{"count":3,"next":null,"previous":null,"results":[{"gene_data":{"alias":["FHR-3","HLF4","FHR3","DOWN16"],"biotype":"protein_coding","hgnc_id":"HGNC:16980","gene_name":"complement factor H related 3","omim_gene":["605336"],"alias_name":null,"gene_symbol":"CFHR3","hgnc_symbol":"CFHR3","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"1:196743925-196763203","ensembl_id":"ENSG00000116785"}},"GRch38":{"90":{"location":"1:196774795-196795406","ensembl_id":"ENSG00000116785"}}},"hgnc_date_symbol_changed":"2006-02-28"},"entity_type":"gene","entity_name":"CFHR3","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["16998489","17367211"],"evidence":["Expert Review Green","UKGTN","Literature"],"phenotypes":["Hemolytic uremic syndrome, atypical, susceptibility to\t235400"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":[],"panel":{"id":139,"hash_id":"563248da22c1fc58285b283a","name":"Atypical haemolytic uraemic syndrome","disease_group":"Renal and urinary tract disorders","disease_sub_group":"Syndromes with prominent renal abnormalities","status":"public","version":"2.1","version_created":"2019-08-19T11:44:11.988896Z","relevant_disorders":["R201"],"stats":{"number_of_genes":13,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}},{"gene_data":{"alias":["FHR-3","HLF4","FHR3","DOWN16"],"biotype":"protein_coding","hgnc_id":"HGNC:16980","gene_name":"complement factor H related 3","omim_gene":["605336"],"alias_name":null,"gene_symbol":"CFHR3","hgnc_symbol":"CFHR3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"1:196743925-196763203","ensembl_id":"ENSG00000116785"}},"GRch38":{"90":{"location":"1:196774795-196795406","ensembl_id":"ENSG00000116785"}}},"hgnc_date_symbol_changed":"2006-02-28"},"entity_type":"gene","entity_name":"CFHR3","confidence_level":"2","penetrance":null,"mode_of_pathogenicity":null,"publications":[],"evidence":["Expert Review Amber","IUIS Classification February 2018","Victorian Clinical Genetics Services","GRID V2.0"],"phenotypes":["Age related macular degeneration","Atypical hemolytic uremic syndrome susceptibility","Older onset atypical hemolytic-uremic syndrome, disseminated neisserial infections","Complement Deficiencies"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":[],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["FHR-3","HLF4","FHR3","DOWN16"],"biotype":"protein_coding","hgnc_id":"HGNC:16980","gene_name":"complement factor H related 3","omim_gene":["605336"],"alias_name":null,"gene_symbol":"CFHR3","hgnc_symbol":"CFHR3","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"1:196743925-196763203","ensembl_id":"ENSG00000116785"}},"GRch38":{"90":{"location":"1:196774795-196795406","ensembl_id":"ENSG00000116785"}}},"hgnc_date_symbol_changed":"2006-02-28"},"entity_type":"gene","entity_name":"CFHR3","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["16998489","17367211"],"evidence":["Expert Review Green","NHS GMS"],"phenotypes":["Hemolytic uremic syndrome, atypical, susceptibility to 235400"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":[],"panel":{"id":678,"hash_id":null,"name":"Unexplained paediatric onset end-stage renal disease","disease_group":"","disease_sub_group":"","status":"public","version":"0.43","version_created":"2019-09-25T12:25:36.245604Z","relevant_disorders":["R257"],"stats":{"number_of_genes":229,"number_of_strs":0,"number_of_regions":3},"types":[{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}}]}