":1893,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}}]}