{"count":6,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:16882","gene_name":"hyperpolarization activated cyclic nucleotide gated potassium channel 4","omim_gene":["605206"],"alias_name":null,"gene_symbol":"HCN4","hgnc_symbol":"HCN4","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"15:73612200-73661605","ensembl_id":"ENSG00000138622"}},"GRch38":{"90":{"location":"15:73319859-73369264","ensembl_id":"ENSG00000138622"}}},"hgnc_date_symbol_changed":"2002-09-02"},"entity_type":"gene","entity_name":"HCN4","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["ClinGen","Expert Review Red"],"phenotypes":["Familial thoracic aortic aneurysm and aortic dissection"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":210,"hash_id":"594be3878f62037ee3e7e72f","name":"ClinGen_Familial thoracic aortic aneurysm and aortic dissection","disease_group":"","disease_sub_group":"","status":"public","version":"0.10","version_created":"2017-11-05T02:37:20.232365Z","relevant_disorders":[],"stats":{"number_of_genes":53,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"ClinGen Curated genes","slug":"clingen-curated-genes","description":"ClinGen Curated genes"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:16882","gene_name":"hyperpolarization activated cyclic nucleotide gated potassium channel 4","omim_gene":["605206"],"alias_name":null,"gene_symbol":"HCN4","hgnc_symbol":"HCN4","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"15:73612200-73661605","ensembl_id":"ENSG00000138622"}},"GRch38":{"90":{"location":"15:73319859-73369264","ensembl_id":"ENSG00000138622"}}},"hgnc_date_symbol_changed":"2002-09-02"},"entity_type":"gene","entity_name":"HCN4","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green"],"phenotypes":["Brugada syndrome 8"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":468,"hash_id":null,"name":"Cardiac arrhythmias","disease_group":"","disease_sub_group":"","status":"public","version":"1.2","version_created":"2019-06-20T15:14:56.920397Z","relevant_disorders":["Cardiac arrythmias"],"stats":{"number_of_genes":43,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:16882","gene_name":"hyperpolarization activated cyclic nucleotide gated potassium channel 4","omim_gene":["605206"],"alias_name":null,"gene_symbol":"HCN4","hgnc_symbol":"HCN4","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"15:73612200-73661605","ensembl_id":"ENSG00000138622"}},"GRch38":{"90":{"location":"15:73319859-73369264","ensembl_id":"ENSG00000138622"}}},"hgnc_date_symbol_changed":"2002-09-02"},"entity_type":"gene","entity_name":"HCN4","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Amber","South West GLH"],"phenotypes":[],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":506,"hash_id":null,"name":"Progressive cardiac conduction disease","disease_group":"","disease_sub_group":"","status":"public","version":"0.28","version_created":"2019-09-09T16:10:26.535463Z","relevant_disorders":["R328"],"stats":{"number_of_genes":15,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:16882","gene_name":"hyperpolarization activated cyclic nucleotide gated potassium channel 4","omim_gene":["605206"],"alias_name":null,"gene_symbol":"HCN4","hgnc_symbol":"HCN4","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"15:73612200-73661605","ensembl_id":"ENSG00000138622"}},"GRch38":{"90":{"location":"15:73319859-73369264","ensembl_id":"ENSG00000138622"}}},"hgnc_date_symbol_changed":"2002-09-02"},"entity_type":"gene","entity_name":"HCN4","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":["30420954","19862833","16301704"],"evidence":["North West GLH","Brugada syndrome (Version 1.7)"],"phenotypes":["Sick sinus syndrome 2 (163800)","Brugada syndrome 8 (613123)"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":224,"hash_id":"58c7f6858f620328d77ce711","name":"Short QT syndrome","disease_group":"","disease_sub_group":"","status":"public","version":"1.23","version_created":"2019-09-30T12:24:45.336900Z","relevant_disorders":["R130"],"stats":{"number_of_genes":40,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:16882","gene_name":"hyperpolarization activated cyclic nucleotide gated potassium channel 4","omim_gene":["605206"],"alias_name":null,"gene_symbol":"HCN4","hgnc_symbol":"HCN4","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"15:73612200-73661605","ensembl_id":"ENSG00000138622"}},"GRch38":{"90":{"location":"15:73319859-73369264","ensembl_id":"ENSG00000138622"}}},"hgnc_date_symbol_changed":"2002-09-02"},"entity_type":"gene","entity_name":"HCN4","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["27761167"],"evidence":["Expert Review Red","South West GLH","London South GLH","North West GLH","Expert list","Emory Genetics Laboratory","Radboud University Medical Center, Nijmegen","UKGTN"],"phenotypes":["Sick sinus syndrome 2 (163800)","Brugada syndrome 8","Brugada syndrome 8 (613123)"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":13,"hash_id":"55a3a78122c1fc6711b0c6b5","name":"Brugada syndrome","disease_group":"Cardiovascular disorders","disease_sub_group":"Cardiac arrhythmia","status":"public","version":"1.45","version_created":"2019-09-27T09:16:09.959851Z","relevant_disorders":["R128"],"stats":{"number_of_genes":23,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:16882","gene_name":"hyperpolarization activated cyclic nucleotide gated potassium channel 4","omim_gene":["605206"],"alias_name":null,"gene_symbol":"HCN4","hgnc_symbol":"HCN4","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"15:73612200-73661605","ensembl_id":"ENSG00000138622"}},"GRch38":{"90":{"location":"15:73319859-73369264","ensembl_id":"ENSG00000138622"}}},"hgnc_date_symbol_changed":"2002-09-02"},"entity_type":"gene","entity_name":"HCN4","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["19862833","27761167","16301704","30420954"],"evidence":["London South GLH","North West GLH","Expert Review Green","London South GLH","North West GLH","Expert Review Green"],"phenotypes":["Sick sinus syndrome 2 (163800)","Brugada syndrome 8","Brugada syndrome 8 (613123)"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":750,"hash_id":null,"name":"Sudden cardiac death","disease_group":"","disease_sub_group":"","status":"public","version":"0.10","version_created":"2019-09-24T10:05:54.784946Z","relevant_disorders":["Molecular autopsy","R138"],"stats":{"number_of_genes":119,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}}]}
