{"count":2,"next":null,"previous":null,"results":[{"gene_data":{"alias":["RNASE5","RAA1"],"biotype":"protein_coding","hgnc_id":"HGNC:483","gene_name":"angiogenin","omim_gene":["105850"],"alias_name":["ribonuclease A family member 5"],"gene_symbol":"ANG","hgnc_symbol":"ANG","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"14:21152336-21167130","ensembl_id":"ENSG00000214274"}},"GRch38":{"90":{"location":"14:20684177-20698971","ensembl_id":"ENSG00000214274"}}},"hgnc_date_symbol_changed":"1989-05-23"},"entity_type":"gene","entity_name":"ANG","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["16501576","26753798","17886298","26255299"],"evidence":["Wessex and West Midlands GLH","Yorkshire and North East GLH","NHS GMS","London North GLH","Expert Review Green"],"phenotypes":["Amyotrophic lateral sclerosis 9, 611895","Amyotrophic Lateral Sclerosis, Dominant","familial amyotrophic lateral sclerosis (ALS9)"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":474,"hash_id":null,"name":"Neurodegenerative disorders - adult onset","disease_group":"","disease_sub_group":"","status":"public","version":"1.106","version_created":"2019-09-20T16:19:10.101841Z","relevant_disorders":["R58"],"stats":{"number_of_genes":395,"number_of_strs":18,"number_of_regions":4},"types":[{"name":"GMS Rare Disease Virtual","slug":"gms-rare-disease-virtual","description":"This is a panel for the Genomic Medicine Service for an exome/genome/panel based test that requires a virtual gene panel for rare disease in the Test Directory."}]}},{"gene_data":{"alias":["RNASE5","RAA1"],"biotype":"protein_coding","hgnc_id":"HGNC:483","gene_name":"angiogenin","omim_gene":["105850"],"alias_name":["ribonuclease A family member 5"],"gene_symbol":"ANG","hgnc_symbol":"ANG","hgnc_release":"2017-11-03T00:00:00","ensembl_genes":{"GRch37":{"82":{"location":"14:21152336-21167130","ensembl_id":"ENSG00000214274"}},"GRch38":{"90":{"location":"14:20684177-20698971","ensembl_id":"ENSG00000214274"}}},"hgnc_date_symbol_changed":"1989-05-23"},"entity_type":"gene","entity_name":"ANG","confidence_level":"3","penetrance":"Complete","mode_of_pathogenicity":"","publications":["PMID: 26753798 - meta-analysis reporting that the rs11701 SNP is not associated with ALS","PMID: 26255299 - meta-analysis concluding that the K17I variant increases the risk for ALS and familial ALS but not sporadic ALS in Caucasian patients","PMID: 25907842 - 31 Chinese Han families with familial amyotrophic lateral sclerosis were screened but no ANG gene variants were found, suggesting it is a rare cause of ALS in this population","PMID: 25372031 functional investigation of ANG variants."],"evidence":["Expert Review Green","Radboud University Medical Center, Nijmegen","Illumina TruGenome Clinical Sequencing Services"],"phenotypes":["Amyotrophic Lateral Sclerosis, Dominant","Amyotrophic lateral sclerosis 9, 611895","familial amyotrophic lateral sclerosis (ALS9)"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","tags":[],"panel":{"id":263,"hash_id":"55d30b0322c1fc2ff2a5bf7b","name":"Amyotrophic lateral sclerosis/motor neuron disease","disease_group":"Neurology and neurodevelopmental disorders","disease_sub_group":"Neurodegenerative disorders","status":"public","version":"1.29","version_created":"2019-06-20T15:14:55.521778Z","relevant_disorders":["Amyotrophic lateral sclerosis or motor neuron disease"],"stats":{"number_of_genes":30,"number_of_strs":4,"number_of_regions":0},"types":[{"name":"Rare Disease 100K","slug":"rare-disease-100k","description":"Rare Disease 100K"}]}}]}