{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:24475","gene_name":"dimethylglycine dehydrogenase","omim_gene":["605849"],"alias_name":null,"gene_symbol":"DMGDH","hgnc_symbol":"DMGDH","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"5:78293438-78531861","ensembl_id":"ENSG00000132837"}},"GRch38":{"90":{"location":"5:78997606-79236038","ensembl_id":"ENSG00000132837"}}},"hgnc_date_symbol_changed":"2004-05-12"},"entity_type":"gene","entity_name":"DMGDH","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["11231903 - case study","27604308","18937046 - functional study expressing the variant form in E.coli showed a decrease in activity"],"evidence":["Expert Review Red","Literature"],"phenotypes":["Dimethylglycinuria (Disorders and variants of enzymes that oxidise xenobiotics other than cytochrome P450)","Dimethylglycine dehydrogenase deficiency  605850"],"mode_of_inheritance":"Unknown","tags":[],"panel":{"id":302,"hash_id":"5763f1518f620350a22bccdb","name":"Undiagnosed metabolic disorders","disease_group":"Metabolic disorders","disease_sub_group":"Specific metabolic abnormalities","status":"public","version":"1.373","version_created":"2019-10-08T14:47:17.153678Z","relevant_disorders":["Undiagnosed Metabolic Panel"],"stats":{"number_of_genes":744,"number_of_strs":1,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":[],"biotype":"protein_coding","hgnc_id":"HGNC:24475","gene_name":"dimethylglycine dehydrogenase","omim_gene":["605849"],"alias_name":null,"gene_symbol":"DMGDH","hgnc_symbol":"DMGDH","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"5:78293438-78531861","ensembl_id":"ENSG00000132837"}},"GRch38":{"90":{"location":"5:78997606-79236038","ensembl_id":"ENSG00000132837"}}},"hgnc_date_symbol_changed":"2004-05-12"},"entity_type":"gene","entity_name":"DMGDH","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":"","publications":["27604308","18937046 - functional study expressing the variant form in E.coli showed a decrease in activity","11231903 - case study"],"evidence":["London North GLH","NHS GMS","Expert Review Red"],"phenotypes":["Dimethylglycine dehydrogenase deficiency  605850","Dimethylglycinuria (Disorders and variants of enzymes that oxidise xenobiotics other than cytochrome P450)"],"mode_of_inheritance":"Unknown","tags":[],"panel":{"id":467,"hash_id":null,"name":"Inborn errors of metabolism","disease_group":"","disease_sub_group":"","status":"public","version":"1.348","version_created":"2019-10-09T08:19:52.386941Z","relevant_disorders":["Likely inborn error of metabolism - targeted testing not possible"],"stats":{"number_of_genes":877,"number_of_strs":2,"number_of_regions":1},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"Component Of Super Panel","slug":"component-of-super-panel","description":"This panel is a component of a Super Panel"}]}}]}
