{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["FHR2"],"biotype":"protein_coding","hgnc_id":"HGNC:4890","gene_name":"complement factor H related 2","omim_gene":["600889"],"alias_name":null,"gene_symbol":"CFHR2","hgnc_symbol":"CFHR2","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"1:196788898-196928356","ensembl_id":"ENSG00000080910"}},"GRch38":{"90":{"location":"1:196943772-196959226","ensembl_id":"ENSG00000080910"}}},"hgnc_date_symbol_changed":"2006-02-28"},"entity_type":"gene","entity_name":"CFHR2","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["24172683","24334459","23728178","20800271","22456601","27458560"],"evidence":["Expert Review Green","Expert list"],"phenotypes":["C3 glomerulopathy","C3G","Immune complex MPGN","IC-MPGN","Immune-complex-mediated MPGN"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":["currently-ngs-unreportable"],"panel":{"id":83,"hash_id":"58c805938f6203413360f1cb","name":"Membranoproliferative glomerulonephritis","disease_group":"Renal and urinary tract disorders","disease_sub_group":"Syndromes with prominent renal abnormalities","status":"public","version":"2.1","version_created":"2019-10-09T07:08:35.885497Z","relevant_disorders":["PMG","MPGN","Primary Membranoproliferative Glomerulonephritis","Primary membranoproliferative glomerulonephritis","R197"],"stats":{"number_of_genes":9,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}},{"gene_data":{"alias":["FHR2"],"biotype":"protein_coding","hgnc_id":"HGNC:4890","gene_name":"complement factor H related 2","omim_gene":["600889"],"alias_name":null,"gene_symbol":"CFHR2","hgnc_symbol":"CFHR2","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"1:196788898-196928356","ensembl_id":"ENSG00000080910"}},"GRch38":{"90":{"location":"1:196943772-196959226","ensembl_id":"ENSG00000080910"}}},"hgnc_date_symbol_changed":"2006-02-28"},"entity_type":"gene","entity_name":"CFHR2","confidence_level":"1","penetrance":null,"mode_of_pathogenicity":null,"publications":[],"evidence":["IUIS Classification February 2018","Victorian Clinical Genetics Services","Expert Review Red","GRID V2.0"],"phenotypes":["Age related macular degeneration","Atypical hemolytic uremic syndrome susceptibility","Older onset atypical hemolytic-uremic syndrome, disseminated neisserial infections","Complement Deficiencies"],"mode_of_inheritance":"Unknown","tags":[],"panel":{"id":398,"hash_id":null,"name":"Primary immunodeficiency","disease_group":"","disease_sub_group":"","status":"public","version":"1.132","version_created":"2019-09-27T14:37:49.085568Z","relevant_disorders":["Primary immunodeficiency disorders","A- or hypo-gammaglobulinaemia","Congenital neutropaenia","Agranulocytosis","Combined B and T cell defect","Inherited complement deficiency","SCID","Primary immune disorder","Primary immunodeficiency","A-gammaglobulinaemia","Agammaglobulinaemia","hypo-gammaglobulinaemia","hypogammaglobulinemia","immune deficiency syndromes","Severe combined immunodeficiency","Congenital neutopenia","Familial haemophagocytic lymphohistiocytic disorders","Familial hemophagocytic lymphohistiocytic disorders","PID","Sepsis","Disseminated non-tuberculous mycobacterial infection","R15"],"stats":{"number_of_genes":395,"number_of_strs":0,"number_of_regions":2},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}}]}