{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["APPL"],"biotype":"protein_coding","hgnc_id":"HGNC:24035","gene_name":"adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1","omim_gene":["604299"],"alias_name":["DCC-interacting protein 13-alpha"],"gene_symbol":"APPL1","hgnc_symbol":"APPL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:57261765-57307496","ensembl_id":"ENSG00000157500"}},"GRch38":{"90":{"location":"3:57227737-57273468","ensembl_id":"ENSG00000157500"}}},"hgnc_date_symbol_changed":"2007-01-26"},"entity_type":"gene","entity_name":"APPL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["NHS GMS","Expert Review Green","Expert Review Green","NHS GMS"],"phenotypes":["{Maturity-onset diabetes of the young, type 14}, 616511"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":152,"hash_id":"553f9745bb5a1616e5ed45e9","name":"Familial diabetes","disease_group":"Endocrine disorders","disease_sub_group":"Disorders of unusual phenotypes","status":"public","version":"1.38","version_created":"2019-06-20T15:15:02.453936Z","relevant_disorders":["Familial young-onset non-insulin-dependent diabetes"],"stats":{"number_of_genes":56,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}},{"gene_data":{"alias":["APPL"],"biotype":"protein_coding","hgnc_id":"HGNC:24035","gene_name":"adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1","omim_gene":["604299"],"alias_name":["DCC-interacting protein 13-alpha"],"gene_symbol":"APPL1","hgnc_symbol":"APPL1","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:57261765-57307496","ensembl_id":"ENSG00000157500"}},"GRch38":{"90":{"location":"3:57227737-57273468","ensembl_id":"ENSG00000157500"}}},"hgnc_date_symbol_changed":"2007-01-26"},"entity_type":"gene","entity_name":"APPL1","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":[],"evidence":["Expert Review Green","NHS GMS"],"phenotypes":["{Maturity-onset diabetes of the young, type 14}, 616511","Diabetes"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":472,"hash_id":null,"name":"Monogenic diabetes","disease_group":"","disease_sub_group":"","status":"public","version":"2.1","version_created":"2019-07-31T13:20:07.800002Z","relevant_disorders":["R141"],"stats":{"number_of_genes":77,"number_of_strs":0,"number_of_regions":1},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."},{"name":"GMS signed-off","slug":"gms-signed-off","description":"This panel has undergone review by a NHSE GMS disease specialist group and processes to be signed-off for use within the GMS."}]}}]}