{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["ME2","HFMI2","FMI2","CDHF9","ADGRC1"],"biotype":"protein_coding","hgnc_id":"HGNC:1850","gene_name":"cadherin EGF LAG seven-pass G-type receptor 1","omim_gene":["604523"],"alias_name":["flamingo homolog 2 (Drosophila)","adhesion G protein-coupled receptor C1"],"gene_symbol":"CELSR1","hgnc_symbol":"CELSR1","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"22:46756731-46933067","ensembl_id":"ENSG00000075275"}},"GRch38":{"90":{"location":"22:46360834-46537170","ensembl_id":"ENSG00000075275"}}},"hgnc_date_symbol_changed":"2000-02-14"},"entity_type":"gene","entity_name":"CELSR1","confidence_level":"1","penetrance":"Complete","mode_of_pathogenicity":"","publications":[],"evidence":["Expert"],"phenotypes":[],"mode_of_inheritance":"","tags":[],"panel":{"id":126,"hash_id":"558ac48fbb5a16630dcfeaad","name":"Hearing loss","disease_group":"Hearing and ear disorders","disease_sub_group":"Non-syndromic hearing loss","status":"public","version":"2.2","version_created":"2019-09-03T14:01:56.987667Z","relevant_disorders":["Congenital hearing impairment","Autosomal dominant deafness","Congenital hearing impairment (profound/severe)","R67"],"stats":{"number_of_genes":358,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."},{"name":"GMS Rare Disease","slug":"gms-rare-disease","description":"This panel type is used for GMS panels that are not virtual (i.e. could be a wet lab test)"}]}},{"gene_data":{"alias":["ME2","HFMI2","FMI2","CDHF9","ADGRC1"],"biotype":"protein_coding","hgnc_id":"HGNC:1850","gene_name":"cadherin EGF LAG seven-pass G-type receptor 1","omim_gene":["604523"],"alias_name":["flamingo homolog 2 (Drosophila)","adhesion G protein-coupled receptor C1"],"gene_symbol":"CELSR1","hgnc_symbol":"CELSR1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"22:46756731-46933067","ensembl_id":"ENSG00000075275"}},"GRch38":{"90":{"location":"22:46360834-46537170","ensembl_id":"ENSG00000075275"}}},"hgnc_date_symbol_changed":"2000-02-14"},"entity_type":"gene","entity_name":"CELSR1","confidence_level":"3","penetrance":"Incomplete","mode_of_pathogenicity":null,"publications":["31403174","26855770","31215153"],"evidence":["Expert Review Green","Expert list"],"phenotypes":["hereditary lymphedema"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":65,"hash_id":"57ee82ef8f62035c9b2d0487","name":"Primary lymphoedema","disease_group":"Cardiovascular disorders","disease_sub_group":"Lymphatic Disorders","status":"public","version":"2.0","version_created":"2019-10-02T14:10:33.689992Z","relevant_disorders":["Lymphatic Disorders","Meiges disease","Meige disease","Milroy disease","Lymphoedema distichiasis","Lipoedema disease","R136"],"stats":{"number_of_genes":51,"number_of_strs":0,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"},{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}}]}