{"count":3,"next":null,"previous":null,"results":[{"gene_data":{"alias":["ALS19","HER4"],"biotype":"protein_coding","hgnc_id":"HGNC:3432","gene_name":"erb-b2 receptor tyrosine kinase 4","omim_gene":["600543"],"alias_name":["human epidermal growth factor receptor 4"],"gene_symbol":"ERBB4","hgnc_symbol":"ERBB4","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"2:212240446-213403565","ensembl_id":"ENSG00000178568"}},"GRch38":{"90":{"location":"2:211375717-212538841","ensembl_id":"ENSG00000178568"}}},"hgnc_date_symbol_changed":"1995-09-07"},"entity_type":"gene","entity_name":"ERBB4","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":"","publications":["24119685"],"evidence":["Expert Review Amber","NHS GMS","Yorkshire and North East GLH"],"phenotypes":["Amyotrophic lateral sclerosis 19, 615515"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":474,"hash_id":null,"name":"Neurodegenerative disorders - adult onset","disease_group":"","disease_sub_group":"","status":"public","version":"1.106","version_created":"2019-09-20T16:19:10.101841Z","relevant_disorders":["R58"],"stats":{"number_of_genes":395,"number_of_strs":18,"number_of_regions":4},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["ALS19","HER4"],"biotype":"protein_coding","hgnc_id":"HGNC:3432","gene_name":"erb-b2 receptor tyrosine kinase 4","omim_gene":["600543"],"alias_name":["human epidermal growth factor receptor 4"],"gene_symbol":"ERBB4","hgnc_symbol":"ERBB4","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"2:212240446-213403565","ensembl_id":"ENSG00000178568"}},"GRch38":{"90":{"location":"2:211375717-212538841","ensembl_id":"ENSG00000178568"}}},"hgnc_date_symbol_changed":"1995-09-07"},"entity_type":"gene","entity_name":"ERBB4","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Red","Radboud University Medical Center, Nijmegen"],"phenotypes":["Amyotrophic lateral sclerosis 19, 615515"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":263,"hash_id":"55d30b0322c1fc2ff2a5bf7b","name":"Amyotrophic lateral sclerosis/motor neuron disease","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Neurodegenerative disorders","status":"public","version":"1.29","version_created":"2019-06-20T15:14:55.521778Z","relevant_disorders":["Amyotrophic lateral sclerosis or motor neuron disease"],"stats":{"number_of_genes":30,"number_of_strs":4,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["ALS19","HER4"],"biotype":"protein_coding","hgnc_id":"HGNC:3432","gene_name":"erb-b2 receptor tyrosine kinase 4","omim_gene":["600543"],"alias_name":["human epidermal growth factor receptor 4"],"gene_symbol":"ERBB4","hgnc_symbol":"ERBB4","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"2:212240446-213403565","ensembl_id":"ENSG00000178568"}},"GRch38":{"90":{"location":"2:211375717-212538841","ensembl_id":"ENSG00000178568"}}},"hgnc_date_symbol_changed":"1995-09-07"},"entity_type":"gene","entity_name":"ERBB4","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert"],"phenotypes":[],"mode_of_inheritance":"","tags":[],"panel":{"id":126,"hash_id":"558ac48fbb5a16630dcfeaad","name":"Hearing loss","disease_group":"Hearing and ear disorders","disease_sub_group":"Non-syndromic hearing loss","status":"public","version":"2.2","version_created":"2019-09-03T14:01:56.987667Z","relevant_disorders":["Congenital hearing impairment","Autosomal dominant deafness","Congenital hearing impairment (profound/severe)","R67"],"stats":{"number_of_genes":358,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}}]}