{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["DFNA40"],"biotype":"protein_coding","hgnc_id":"HGNC:2418","gene_name":"crystallin mu","omim_gene":["123740"],"alias_name":["thiomorpholine-carboxylate dehydrogenase"],"gene_symbol":"CRYM","hgnc_symbol":"CRYM","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"16:21250195-21314404","ensembl_id":"ENSG00000103316"}},"GRch38":{"90":{"location":"16:21238874-21303083","ensembl_id":"ENSG00000103316"}}},"hgnc_date_symbol_changed":"1992-11-26"},"entity_type":"gene","entity_name":"CRYM","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["12471561","18448257","24676347","26915689","16740909","17264173"],"evidence":["ClinGen","Expert Review Red"],"phenotypes":["autosomal dominant nonsyndromic deafness 40"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":64,"hash_id":"58ee38f88f62033bda307d54","name":"ClinGen Gene Validity Curations","disease_group":"","disease_sub_group":"","status":"public","version":"0.64","version_created":"2019-06-20T15:10:34.572009Z","relevant_disorders":[],"stats":{"number_of_genes":47,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"ClinGen Curated genes","slug":"clingen-curated-genes","description":"ClinGen Curated genes"}]}},{"gene_data":{"alias":["DFNA40"],"biotype":"protein_coding","hgnc_id":"HGNC:2418","gene_name":"crystallin mu","omim_gene":["123740"],"alias_name":["thiomorpholine-carboxylate dehydrogenase"],"gene_symbol":"CRYM","hgnc_symbol":"CRYM","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"16:21250195-21314404","ensembl_id":"ENSG00000103316"}},"GRch38":{"90":{"location":"16:21238874-21303083","ensembl_id":"ENSG00000103316"}}},"hgnc_date_symbol_changed":"1992-11-26"},"entity_type":"gene","entity_name":"CRYM","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":["12471561","1384048","1478656","16740909","9328354"],"evidence":["Expert Review Red","Expert","Radboud University Medical Center, Nijmegen","Emory Genetics Laboratory","UKGTN"],"phenotypes":["hearing loss","Deafness, autosomal dominant 40"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":126,"hash_id":"558ac48fbb5a16630dcfeaad","name":"Hearing loss","disease_group":"Hearing and ear disorders","disease_sub_group":"Non-syndromic hearing loss","status":"public","version":"2.2","version_created":"2019-09-03T14:01:56.987667Z","relevant_disorders":["Congenital hearing impairment","Autosomal dominant deafness","Congenital hearing impairment (profound/severe)","R67"],"stats":{"number_of_genes":358,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}}]}