{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["MIRK"],"biotype":"protein_coding","hgnc_id":"HGNC:3092","gene_name":"dual specificity tyrosine phosphorylation regulated kinase 1B","omim_gene":["604556"],"alias_name":["minibrain-related kinase"],"gene_symbol":"DYRK1B","hgnc_symbol":"DYRK1B","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"19:40315990-40324841","ensembl_id":"ENSG00000105204"}},"GRch38":{"90":{"location":"19:39825350-39834201","ensembl_id":"ENSG00000105204"}}},"hgnc_date_symbol_changed":"1999-01-29"},"entity_type":"gene","entity_name":"DYRK1B","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS","Expert Review Green","Expert Review Green","NHS GMS"],"phenotypes":["Abdominal obesity-metabolic syndrome 3, 615812"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":152,"hash_id":"553f9745bb5a1616e5ed45e9","name":"Familial diabetes","disease_group":"Endocrine disorders","disease_sub_group":"Disorders of unusual phenotypes","status":"public","version":"1.38","version_created":"2019-06-20T15:15:02.453936Z","relevant_disorders":["Familial young-onset non-insulin-dependent diabetes"],"stats":{"number_of_genes":56,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["MIRK"],"biotype":"protein_coding","hgnc_id":"HGNC:3092","gene_name":"dual specificity tyrosine phosphorylation regulated kinase 1B","omim_gene":["604556"],"alias_name":["minibrain-related kinase"],"gene_symbol":"DYRK1B","hgnc_symbol":"DYRK1B","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"19:40315990-40324841","ensembl_id":"ENSG00000105204"}},"GRch38":{"90":{"location":"19:39825350-39834201","ensembl_id":"ENSG00000105204"}}},"hgnc_date_symbol_changed":"1999-01-29"},"entity_type":"gene","entity_name":"DYRK1B","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","NHS GMS"],"phenotypes":["Abdominal obesity-metabolic syndrome 3, 615812","Metabolic syndrome (coronary artery disease, hypertension, central obesity and diabetes)"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":472,"hash_id":null,"name":"Monogenic diabetes","disease_group":"","disease_sub_group":"","status":"public","version":"2.1","version_created":"2019-07-31T13:20:07.800002Z","relevant_disorders":["R141"],"stats":{"number_of_genes":77,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}}]}