P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs749433287		7p11.2	7	55019285	C	T	P	L	3	3		missense	0.0015	benign	0.01	deleterious, deleterious - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773069229		7p11.2	7	55019284	C	T	P	S	3	3		missense	0.05633	benign	0.12	deleterious, tolerated, tolerated - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773069229		7p11.2	7	55019284	C	A	P	T	3	3		missense	0.0405	benign	0.035	deleterious, tolerated - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771210838		7p11.2	7	55019288	C	T	S	F	4	4		missense	0.001	benign	0.03	deleterious, deleterious - low confidence, tolerated - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771210838		7p11.2	7	55019288	C	A	S	Y	4	4		missense	0.0	benign	0.03	deleterious, deleterious - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759582787		7p11.2	7	55019291	G	C	G	A	5	5		missense	0.201	benign	0.295	tolerated, tolerated - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759582787		7p11.2	7	55019291	G	A	G	E	5	5		missense	0.01167	benign	0.04333	deleterious, deleterious - low confidence, tolerated - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs774487133		7p11.2	7	55019290	G	C	G	R	5	5		missense	0.021	benign	0.175	tolerated, tolerated - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs767651648		7p11.2	7	55019293	A	G	T	A	6	6		missense	0.0	benign	0.545	tolerated, tolerated - low confidence	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000372969	
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs761183109		7p11.2	7	55019296	G	C	A	P	7	7		missense	0.001	benign	0.07	deleterious, tolerated, tolerated - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs761183109		7p11.2	7	55019296	G	T	A	S	7	7		missense	0.001	benign	0.06333	deleterious, tolerated, tolerated - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754259847		7p11.2	7	55019299	G	A	G	R	8	8		missense	0.0	benign	0.235	tolerated, tolerated - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754259847		7p11.2	7	55019299	G	C	G	R	8	8		missense	0.0015	benign	0.55	tolerated, tolerated - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1217714114		7p11.2	7	55019306	C	A	A	E	10	10		missense	0.045	benign	0.26	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs567894670		7p11.2	7	55019315	C	T	A	V	13	13	7.99E-4	missense	0.0	benign	0.52	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1180577495		7p11.2	7	55019327	C	T	A	V	17	17		missense	0.0	benign	0.65	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs754527029		7p11.2	7	55019329	C	T	L	F	18	18		missense	0.221	benign	0.12	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs780865931		7p11.2	7	55019333	G	C	C	S	19	19		missense	0.003	benign	0.46	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1028735720		7p11.2	7	55019336	C	A	P	Q	20	20		missense	0.0	benign	0.31	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1028735720		7p11.2	7	55019336	C	G	P	R	20	20		missense	0.0	benign	0.52	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1194702075		7p11.2	7	55019339	C	A	A	E	21	21		missense	0.062	benign	0.45	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373129709		7p11.2	7	55019338	G	T	A	S	21	21		missense	0.051	benign	0.59	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373129709		7p11.2	7	55019338	G	A	A	T	21	21		missense	0.0	benign	0.48	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1194702075		7p11.2	7	55019339	C	T	A	V	21	21		missense	0.037	benign	0.44	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1257423707		7p11.2	7	55019342	G	A	S	N	22	22		missense	0.015	benign	0.49	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs987102148		7p11.2	7	55019344	C	T	R	W	23	23		missense	0.0	benign	0.19	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs911767401		7p11.2	7	55019347	G	A	A	T	24	24		missense	0.021	benign	0.19	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs749088691		7p11.2	7	55019359	A	G	K	E	28	28		missense	0.01	benign	0.37	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs774551548		7p11.2	7	55019363	A	C	K	T	29	29		missense	0.028	benign	0.28	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs746023542		7p11.2	7	55142292	A	G	Q	R	32	32		missense	0.4705	benign, probably damaging	0.58	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs772311777		7p11.2	7	55142294	G	A	G	S	33	33		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs144158123		7p11.2	7	55142298	C	T	T	M	34	34		missense	0.77633	possibly damaging, probably damaging	0.05667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs144158123		7p11.2	7	55142298	C	G	T	R	34	34		missense	0.869	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1406387936		7p11.2	7	55142301	G	A	S	N	35	35		missense	0.0	benign	0.24	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs375919121		7p11.2	7	55142313	C	T	T	M	39	39		missense	0.8595	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1442908038		7p11.2	7	55142321	G	A	G	S	42	42		missense	0.53133	benign, possibly damaging, probably damaging	0.44	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1001476056		7p11.2	7	55142328	T	C	F	S	44	44		missense	0.0	benign	0.43	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1052582656		7p11.2	7	55142335	T	A	D	E	46	46		missense	0.026	benign	0.11	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1343024399		7p11.2	7	55142334	A	T	D	V	46	46		missense	0.45025	benign, possibly damaging, probably damaging	0.1025	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1263793183		7p11.2	7	55142340	T	C	F	S	48	48		missense	0.71	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs759219499		7p11.2	7	55142355	G	A	R	K	53	53		missense	0.003	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs767259994		7p11.2	7	55142364	A	G	N	S	56	56		missense	0.003	benign	0.84	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs763572530		7p11.2	7	55142373	A	C	E	A	59	59		missense	0.82	possibly damaging, probably damaging	0.015	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs760228905		7p11.2	7	55142372	G	A	E	K	59	59		missense	0.67875	benign, possibly damaging, probably damaging	0.0275	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1470757416		7p11.2	7	55142408	C	T	Q	*	71	71		stop gained					0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369580836		7p11.2	7	55142409	A	C	Q	P	71	71		missense	0.006	benign	0.09	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369580836		7p11.2	7	55142409	A	G	Q	R	71	71		missense	0.497	benign, possibly damaging	0.2	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1269583681		7p11.2	7	55142416	T	G	N	K	73	73		missense	0.06	benign	0.07	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs778638117		7p11.2	7	55142423	C	A	L	I	76	76		missense	0.9055	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs374986786		7p11.2	7	55143305	A	G	T	A	81	81		missense	0.038	benign	0.04	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1309796320		7p11.2	7	55143308	A	G	I	V	82	82		missense	0.85567	possibly damaging, probably damaging	0.03	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1282801317		7p11.2	7	55143316	G	C	E	D	84	84		missense	0.996	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs753319070		7p11.2	7	55143314	G	A	E	K	84	84		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs753319070		7p11.2	7	55143314	G	C	E	Q	84	84		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs765137528		7p11.2	7	55143327	A	G	Y	C	88	88		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs750399097		7p11.2	7	55143332	C	T	L	F	90	90		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs142061256		7p11.2	7	55143333	T	A	L	H	90	90		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs779879611		7p11.2	7	55143339	C	T	A	V	92	92		missense	0.961	probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1422504667		7p11.2	7	55143348	C	T	T	I	95	95		missense	0.134	benign	0.13	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1260357262		7p11.2	7	55143350	G	A	V	M	96	96		missense	0.889	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs755189573		7p11.2	7	55143353	G	C	E	Q	97	97		missense	0.35	benign	0.33	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17289589		7p11.2	7	55143357	G	T	R	L	98	98		missense	0.047	benign	0.28	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs17289589	COSM4680391	7p11.2	7	55143357	G	A	R	Q	98	98		missense	0.007	benign	0.32	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,NCI-TCGA	rs376963968	COSM6047689	7p11.2	7	55143363	C	A	P	H	100	100		missense	0.559	benign, possibly damaging	0.04667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl	rs866460345	COSM4892885	7p11.2	7	55143362	C	T	P	S	100	100		missense	0.8665	possibly damaging, probably damaging	0.015	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs141271101		7p11.2	7	55143379	G	C	Q	H	105	105		missense	0.9075	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771366736		7p11.2	7	55143380	A	G	I	V	106	106		missense	0.031	benign	0.15	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519888	COSM1451537	7p11.2	7	55143386	A	G	R	G	108	108		missense	1.0	probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000424206,ClinVar:RCV000434481	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519828	COSM5576118	7p11.2	7	55143387	G	A	R	K	108	108		missense	1.0	probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000432019	
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs145113601		7p11.2	7	55143390	G	C	G	A	109	109		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1488843432		7p11.2	7	55143397	G	A	M	I	111	111		missense	0.0	benign	0.13	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746631025		7p11.2	7	55143396	T	C	M	T	111	111		missense	0.0	benign	0.56	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1385682568		7p11.2	7	55143402	A	T	Y	F	113	113		missense	0.576	benign, possibly damaging	0.225	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1219568637	COSM5835422	7p11.2	7	55143404	G	A	E	K	114	114		missense	0.011	benign	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1332428616		7p11.2	7	55143407	A	C	N	H	115	115		missense	0.4832	benign, possibly damaging, probably damaging	0.046	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773596817		7p11.2	7	55143409	T	A	N	K	115	115		missense	0.361	benign, possibly damaging	0.14	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1247204001		7p11.2	7	55143417	C	G	A	G	118	118		missense	0.573	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1249939049		7p11.2	7	55143416	G	T	A	S	118	118		missense	0.9285	possibly damaging, probably damaging	0.1	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1229095978		7p11.2	7	55143432	C	T	S	F	123	123		missense	0.592	benign, possibly damaging, probably damaging	0.30333	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1295285127		7p11.2	7	55143438	A	G	Y	C	125	125		missense	0.968	probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs377444977		7p11.2	7	55143443	G	A	A	T	127	127		missense	0.001	benign	0.58	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1485906237		7p11.2	7	55143444	C	T	A	V	127	127		missense	0.0	benign	0.09	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs762889647		7p11.2	7	55143450	A	C	K	T	129	129		missense	0.007	benign	0.37	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1485016142		7p11.2	7	55143455	G	A	G	R	131	131		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs751337426		7p11.2	7	55143464	G	A	E	K	134	134		missense	0.3735	benign, possibly damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754854319		7p11.2	7	55143473	A	G	M	V	137	137		missense	0.084	benign	0.03	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1437762652		7p11.2	7	55143477	G	A	R	K	138	138		missense	0.018	benign	0.74	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs767608234		7p11.2	7	55143487	G	T	Q	H	141	141		missense	0.303	benign, possibly damaging	0.02333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1198703773		7p11.2	7	55146614	C	A	H	N	145	145		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780476417		7p11.2	7	55146615	A	G	H	R	145	145		missense	0.0	benign	0.32	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs532655845		7p11.2	7	55146620	G	C	A	P	147	147	2.0E-4	missense	0.403	benign, possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,NCI-TCGA,TOPMed,gnomAD	rs532655845		7p11.2	7	55146620	G	A	A	T	147	147	2.0E-4	missense	0.026	benign	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759532524		7p11.2	7	55146627	G	A	R	Q	149	149		missense	0.2575	benign, possibly damaging	0.375	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs774146556	COSM3412169	7p11.2	7	55146626	C	T	R	W	149	149		missense	0.34	benign, probably damaging	0.08333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1398462122		7p11.2	7	55146629	T	C	F	L	150	150		missense	0.0805	benign	0.045	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs551591429		7p11.2	7	55146636	A	G	N	S	152	152	2.0E-4	missense	0.054	benign	0.38	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs919891568		7p11.2	7	55146644	G	T	A	S	155	155		missense	0.007	benign	0.42	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs937907395		7p11.2	7	55146653	A	G	N	D	158	158		missense	0.2725	benign, possibly damaging	0.225	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs761795138		7p11.2	7	55146675	G	A	R	Q	165	165		missense	0.007	benign	0.68	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs587778252		7p11.2	7	55146674	C	T	R	W	165	165		missense	0.4455	benign, possibly damaging	0.26	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs765416003		7p11.2	7	55146681	T	C	I	T	167	167		missense	0.988	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs530692924		7p11.2	7	55146683	G	C	V	L	168	168	2.0E-4	missense	0.056	benign	0.23	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs758945260		7p11.2	7	55146690	G	T	S	I	170	170		missense	0.017	benign	0.04	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs758945260		7p11.2	7	55146690	G	A	S	N	170	170		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs17289686		7p11.2	7	55146694	C	A	D	E	171	171	3.99E-4	missense	0.001	benign	0.72	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770290445		7p11.2	7	55146711	C	T	S	L	177	177		missense	0.003	benign	0.18	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770290445		7p11.2	7	55146711	C	G	S	W	177	177		missense	0.9005	possibly damaging, probably damaging	0.015	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs745755245		7p11.2	7	55146715	G	A	M	I	178	178		missense	0.001	benign	0.82	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1219334377		7p11.2	7	55146713	A	G	M	V	178	178		missense	0.0	benign	0.22	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs772071414		7p11.2	7	55146728	C	G	H	D	183	183		missense	0.007	benign	0.42	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs772071414		7p11.2	7	55146728	C	A	H	N	183	183		missense	0.0	benign	0.98	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs921852102		7p11.2	7	55146732	T	C	L	P	184	184		missense	0.0	benign	0.4	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs921852102		7p11.2	7	55146732	T	A	L	Q	184	184		missense	0.003	benign	0.6	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1224862076		7p11.2	7	55146731	C	G	L	V	184	184		missense	0.003	benign	0.31	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770074413		7p11.2	7	55151308	C	A	P	T	192	192		missense	0.146	benign	0.045	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs766507267		7p11.2	7	55151321	A	G	N	S	196	196		missense	0.021	benign	0.27	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1335854310		7p11.2	7	55151327	G	A	S	N	198	198		missense	0.2725	benign, possibly damaging	0.33	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs767829342		7p11.2	7	55151344	G	A	E	K	204	204		missense	0.001	benign	0.46	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs779156097		7p11.2	7	55152549	C	G	T	S	211	211		missense	0.878	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs750423932		7p11.2	7	55152551	A	C	K	Q	212	212		missense	0.625	benign, possibly damaging, probably damaging	0.00667	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1372330611		7p11.2	7	55152564	C	G	A	G	216	216		missense	0.992	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1190573231		7p11.2	7	55152563	G	A	A	T	216	216		missense	0.9455	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs776050604		7p11.2	7	55152571	G	T	Q	H	218	218		missense	0.7655	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs761098433		7p11.2	7	55152575	T	C	S	P	220	220		missense	0.56675	benign, probably damaging	0.0825	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs776886714		7p11.2	7	55152578	G	A	G	R	221	221		missense	0.067	benign	0.2	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs776886714		7p11.2	7	55152578	G	T	G	W	221	221		missense	0.666	benign, probably damaging	0.035	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751295137		7p11.2	7	55152582	G	A	R	H	222	222		missense	0.965	possibly damaging, probably damaging	0.06333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs759106015		7p11.2	7	55152588	G	A	R	H	224	224		missense	0.913	possibly damaging, probably damaging	0.33	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1046438724	COSM3639726	7p11.2	7	55152597	C	T	S	F	227	227		missense	0.2485	benign, possibly damaging	0.625	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs766952405		7p11.2	7	55152596	T	C	S	P	227	227		missense	0.267	benign, possibly damaging	0.185	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs752616839		7p11.2	7	55152600	C	A	P	H	228	228		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1247276424		7p11.2	7	55152602	A	G	S	G	229	229		missense	0.47933	benign, possibly damaging	0.03333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1291943679		7p11.2	7	55152603	G	A	S	N	229	229		missense	0.3905	benign, possibly damaging	0.255	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1357816760		7p11.2	7	55152604	T	A	S	R	229	229		missense	0.6474	benign, possibly damaging, probably damaging	0.072	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1203062307		7p11.2	7	55152606	A	C	D	A	230	230		missense	0.981	probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC	rs756040606		7p11.2	7	55152608	T	G	C	G	231	231		missense	0.998	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs777575581		7p11.2	7	55152609	G	C	C	S	231	231		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1447176163		7p11.2	7	55152633	G	C	G	A	239	239		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs370744986		7p11.2	7	55152639	C	T	T	I	241	241		missense	0.9335	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs554981236		7p11.2	7	55152647	C	G	R	G	244	244	2.0E-4	missense	0.40425	benign, possibly damaging	0.0475	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs200664836		7p11.2	7	55152648	G	A	R	Q	244	244	2.0E-4	missense	0.031	benign	0.2	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs554981236		7p11.2	7	55152647	C	T	R	W	244	244	2.0E-4	missense	0.918	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780001754		7p11.2	7	55152656	G	C	D	H	247	247		missense	0.878	possibly damaging, probably damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780001754		7p11.2	7	55152656	G	A	D	N	247	247		missense	0.38567	benign, possibly damaging	0.03667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs765893589		7p11.2	7	55152663	T	C	L	P	249	249		missense	0.996	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs775252718		7p11.2	7	55154017	C	G	R	G	252	252		missense	0.65075	benign, possibly damaging, probably damaging	0.025	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs760101437	COSM1176674	7p11.2	7	55154018	G	A	R	H	252	252		missense	0.0305	benign	0.07	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs374084791		7p11.2	7	55154021	A	G	K	R	253	253	5.99E-4	missense	0.003	benign	0.36	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs776490661		7p11.2	7	55154026	C	T	R	*	255	255		stop gained					0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs372202099		7p11.2	7	55154027	G	A	R	Q	255	255		missense	0.003	benign	0.17	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs138847501		7p11.2	7	55154032	G	A	E	K	257	257		missense	0.247	benign	0.04	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs766478921		7p11.2	7	55154039	C	T	T	M	259	259		missense	0.888	possibly damaging, probably damaging	0.105	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1396651256		7p11.2	7	55154038	A	C	T	P	259	259		missense	0.999	probably damaging	0.04	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1057519829		7p11.2	7	55154050	A	G	T	A	263	263		missense	0.003	benign	0.85	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	dbSNP,gnomAD	rs1057519829	COSM21684	7p11.2	7	55154050	A	C	T	P	263	263		missense	0.422	benign, possibly damaging	0.205	tolerated	1	Neoplasm of brain				ClinVar:RCV000444169	
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748627278		7p11.2	7	55154057	C	A	P	H	265	265		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17336639		7p11.2	7	55154060	C	A	P	Q	266	266		missense	0.021	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17336639		7p11.2	7	55154060	C	G	P	R	266	266		missense	0.38	benign, possibly damaging	0.295	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1483973439		7p11.2	7	55154066	T	C	M	T	268	268		missense	0.3645	benign, possibly damaging	0.31	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1220356597		7p11.2	7	55154068	C	T	L	F	269	269		missense	0.4345	benign, possibly damaging	0.15	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1268199326		7p11.2	7	55154078	C	A	P	H	272	272		missense	0.8905	possibly damaging, probably damaging	0.025	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1412517681		7p11.2	7	55154083	A	G	T	A	274	274		missense	0.0295	benign	0.04	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs966001143		7p11.2	7	55154084	C	T	T	M	274	274		missense	0.8685	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs771396903		7p11.2	7	55154090	A	G	Q	R	276	276		missense	0.25767	benign, possibly damaging	0.07333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1215369904		7p11.2	7	55154093	T	C	M	T	277	277		missense	0.38767	benign, possibly damaging	0.02667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs918710688		7p11.2	7	55154105	C	G	P	R	281	281		missense	0.8725	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs199796955		7p11.2	7	55154107	G	A	E	K	282	282		missense	0.011	benign	0.17	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs776146284		7p11.2	7	55154116	T	C	Y	H	285	285		missense	0.998	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs149840192	COSM21685	7p11.2	7	55154129	C	A	A	D	289	289		missense	0.595	benign, possibly damaging, probably damaging	0.01667	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000434840,ClinVar:RCV000427425,ClinVar:RCV000443311	
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,dbSNP,gnomAD	rs769696078	COSM21686	7p11.2	7	55154128	G	A	A	T	289	289		missense	0.9275	possibly damaging, probably damaging	0.01	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000443246,ClinVar:RCV000433672,ClinVar:RCV000422848	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs149840192	COSM4966963	7p11.2	7	55154129	C	T	A	V	289	289		missense	0.953	probably damaging	0.03	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000423404,ClinVar:RCV000423749,ClinVar:RCV000439402	
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1020654485		7p11.2	7	55154132	C	T	T	I	290	290		missense	0.74467	benign, possibly damaging, probably damaging	0.53	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1220574404		7p11.2	7	55154135	G	T	C	F	291	291		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC	rs762649354		7p11.2	7	55154138	T	C	V	A	292	292		missense	0.909	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,NCI-TCGA,TOPMed,gnomAD	rs150549265		7p11.2	7	55154137	G	A	V	M	292	292		missense	0.9	possibly damaging, probably damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs751667358		7p11.2	7	55154152	C	T	R	C	297	297		missense	0.569	possibly damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs779094647		7p11.2	7	55155841	G	T	V	L	301	301		missense	0.66633	benign, possibly damaging, probably damaging	0.01333	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs182002674		7p11.2	7	55155852	C	A	H	Q	304	304	3.99E-4	missense	0.502	benign, possibly damaging, probably damaging	0.31333	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1277911361		7p11.2	7	55155851	A	G	H	R	304	304		missense	0.46467	benign, possibly damaging	0.16	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1278838499		7p11.2	7	55155853	G	T	G	C	305	305		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1321610304		7p11.2	7	55155859	T	C	C	R	307	307		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs749132706		7p11.2	7	55155862	G	A	V	I	308	308		missense	0.92033	possibly damaging, probably damaging	0.02333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1444692842		7p11.2	7	55155865	C	G	R	G	309	309		missense	0.998	probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs770879879		7p11.2	7	55155875	G	C	G	A	312	312		missense	0.014	benign	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs149321481		7p11.2	7	55155878	C	T	A	V	313	313		missense	0.005	benign	0.16	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,NCI-TCGA	rs552062864		7p11.2	7	55155880	G	A	D	N	314	314	2.0E-4	missense	0.013	benign	0.71	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs745658347		7p11.2	7	55155884	G	A	S	N	315	315		missense	0.095	benign	0.255	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1484032303		7p11.2	7	55155887	A	G	Y	C	316	316		missense	0.791	possibly damaging	0.045	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs775800262		7p11.2	7	55155894	G	T	M	I	318	318		missense	0.0	benign	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1175454134		7p11.2	7	55155895	G	T	E	*	319	319		stop gained					0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs764038041		7p11.2	7	55155903	C	A	D	E	321	321		missense	0.096	benign	0.045	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs776791214		7p11.2	7	55155904	G	A	G	S	322	322		missense	0.95067	possibly damaging, probably damaging	0.04333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs367680488		7p11.2	7	55155908	T	C	V	A	323	323		missense	0.2175	benign	0.045	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs761844164	COSM145361	7p11.2	7	55155907	G	A	V	I	323	323		missense	0.005	benign	0.96	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1343888047		7p11.2	7	55155910	C	T	R	C	324	324		missense	0.925	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs758748662	COSM3881813	7p11.2	7	55155911	G	A	R	H	324	324		missense	0.5916	benign, possibly damaging, probably damaging	0.048	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs766740458		7p11.2	7	55155913	A	C	K	Q	325	325		missense	0.4505	benign, possibly damaging	0.265	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs886037891		7p11.2	7	55155917	G	T	C	F	326	326		missense	1.0	probably damaging	0.0	deleterious	0	Cowden syndrome 1 (CWS1)	The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and Proteus-like syndrome.	MIM:158350		pubmed:15604628,pubmed:20301661,pubmed:24493721,pubmed:25394175,ClinVar:RCV000256393	
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs144460286		7p11.2	7	55155922	A	C	K	Q	328	328		missense	0.527	benign, probably damaging	0.195	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs777342222		7p11.2	7	55155925	T	C	C	R	329	329		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs778901010		7p11.2	7	55155929	A	G	E	G	330	330		missense	0.106	benign	0.42	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs139429793		7p11.2	7	55155928	G	A	E	K	330	330		missense	0.176	benign	0.75	tolerated	0	Lung adenocarcinoma				pubmed:23562183,pubmed:24627688,pubmed:25311215,ClinVar:RCV000677876	
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs778901010		7p11.2	7	55155929	A	T	E	V	330	330		missense	0.441	benign, possibly damaging	0.155	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771929085		7p11.2	7	55155941	G	A	R	H	334	334		missense	0.123	benign	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1284204782		7p11.2	7	55156550	A	C	I	L	342	342		missense	0.014	benign	0.12	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1381010963		7p11.2	7	55156551	T	C	I	T	342	342		missense	0.005	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed	rs771398183		7p11.2	7	55156554	G	T	G	V	343	343		missense	0.8615	possibly damaging, probably damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,TOPMed	rs371234907		7p11.2	7	55156569	C	T	S	L	348	348		missense	0.001	benign	0.18	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs767790289	COSM3881815	7p11.2	7	55156577	A	G	I	V	351	351		missense	0.005	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs753466844		7p11.2	7	55156587	C	T	T	M	354	354		missense	0.69967	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1423110562		7p11.2	7	55156596	A	T	K	I	357	357		missense	0.329	benign	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl	rs1164954595	COSM2155594	7p11.2	7	55156614	C	T	T	I	363	363		missense	0.982	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs749927550		7p11.2	7	55156628	G	C	D	H	368	368		missense	0.68433	benign, possibly damaging, probably damaging	0.02333	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs758017949		7p11.2	7	55156629	A	T	D	V	368	368		missense	0.833	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780131926		7p11.2	7	55156631	C	A	L	I	369	369		missense	0.3535	benign, possibly damaging	0.15	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1405999227		7p11.2	7	55156637	A	G	I	V	371	371		missense	0.515	benign, possibly damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1341708803		7p11.2	7	55156652	T	C	F	L	376	376		missense	0.3245	benign, possibly damaging	0.37	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs755972013		7p11.2	7	55156772	C	A	H	N	383	383		missense	0.001	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1169461493		7p11.2	7	55156773	A	G	H	R	383	383		missense	0.0	benign	0.36	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1197499057		7p11.2	7	55156794	A	C	Q	P	390	390		missense	0.058	benign	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1389500636		7p11.2	7	55156796	G	A	E	K	391	391		missense	0.003	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	dbSNP,gnomAD	rs587778246		7p11.2	7	55156802	G	C	D	H	393	393		missense	0.78067	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1178642122		7p11.2	7	55156807	T	G	I	M	394	394		missense	0.804	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs757265130		7p11.2	7	55156817	G	A	V	I	398	398		missense	0.0305	benign	0.04	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC	rs777165081		7p11.2	7	55157665	T	A	F	I	404	404		missense	0.5964	benign, possibly damaging, probably damaging	0.074	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1230904747		7p11.2	7	55157672	T	A	L	Q	406	406		missense	0.728	possibly damaging, probably damaging	0.295	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1179620001		7p11.2	7	55157674	A	G	I	V	407	407		missense	0.845	possibly damaging, probably damaging	0.03333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs770466526		7p11.2	7	55157693	A	G	N	S	413	413		missense	0.57	benign, probably damaging	0.235	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1424097500		7p11.2	7	55157696	G	T	R	M	414	414		missense	0.003	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1274543317		7p11.2	7	55157699	C	A	T	K	415	415		missense	0.76733	benign, probably damaging	0.12	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs758956103		7p11.2	7	55157703	C	G	D	E	416	416		missense	0.3465	benign, possibly damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1456537863		7p11.2	7	55157705	T	G	L	R	417	417		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1390766480		7p11.2	7	55157707	C	T	H	Y	418	418		missense	0.02	benign	0.12	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs760639592		7p11.2	7	55157716	G	A	E	K	421	421		missense	0.728	benign, possibly damaging, probably damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1230287644		7p11.2	7	55157727	A	T	E	D	424	424		missense	0.5455	benign, possibly damaging	0.16	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs558565565		7p11.2	7	55157728	A	G	I	V	425	425		missense	0.007	benign	0.94	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,dbSNP,gnomAD	rs606231253		7p11.2	7	55157738	G	A	G	D	428	428		missense	1.0	probably damaging	0.0	deleterious	0	Inflammatory skin and bowel disease, neonatal, 2 (NISBD2)		MIM:616069		ClinVar:RCV000144851	
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs765369188		7p11.2	7	55157744	C	A	T	N	430	430		missense	0.773	benign, possibly damaging, probably damaging	0.02667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1171743336		7p11.2	7	55160139	T	A	H	Q	433	433		missense	0.005	benign	0.46	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs750713244		7p11.2	7	55157753	A	G	H	R	433	433		missense	0.013	benign	0.33	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1345387967		7p11.2	7	55160146	T	A	F	I	436	436		missense	0.361	benign, possibly damaging	0.17	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1166858113	COSM1090876	7p11.2	7	55160161	G	A	V	I	441	441		missense	0.012	benign	0.5	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs765091640		7p11.2	7	55160165	G	A	S	N	442	442		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1032006770		7p11.2	7	55160171	A	G	N	S	444	444		missense	0.0	benign	0.54	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs372990493		7p11.2	7	55160173	A	G	I	V	445	445		missense	0.3465	benign, possibly damaging	0.2	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1310061365		7p11.2	7	55160177	C	T	T	I	446	446		missense	0.459	benign, possibly damaging	0.03667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs763266323		7p11.2	7	55160184	G	C	L	F	448	448		missense	1.0	probably damaging	0.04	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs377567759		7p11.2	7	55160191	C	T	R	C	451	451		missense	0.996	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751667594		7p11.2	7	55160192	G	A	R	H	451	451		missense	0.997	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751667594		7p11.2	7	55160192	G	T	R	L	451	451		missense	0.925	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1226827460		7p11.2	7	55160195	C	T	S	F	452	452		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1177337471		7p11.2	7	55160207	T	C	I	T	456	456		missense	0.9005	possibly damaging, probably damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1340811850		7p11.2	7	55160210	G	A	S	N	457	457		missense	0.8085	possibly damaging, probably damaging	0.0525	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs146711874		7p11.2	7	55160214	T	G	D	E	458	458	2.0E-4	missense	0.806	possibly damaging, probably damaging	0.115	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs753269876		7p11.2	7	55160218	G	A	D	N	460	460		missense	0.62733	benign, possibly damaging, probably damaging	0.59	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1197924233		7p11.2	7	55160226	A	G	I	M	462	462		missense	0.3895	benign, possibly damaging	0.155	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746763556		7p11.2	7	55160230	T	G	S	A	464	464		missense	0.051	benign	0.49	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746763556		7p11.2	7	55160230	T	A	S	T	464	464		missense	0.006	benign	0.88	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1389684767		7p11.2	7	55160257	A	G	N	D	473	473		missense	0.001	benign	0.51	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1221992080	COSM122790	7p11.2	7	55160263	A	G	I	V	475	475		missense	0.02	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746521110		7p11.2	7	55160267	A	G	N	S	476	476		missense	0.0035	benign	0.07	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs768208443		7p11.2	7	55160277	A	C	K	N	479	479		missense	0.005	benign	0.34	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs147732025		7p11.2	7	55160278	C	A	L	M	480	480	3.99E-4	missense	0.735	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs147732025		7p11.2	7	55160278	C	G	L	V	480	480	3.99E-4	missense	0.29833	benign, possibly damaging	0.04	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs587778247		7p11.2	7	55160283	T	G	F	L	481	481		missense	0.67	benign, possibly damaging, probably damaging	0.14	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs982033612		7p11.2	7	55160294	G	C	G	A	485	485		missense	0.001	benign	0.78	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769434273		7p11.2	7	55160293	G	T	G	C	485	485		missense	0.51133	benign, possibly damaging	0.04	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769434273		7p11.2	7	55160293	G	A	G	S	485	485		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1271375100		7p11.2	7	55160303	C	G	T	S	488	488		missense	0.018	benign	0.27	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519760		7p11.2	7	55160314	A	G	S	G	492	492		missense	0.013	benign	0.35	tolerated	1	Neoplasm of the large intestine				pubmed:23012255,ClinVar:RCV000429440	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519860		7p11.2	7	55160316	C	A	S	R	492	492		missense	0.001	benign	0.26	tolerated	1	Neoplasm of the large intestine				pubmed:23012255,ClinVar:RCV000423834	
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs766676440		7p11.2	7	55160324	G	A	G	D	495	495		missense	0.005	benign	0.53	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs774773441		7p11.2	7	55160331	C	A	N	K	497	497		missense	0.0	benign	0.56	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs927866979		7p11.2	7	55160333	G	C	S	T	498	498		missense	0.0	benign	0.49	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1206537132		7p11.2	7	55160338	A	G	K	E	500	500		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs760711480		7p11.2	7	55161507	G	A	G	S	503	503		missense	0.048	benign	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1334180707		7p11.2	7	55161510	C	G	Q	E	504	504		missense	0.026	benign	0.23	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1188823834		7p11.2	7	55161512	G	C	Q	H	504	504		missense	0.0	benign	0.68	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1287531915		7p11.2	7	55161523	C	A	A	D	508	508		missense	0.015	benign	0.13	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1287531915		7p11.2	7	55161523	C	G	A	G	508	508		missense	5.0E-4	benign	0.08	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1407608935		7p11.2	7	55161522	G	A	A	T	508	508		missense	0.0	benign	0.14	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1240855741		7p11.2	7	55161526	T	C	L	S	509	509		missense	0.9435	possibly damaging, probably damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs371114444		7p11.2	7	55161532	C	A	S	Y	511	511		missense	0.996	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,dbSNP,gnomAD	rs587778248	COSM3639738	7p11.2	7	55161534	C	T	P	S	512	512		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754646330		7p11.2	7	55161537	G	T	E	*	513	513		stop gained					0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1339627647		7p11.2	7	55161538	A	C	E	A	513	513		missense	0.005	benign	0.51	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754646330		7p11.2	7	55161537	G	A	E	K	513	513		missense	0.309	benign	0.17	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs564398642		7p11.2	7	55161553	C	T	P	L	518	518	2.0E-4	missense	0.721	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed	rs368484180		7p11.2	7	55161552	C	T	P	S	518	518		missense	0.7678	benign, possibly damaging, probably damaging	0.056	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs116057045		7p11.2	7	55161557	G	T	E	D	519	519	2.0E-4	missense	0.0	benign	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs749186957		7p11.2	7	55161556	A	G	E	G	519	519		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,dbSNP,gnomAD	rs2227983		7p11.2	7	55161562	G	A	R	K	521	521		missense	0.0	benign	0.39	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs2227983		7p11.2	7	55161562	G	A	R	K	521	521	0.2921	missense	0.0	benign	0.44	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs2227983		7p11.2	7	55161562	G	T	R	M	521	521	0.2921	missense	0.0	benign	0.04	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs2227983		7p11.2	7	55161562	G	C	R	T	521	521	0.2921	missense	0.0	benign	0.77	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs587778249		7p11.2	7	55161570	G	A	V	I	524	524		missense	0.049	benign	0.06	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs587778249		7p11.2	7	55161570	G	C	V	L	524	524		missense	0.01	benign	0.84	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs768627073		7p11.2	7	55161579	C	G	R	G	527	527		missense	0.353	benign, possibly damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs150477666		7p11.2	7	55161580	G	A	R	Q	527	527		missense	0.001	benign	0.2	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs768627073		7p11.2	7	55161579	C	T	R	W	527	527		missense	0.658	possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs762336338		7p11.2	7	55161582	A	G	N	D	528	528		missense	0.043	benign	0.24	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1330512770		7p11.2	7	55161592	G	A	R	Q	531	531		missense	0.9485	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs752350337		7p11.2	7	55161607	T	C	V	A	536	536		missense	0.7485	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs767193132	COSM382936	7p11.2	7	55161606	G	A	V	M	536	536		missense	0.656	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1275660363		7p11.2	7	55161611	C	G	D	E	537	537		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1038997598		7p11.2	7	55161609	G	A	D	N	537	537		missense	0.001	benign	0.11	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1209490447		7p11.2	7	55161613	A	C	K	T	538	538		missense	0.001	benign	0.25	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1340266257		7p11.2	7	55161620	C	A	N	K	540	540		missense	0.926	possibly damaging, probably damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1208487495	COSM3639740	7p11.2	7	55161621	C	T	L	F	541	541		missense	0.0	benign	0.51	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs755584255		7p11.2	7	55161630	G	A	G	S	544	544		missense	0.917	possibly damaging, probably damaging	0.015	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778985185		7p11.2	7	55163734	G	A	E	K	545	545		missense	0.46875	benign, possibly damaging, probably damaging	0.0725	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519830		7p11.2	7	55163737	C	T	P	S	546	546		missense	0.58633	benign, possibly damaging, probably damaging	0.28	tolerated	1	Head and Neck Neoplasms				ClinVar:RCV000443890	
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1427028322		7p11.2	7	55163740	A	G	R	G	547	547		missense	0.817	possibly damaging, probably damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1419611893		7p11.2	7	55163747	T	C	F	S	549	549		missense	0.606	benign, possibly damaging	0.025	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs940873450		7p11.2	7	55163753	A	T	E	V	551	551		missense	0.0	benign	0.45	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1162236403		7p11.2	7	55163756	A	G	N	S	552	552		missense	0.015	benign	0.2	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs779741928		7p11.2	7	55163762	A	G	E	G	554	554		missense	0.155	benign	0.35	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs747203424		7p11.2	7	55163769	A	G	I	M	556	556		missense	0.003	benign	0.36	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1488695603		7p11.2	7	55163770	C	T	Q	*	557	557		stop gained					0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748219780		7p11.2	7	55163779	C	T	P	S	560	560		missense	0.042	benign	0.21	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748219780		7p11.2	7	55163779	C	A	P	T	560	560		missense	0.294	benign	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769918274		7p11.2	7	55163782	G	C	E	Q	561	561		missense	0.67367	benign, possibly damaging, probably damaging	0.33667	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs773651001		7p11.2	7	55163791	C	T	P	S	564	564		missense	0.011	benign	0.15	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs773651001		7p11.2	7	55163791	C	A	P	T	564	564		missense	0.079	benign	0.1	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1258211270		7p11.2	7	55163795	A	G	Q	R	565	565		missense	0.68733	benign, possibly damaging, probably damaging	0.20667	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771278492		7p11.2	7	55163800	A	G	M	V	567	567		missense	0.018	benign	0.04	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1228970909		7p11.2	7	55163805	C	A	N	K	568	568		missense	0.21267	benign, possibly damaging	0.29667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs774558548		7p11.2	7	55163810	C	G	T	S	570	570		missense	0.6505	benign, possibly damaging, probably damaging	0.15	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759987693		7p11.2	7	55163816	C	G	T	R	572	572		missense	0.5785	benign, possibly damaging	0.35	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1294381114		7p11.2	7	55163818	G	A	G	R	573	573		missense	0.988	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs370810719		7p11.2	7	55163822	G	A	R	Q	574	574		missense	0.112	benign	0.07	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs760471492		7p11.2	7	55163821	C	T	R	W	574	574		missense	0.829	possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1249099747		7p11.2	7	55165281	G	A	G	E	575	575		missense	0.871	possibly damaging, probably damaging	0.1	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs556794990		7p11.2	7	55165290	A	G	N	S	578	578	2.0E-4	missense	0.0	benign	0.18	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs761585117		7p11.2	7	55165296	T	C	I	T	580	580		missense	0.009	benign	0.73	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs764787649		7p11.2	7	55165298	C	A	Q	K	581	581		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1376117521		7p11.2	7	55165299	A	C	Q	P	581	581		missense	0.22867	benign, possibly damaging	0.11667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1306429085		7p11.2	7	55165301	T	C	C	R	582	582		missense	0.998	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1447966312		7p11.2	7	55165305	C	T	A	V	583	583		missense	0.5795	benign, possibly damaging, probably damaging	0.0575	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs956386356		7p11.2	7	55165309	C	G	H	Q	584	584		missense	0.9235	possibly damaging, probably damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1281578598		7p11.2	7	55165315	T	G	I	M	586	586		missense	0.334	benign	0.06	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs542237406		7p11.2	7	55165314	T	A	I	N	586	586	2.0E-4	missense	0.204	benign	0.055	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs542237406		7p11.2	7	55165314	T	C	I	T	586	586	2.0E-4	missense	0.04	benign	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs953188147		7p11.2	7	55165313	A	G	I	V	586	586		missense	0.0	benign	0.055	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs989939484		7p11.2	7	55165319	G	A	G	S	588	588		missense	0.9405	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751570775		7p11.2	7	55165323	C	A	P	H	589	589		missense	0.989	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751570775	COSM747428	7p11.2	7	55165323	C	T	P	L	589	589		missense	0.51767	benign, possibly damaging, probably damaging	0.12667	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1235180640		7p11.2	7	55165322	C	T	P	S	589	589		missense	0.6406	benign, possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs144943614		7p11.2	7	55165331	G	A	V	I	592	592	3.99E-4	missense	0.48825	benign, possibly damaging	0.0475	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs756307243		7p11.2	7	55165336	G	C	K	N	593	593		missense	0.58033	benign, possibly damaging, probably damaging	0.19333	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778011429		7p11.2	7	55165338	C	T	T	I	594	594		missense	0.387	benign, possibly damaging	0.025	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778011429		7p11.2	7	55165338	C	A	T	N	594	594		missense	0.197	benign, possibly damaging	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1477025000		7p11.2	7	55165344	C	T	P	L	596	596		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs757419349		7p11.2	7	55165346	G	T	A	S	597	597		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,dbSNP,gnomAD	rs139236063	COSM3412197	7p11.2	7	55165350	G	C	G	A	598	598		missense	0.67533	benign, possibly damaging, probably damaging	0.01	deleterious	1	Neoplasm of brain				ClinVar:RCV000440786,ClinVar:RCV000423114	
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,dbSNP,gnomAD	rs139236063	COSM4967213	7p11.2	7	55165350	G	T	G	V	598	598		missense	0.94	possibly damaging, probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000436167,ClinVar:RCV000434448	
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1206543227		7p11.2	7	55165353	T	A	V	D	599	599		missense	0.637	benign, possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs746395542		7p11.2	7	55165355	A	T	M	L	600	600		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs149375515		7p11.2	7	55165356	T	C	M	T	600	600		missense	0.122	benign	0.24	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs746395542		7p11.2	7	55165355	A	G	M	V	600	600		missense	0.018	benign	0.22	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,TOPMed	rs201498575		7p11.2	7	55165359	G	A	G	E	601	601	2.0E-4	missense	0.7448	benign, possibly damaging, probably damaging	0.054	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769537072		7p11.2	7	55165366	C	A	N	K	603	603		missense	0.517	benign, probably damaging	0.655	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs913231421		7p11.2	7	55165368	A	G	N	S	604	604		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1436144358		7p11.2	7	55165370	A	G	T	A	605	605		missense	0.2715	benign, possibly damaging	0.395	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs143152775		7p11.2	7	55165373	C	G	L	V	606	606		missense	0.03	benign	0.08	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs201061916		7p11.2	7	55165388	G	A	A	T	611	611		missense	0.008	benign	0.08	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1214761095		7p11.2	7	55165391	G	A	D	N	612	612		missense	0.62567	benign, possibly damaging, probably damaging	0.18333	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs764290273		7p11.2	7	55165394	G	A	A	T	613	613		missense	0.056	benign	0.36	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs750850720		7p11.2	7	55165398	G	A	G	D	614	614		missense	0.0	benign	0.36	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs779076899		7p11.2	7	55165397	G	C	G	R	614	614		missense	0.024	benign	0.38	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs779076899		7p11.2	7	55165397	G	A	G	S	614	614		missense	0.0	benign	0.29	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC	rs756534868		7p11.2	7	55165404	T	C	V	A	616	616		missense	0.033	benign	0.72	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA	rs150899403	COSM35825	7p11.2	7	55165416	G	A	C	Y	620	620		missense	0.894	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs747376358		7p11.2	7	55165424	A	T	N	Y	623	623		missense	0.915	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA	rs28384376	COSM13560	7p11.2	7	55165428	G	T	C	F	624	624		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs753315940		7p11.2	7	55165436	G	A	G	R	627	627		missense	0.914	possibly damaging, probably damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs552265738		7p11.2	7	55171185	C	T	P	S	631	631	3.99E-4	missense	0.474	benign, possibly damaging	0.1	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1157210752		7p11.2	7	55171191	C	T	L	F	633	633		missense	0.48767	benign, possibly damaging	0.36667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs765068810		7p11.2	7	55171194	G	A	E	K	634	634		missense	0.0	benign	0.8	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs957617087		7p11.2	7	55171197	G	A	G	S	635	635		missense	0.876	possibly damaging, probably damaging	0.07333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs762592162		7p11.2	7	55171206	A	G	T	A	638	638		missense	0.0	benign	0.78	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,NCI-TCGA,gnomAD	rs571064657	COSM1318972	7p11.2	7	55171207	C	T	T	M	638	638	2.0E-4	missense	0.006	benign	0.25	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs952307505		7p11.2	7	55171210	A	G	N	S	639	639		missense	0.0	benign	0.71	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs200989322		7p11.2	7	55171212	G	T	G	W	640	640	2.0E-4	missense	0.386	benign, possibly damaging	0.19	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1467090960		7p11.2	7	55172984	C	T	P	S	641	641		missense	0.0	benign	0.91	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,dbSNP,gnomAD	rs770443325		7p11.2	7	55172994	C	T	P	L	644	644		missense	0.599	benign, possibly damaging, probably damaging	0.06667	tolerated	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000259941	
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770443325		7p11.2	7	55172994	C	G	P	R	644	644		missense	0.84733	possibly damaging, probably damaging	0.02333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs772046081	COSM375343	7p11.2	7	55172997	C	G	S	C	645	645		missense	0.9275	possibly damaging, probably damaging	0.18	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs140516819		7p11.2	7	55172999	A	C	I	L	646	646	3.99E-4	missense	0.5335	benign, possibly damaging	0.145	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1300062728		7p11.2	7	55173000	T	G	I	S	646	646		missense	0.73767	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs140516819		7p11.2	7	55172999	A	G	I	V	646	646	3.99E-4	missense	0.019	benign	0.08	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs764359156		7p11.2	7	55173002	G	A	A	T	647	647		missense	0.74367	benign, possibly damaging, probably damaging	0.05667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs776728879		7p11.2	7	55173006	C	T	T	I	648	648		missense	0.0125	benign	0.06	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs776728879		7p11.2	7	55173006	C	G	T	S	648	648		missense	0.0205	benign	0.06	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs758954817		7p11.2	7	55173015	T	G	V	G	651	651		missense	0.457	benign, possibly damaging	0.10333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	dbSNP	rs1562783502	COSM35840	7p11.2	7	55173014	G	A	V	M	651	651		missense	0.863	possibly damaging	0.01	deleterious	0	Hereditary cancer				ClinVar:RCV000709009	
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1467640610		7p11.2	7	55173020	G	T	A	S	653	653		missense	0.0	benign	0.26	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs767037049		7p11.2	7	55173026	C	T	L	F	655	655		missense	0.011	benign	0.55	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs767037049		7p11.2	7	55173026	C	G	L	V	655	655		missense	0.16	benign	0.15	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed	rs755356995		7p11.2	7	55173039	T	C	V	A	659	659		missense	0.0525	benign	0.045	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes	rs201580890		7p11.2	7	55173038	G	C	V	L	659	659	2.0E-4	missense	0.007	benign	0.43	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1426364365		7p11.2	7	55173041	G	A	V	M	660	660		missense	0.005	benign	0.25	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1424043738		7p11.2	7	55173050	G	A	G	R	663	663		missense	0.3	benign	0.35	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs756705853		7p11.2	7	55173053	A	T	I	F	664	664		missense	0.005	benign	0.43	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1393556056		7p11.2	7	55173054	T	C	I	T	664	664		missense	0.01	benign	0.12	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs745422316		7p11.2	7	55173056	G	A	G	S	665	665		missense	0.446	benign, possibly damaging	0.18667	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771988878		7p11.2	7	55173059	C	T	L	F	666	666		missense	0.5575	benign, possibly damaging	0.09	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771988878		7p11.2	7	55173059	C	G	L	V	666	666		missense	0.012	benign	0.78	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs746757722		7p11.2	7	55173065	A	C	M	L	668	668		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs746757722		7p11.2	7	55173065	A	G	M	V	668	668		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1231769201	COSM1090883	7p11.2	7	55173068	C	T	R	*	669	669		stop gained	-1.0	unknown	-1.0	unknown	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs768336804		7p11.2	7	55173069	G	A	R	Q	669	669		missense	0.8715	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs776875545		7p11.2	7	55173073	G	T	R	S	670	670		missense	0.64567	benign, possibly damaging, probably damaging	0.03	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs770193776		7p11.2	7	55173074	C	T	R	C	671	671		missense	0.925	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1266662784		7p11.2	7	55173075	G	A	R	H	671	671		missense	0.64267	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1199980775		7p11.2	7	55173080	A	G	I	V	673	673		missense	0.2355	benign	0.045	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs17337079		7p11.2	7	55173083	G	T	V	F	674	674		missense	0.61967	benign, possibly damaging, probably damaging	0.01667	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs17337079		7p11.2	7	55173083	G	A	V	I	674	674		missense	0.021	benign	0.26	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs150423237		7p11.2	7	55173087	G	A	R	Q	675	675		missense	0.978	probably damaging	0.0	deleterious	0	Hereditary cancer				ClinVar:RCV000709010	
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1417155613		7p11.2	7	55173092	C	T	R	C	677	677		missense	0.989	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs756870976	COSM22555	7p11.2	7	55173093	G	A	R	H	677	677		missense	0.688	benign, probably damaging	0.12	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1167057229		7p11.2	7	55173095	A	G	T	A	678	678		missense	0.6825	benign, probably damaging	0.745	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs138193597		7p11.2	7	55173096	C	T	T	M	678	678		missense	0.997	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373336251		7p11.2	7	55173102	G	A	R	Q	680	680		missense	0.984	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs369399038		7p11.2	7	55173101	C	T	R	W	680	680		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1338409357		7p11.2	7	55173107	C	A	L	M	682	682		missense	0.68	benign, possibly damaging, probably damaging	0.01333	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1338409357		7p11.2	7	55173107	C	G	L	V	682	682		missense	0.2965	benign, possibly damaging	0.025	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1427460008		7p11.2	7	55173114	A	G	Q	R	684	684		missense	0.566	benign, possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1305428034		7p11.2	7	55173120	G	A	R	K	686	686		missense	0.01	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1314649810		7p11.2	7	55173122	G	A	E	K	687	687		missense	0.7105	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs749554270		7p11.2	7	55173921	C	T	L	F	688	688		missense	0.9085	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517083		7p11.2	7	55173924	G	C	V	L	689	689		missense	0.58733	benign, possibly damaging, probably damaging	0.04333	deleterious, tolerated	1						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519794		7p11.2	7	55173927	G	A	E	K	690	690		missense	0.7765	possibly damaging, probably damaging	0.0	deleterious	1	Endometrial Endometrioid Adenocarcinoma, Variant with Squamous Differentiation				ClinVar:RCV000438760	
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1168763004		7p11.2	7	55173930	C	A	P	T	691	691		missense	0.997	probably damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913427		7p11.2	7	55174773	G	A	E	K	693	693		missense	0.5285	benign, probably damaging	0.005	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000424472	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517097		7p11.2	7	55174777	T	C	L	S	694	694		missense	0.992	probably damaging	0.0	deleterious	1	Squamous cell lung carcinoma		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000434243,ClinVar:RCV000443228	
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs936074781		7p11.2	7	55173948	G	C	E	Q	697	697		missense	0.7015	benign, probably damaging	0.245	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1331500903		7p11.2	7	55173959	C	A	N	K	700	700		missense	0.8095	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs774261340		7p11.2	7	55173960	C	A	Q	K	701	701		missense	0.5455	benign, possibly damaging	0.23	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1273890779		7p11.2	7	55173966	C	T	L	F	703	703		missense	0.003	benign	0.69	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1220800698		7p11.2	7	55173977	C	G	I	M	706	706		missense	0.947	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517084		7p11.2	7	55173976	T	C	I	T	706	706		missense	0.7685	possibly damaging, probably damaging	0.005	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	dbSNP,gnomAD	rs121913418		7p11.2	7	55174818	G	A	D	N	708	708		missense	0.305	benign	0.0	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000425618	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517085		7p11.2	7	55173985	A	C	E	A	709	709		missense	0.818	possibly damaging	0.01	deleterious	1	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000206908	
P00533	EGFR	Epidermal growth factor receptor	NCI-TCGA	rs397517086	COSM51525	7p11.2	7	55173986_55173988AA	C	-	E	D	709	710		inframe deletion	-1.0	unknown	-1.0	unknown	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517085		7p11.2	7	55173985	A	G	E	G	709	709		missense	0.935	probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,dbSNP,gnomAD	rs727504256	COSM12988	7p11.2	7	55173984	G	A	E	K	709	709		missense	0.65967	benign, possibly damaging, probably damaging	0.01	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517085		7p11.2	7	55173985	A	T	E	V	709	709		missense	0.93	probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1317269653		7p11.2	7	55173987	A	G	T	A	710	710		missense	0.4445	benign, possibly damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373578289		7p11.2	7	55173997	A	G	K	R	713	713		missense	0.527	benign, possibly damaging, probably damaging	0.32333	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs373578289		7p11.2	7	55173997	A	C	K	T	713	713		missense	0.8775	possibly damaging, probably damaging	0.0	deleterious	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000268060	
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1300698331		7p11.2	7	55174005	A	G	K	E	716	716		missense	0.583	benign, possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs121913428	COSM6239	7p11.2	7	55174015	G	C	G	A	719	719		missense	0.982	probably damaging	0.02	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000038381	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs28929495	COSM6253	7p11.2	7	55174014	G	T	G	C	719	719		missense	1.0	probably damaging	0.0	deleterious	1	Lung adenocarcinoma				ClinVar:RCV000426731,pubmed:23562183,pubmed:24627688,pubmed:25311215,ClinVar:RCV000433465	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs121913428	COSM18425	7p11.2	7	55174015	G	A	G	D	719	719		missense	0.995	probably damaging	0.0	deleterious	1	Squamous cell lung carcinoma				ClinVar:RCV000428419,pubmed:23562183,pubmed:24627688,pubmed:25311215,ClinVar:RCV000439067,pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000418583,ClinVar:RCV000420993	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs28929495		7p11.2	7	55174014	G	C	G	R	719	719		missense	0.997	probably damaging	0.0	deleterious	0	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000114405	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs28929495		7p11.2	7	55174014	G	A	G	S	719	719		missense	0.999	probably damaging	0.0	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000423860	
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs772799315		7p11.2	7	55174018	C	G	S	C	720	720		missense	0.9145	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs762494280		7p11.2	7	55174024	C	T	A	V	722	722		missense	0.558	benign, possibly damaging, probably damaging	0.18333	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	dbSNP,gnomAD	rs483352806		7p11.2	7	55181336	G	A	R	H	723	723		missense	0.996	probably damaging	0.0	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000150627	
P00533	EGFR	Epidermal growth factor receptor	TOPMed,dbSNP,gnomAD	rs1051753269	COSM13979	7p11.2	7	55174029	G	A	G	S	724	724		missense	1.0	probably damaging	0.03	deleterious	1	Neoplasm of the large intestine				pubmed:23012255,ClinVar:RCV000421183	
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs767505234		7p11.2	7	55174033	C	T	T	M	725	725		missense	0.935	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs483352805		7p11.2	7	55174035	G	A	V	M	726	726		missense	0.992	probably damaging	0.0	deleterious	0	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000114409	
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs138240620		7p11.2	7	55174039	A	G	Y	C	727	727	2.0E-4	missense	0.5375	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771995749		7p11.2	7	55174726	T	C	L	P	730	730		missense	0.785	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771995749		7p11.2	7	55174726	T	G	L	R	730	730		missense	0.61933	benign, possibly damaging, probably damaging	0.01667	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913434		7p11.2	7	55174725	C	G	L	V	730	730		missense	0.5	benign, probably damaging	0.355	tolerated	0	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000114407	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs121913467	COSM13432	7p11.2	7	55174730	G	A	W	*	731	731		stop gained	-1.0	unknown	-1.0	unknown	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000444748	
P00533	EGFR	Epidermal growth factor receptor	dbSNP,gnomAD	rs397517089		7p11.2	7	55174729	G	A	W	*	731	731		stop gained					1						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs397517089		7p11.2	7	55174729	G	T	W	L	731	731		missense	0.7295	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913446		7p11.2	7	55174735	C	T	P	L	733	733		missense	0.9265	possibly damaging, probably damaging	0.0	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			ClinVar:RCV000441469,pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000428149	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913420		7p11.2	7	55174737	G	A	E	K	734	734		missense	0.7355	possibly damaging, probably damaging	0.0	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000424211	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913430		7p11.2	7	55174740	G	A	G	S	735	735		missense	0.9325	possibly damaging, probably damaging	0.0	deleterious	1	Prostate neoplasm				pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000434054,ClinVar:RCV000442962	
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1488735128		7p11.2	7	55174750	T	C	V	A	738	738		missense	0.57533	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs780083331		7p11.2	7	55174754	A	T	K	N	739	739		missense	0.6195	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517092		7p11.2	7	55174756	T	C	I	T	740	740		missense	0.6955	possibly damaging, probably damaging	0.01	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs747133806		7p11.2	7	55174755	A	G	I	V	740	740		missense	0.3755	benign, possibly damaging	0.045	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913466		7p11.2	7	55174762	T	C	V	A	742	742		missense	0.922	probably damaging	0.01	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000423407	
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,dbSNP,gnomAD	rs587778250	COSM1090888	7p11.2	7	55174761	G	A	V	I	742	742		missense	0.8725	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs759256622	COSM26509	7p11.2	7	55174764	G	A	A	T	743	743		missense	0.998	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl	rs1554348865	COSM28512	7p11.2	7	55174767	A	G	I	V	744	744		missense	0.636	benign, probably damaging	0.035	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913433		7p11.2	7	55174771	A	G	K	R	745	745		missense	0.995	probably damaging	0.0	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000433245	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913427		7p11.2	7	55174773	G	C	E	Q	746	746		missense	0.5285	benign, probably damaging	0.0	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000154381	
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1379373864		7p11.2	7	55174780	G	A	R	K	748	748		missense	0.59933	benign, possibly damaging, probably damaging	0.03667	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1338629905		7p11.2	7	55174781	A	T	R	S	748	748		missense	0.699	benign, possibly damaging, probably damaging	0.05667	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs1057520037		7p11.2	7	55174782	G	C	E	Q	749	749		missense	0.9085	possibly damaging, probably damaging	0.0	deleterious	1	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000444877	
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1468115455		7p11.2	7	55174786	C	G	A	G	750	750		missense	0.5175	benign, probably damaging	0.26	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs121913229	COSM6219	7p11.2	7	55174785	G	C	A	P	750	750		missense	0.998	probably damaging	0.19	tolerated	1						
P00533	EGFR	Epidermal growth factor receptor	ExAC,dbSNP,gnomAD	rs727504316		7p11.2	7	55174789	C	T	T	I	751	751		missense	0.994	probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1373423544		7p11.2	7	55174791	T	A	S	T	752	752		missense	0.61833	benign, possibly damaging, probably damaging	0.02333	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913464		7p11.2	7	55174792	C	A	S	Y	752	752		missense	0.996	probably damaging	0.0	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000432149	
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs559717059	COSM1168015	7p11.2	7	55174795	C	T	P	L	753	753		missense	0.68367	benign, possibly damaging, probably damaging	0.01333	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,dbSNP,gnomAD	rs121913231	COSM6268	7p11.2	7	55174794	C	T	P	S	753	753		missense	0.61733	benign, possibly damaging, probably damaging	0.04667	deleterious, tolerated	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			ClinVar:RCV000441908,pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000436542	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs397517101	COSM85993	7p11.2	7	55174797	A	G	K	E	754	754		missense	0.67933	benign, possibly damaging, probably damaging	0.01667	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs397517102		7p11.2	7	55174807	A	T	K	M	757	757		missense	0.7745	possibly damaging, probably damaging	0.03	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs397517102		7p11.2	7	55174807	A	G	K	R	757	757		missense	0.516	benign, probably damaging	0.2	tolerated	0	Lung adenocarcinoma				pubmed:23562183,pubmed:24627688,pubmed:25311215,ClinVar:RCV000677877	
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs761470472		7p11.2	7	55174810	A	G	E	G	758	758		missense	0.9095	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs121913418		7p11.2	7	55174818	G	A	D	N	761	761		missense	0.995	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	dbSNP,gnomAD	rs121913418		7p11.2	7	55174818	G	T	D	Y	761	761		missense	0.982	probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1476693500		7p11.2	7	55181297	C	T	A	V	763	763		missense	0.815	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs374873413		7p11.2	7	55181302	G	C	V	L	765	765		missense	0.70833	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs374873413		7p11.2	7	55181302	G	A	V	M	765	765		missense	0.7755	possibly damaging, probably damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1322818258		7p11.2	7	55181307	G	A	M	I	766	766		missense	0.8275	possibly damaging, probably damaging	0.085	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1323967615		7p11.2	7	55181305	A	T	M	L	766	766		missense	0.714	possibly damaging, probably damaging	0.025	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517107		7p11.2	7	55181309	C	T	A	V	767	767		missense	0.717	benign, probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs756614898		7p11.2	7	55181311	A	G	S	G	768	768		missense	0.569	benign, possibly damaging, probably damaging	0.42	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs121913465	COSM6241	7p11.2	7	55181312	G	T	S	I	768	768		missense	1.0	probably damaging	0.0	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000038407	
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778199483		7p11.2	7	55181313	C	G	S	R	768	768		missense	0.8365	possibly damaging, probably damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs147149347		7p11.2	7	55181314	G	C	V	L	769	769		missense	0.54	benign, possibly damaging, probably damaging	0.27667	tolerated	1						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs147149347		7p11.2	7	55181314	G	T	V	L	769	769		missense	0.54	benign, possibly damaging, probably damaging	0.27667	tolerated	1						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs147149347		7p11.2	7	55181314	G	A	V	M	769	769		missense	0.6885	benign, probably damaging	0.34	tolerated	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000206947	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs727503020		7p11.2	7	55181320	A	G	N	D	771	771		missense	0.031	benign	0.105	deleterious, tolerated	1						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs746677478		7p11.2	7	55181323	C	G	P	A	772	772		missense	0.007	benign	0.11	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs768468531		7p11.2	7	55181328	C	G	H	Q	773	773		missense	0.8645	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913432		7p11.2	7	55181327	A	G	H	R	773	773		missense	0.072	benign	0.0	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000420488	
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,TOPMed,gnomAD	rs567477136		7p11.2	7	55181329	G	C	V	L	774	774	2.0E-4	missense	0.513	benign, possibly damaging, probably damaging	0.37	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,NCI-TCGA,TOPMed,gnomAD	rs567477136	COSM13006	7p11.2	7	55181329	G	A	V	M	774	774		missense	0.996	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1275022697		7p11.2	7	55181335	C	T	R	C	776	776		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs483352806		7p11.2	7	55181336	G	A	R	H	776	776		missense	0.7425	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517119		7p11.2	7	55181344	G	T	G	C	779	779		missense	0.998	probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517120		7p11.2	7	55181345	G	T	G	V	779	779		missense	1.0	probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517127		7p11.2	7	55191749	G	C	V	L	781	781		missense	0.694	benign, probably damaging	0.015	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1424329195		7p11.2	7	55181360	C	G	S	C	784	784		missense	0.891	possibly damaging, probably damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1424329195		7p11.2	7	55181360	C	T	S	F	784	784		missense	0.7055	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs762672864		7p11.2	7	55181365	G	C	V	L	786	786		missense	0.524	benign, possibly damaging, probably damaging	0.28	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs762672864		7p11.2	7	55181365	G	A	V	M	786	786		missense	0.868	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs1050171		7p11.2	7	55181370	G	C	Q	H	787	787	0.4327	missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1458440474		7p11.2	7	55181369	A	C	Q	P	787	787		missense	0.703	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs767674013		7p11.2	7	55181374	A	C	I	L	789	789		missense	0.078	benign	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs121434569		7p11.2	7	55181378	C	T	T	M	790	790		missense	0.904	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs121434569		7p11.2	7	55181378	C	T	T	M	790	790		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,dbSNP,gnomAD	rs121434569	COSM6240	7p11.2	7	55181378	C	T	T	M	790	790		missense	0.9035	possibly damaging, probably damaging	0.0	deleterious	0	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000154233	
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs121434569		7p11.2	7	55181378	C	T	T	M	790	790		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1413493019		7p11.2	7	55181382	G	T	Q	H	791	791		missense	0.97	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,TOPMed	rs370289230		7p11.2	7	55181389	C	A	P	T	794	794		missense	0.645	benign, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754426793		7p11.2	7	55181395	G	A	G	S	796	796		missense	0.998	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519861		7p11.2	7	55181398	T	A	C	S	797	797		missense	0.61	benign, possibly damaging, probably damaging	0.18667	tolerated	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000440892	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs483352807		7p11.2	7	55181402	T	A	L	H	798	798		missense	0.999	probably damaging	0.0	deleterious	0	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000114408	
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs779394350		7p11.2	7	55181411	A	G	Y	C	801	801		missense	0.995	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs757642107		7p11.2	7	55181410	T	C	Y	H	801	801		missense	0.748	possibly damaging, probably damaging	0.33	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1351046105		7p11.2	7	55181413	G	T	V	F	802	802		missense	0.942	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1351046105		7p11.2	7	55181413	G	A	V	I	802	802		missense	0.298	benign	0.06	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1263602634		7p11.2	7	55181417	G	A	R	Q	803	803		missense	0.543	benign, probably damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,dbSNP,gnomAD	rs1215679186		7p11.2	7	55181416	C	T	R	W	803	803		missense	0.999	probably damaging	0.0	deleterious	0	Hereditary cancer				ClinVar:RCV000709012	
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,gnomAD	rs552733360		7p11.2	7	55181419	G	A	E	K	804	804	2.0E-4	missense	0.5675	benign, possibly damaging	0.08	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121434568		7p11.2	7	55191822	T	A	L	Q	805	805		missense	0.985	probably damaging	0.0	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000419082	
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs754652044		7p11.2	7	55181425	A	G	K	E	806	806		missense	0.52	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913444		7p11.2	7	55191831	T	C	L	P	808	808		missense	0.933	probably damaging	0.0	deleterious	1	Squamous cell lung carcinoma				ClinVar:RCV000427689	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913444		7p11.2	7	55191831	T	G	L	R	808	808		missense	0.921	probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913431		7p11.2	7	55181438	G	A	G	D	810	810		missense	0.6365	benign, probably damaging	0.055	deleterious, tolerated	1	Squamous cell carcinoma				ClinVar:RCV000425650	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913230		7p11.2	7	55181437	G	A	G	S	810	810		missense	0.6565	benign, probably damaging	0.06	deleterious, tolerated	1	Squamous cell carcinoma				ClinVar:RCV000444211	
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1378775962	COSM4826463	7p11.2	7	55181441	C	G	S	C	811	811		missense	0.92	probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1278942267		7p11.2	7	55181452	C	T	L	F	815	815		missense	0.8195	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1418675303		7p11.2	7	55181455	A	G	N	D	816	816		missense	0.5775	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs367859869		7p11.2	7	55181472	C	G	I	M	821	821		missense	0.999	probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs397517125		7p11.2	7	55181473	G	A	A	T	822	822		missense	0.854	possibly damaging, probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	ExAC,dbSNP,gnomAD	rs483352808		7p11.2	7	55191720	G	A	G	D	824	824		missense	1.0	probably damaging	0.03	deleterious	0	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000114406	
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1474170437		7p11.2	7	55191724	G	T	M	I	825	825		missense	0.997	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP	rs150749913		7p11.2	7	55191729	A	T	Y	F	827	827		missense	0.9295	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1256743514		7p11.2	7	55191728	T	C	Y	H	827	827		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,dbSNP	rs1489158055		7p11.2	7	55191734	G	C	E	Q	829	829		missense	0.945	probably damaging	0.01	deleterious	0	Hereditary cancer				ClinVar:RCV000709013	
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,NCI-TCGA,TOPMed,dbSNP,gnomAD	rs371228501	COSM24846	7p11.2	7	55191740	C	T	R	C	831	831	1.9999999494757503E-4	missense	0.653	benign, probably damaging	0.01	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs150036236		7p11.2	7	55191741	G	A	R	H	831	831		missense	0.5135	benign, probably damaging	0.205	tolerated	0	Squamous cell lung carcinoma				pubmed:23562183,pubmed:24627688,pubmed:25311215,ClinVar:RCV000677878,ClinVar:RCV000677875	
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs745812480	COSM28286	7p11.2	7	55191743	C	T	R	C	832	832		missense	0.65	benign, possibly damaging, probably damaging	0.01333	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs772091823		7p11.2	7	55191744	G	A	R	H	832	832		missense	0.41	benign, possibly damaging	0.26	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs772091823		7p11.2	7	55191744	G	T	R	L	832	832		missense	0.497	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs397517126	COSM13424	7p11.2	7	55191746	T	G	L	V	833	833		missense	0.63767	benign, possibly damaging, probably damaging	0.01667	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517127		7p11.2	7	55191749	G	T	V	L	834	834		missense	0.98	probably damaging	0.03	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000038435	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517128		7p11.2	7	55191753	A	T	H	L	835	835		missense	1.0	probably damaging	0.0	deleterious	1	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000206918	
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs374952732		7p11.2	7	55191755	C	T	R	C	836	836		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs146121458	COSM133566	7p11.2	7	55191756	G	A	R	H	836	836		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs761920220		7p11.2	7	55191758	G	A	D	N	837	837		missense	0.7625	possibly damaging, probably damaging	0.23	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1402174871		7p11.2	7	55191759	A	T	D	V	837	837		missense	0.97	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs864621996		7p11.2	7	55191761	C	G	L	V	838	838		missense	0.876	possibly damaging, probably damaging	0.005	deleterious	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000206923	
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs143884981		7p11.2	7	55191767	G	A	A	T	840	840		missense	0.876	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs773720036		7p11.2	7	55191772	G	C	R	S	841	841		missense	0.995	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,dbSNP,gnomAD	rs146795390		7p11.2	7	55191776	G	A	V	I	843	843		missense	0.73167	benign, possibly damaging, probably damaging	0.05333	deleterious, tolerated	1	Head and Neck Neoplasms				ClinVar:RCV000426205	
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs148934350		7p11.2	7	55191792	C	T	P	L	848	848		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,dbSNP,gnomAD	rs148934350	COSM22943	7p11.2	7	55191792	C	T	P	L	848	848		missense	0.932	probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs148934350		7p11.2	7	55191792	C	A	P	Q	848	848		missense	0.927	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1433831615		7p11.2	7	55191796	G	T	Q	H	849	849		missense	0.62233	benign, possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,dbSNP,gnomAD	rs1292517709		7p11.2	7	55191804	A	G	K	R	852	852		missense	1.0	probably damaging	0.01	deleterious	0	Hereditary cancer				ClinVar:RCV000709015	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs121913443		7p11.2	7	55191821	C	A	L	M	858	858		missense	0.928	probably damaging	0.01	deleterious	1	Non-small cell lung cancer (NSCLC)	Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor.			pubmed:23667368,pubmed:24627688,pubmed:24673736,pubmed:24868098,ClinVar:RCV000431153	
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs121434568	COSM6224	7p11.2	7	55191822	T	G	L	R	858	858		missense	0.999	probably damaging	0.0	deleterious	1	Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, somatic				pubmed:23562183,ClinVar:RCV000018084,ClinVar:RCV000018083	
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs763666690		7p11.2	7	55191825	C	T	A	V	859	859		missense	0.995	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517130		7p11.2	7	55191829	A	T	K	N	860	860		missense	0.946	probably damaging	0.05	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs121913444	COSM6213	7p11.2	7	55191831	T	A	L	Q	861	861		missense	0.4505	benign, possibly damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs909797662		7p11.2	7	55191837	G	A	G	D	863	863		missense	0.5295	benign, probably damaging	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1171287261		7p11.2	7	55191839	G	A	A	T	864	864		missense	0.555	benign, probably damaging	0.265	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs756703787	COSM13198	7p11.2	7	55191845	G	A	E	K	866	866		missense	0.6825	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517132		7p11.2	7	55191846	A	T	E	V	866	866		missense	0.932	probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	dbSNP,gnomAD	rs104886013		7p11.2	7	55191851	G	A	E	K	868	868		missense	0.435	benign, possibly damaging	0.14	deleterious, tolerated	1	Familial cancer of breast	BRCA1- and BRCA2-associated hereditary breast and ovarian cancer syndrome (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (includes fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a BRCA2 pathogenic variant.	MIM:114480		pubmed:15604628,pubmed:17508274,pubmed:18163131,pubmed:20301425,pubmed:24366376,pubmed:24366402,pubmed:24432435,ClinVar:RCV000119351	
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs104886013		7p11.2	7	55191851	G	C	E	Q	868	868		missense	0.414	benign, possibly damaging	0.065	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1440961719		7p11.2	7	55191855	A	G	Y	C	869	869		missense	0.987	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517134		7p11.2	7	55191861	C	G	A	G	871	871		missense	0.5095	benign, probably damaging	0.05	deleterious, tolerated	1						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs766161581		7p11.2	7	55192777	G	C	K	N	879	879		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs751549547		7p11.2	7	55192783	G	T	M	I	881	881		missense	0.33	benign, possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517136		7p11.2	7	55192782	T	C	M	T	881	881		missense	0.7445	possibly damaging, probably damaging	0.0	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs956455215		7p11.2	7	55192781	A	G	M	V	881	881		missense	0.349	benign, possibly damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs754772262		7p11.2	7	55192791	A	G	E	G	884	884		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs397517137		7p11.2	7	55192794	C	T	S	L	885	885		missense	1.0	probably damaging	0.01	deleterious	1						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs756403828		7p11.2	7	55192804	C	G	H	Q	888	888		missense	0.7015	benign, probably damaging	0.24	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs748000023		7p11.2	7	55192803	A	G	H	R	888	888		missense	0.5365	benign, probably damaging	0.505	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs987884612		7p11.2	7	55192812	A	G	Y	C	891	891		missense	0.99	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1468532072		7p11.2	7	55192814	A	G	T	A	892	892		missense	0.8315	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs151064287		7p11.2	7	55192815	C	T	T	I	892	892		missense	0.977	probably damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs749270913		7p11.2	7	55192822	G	T	Q	H	894	894		missense	0.6155	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1334821010		7p11.2	7	55192830	T	C	V	A	897	897		missense	0.942	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1238258563		7p11.2	7	55192829	G	A	V	I	897	897		missense	0.694	benign, probably damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1009023863		7p11.2	7	55198717	G	C	G	A	901	901		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1399582136		7p11.2	7	55192841	G	C	G	R	901	901		missense	0.998	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs779015469		7p11.2	7	55198719	G	T	V	L	902	902		missense	0.8985	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1375731369		7p11.2	7	55198723	C	G	T	S	903	903		missense	0.943	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs538497054		7p11.2	7	55198725	G	A	V	I	904	904	5.99E-4	missense	0.56867	benign, possibly damaging, probably damaging	0.36667	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1218871031	COSM6178049	7p11.2	7	55198734	T	A	L	M	907	907		missense	0.704	benign, probably damaging	0.11	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1431327306		7p11.2	7	55198738	T	C	M	T	908	908		missense	0.621	benign, probably damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1011342626		7p11.2	7	55198750	C	A	S	Y	912	912		missense	0.699	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1275784384		7p11.2	7	55198760	T	A	Y	*	915	915		stop gained					0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1203302510		7p11.2	7	55198762	A	G	D	G	916	916		missense	0.607	benign, possibly damaging, probably damaging	0.00333	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs376822837		7p11.2	7	55198761	G	A	D	N	916	916		missense	0.5905	benign, possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs775695605		7p11.2	7	55198764	G	A	G	R	917	917		missense	0.6835	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1321754240		7p11.2	7	55198767	A	T	I	F	918	918		missense	0.57367	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1390478413		7p11.2	7	55198770	C	A	P	T	919	919		missense	0.5145	benign, probably damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770529788	COSM28515	7p11.2	7	55198778	C	A	S	R	921	921		missense	0.509	benign, probably damaging	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs961150162	COSM3639753	7p11.2	7	55198779	G	A	E	K	922	922		missense	0.3745	benign, possibly damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs961150162		7p11.2	7	55198779	G	C	E	Q	922	922		missense	0.56367	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs773998239		7p11.2	7	55198780	A	T	E	V	922	922		missense	0.55133	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1421825015		7p11.2	7	55198786	C	T	S	F	924	924		missense	0.687	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs759179459		7p11.2	7	55198791	A	C	I	L	926	926		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs767507216		7p11.2	7	55198792	T	A	I	N	926	926		missense	0.68667	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs767507216		7p11.2	7	55198792	T	C	I	T	926	926		missense	0.3705	benign, possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1247205023		7p11.2	7	55198801	A	G	K	R	929	929		missense	0.5135	benign, possibly damaging	0.1	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1223694747		7p11.2	7	55198809	C	T	R	C	932	932		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,NCI-TCGA,TOPMed,gnomAD	rs575565383	COSM3923814	7p11.2	7	55198815	C	T	P	S	934	934	3.9999998989515007E-4	missense	0.66525	benign, possibly damaging, probably damaging	0.09	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,dbSNP,gnomAD	rs17290699		7p11.2	7	55201204	A	C	H	P	935	935		missense	0.003	benign	0.29	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs763924711		7p11.2	7	55198829	A	G	I	M	938	938		missense	0.665	possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs753612121		7p11.2	7	55198833	A	G	T	A	940	940		missense	0.8	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs757493321		7p11.2	7	55198838	C	G	I	M	941	941		missense	0.999	probably damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1271051562		7p11.2	7	55198840	A	C	D	A	942	942		missense	0.895	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs967910623		7p11.2	7	55198839	G	C	D	H	942	942		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs967910623		7p11.2	7	55198839	G	A	D	N	942	942		missense	0.8855	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1375457410		7p11.2	7	55198843	T	A	V	D	943	943		missense	0.999	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs779164024		7p11.2	7	55198848	A	G	M	V	945	945		missense	0.925	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1169803481		7p11.2	7	55198851	A	G	I	V	946	946		missense	0.55	benign, probably damaging	0.625	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs368698152		7p11.2	7	55198854	A	C	M	L	947	947		missense	0.73433	benign, possibly damaging, probably damaging	0.04	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs368698152		7p11.2	7	55198854	A	G	M	V	947	947		missense	0.976	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs542967903		7p11.2	7	55198857	G	A	V	I	948	948	2.0E-4	missense	0.764	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs201830126		7p11.2	7	55200330	G	A	A	T	955	955	2.0E-4	missense	0.936	possibly damaging, probably damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	Ensembl,dbSNP	rs104886026		7p11.2	7	55200333	G	A	D	N	956	956		missense	0.3665	benign, possibly damaging	0.38	tolerated	1	Endometrial carcinoma		MIM:608089		pubmed:24493721,pubmed:24905773,ClinVar:RCV000119366	
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1185470008		7p11.2	7	55200334	A	T	D	V	956	956		missense	0.5175	benign, possibly damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1368179445		7p11.2	7	55200340	G	A	R	H	958	958		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1359029869		7p11.2	7	55200345	A	G	K	E	960	960		missense	0.928	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs17337451		7p11.2	7	55200351	C	T	R	C	962	962		missense	0.784	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs17337451		7p11.2	7	55200351	C	G	R	G	962	962		missense	0.553	benign, probably damaging	0.035	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,dbSNP,gnomAD	rs144496976		7p11.2	7	55200352	G	A	R	H	962	962		missense	0.487	possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs17337451		7p11.2	7	55200351	C	A	R	S	962	962		missense	0.70967	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751632602		7p11.2	7	55200355	A	G	E	G	963	963		missense	0.762	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	dbSNP	rs1562805773		7p11.2	7	55201297	C	A	P	Q	966	966		missense					1	Glioblastoma multiforme, somatic				ClinVar:RCV000786032	
P00533	EGFR	Epidermal growth factor receptor	dbSNP	rs1562805765		7p11.2	7	55201296	C	A	P	T	966	966		missense					1	Glioblastoma multiforme, somatic				ClinVar:RCV000786033	
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1383485737		7p11.2	7	55200363	A	G	I	V	966	966		missense	0.0	benign	0.22	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs755504552		7p11.2	7	55200376	A	G	K	R	970	970		missense	0.005	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs781609053		7p11.2	7	55200379	T	C	M	T	971	971		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748491031		7p11.2	7	55200384	C	T	R	*	973	973		stop gained					0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748491031		7p11.2	7	55200384	C	G	R	G	973	973		missense	0.884	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs756554871		7p11.2	7	55200385	G	A	R	Q	973	973		missense	0.5545	benign, probably damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1486130926		7p11.2	7	55200387	G	A	D	N	974	974		missense	0.655	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1215599430		7p11.2	7	55200391	C	T	P	L	975	975		missense	1.0	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1486804407		7p11.2	7	55200393	C	G	Q	E	976	976		missense	0.115	benign	0.06	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs745490627		7p11.2	7	55200397	G	A	R	H	977	977		missense	0.99	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs745490627		7p11.2	7	55200397	G	C	R	P	977	977		missense	0.996	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1042344966		7p11.2	7	55200410	T	G	I	M	981	981		missense	0.928	possibly damaging, probably damaging	0.005	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771888227		7p11.2	7	55200409	T	C	I	T	981	981		missense	0.91	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs775131364		7p11.2	7	55200412	A	T	Q	L	982	982		missense	0.6255	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs750582201		7p11.2	7	55201191	G	A	D	N	984	984		missense	0.5705	benign, probably damaging	0.2	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs750582201		7p11.2	7	55201191	G	T	D	Y	984	984		missense	0.977	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC	rs779583988		7p11.2	7	55201198	G	A	R	K	986	986		missense	0.504	benign, probably damaging	0.215	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs17290699		7p11.2	7	55201204	A	C	H	P	988	988	0.008986	missense	0.007	benign	0.28	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs17290699		7p11.2	7	55201204	A	G	H	R	988	988	0.008986	missense	0.027	benign	0.5	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs781134348		7p11.2	7	55201209	C	T	P	S	990	990		missense	0.528	benign, probably damaging	0.2	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs748011710		7p11.2	7	55201212	A	G	S	G	991	991		missense	0.513	benign, probably damaging	0.06	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs748011710		7p11.2	7	55201212	A	C	S	R	991	991		missense	0.909	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs771085105		7p11.2	7	55201229	C	A	N	K	996	996		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs762795214		7p11.2	7	55201228	A	G	N	S	996	996		missense	0.001	benign	0.11	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1289194907		7p11.2	7	55201234	A	G	Y	C	998	998		missense	0.97	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs866928399		7p11.2	7	55201236	C	T	R	C	999	999		missense	0.9	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs149248025		7p11.2	7	55201237	G	A	R	H	999	999		missense	0.68	possibly damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs149248025		7p11.2	7	55201237	G	T	R	L	999	999		missense	0.572	benign, possibly damaging	0.015	deleterious	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000381625	
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1319486482		7p11.2	7	55201246	T	C	M	T	1002	1002		missense	0.176	benign	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1225496600		7p11.2	7	55201245	A	G	M	V	1002	1002		missense	0.001	benign	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1256257325		7p11.2	7	55201248	G	A	D	N	1003	1003		missense	0.0	benign	0.05	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs752859687		7p11.2	7	55201258	A	C	D	A	1006	1006		missense	0.119	benign	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs747143752		7p11.2	7	55201265	C	G	D	E	1008	1008		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs747143752		7p11.2	7	55201265	C	A	D	E	1008	1008		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1487738928		7p11.2	7	55201264	A	G	D	G	1008	1008		missense	0.0	benign	0.44	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1162232225		7p11.2	7	55201263	G	A	D	N	1008	1008		missense	0.0	benign	0.12	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs148019583	COSM3639757	7p11.2	7	55201266	G	A	D	N	1009	1009		missense	0.49	benign, possibly damaging	0.035	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs757699239		7p11.2	7	55201269	G	C	V	L	1010	1010		missense	0.003	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs757699239		7p11.2	7	55201269	G	A	V	M	1010	1010		missense	0.013	benign	0.45	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1226829354		7p11.2	7	55201272	G	C	V	L	1011	1011		missense	0.007	benign	0.21	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs995022327		7p11.2	7	55201277	T	A	D	E	1012	1012		missense	0.8045	possibly damaging, probably damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1420841957		7p11.2	7	55201275	G	C	D	H	1012	1012		missense	0.998	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs779716935		7p11.2	7	55201278	G	A	A	T	1013	1013		missense	0.989	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751192280		7p11.2	7	55201281	G	A	D	N	1014	1014		missense	0.785	possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1302295057		7p11.2	7	55201284	G	A	E	K	1015	1015		missense	0.9095	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1345851089		7p11.2	7	55201290	C	T	L	F	1017	1017		missense	0.989	probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1362774341		7p11.2	7	55201293	A	G	I	V	1018	1018		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs747726185		7p11.2	7	55201306	G	A	G	D	1022	1022		missense	0.511	possibly damaging	0.06	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1276184054		7p11.2	7	55201305	G	A	G	S	1022	1022		missense	0.057	benign	0.19	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1275431248		7p11.2	7	55201314	A	T	S	C	1025	1025		missense	0.001	benign	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs777701385		7p11.2	7	55201316	C	G	S	R	1025	1025		missense	0.03	benign	0.26	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1296356016		7p11.2	7	55201326	A	G	T	A	1029	1029		missense	0.114	benign	0.21	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs182857647		7p11.2	7	55201327	C	A	T	K	1029	1029	3.99E-4	missense	0.367	benign, possibly damaging	0.12	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs182857647		7p11.2	7	55201327	C	T	T	M	1029	1029	3.99E-4	missense	0.794	possibly damaging	0.05	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1490923813		7p11.2	7	55201332	C	G	R	G	1031	1031		missense	0.52	benign, possibly damaging, probably damaging	0.07333	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,NCI-TCGA,TOPMed,gnomAD	rs570295933	COSM3881830	7p11.2	7	55201333	G	A	R	Q	1031	1031	2.0E-4	missense	0.63367	benign, possibly damaging, probably damaging	0.13	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1490923813		7p11.2	7	55201332	C	T	R	W	1031	1031		missense	0.908	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs775415330		7p11.2	7	55201335	A	G	T	A	1032	1032		missense	0.58667	benign, possibly damaging, probably damaging	0.3	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs764626121		7p11.2	7	55201341	C	A	L	I	1034	1034		missense	0.882	possibly damaging, probably damaging	0.24	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs34352568		7p11.2	7	55201342	T	C	L	P	1034	1034		missense	0.545	benign, probably damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,dbSNP,gnomAD	rs34352568		7p11.2	7	55201342	T	G	L	R	1034	1034		missense	0.8975	possibly damaging, probably damaging	0.17	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs762218653		7p11.2	7	55201350	T	A	S	T	1037	1037		missense	0.038	benign	0.11	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs765496858		7p11.2	7	55201351	C	A	S	Y	1037	1037		missense	0.8825	possibly damaging, probably damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1420042114		7p11.2	7	55201741	A	G	T	A	1041	1041		missense	0.0	benign	0.79	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1161802556	COSM485465	7p11.2	7	55201745	G	A	S	N	1042	1042		missense	0.56567	benign, possibly damaging, probably damaging	0.08	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs375035197		7p11.2	7	55201748	A	G	N	S	1043	1043		missense	0.003	benign	0.35	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1364225726		7p11.2	7	55201753	T	C	S	P	1045	1045		missense	0.003	benign	0.29	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs773437153		7p11.2	7	55201757	C	A	T	N	1046	1046		missense	0.0	benign	0.5	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1367552759		7p11.2	7	55201760	T	G	V	G	1047	1047		missense	0.0	benign	0.43	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs142442994		7p11.2	7	55201759	G	A	V	M	1047	1047		missense	0.006	benign	0.13	tolerated	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000332908	
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1186558284		7p11.2	7	55201762	G	C	A	P	1048	1048		missense	0.114	benign	0.24	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs78244461		7p11.2	7	55201763	C	T	A	V	1048	1048	9.98E-4	missense	0.0	benign	0.15	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1462369239		7p11.2	7	55201768	A	T	I	F	1050	1050		missense	0.067	benign	0.74	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs529174941		7p11.2	7	55201769	T	G	I	S	1050	1050	2.0E-4	missense	0.03	benign	0.79	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs529174941		7p11.2	7	55201769	T	C	I	T	1050	1050	2.0E-4	missense	0.0	benign	0.49	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs755574890		7p11.2	7	55201772	A	C	D	A	1051	1051		missense	0.034	benign	0.89	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs755574890		7p11.2	7	55201772	A	G	D	G	1051	1051		missense	0.022	benign	0.44	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs758314765		7p11.2	7	55202522	A	C	Q	H	1056	1056		missense	0.273	benign, possibly damaging	0.075	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751466686		7p11.2	7	55202524	G	A	S	N	1057	1057		missense	0.0	benign	0.26	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1321975678		7p11.2	7	55202527	G	C	C	S	1058	1058		missense	0.0	benign	0.42	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1406092971		7p11.2	7	55202530	C	T	P	L	1059	1059		missense	0.0	benign	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs755238987		7p11.2	7	55202529	C	T	P	S	1059	1059		missense	0.099	benign	0.09	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs748111724		7p11.2	7	55202535	A	C	K	Q	1061	1061		missense	0.074	benign	0.53	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1224584642		7p11.2	7	55202542	A	G	D	G	1063	1063		missense	0.2685	benign, possibly damaging	0.27	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1250448734		7p11.2	7	55202544	A	G	S	G	1064	1064		missense	0.0	benign	0.06	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1339648899		7p11.2	7	55202545	G	T	S	I	1064	1064		missense	0.314	benign, possibly damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs769949680		7p11.2	7	55202547	T	A	F	I	1065	1065		missense	0.03	benign	0.41	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778095401		7p11.2	7	55202553	C	A	Q	K	1067	1067		missense	0.494	benign, probably damaging	0.07	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs749783044	COSM3266657	7p11.2	7	55202556	C	T	R	*	1068	1068		stop gained	-1.0	unknown	-1.0	unknown	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,gnomAD	rs374501041		7p11.2	7	55202557	G	C	R	P	1068	1068		missense	0.6755	benign, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,NCI-TCGA,gnomAD	rs374501041		7p11.2	7	55202557	G	A	R	Q	1068	1068		missense	0.6095	benign, probably damaging	0.03	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771471723		7p11.2	7	55202563	G	A	S	N	1070	1070		missense	0.55533	benign, possibly damaging, probably damaging	0.09333	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771471723		7p11.2	7	55202563	G	C	S	T	1070	1070		missense	0.4915	benign, probably damaging	0.48	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs887824842		7p11.2	7	55202569	A	G	D	G	1072	1072		missense	0.5405	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs768226783		7p11.2	7	55202571	C	A	P	T	1073	1073		missense	0.5325	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1161834426		7p11.2	7	55202578	G	A	G	D	1075	1075		missense	0.036	benign	0.63	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs776375114		7p11.2	7	55202577	G	A	G	S	1075	1075		missense	0.0	benign	0.7	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs764780987		7p11.2	7	55202580	G	C	A	P	1076	1076		missense	0.107	benign	0.35	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs764780987		7p11.2	7	55202580	G	A	A	T	1076	1076		missense	0.0	benign	0.55	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs755868272		7p11.2	7	55202581	C	T	A	V	1076	1076		missense	0.0	benign	0.29	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1164785061		7p11.2	7	55202584	T	C	L	S	1077	1077		missense	0.046	benign	0.08	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs751342391		7p11.2	7	55202586	A	G	T	A	1078	1078		missense	0.001	benign	0.76	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs751342391		7p11.2	7	55202586	A	T	T	S	1078	1078		missense	0.001	benign	0.74	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs184614596		7p11.2	7	55202591	G	C	E	D	1079	1079	2.0E-4	missense	0.0	benign	0.29	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1023185448		7p11.2	7	55202592	G	A	D	N	1080	1080		missense	0.149	benign	0.07	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs371229748		7p11.2	7	55202598	A	T	I	L	1082	1082		missense	0.0	benign	0.78	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1051476261		7p11.2	7	55202599	T	G	I	R	1082	1082		missense	0.082	benign	0.25	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs371229748		7p11.2	7	55202598	A	G	I	V	1082	1082		missense	0.0	benign	0.46	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373990043		7p11.2	7	55202603	C	A	D	E	1083	1083		missense	0.021	benign	0.23	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	NCI-TCGA,TOPMed,gnomAD	rs535060253		7p11.2	7	55202604	G	A	D	N	1084	1084		missense	0.61367	benign, possibly damaging, probably damaging	0.14	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1032201502		7p11.2	7	55202610	T	A	F	I	1086	1086		missense	0.5835	benign, probably damaging	0.12	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs749400221		7p11.2	7	55202614	T	G	L	R	1087	1087		missense	0.439	benign	0.41	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs771418435		7p11.2	7	55202617	C	T	P	L	1088	1088		missense	0.576	benign, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs367870311		7p11.2	7	55202622	C	T	P	S	1090	1090		missense	0.60667	benign, possibly damaging, probably damaging	0.10333	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1328333567		7p11.2	7	55202625	G	A	E	K	1091	1091		missense	0.68633	benign, probably damaging	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs775345513	COSM1451620	7p11.2	7	55205273	G	A	V	I	1097	1097		missense	0.0	benign	0.27	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs775345513		7p11.2	7	55205273	G	C	V	L	1097	1097		missense	0.0	benign	0.14	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs760404029		7p11.2	7	55205280	A	C	K	T	1099	1099		missense	0.115	benign	0.36	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs764332519		7p11.2	7	55205286	C	T	P	L	1101	1101		missense	0.034	benign	0.07	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs764332519		7p11.2	7	55205286	C	G	P	R	1101	1101		missense	0.005	benign	0.23	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1268506326		7p11.2	7	55205288	G	T	A	S	1102	1102		missense	0.001	benign	0.76	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1370192881		7p11.2	7	55205292	G	A	G	D	1103	1103		missense	0.057	benign	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs139388758		7p11.2	7	55205291	G	A	G	S	1103	1103		missense	0.057	benign	0.66	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs376598259		7p11.2	7	55205294	T	C	S	P	1104	1104		missense	0.2745	benign, possibly damaging	0.325	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs780439043		7p11.2	7	55205301	A	G	Q	R	1106	1106		missense	0.031	benign	0.44	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1055315772		7p11.2	7	55205309	G	A	V	I	1109	1109		missense	0.003	benign	0.2	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1055315772		7p11.2	7	55205309	G	C	V	L	1109	1109		missense	0.034	benign	0.3	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369498625		7p11.2	7	55205318	A	C	N	H	1112	1112		missense	0.809	possibly damaging	0.15	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs755330584		7p11.2	7	55205319	A	G	N	S	1112	1112		missense	0.542	possibly damaging	0.48	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1485236403		7p11.2	7	55205330	A	G	N	D	1116	1116		missense	0.01	benign	0.64	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1186762640		7p11.2	7	55205332	C	A	N	K	1116	1116		missense	0.01	benign	0.88	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs777435609		7p11.2	7	55205333	C	G	P	A	1117	1117		missense	0.0	benign	0.54	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1442620290		7p11.2	7	55205334	C	A	P	H	1117	1117		missense	0.213	benign	0.1	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1442620290		7p11.2	7	55205334	C	G	P	R	1117	1117		missense	0.062	benign	0.43	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs777435609		7p11.2	7	55205333	C	A	P	T	1117	1117		missense	0.015	benign	0.39	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770749711		7p11.2	7	55205336	G	A	A	T	1118	1118		missense	0.037	benign	0.55	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773996588		7p11.2	7	55205337	C	T	A	V	1118	1118		missense	0.037	benign	0.26	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs902672760		7p11.2	7	55205340	C	G	P	R	1119	1119		missense	0.082	benign	0.055	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs868454218		7p11.2	7	55205339	C	T	P	S	1119	1119		missense	0.003	benign	0.21	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs775317295		7p11.2	7	55205352	C	T	P	L	1123	1123		missense	0.0	benign	0.11	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1358829599		7p11.2	7	55205374	C	A	S	R	1130	1130		missense	0.299	benign	0.36	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs776448547		7p11.2	7	55205382	T	A	V	E	1133	1133		missense	0.261	benign	0.16	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs865825533		7p11.2	7	55205385	G	A	G	D	1134	1134		missense	0.0	benign	0.57	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs762016851		7p11.2	7	55205384	G	A	G	S	1134	1134		missense	0.0	benign	0.61	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs865825533		7p11.2	7	55205385	G	T	G	V	1134	1134		missense	0.018	benign	0.23	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs765499904		7p11.2	7	55205389	C	A	N	K	1135	1135		missense	0.5355	benign, probably damaging	0.155	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1445729019		7p11.2	7	55205391	C	T	P	L	1136	1136		missense	0.789	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs780967013		7p11.2	7	55205393	G	A	E	K	1137	1137		missense	0.7755	possibly damaging, probably damaging	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1473630143		7p11.2	7	55205399	C	T	L	F	1139	1139		missense	0.9475	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs145189325		7p11.2	7	55205411	C	G	Q	E	1143	1143		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1403923057		7p11.2	7	55205413	G	T	Q	H	1143	1143		missense	0.0	benign	0.22	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1452191951		7p11.2	7	55205417	A	C	T	P	1145	1145		missense	0.0	benign	0.63	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1337590341		7p11.2	7	55205421	G	A	C	Y	1146	1146		missense	0.013	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs778725594		7p11.2	7	55205428	C	G	N	K	1148	1148		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1476431328		7p11.2	7	55205427	A	G	N	S	1148	1148		missense	0.0	benign	0.88	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs745321541		7p11.2	7	55205433	C	T	T	I	1150	1150		missense	0.0	benign	0.11	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs368892932		7p11.2	7	55205438	G	C	D	H	1152	1152		missense	0.4055	benign, possibly damaging	0.02	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs368892932		7p11.2	7	55205438	G	A	D	N	1152	1152		missense	0.0	benign	0.15	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1230715733		7p11.2	7	55205441	A	T	S	C	1153	1153		missense	0.315	benign	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,dbSNP,gnomAD	rs149174093		7p11.2	7	55205451	A	C	H	P	1156	1156		missense	0.0	benign	0.05	deleterious, tolerated	0	Hereditary cancer				ClinVar:RCV000709022	
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1320747370		7p11.2	7	55205450	C	T	H	Y	1156	1156		missense	0.0	benign	1.0	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs761608448		7p11.2	7	55205455	G	C	W	C	1157	1157		missense	0.7505	possibly damaging	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1433524783		7p11.2	7	55205459	C	T	Q	*	1159	1159		stop gained					0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed,gnomAD	rs1179392671		7p11.2	7	55205460	A	G	Q	R	1159	1159		missense	0.133	benign	0.17	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs773454677		7p11.2	7	55205466	G	A	G	D	1161	1161		missense	0.003	benign	0.39	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,dbSNP,gnomAD	rs41321844		7p11.2	7	55205469	G	A	S	N	1162	1162		missense	0.0	benign	0.62	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs766347941		7p11.2	7	55205470	C	G	S	R	1162	1162		missense	0.022	benign	0.44	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1318894874		7p11.2	7	55205473	C	A	H	Q	1163	1163		missense	0.132	benign	0.32	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1399981803		7p11.2	7	55205471	C	T	H	Y	1163	1163		missense	0.265	benign	0.54	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1469310856		7p11.2	7	55205483	C	G	L	V	1167	1167		missense	0.777	possibly damaging, probably damaging	0.04	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs751701731		7p11.2	7	55205490	A	G	N	S	1169	1169		missense	0.719	possibly damaging, probably damaging	0.1	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1408630981		7p11.2	7	55205492	C	G	P	A	1170	1170		missense	0.5275	benign, probably damaging	0.05	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs147896627		7p11.2	7	55205502	A	C	Q	P	1173	1173		missense	0.885	possibly damaging, probably damaging	0.205	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs147896627		7p11.2	7	55205502	A	G	Q	R	1173	1173		missense	0.7805	possibly damaging, probably damaging	0.385	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs756556775		7p11.2	7	55205515	T	A	F	L	1177	1177		missense	0.0	benign	0.85	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed	rs556324078		7p11.2	7	55205514	T	C	F	S	1177	1177	2.0E-4	missense	0.2295	benign, possibly damaging	0.555	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1343156007		7p11.2	7	55205521	G	C	K	N	1179	1179		missense	0.001	benign	0.1	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs778656021		7p11.2	7	55205525	G	A	A	T	1181	1181		missense	0.0	benign	0.42	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs199661469		7p11.2	7	55205531	C	T	P	S	1183	1183	2.0E-4	missense	0.0	benign	0.23	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,dbSNP,gnomAD	rs199661469		7p11.2	7	55205531	C	A	P	T	1183	1183		missense	0.0	benign	0.3	tolerated	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000293175	
P00533	EGFR	Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs779422878		7p11.2	7	55205535	A	G	N	S	1184	1184		missense	0.6315	benign, probably damaging	0.045	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs746585833		7p11.2	7	55205538	G	C	G	A	1185	1185		missense	0.646	benign, probably damaging	0.06	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs746585833		7p11.2	7	55205538	G	A	G	D	1185	1185		missense	0.973	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	TOPMed	rs1255635334		7p11.2	7	55205540	A	G	I	V	1186	1186		missense	0.0	benign	0.5	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1272024430		7p11.2	7	55205544	T	G	F	C	1187	1187		missense	0.001	benign	0.08	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs747600559		7p11.2	7	55205550	G	C	G	A	1189	1189		missense	0.007	benign	0.7	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs372948989		7p11.2	7	55205556	C	T	T	I	1191	1191		missense	0.0	benign	0.11	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1480173156		7p11.2	7	55205559	C	G	A	G	1192	1192		missense	0.8725	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs773041247		7p11.2	7	55205558	G	A	A	T	1192	1192		missense	0.9245	possibly damaging, probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1480173156		7p11.2	7	55205559	C	T	A	V	1192	1192		missense	0.943	possibly damaging, probably damaging	0.09	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs749441331		7p11.2	7	55205561	G	A	E	K	1193	1193		missense	0.182	benign	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1379387764		7p11.2	7	55205570	G	A	E	K	1196	1196		missense	0.275	benign	0.01	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs376541336		7p11.2	7	55205575	C	A	Y	*	1197	1197		stop gained					0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs142188270		7p11.2	7	55205576	C	G	L	V	1198	1198	0.001997	missense	0.978	probably damaging	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ExAC,gnomAD	rs768074018		7p11.2	7	55205580	G	C	R	T	1199	1199		missense	0.212	benign	0.21	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs201717672		7p11.2	7	55205586	C	A	A	E	1201	1201	2.0E-4	missense	0.334	benign	0.0	deleterious	0						
P00533	EGFR	Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369585356		7p11.2	7	55205585	G	A	A	T	1201	1201		missense	0.204	benign	0.06	tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ExAC,NCI-TCGA,TOPMed,gnomAD	rs201717672		7p11.2	7	55205586	C	T	A	V	1201	1201	2.0E-4	missense	0.47933	benign, possibly damaging	0.03333	deleterious, tolerated	0						
P00533	EGFR	Epidermal growth factor receptor	gnomAD	rs1301373415		7p11.2	7	55205604	T	G	F	C	1207	1207		missense	0.41	benign	0.01	deleterious - low confidence	0						
P00533	EGFR	Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs35918369		7p11.2	7	55205613	C	T	A	V	1210	1210	2.0E-4	missense	0.985	probably damaging	0.1	tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs749433287		7p11.2	7	55019285	C	T	P	L	3	3		missense	0.0015	benign	0.01	deleterious, deleterious - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773069229		7p11.2	7	55019284	C	T	P	S	3	3		missense	0.05633	benign	0.12	deleterious, tolerated, tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773069229		7p11.2	7	55019284	C	A	P	T	3	3		missense	0.0405	benign	0.035	deleterious, tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs771210838		7p11.2	7	55019288	C	T	S	F	4	4		missense	0.001	benign	0.03	deleterious, deleterious - low confidence, tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs771210838		7p11.2	7	55019288	C	A	S	Y	4	4		missense	0.0	benign	0.03	deleterious, deleterious - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759582787		7p11.2	7	55019291	G	C	G	A	5	5		missense	0.201	benign	0.295	tolerated, tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759582787		7p11.2	7	55019291	G	A	G	E	5	5		missense	0.01167	benign	0.04333	deleterious, deleterious - low confidence, tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs774487133		7p11.2	7	55019290	G	C	G	R	5	5		missense	0.021	benign	0.175	tolerated, tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs767651648		7p11.2	7	55019293	A	G	T	A	6	6		missense	0.0	benign	0.545	tolerated, tolerated - low confidence	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000372969	
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs761183109		7p11.2	7	55019296	G	C	A	P	7	7		missense	0.001	benign	0.07	deleterious, tolerated, tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs761183109		7p11.2	7	55019296	G	T	A	S	7	7		missense	0.001	benign	0.06333	deleterious, tolerated, tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754259847		7p11.2	7	55019299	G	C	G	R	8	8		missense	0.0015	benign	0.55	tolerated, tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754259847		7p11.2	7	55019299	G	A	G	R	8	8		missense	0.0	benign	0.235	tolerated, tolerated - low confidence	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1217714114		7p11.2	7	55019306	C	A	A	E	10	10		missense	0.045	benign	0.26	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs567894670		7p11.2	7	55019315	C	T	A	V	13	13	7.99E-4	missense	0.0	benign	0.52	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1180577495		7p11.2	7	55019327	C	T	A	V	17	17		missense	0.0	benign	0.65	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs754527029		7p11.2	7	55019329	C	T	L	F	18	18		missense	0.221	benign	0.12	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs780865931		7p11.2	7	55019333	G	C	C	S	19	19		missense	0.003	benign	0.46	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1028735720		7p11.2	7	55019336	C	A	P	Q	20	20		missense	0.0	benign	0.31	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1028735720		7p11.2	7	55019336	C	G	P	R	20	20		missense	0.0	benign	0.52	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1194702075		7p11.2	7	55019339	C	A	A	E	21	21		missense	0.062	benign	0.45	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373129709		7p11.2	7	55019338	G	T	A	S	21	21		missense	0.051	benign	0.59	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373129709		7p11.2	7	55019338	G	A	A	T	21	21		missense	0.0	benign	0.48	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1194702075		7p11.2	7	55019339	C	T	A	V	21	21		missense	0.037	benign	0.44	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1257423707		7p11.2	7	55019342	G	A	S	N	22	22		missense	0.015	benign	0.49	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs987102148		7p11.2	7	55019344	C	T	R	W	23	23		missense	0.0	benign	0.19	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs911767401		7p11.2	7	55019347	G	A	A	T	24	24		missense	0.021	benign	0.19	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs749088691		7p11.2	7	55019359	A	G	K	E	28	28		missense	0.01	benign	0.37	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs774551548		7p11.2	7	55019363	A	C	K	T	29	29		missense	0.028	benign	0.28	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs746023542		7p11.2	7	55142292	A	G	Q	R	32	32		missense	0.4705	benign, probably damaging	0.58	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs772311777		7p11.2	7	55142294	G	A	G	S	33	33		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs144158123		7p11.2	7	55142298	C	T	T	M	34	34		missense	0.77633	possibly damaging, probably damaging	0.05667	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs144158123		7p11.2	7	55142298	C	G	T	R	34	34		missense	0.869	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1406387936		7p11.2	7	55142301	G	A	S	N	35	35		missense	0.0	benign	0.24	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs375919121		7p11.2	7	55142313	C	T	T	M	39	39		missense	0.8595	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1442908038		7p11.2	7	55142321	G	A	G	S	42	42		missense	0.53133	benign, possibly damaging, probably damaging	0.44	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1001476056		7p11.2	7	55142328	T	C	F	S	44	44		missense	0.0	benign	0.43	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1052582656		7p11.2	7	55142335	T	A	D	E	46	46		missense	0.026	benign	0.11	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1343024399		7p11.2	7	55142334	A	T	D	V	46	46		missense	0.45025	benign, possibly damaging, probably damaging	0.1025	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1263793183		7p11.2	7	55142340	T	C	F	S	48	48		missense	0.71	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs759219499		7p11.2	7	55142355	G	A	R	K	53	53		missense	0.003	benign	1.0	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs767259994		7p11.2	7	55142364	A	G	N	S	56	56		missense	0.003	benign	0.84	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs763572530		7p11.2	7	55142373	A	C	E	A	59	59		missense	0.82	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs760228905		7p11.2	7	55142372	G	A	E	K	59	59		missense	0.67875	benign, possibly damaging, probably damaging	0.0275	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1470757416		7p11.2	7	55142408	C	T	Q	*	71	71		stop gained					0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369580836		7p11.2	7	55142409	A	C	Q	P	71	71		missense	0.006	benign	0.09	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369580836		7p11.2	7	55142409	A	G	Q	R	71	71		missense	0.497	benign, possibly damaging	0.2	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1269583681		7p11.2	7	55142416	T	G	N	K	73	73		missense	0.06	benign	0.07	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs778638117		7p11.2	7	55142423	C	A	L	I	76	76		missense	0.9055	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs374986786		7p11.2	7	55143305	A	G	T	A	81	81		missense	0.038	benign	0.04	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1309796320		7p11.2	7	55143308	A	G	I	V	82	82		missense	0.85567	possibly damaging, probably damaging	0.03	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1282801317		7p11.2	7	55143316	G	C	E	D	84	84		missense	0.996	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs753319070		7p11.2	7	55143314	G	A	E	K	84	84		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs753319070		7p11.2	7	55143314	G	C	E	Q	84	84		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs765137528		7p11.2	7	55143327	A	G	Y	C	88	88		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs750399097		7p11.2	7	55143332	C	T	L	F	90	90		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs142061256		7p11.2	7	55143333	T	A	L	H	90	90		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs779879611		7p11.2	7	55143339	C	T	A	V	92	92		missense	0.961	probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1422504667		7p11.2	7	55143348	C	T	T	I	95	95		missense	0.134	benign	0.13	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1260357262		7p11.2	7	55143350	G	A	V	M	96	96		missense	0.889	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs755189573		7p11.2	7	55143353	G	C	E	Q	97	97		missense	0.35	benign	0.33	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17289589		7p11.2	7	55143357	G	T	R	L	98	98		missense	0.047	benign	0.28	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs17289589	COSM4680391	7p11.2	7	55143357	G	A	R	Q	98	98		missense	0.007	benign	0.32	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,NCI-TCGA	rs376963968	COSM6047689	7p11.2	7	55143363	C	A	P	H	100	100		missense	0.559	benign, possibly damaging	0.04667	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	Ensembl	rs866460345	COSM4892885	7p11.2	7	55143362	C	T	P	S	100	100		missense	0.8665	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs141271101		7p11.2	7	55143379	G	C	Q	H	105	105		missense	0.9075	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs771366736		7p11.2	7	55143380	A	G	I	V	106	106		missense	0.031	benign	0.15	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519888	COSM1451537	7p11.2	7	55143386	A	G	R	G	108	108		missense	1.0	probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000424206,ClinVar:RCV000434481	
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519828	COSM5576118	7p11.2	7	55143387	G	A	R	K	108	108		missense	1.0	probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000432019	
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs145113601		7p11.2	7	55143390	G	C	G	A	109	109		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1488843432		7p11.2	7	55143397	G	A	M	I	111	111		missense	0.0	benign	0.13	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746631025		7p11.2	7	55143396	T	C	M	T	111	111		missense	0.0	benign	0.56	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1385682568		7p11.2	7	55143402	A	T	Y	F	113	113		missense	0.576	benign, possibly damaging	0.225	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1219568637	COSM5835422	7p11.2	7	55143404	G	A	E	K	114	114		missense	0.011	benign	0.05	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1332428616		7p11.2	7	55143407	A	C	N	H	115	115		missense	0.4832	benign, possibly damaging, probably damaging	0.046	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773596817		7p11.2	7	55143409	T	A	N	K	115	115		missense	0.361	benign, possibly damaging	0.14	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1247204001		7p11.2	7	55143417	C	G	A	G	118	118		missense	0.573	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1249939049		7p11.2	7	55143416	G	T	A	S	118	118		missense	0.9285	possibly damaging, probably damaging	0.1	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1229095978		7p11.2	7	55143432	C	T	S	F	123	123		missense	0.592	benign, possibly damaging, probably damaging	0.30333	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1295285127		7p11.2	7	55143438	A	G	Y	C	125	125		missense	0.968	probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs377444977		7p11.2	7	55143443	G	A	A	T	127	127		missense	0.001	benign	0.58	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1485906237		7p11.2	7	55143444	C	T	A	V	127	127		missense	0.0	benign	0.09	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs762889647		7p11.2	7	55143450	A	C	K	T	129	129		missense	0.007	benign	0.37	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1485016142		7p11.2	7	55143455	G	A	G	R	131	131		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs751337426		7p11.2	7	55143464	G	A	E	K	134	134		missense	0.3735	benign, possibly damaging	0.03	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754854319		7p11.2	7	55143473	A	G	M	V	137	137		missense	0.084	benign	0.03	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1437762652		7p11.2	7	55143477	G	A	R	K	138	138		missense	0.018	benign	0.74	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs767608234		7p11.2	7	55143487	G	T	Q	H	141	141		missense	0.303	benign, possibly damaging	0.02333	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1198703773		7p11.2	7	55146614	C	A	H	N	145	145		missense	0.0	benign	1.0	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780476417		7p11.2	7	55146615	A	G	H	R	145	145		missense	0.0	benign	0.32	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs532655845		7p11.2	7	55146620	G	C	A	P	147	147	2.0E-4	missense	0.403	benign, possibly damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ExAC,NCI-TCGA,TOPMed,gnomAD	rs532655845		7p11.2	7	55146620	G	A	A	T	147	147	2.0E-4	missense	0.026	benign	0.03	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759532524		7p11.2	7	55146627	G	A	R	Q	149	149		missense	0.2575	benign, possibly damaging	0.375	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs774146556	COSM3412169	7p11.2	7	55146626	C	T	R	W	149	149		missense	0.34	benign, probably damaging	0.08333	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1398462122		7p11.2	7	55146629	T	C	F	L	150	150		missense	0.0805	benign	0.045	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs551591429		7p11.2	7	55146636	A	G	N	S	152	152	2.0E-4	missense	0.054	benign	0.38	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs919891568		7p11.2	7	55146644	G	T	A	S	155	155		missense	0.007	benign	0.42	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs937907395		7p11.2	7	55146653	A	G	N	D	158	158		missense	0.2725	benign, possibly damaging	0.225	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs761795138		7p11.2	7	55146675	G	A	R	Q	165	165		missense	0.007	benign	0.68	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs587778252		7p11.2	7	55146674	C	T	R	W	165	165		missense	0.4455	benign, possibly damaging	0.26	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs765416003		7p11.2	7	55146681	T	C	I	T	167	167		missense	0.988	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs530692924		7p11.2	7	55146683	G	C	V	L	168	168	2.0E-4	missense	0.056	benign	0.23	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs758945260		7p11.2	7	55146690	G	T	S	I	170	170		missense	0.017	benign	0.04	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs758945260		7p11.2	7	55146690	G	A	S	N	170	170		missense	0.0	benign	1.0	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs17289686		7p11.2	7	55146694	C	A	D	E	171	171	3.99E-4	missense	0.001	benign	0.72	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770290445		7p11.2	7	55146711	C	T	S	L	177	177		missense	0.003	benign	0.18	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770290445		7p11.2	7	55146711	C	G	S	W	177	177		missense	0.9005	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs745755245		7p11.2	7	55146715	G	A	M	I	178	178		missense	0.001	benign	0.82	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1219334377		7p11.2	7	55146713	A	G	M	V	178	178		missense	0.0	benign	0.22	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs772071414		7p11.2	7	55146728	C	G	H	D	183	183		missense	0.007	benign	0.42	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs772071414		7p11.2	7	55146728	C	A	H	N	183	183		missense	0.0	benign	0.98	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs921852102		7p11.2	7	55146732	T	C	L	P	184	184		missense	0.0	benign	0.4	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs921852102		7p11.2	7	55146732	T	A	L	Q	184	184		missense	0.003	benign	0.6	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1224862076		7p11.2	7	55146731	C	G	L	V	184	184		missense	0.003	benign	0.31	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770074413		7p11.2	7	55151308	C	A	P	T	192	192		missense	0.146	benign	0.045	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs766507267		7p11.2	7	55151321	A	G	N	S	196	196		missense	0.021	benign	0.27	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1335854310		7p11.2	7	55151327	G	A	S	N	198	198		missense	0.2725	benign, possibly damaging	0.33	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs767829342		7p11.2	7	55151344	G	A	E	K	204	204		missense	0.001	benign	0.46	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs779156097		7p11.2	7	55152549	C	G	T	S	211	211		missense	0.878	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs750423932		7p11.2	7	55152551	A	C	K	Q	212	212		missense	0.625	benign, possibly damaging, probably damaging	0.00667	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1372330611		7p11.2	7	55152564	C	G	A	G	216	216		missense	0.992	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1190573231		7p11.2	7	55152563	G	A	A	T	216	216		missense	0.9455	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs776050604		7p11.2	7	55152571	G	T	Q	H	218	218		missense	0.7655	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs761098433		7p11.2	7	55152575	T	C	S	P	220	220		missense	0.56675	benign, probably damaging	0.0825	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs776886714		7p11.2	7	55152578	G	A	G	R	221	221		missense	0.067	benign	0.2	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs776886714		7p11.2	7	55152578	G	T	G	W	221	221		missense	0.666	benign, probably damaging	0.035	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751295137		7p11.2	7	55152582	G	A	R	H	222	222		missense	0.965	possibly damaging, probably damaging	0.06333	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs759106015		7p11.2	7	55152588	G	A	R	H	224	224		missense	0.913	possibly damaging, probably damaging	0.33	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1046438724	COSM3639726	7p11.2	7	55152597	C	T	S	F	227	227		missense	0.2485	benign, possibly damaging	0.625	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs766952405		7p11.2	7	55152596	T	C	S	P	227	227		missense	0.267	benign, possibly damaging	0.185	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs752616839		7p11.2	7	55152600	C	A	P	H	228	228		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1247276424		7p11.2	7	55152602	A	G	S	G	229	229		missense	0.47933	benign, possibly damaging	0.03333	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1291943679		7p11.2	7	55152603	G	A	S	N	229	229		missense	0.3905	benign, possibly damaging	0.255	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1357816760		7p11.2	7	55152604	T	A	S	R	229	229		missense	0.6474	benign, possibly damaging, probably damaging	0.072	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1203062307		7p11.2	7	55152606	A	C	D	A	230	230		missense	0.981	probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC	rs756040606		7p11.2	7	55152608	T	G	C	G	231	231		missense	0.998	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs777575581		7p11.2	7	55152609	G	C	C	S	231	231		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1447176163		7p11.2	7	55152633	G	C	G	A	239	239		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs370744986		7p11.2	7	55152639	C	T	T	I	241	241		missense	0.9335	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs554981236		7p11.2	7	55152647	C	G	R	G	244	244	2.0E-4	missense	0.40425	benign, possibly damaging	0.0475	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs200664836		7p11.2	7	55152648	G	A	R	Q	244	244	2.0E-4	missense	0.031	benign	0.2	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs554981236		7p11.2	7	55152647	C	T	R	W	244	244	2.0E-4	missense	0.918	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780001754		7p11.2	7	55152656	G	C	D	H	247	247		missense	0.878	possibly damaging, probably damaging	0.02	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780001754		7p11.2	7	55152656	G	A	D	N	247	247		missense	0.38567	benign, possibly damaging	0.03667	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs765893589		7p11.2	7	55152663	T	C	L	P	249	249		missense	0.996	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs775252718		7p11.2	7	55154017	C	G	R	G	252	252		missense	0.65075	benign, possibly damaging, probably damaging	0.025	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs760101437	COSM1176674	7p11.2	7	55154018	G	A	R	H	252	252		missense	0.0305	benign	0.07	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs374084791		7p11.2	7	55154021	A	G	K	R	253	253	5.99E-4	missense	0.003	benign	0.36	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs776490661		7p11.2	7	55154026	C	T	R	*	255	255		stop gained					0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs372202099		7p11.2	7	55154027	G	A	R	Q	255	255		missense	0.003	benign	0.17	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs138847501		7p11.2	7	55154032	G	A	E	K	257	257		missense	0.247	benign	0.04	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs766478921		7p11.2	7	55154039	C	T	T	M	259	259		missense	0.888	possibly damaging, probably damaging	0.105	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1396651256		7p11.2	7	55154038	A	C	T	P	259	259		missense	0.999	probably damaging	0.04	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1057519829		7p11.2	7	55154050	A	G	T	A	263	263		missense	0.003	benign	0.85	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	dbSNP,gnomAD	rs1057519829	COSM21684	7p11.2	7	55154050	A	C	T	P	263	263		missense	0.422	benign, possibly damaging	0.205	tolerated	1	Neoplasm of brain				ClinVar:RCV000444169	
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748627278		7p11.2	7	55154057	C	A	P	H	265	265		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17336639		7p11.2	7	55154060	C	A	P	Q	266	266		missense	0.021	benign	1.0	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17336639		7p11.2	7	55154060	C	G	P	R	266	266		missense	0.38	benign, possibly damaging	0.295	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1483973439		7p11.2	7	55154066	T	C	M	T	268	268		missense	0.3645	benign, possibly damaging	0.31	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1220356597		7p11.2	7	55154068	C	T	L	F	269	269		missense	0.4345	benign, possibly damaging	0.15	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1268199326		7p11.2	7	55154078	C	A	P	H	272	272		missense	0.8905	possibly damaging, probably damaging	0.025	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1412517681		7p11.2	7	55154083	A	G	T	A	274	274		missense	0.0295	benign	0.04	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs966001143		7p11.2	7	55154084	C	T	T	M	274	274		missense	0.8685	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs771396903		7p11.2	7	55154090	A	G	Q	R	276	276		missense	0.25767	benign, possibly damaging	0.07333	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1215369904		7p11.2	7	55154093	T	C	M	T	277	277		missense	0.38767	benign, possibly damaging	0.02667	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs918710688		7p11.2	7	55154105	C	G	P	R	281	281		missense	0.8725	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs199796955		7p11.2	7	55154107	G	A	E	K	282	282		missense	0.011	benign	0.17	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs776146284		7p11.2	7	55154116	T	C	Y	H	285	285		missense	0.998	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	Ensembl,dbSNP	rs149840192	COSM21685	7p11.2	7	55154129	C	A	A	D	289	289		missense	0.595	benign, possibly damaging, probably damaging	0.01667	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000434840,ClinVar:RCV000427425,ClinVar:RCV000443311	
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,NCI-TCGA,dbSNP,gnomAD	rs769696078	COSM21686	7p11.2	7	55154128	G	A	A	T	289	289		missense	0.9275	possibly damaging, probably damaging	0.01	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000443246,ClinVar:RCV000433672,ClinVar:RCV000422848	
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs149840192	COSM4966963	7p11.2	7	55154129	C	T	A	V	289	289		missense	0.953	probably damaging	0.03	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000423404,ClinVar:RCV000423749,ClinVar:RCV000439402	
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1020654485		7p11.2	7	55154132	C	T	T	I	290	290		missense	0.74467	benign, possibly damaging, probably damaging	0.53	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1220574404		7p11.2	7	55154135	G	T	C	F	291	291		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC	rs762649354		7p11.2	7	55154138	T	C	V	A	292	292		missense	0.909	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,NCI-TCGA,TOPMed,gnomAD	rs150549265		7p11.2	7	55154137	G	A	V	M	292	292		missense	0.9	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs751667358		7p11.2	7	55154152	C	T	R	C	297	297		missense	0.569	possibly damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs779094647		7p11.2	7	55155841	G	T	V	L	301	301		missense	0.66633	benign, possibly damaging, probably damaging	0.01333	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs182002674		7p11.2	7	55155852	C	A	H	Q	304	304	3.99E-4	missense	0.502	benign, possibly damaging, probably damaging	0.31333	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1277911361		7p11.2	7	55155851	A	G	H	R	304	304		missense	0.46467	benign, possibly damaging	0.16	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1278838499		7p11.2	7	55155853	G	T	G	C	305	305		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1321610304		7p11.2	7	55155859	T	C	C	R	307	307		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs749132706		7p11.2	7	55155862	G	A	V	I	308	308		missense	0.92033	possibly damaging, probably damaging	0.02333	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1444692842		7p11.2	7	55155865	C	G	R	G	309	309		missense	0.998	probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs770879879		7p11.2	7	55155875	G	C	G	A	312	312		missense	0.014	benign	0.02	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs149321481		7p11.2	7	55155878	C	T	A	V	313	313		missense	0.005	benign	0.16	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	1000Genomes,NCI-TCGA	rs552062864		7p11.2	7	55155880	G	A	D	N	314	314	2.0E-4	missense	0.013	benign	0.71	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs745658347		7p11.2	7	55155884	G	A	S	N	315	315		missense	0.095	benign	0.255	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1484032303		7p11.2	7	55155887	A	G	Y	C	316	316		missense	0.791	possibly damaging	0.045	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs775800262		7p11.2	7	55155894	G	T	M	I	318	318		missense	0.0	benign	0.05	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1175454134		7p11.2	7	55155895	G	T	E	*	319	319		stop gained					0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs764038041		7p11.2	7	55155903	C	A	D	E	321	321		missense	0.096	benign	0.045	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs776791214		7p11.2	7	55155904	G	A	G	S	322	322		missense	0.95067	possibly damaging, probably damaging	0.04333	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs367680488		7p11.2	7	55155908	T	C	V	A	323	323		missense	0.2175	benign	0.045	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs761844164	COSM145361	7p11.2	7	55155907	G	A	V	I	323	323		missense	0.005	benign	0.96	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1343888047		7p11.2	7	55155910	C	T	R	C	324	324		missense	0.925	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs758748662	COSM3881813	7p11.2	7	55155911	G	A	R	H	324	324		missense	0.5916	benign, possibly damaging, probably damaging	0.048	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs766740458		7p11.2	7	55155913	A	C	K	Q	325	325		missense	0.4505	benign, possibly damaging	0.265	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	Ensembl,dbSNP	rs886037891		7p11.2	7	55155917	G	T	C	F	326	326		missense	1.0	probably damaging	0.0	deleterious	0	Cowden syndrome 1 (CWS1)	The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and Proteus-like syndrome.	MIM:158350		pubmed:15604628,pubmed:20301661,pubmed:24493721,pubmed:25394175,ClinVar:RCV000256393	
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs144460286		7p11.2	7	55155922	A	C	K	Q	328	328		missense	0.527	benign, probably damaging	0.195	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs777342222		7p11.2	7	55155925	T	C	C	R	329	329		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs778901010		7p11.2	7	55155929	A	G	E	G	330	330		missense	0.106	benign	0.42	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs139429793		7p11.2	7	55155928	G	A	E	K	330	330		missense	0.176	benign	0.75	tolerated	0	Lung adenocarcinoma				pubmed:23562183,pubmed:24627688,pubmed:25311215,ClinVar:RCV000677876	
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs778901010		7p11.2	7	55155929	A	T	E	V	330	330		missense	0.441	benign, possibly damaging	0.155	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs771929085		7p11.2	7	55155941	G	A	R	H	334	334		missense	0.123	benign	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1284204782		7p11.2	7	55156550	A	C	I	L	342	342		missense	0.014	benign	0.12	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1381010963		7p11.2	7	55156551	T	C	I	T	342	342		missense	0.005	benign	1.0	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed	rs771398183		7p11.2	7	55156554	G	T	G	V	343	343		missense	0.8615	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ESP,TOPMed	rs371234907		7p11.2	7	55156569	C	T	S	L	348	348		missense	0.001	benign	0.18	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs767790289	COSM3881815	7p11.2	7	55156577	A	G	I	V	351	351		missense	0.005	benign	1.0	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs753466844		7p11.2	7	55156587	C	T	T	M	354	354		missense	0.69967	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1423110562		7p11.2	7	55156596	A	T	K	I	357	357		missense	0.329	benign	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	Ensembl	rs1164954595	COSM2155594	7p11.2	7	55156614	C	T	T	I	363	363		missense	0.982	probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs749927550		7p11.2	7	55156628	G	C	D	H	368	368		missense	0.68433	benign, possibly damaging, probably damaging	0.02333	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs758017949		7p11.2	7	55156629	A	T	D	V	368	368		missense	0.833	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780131926		7p11.2	7	55156631	C	A	L	I	369	369		missense	0.3535	benign, possibly damaging	0.15	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1405999227		7p11.2	7	55156637	A	G	I	V	371	371		missense	0.515	benign, possibly damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1341708803		7p11.2	7	55156652	T	C	F	L	376	376		missense	0.3245	benign, possibly damaging	0.37	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs755972013		7p11.2	7	55156772	C	A	H	N	383	383		missense	0.001	benign	1.0	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1169461493		7p11.2	7	55156773	A	G	H	R	383	383		missense	0.0	benign	0.36	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1197499057		7p11.2	7	55156794	A	C	Q	P	390	390		missense	0.058	benign	0.02	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	TOPMed	rs1389500636		7p11.2	7	55156796	G	A	E	K	391	391		missense	0.003	benign	1.0	tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	dbSNP,gnomAD	rs587778246		7p11.2	7	55156802	G	C	D	H	393	393		missense	0.78067	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	gnomAD	rs1178642122		7p11.2	7	55156807	T	G	I	M	394	394		missense	0.804	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC,gnomAD	rs757265130		7p11.2	7	55156817	G	A	V	I	398	398		missense	0.0305	benign	0.04	deleterious, tolerated	0						
P00533-2	EGFR	Isoform 2 of Epidermal growth factor receptor	ExAC	rs778894573		7p11.2	7	55156836	T	A	L	*	404	404		stop gained					0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs749433287		7p11.2	7	55019285	C	T	P	L	3	3		missense	0.0015	benign	0.01	deleterious, deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773069229		7p11.2	7	55019284	C	T	P	S	3	3		missense	0.05633	benign	0.12	deleterious, tolerated, tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773069229		7p11.2	7	55019284	C	A	P	T	3	3		missense	0.0405	benign	0.035	deleterious, tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs771210838		7p11.2	7	55019288	C	T	S	F	4	4		missense	0.001	benign	0.03	deleterious, deleterious - low confidence, tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs771210838		7p11.2	7	55019288	C	A	S	Y	4	4		missense	0.0	benign	0.03	deleterious, deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759582787		7p11.2	7	55019291	G	C	G	A	5	5		missense	0.201	benign	0.295	tolerated, tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759582787		7p11.2	7	55019291	G	A	G	E	5	5		missense	0.01167	benign	0.04333	deleterious, deleterious - low confidence, tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs774487133		7p11.2	7	55019290	G	C	G	R	5	5		missense	0.021	benign	0.175	tolerated, tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs767651648		7p11.2	7	55019293	A	G	T	A	6	6		missense	0.0	benign	0.545	tolerated, tolerated - low confidence	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000372969	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs761183109		7p11.2	7	55019296	G	C	A	P	7	7		missense	0.001	benign	0.07	deleterious, tolerated, tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs761183109		7p11.2	7	55019296	G	T	A	S	7	7		missense	0.001	benign	0.06333	deleterious, tolerated, tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754259847		7p11.2	7	55019299	G	C	G	R	8	8		missense	0.0015	benign	0.55	tolerated, tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754259847		7p11.2	7	55019299	G	A	G	R	8	8		missense	0.0	benign	0.235	tolerated, tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1217714114		7p11.2	7	55019306	C	A	A	E	10	10		missense	0.045	benign	0.26	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs567894670		7p11.2	7	55019315	C	T	A	V	13	13	7.99E-4	missense	0.0	benign	0.52	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1180577495		7p11.2	7	55019327	C	T	A	V	17	17		missense	0.0	benign	0.65	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs754527029		7p11.2	7	55019329	C	T	L	F	18	18		missense	0.221	benign	0.12	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs780865931		7p11.2	7	55019333	G	C	C	S	19	19		missense	0.003	benign	0.46	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1028735720		7p11.2	7	55019336	C	A	P	Q	20	20		missense	0.0	benign	0.31	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1028735720		7p11.2	7	55019336	C	G	P	R	20	20		missense	0.0	benign	0.52	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1194702075		7p11.2	7	55019339	C	A	A	E	21	21		missense	0.062	benign	0.45	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373129709		7p11.2	7	55019338	G	T	A	S	21	21		missense	0.051	benign	0.59	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373129709		7p11.2	7	55019338	G	A	A	T	21	21		missense	0.0	benign	0.48	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1194702075		7p11.2	7	55019339	C	T	A	V	21	21		missense	0.037	benign	0.44	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1257423707		7p11.2	7	55019342	G	A	S	N	22	22		missense	0.015	benign	0.49	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs987102148		7p11.2	7	55019344	C	T	R	W	23	23		missense	0.0	benign	0.19	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs911767401		7p11.2	7	55019347	G	A	A	T	24	24		missense	0.021	benign	0.19	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs749088691		7p11.2	7	55019359	A	G	K	E	28	28		missense	0.01	benign	0.37	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs774551548		7p11.2	7	55019363	A	C	K	T	29	29		missense	0.028	benign	0.28	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs746023542		7p11.2	7	55142292	A	G	Q	R	32	32		missense	0.4705	benign, probably damaging	0.58	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs772311777		7p11.2	7	55142294	G	A	G	S	33	33		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs144158123		7p11.2	7	55142298	C	T	T	M	34	34		missense	0.77633	possibly damaging, probably damaging	0.05667	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs144158123		7p11.2	7	55142298	C	G	T	R	34	34		missense	0.869	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1406387936		7p11.2	7	55142301	G	A	S	N	35	35		missense	0.0	benign	0.24	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs375919121		7p11.2	7	55142313	C	T	T	M	39	39		missense	0.8595	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1442908038		7p11.2	7	55142321	G	A	G	S	42	42		missense	0.53133	benign, possibly damaging, probably damaging	0.44	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1001476056		7p11.2	7	55142328	T	C	F	S	44	44		missense	0.0	benign	0.43	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1052582656		7p11.2	7	55142335	T	A	D	E	46	46		missense	0.026	benign	0.11	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1343024399		7p11.2	7	55142334	A	T	D	V	46	46		missense	0.45025	benign, possibly damaging, probably damaging	0.1025	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1263793183		7p11.2	7	55142340	T	C	F	S	48	48		missense	0.71	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs759219499		7p11.2	7	55142355	G	A	R	K	53	53		missense	0.003	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs767259994		7p11.2	7	55142364	A	G	N	S	56	56		missense	0.003	benign	0.84	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs763572530		7p11.2	7	55142373	A	C	E	A	59	59		missense	0.82	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs760228905		7p11.2	7	55142372	G	A	E	K	59	59		missense	0.67875	benign, possibly damaging, probably damaging	0.0275	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1470757416		7p11.2	7	55142408	C	T	Q	*	71	71		stop gained					0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369580836		7p11.2	7	55142409	A	C	Q	P	71	71		missense	0.006	benign	0.09	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369580836		7p11.2	7	55142409	A	G	Q	R	71	71		missense	0.497	benign, possibly damaging	0.2	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1269583681		7p11.2	7	55142416	T	G	N	K	73	73		missense	0.06	benign	0.07	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs778638117		7p11.2	7	55142423	C	A	L	I	76	76		missense	0.9055	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs374986786		7p11.2	7	55143305	A	G	T	A	81	81		missense	0.038	benign	0.04	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1309796320		7p11.2	7	55143308	A	G	I	V	82	82		missense	0.85567	possibly damaging, probably damaging	0.03	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1282801317		7p11.2	7	55143316	G	C	E	D	84	84		missense	0.996	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs753319070		7p11.2	7	55143314	G	A	E	K	84	84		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs753319070		7p11.2	7	55143314	G	C	E	Q	84	84		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs765137528		7p11.2	7	55143327	A	G	Y	C	88	88		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs750399097		7p11.2	7	55143332	C	T	L	F	90	90		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs142061256		7p11.2	7	55143333	T	A	L	H	90	90		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs779879611		7p11.2	7	55143339	C	T	A	V	92	92		missense	0.961	probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1422504667		7p11.2	7	55143348	C	T	T	I	95	95		missense	0.134	benign	0.13	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1260357262		7p11.2	7	55143350	G	A	V	M	96	96		missense	0.889	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs755189573		7p11.2	7	55143353	G	C	E	Q	97	97		missense	0.35	benign	0.33	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17289589		7p11.2	7	55143357	G	T	R	L	98	98		missense	0.047	benign	0.28	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs17289589	COSM4680391	7p11.2	7	55143357	G	A	R	Q	98	98		missense	0.007	benign	0.32	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,NCI-TCGA	rs376963968	COSM6047689	7p11.2	7	55143363	C	A	P	H	100	100		missense	0.559	benign, possibly damaging	0.04667	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl	rs866460345	COSM4892885	7p11.2	7	55143362	C	T	P	S	100	100		missense	0.8665	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs141271101		7p11.2	7	55143379	G	C	Q	H	105	105		missense	0.9075	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs771366736		7p11.2	7	55143380	A	G	I	V	106	106		missense	0.031	benign	0.15	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519888	COSM1451537	7p11.2	7	55143386	A	G	R	G	108	108		missense	1.0	probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000424206,ClinVar:RCV000434481	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519828	COSM5576118	7p11.2	7	55143387	G	A	R	K	108	108		missense	1.0	probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000432019	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs145113601		7p11.2	7	55143390	G	C	G	A	109	109		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1488843432		7p11.2	7	55143397	G	A	M	I	111	111		missense	0.0	benign	0.13	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746631025		7p11.2	7	55143396	T	C	M	T	111	111		missense	0.0	benign	0.56	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1385682568		7p11.2	7	55143402	A	T	Y	F	113	113		missense	0.576	benign, possibly damaging	0.225	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1219568637	COSM5835422	7p11.2	7	55143404	G	A	E	K	114	114		missense	0.011	benign	0.05	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1332428616		7p11.2	7	55143407	A	C	N	H	115	115		missense	0.4832	benign, possibly damaging, probably damaging	0.046	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773596817		7p11.2	7	55143409	T	A	N	K	115	115		missense	0.361	benign, possibly damaging	0.14	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1247204001		7p11.2	7	55143417	C	G	A	G	118	118		missense	0.573	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1249939049		7p11.2	7	55143416	G	T	A	S	118	118		missense	0.9285	possibly damaging, probably damaging	0.1	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1229095978		7p11.2	7	55143432	C	T	S	F	123	123		missense	0.592	benign, possibly damaging, probably damaging	0.30333	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1295285127		7p11.2	7	55143438	A	G	Y	C	125	125		missense	0.968	probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs377444977		7p11.2	7	55143443	G	A	A	T	127	127		missense	0.001	benign	0.58	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1485906237		7p11.2	7	55143444	C	T	A	V	127	127		missense	0.0	benign	0.09	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs762889647		7p11.2	7	55143450	A	C	K	T	129	129		missense	0.007	benign	0.37	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1485016142		7p11.2	7	55143455	G	A	G	R	131	131		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs751337426		7p11.2	7	55143464	G	A	E	K	134	134		missense	0.3735	benign, possibly damaging	0.03	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754854319		7p11.2	7	55143473	A	G	M	V	137	137		missense	0.084	benign	0.03	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1437762652		7p11.2	7	55143477	G	A	R	K	138	138		missense	0.018	benign	0.74	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs767608234		7p11.2	7	55143487	G	T	Q	H	141	141		missense	0.303	benign, possibly damaging	0.02333	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1198703773		7p11.2	7	55146614	C	A	H	N	145	145		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780476417		7p11.2	7	55146615	A	G	H	R	145	145		missense	0.0	benign	0.32	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs532655845		7p11.2	7	55146620	G	C	A	P	147	147	2.0E-4	missense	0.403	benign, possibly damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,NCI-TCGA,TOPMed,gnomAD	rs532655845		7p11.2	7	55146620	G	A	A	T	147	147	2.0E-4	missense	0.026	benign	0.03	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759532524		7p11.2	7	55146627	G	A	R	Q	149	149		missense	0.2575	benign, possibly damaging	0.375	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs774146556	COSM3412169	7p11.2	7	55146626	C	T	R	W	149	149		missense	0.34	benign, probably damaging	0.08333	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1398462122		7p11.2	7	55146629	T	C	F	L	150	150		missense	0.0805	benign	0.045	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs551591429		7p11.2	7	55146636	A	G	N	S	152	152	2.0E-4	missense	0.054	benign	0.38	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs919891568		7p11.2	7	55146644	G	T	A	S	155	155		missense	0.007	benign	0.42	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs937907395		7p11.2	7	55146653	A	G	N	D	158	158		missense	0.2725	benign, possibly damaging	0.225	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs761795138		7p11.2	7	55146675	G	A	R	Q	165	165		missense	0.007	benign	0.68	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs587778252		7p11.2	7	55146674	C	T	R	W	165	165		missense	0.4455	benign, possibly damaging	0.26	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs765416003		7p11.2	7	55146681	T	C	I	T	167	167		missense	0.988	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs530692924		7p11.2	7	55146683	G	C	V	L	168	168	2.0E-4	missense	0.056	benign	0.23	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs758945260		7p11.2	7	55146690	G	T	S	I	170	170		missense	0.017	benign	0.04	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs758945260		7p11.2	7	55146690	G	A	S	N	170	170		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs17289686		7p11.2	7	55146694	C	A	D	E	171	171	3.99E-4	missense	0.001	benign	0.72	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770290445		7p11.2	7	55146711	C	T	S	L	177	177		missense	0.003	benign	0.18	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770290445		7p11.2	7	55146711	C	G	S	W	177	177		missense	0.9005	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs745755245		7p11.2	7	55146715	G	A	M	I	178	178		missense	0.001	benign	0.82	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1219334377		7p11.2	7	55146713	A	G	M	V	178	178		missense	0.0	benign	0.22	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs772071414		7p11.2	7	55146728	C	G	H	D	183	183		missense	0.007	benign	0.42	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs772071414		7p11.2	7	55146728	C	A	H	N	183	183		missense	0.0	benign	0.98	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs921852102		7p11.2	7	55146732	T	C	L	P	184	184		missense	0.0	benign	0.4	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs921852102		7p11.2	7	55146732	T	A	L	Q	184	184		missense	0.003	benign	0.6	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1224862076		7p11.2	7	55146731	C	G	L	V	184	184		missense	0.003	benign	0.31	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770074413		7p11.2	7	55151308	C	A	P	T	192	192		missense	0.146	benign	0.045	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs766507267		7p11.2	7	55151321	A	G	N	S	196	196		missense	0.021	benign	0.27	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1335854310		7p11.2	7	55151327	G	A	S	N	198	198		missense	0.2725	benign, possibly damaging	0.33	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs767829342		7p11.2	7	55151344	G	A	E	K	204	204		missense	0.001	benign	0.46	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs779156097		7p11.2	7	55152549	C	G	T	S	211	211		missense	0.878	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs750423932		7p11.2	7	55152551	A	C	K	Q	212	212		missense	0.625	benign, possibly damaging, probably damaging	0.00667	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1372330611		7p11.2	7	55152564	C	G	A	G	216	216		missense	0.992	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1190573231		7p11.2	7	55152563	G	A	A	T	216	216		missense	0.9455	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs776050604		7p11.2	7	55152571	G	T	Q	H	218	218		missense	0.7655	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs761098433		7p11.2	7	55152575	T	C	S	P	220	220		missense	0.56675	benign, probably damaging	0.0825	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs776886714		7p11.2	7	55152578	G	A	G	R	221	221		missense	0.067	benign	0.2	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs776886714		7p11.2	7	55152578	G	T	G	W	221	221		missense	0.666	benign, probably damaging	0.035	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751295137		7p11.2	7	55152582	G	A	R	H	222	222		missense	0.965	possibly damaging, probably damaging	0.06333	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs759106015		7p11.2	7	55152588	G	A	R	H	224	224		missense	0.913	possibly damaging, probably damaging	0.33	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1046438724	COSM3639726	7p11.2	7	55152597	C	T	S	F	227	227		missense	0.2485	benign, possibly damaging	0.625	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs766952405		7p11.2	7	55152596	T	C	S	P	227	227		missense	0.267	benign, possibly damaging	0.185	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs752616839		7p11.2	7	55152600	C	A	P	H	228	228		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1247276424		7p11.2	7	55152602	A	G	S	G	229	229		missense	0.47933	benign, possibly damaging	0.03333	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1291943679		7p11.2	7	55152603	G	A	S	N	229	229		missense	0.3905	benign, possibly damaging	0.255	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1357816760		7p11.2	7	55152604	T	A	S	R	229	229		missense	0.6474	benign, possibly damaging, probably damaging	0.072	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1203062307		7p11.2	7	55152606	A	C	D	A	230	230		missense	0.981	probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC	rs756040606		7p11.2	7	55152608	T	G	C	G	231	231		missense	0.998	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs777575581		7p11.2	7	55152609	G	C	C	S	231	231		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1447176163		7p11.2	7	55152633	G	C	G	A	239	239		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs370744986		7p11.2	7	55152639	C	T	T	I	241	241		missense	0.9335	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs554981236		7p11.2	7	55152647	C	G	R	G	244	244	2.0E-4	missense	0.40425	benign, possibly damaging	0.0475	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs200664836		7p11.2	7	55152648	G	A	R	Q	244	244	2.0E-4	missense	0.031	benign	0.2	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs554981236		7p11.2	7	55152647	C	T	R	W	244	244	2.0E-4	missense	0.918	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780001754		7p11.2	7	55152656	G	C	D	H	247	247		missense	0.878	possibly damaging, probably damaging	0.02	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780001754		7p11.2	7	55152656	G	A	D	N	247	247		missense	0.38567	benign, possibly damaging	0.03667	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs765893589		7p11.2	7	55152663	T	C	L	P	249	249		missense	0.996	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs775252718		7p11.2	7	55154017	C	G	R	G	252	252		missense	0.65075	benign, possibly damaging, probably damaging	0.025	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs760101437	COSM1176674	7p11.2	7	55154018	G	A	R	H	252	252		missense	0.0305	benign	0.07	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs374084791		7p11.2	7	55154021	A	G	K	R	253	253	5.99E-4	missense	0.003	benign	0.36	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs776490661		7p11.2	7	55154026	C	T	R	*	255	255		stop gained					0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs372202099		7p11.2	7	55154027	G	A	R	Q	255	255		missense	0.003	benign	0.17	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs138847501		7p11.2	7	55154032	G	A	E	K	257	257		missense	0.247	benign	0.04	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs766478921		7p11.2	7	55154039	C	T	T	M	259	259		missense	0.888	possibly damaging, probably damaging	0.105	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1396651256		7p11.2	7	55154038	A	C	T	P	259	259		missense	0.999	probably damaging	0.04	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1057519829		7p11.2	7	55154050	A	G	T	A	263	263		missense	0.003	benign	0.85	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	dbSNP,gnomAD	rs1057519829	COSM21684	7p11.2	7	55154050	A	C	T	P	263	263		missense	0.422	benign, possibly damaging	0.205	tolerated	1	Neoplasm of brain				ClinVar:RCV000444169	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748627278		7p11.2	7	55154057	C	A	P	H	265	265		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17336639		7p11.2	7	55154060	C	A	P	Q	266	266		missense	0.021	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17336639		7p11.2	7	55154060	C	G	P	R	266	266		missense	0.38	benign, possibly damaging	0.295	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1483973439		7p11.2	7	55154066	T	C	M	T	268	268		missense	0.3645	benign, possibly damaging	0.31	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1220356597		7p11.2	7	55154068	C	T	L	F	269	269		missense	0.4345	benign, possibly damaging	0.15	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1268199326		7p11.2	7	55154078	C	A	P	H	272	272		missense	0.8905	possibly damaging, probably damaging	0.025	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1412517681		7p11.2	7	55154083	A	G	T	A	274	274		missense	0.0295	benign	0.04	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs966001143		7p11.2	7	55154084	C	T	T	M	274	274		missense	0.8685	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs771396903		7p11.2	7	55154090	A	G	Q	R	276	276		missense	0.25767	benign, possibly damaging	0.07333	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1215369904		7p11.2	7	55154093	T	C	M	T	277	277		missense	0.38767	benign, possibly damaging	0.02667	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs918710688		7p11.2	7	55154105	C	G	P	R	281	281		missense	0.8725	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs199796955		7p11.2	7	55154107	G	A	E	K	282	282		missense	0.011	benign	0.17	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs776146284		7p11.2	7	55154116	T	C	Y	H	285	285		missense	0.998	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,dbSNP	rs149840192	COSM21685	7p11.2	7	55154129	C	A	A	D	289	289		missense	0.595	benign, possibly damaging, probably damaging	0.01667	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000434840,ClinVar:RCV000427425,ClinVar:RCV000443311	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,dbSNP,gnomAD	rs769696078	COSM21686	7p11.2	7	55154128	G	A	A	T	289	289		missense	0.9275	possibly damaging, probably damaging	0.01	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000443246,ClinVar:RCV000433672,ClinVar:RCV000422848	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs149840192	COSM4966963	7p11.2	7	55154129	C	T	A	V	289	289		missense	0.953	probably damaging	0.03	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000423404,ClinVar:RCV000423749,ClinVar:RCV000439402	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1020654485		7p11.2	7	55154132	C	T	T	I	290	290		missense	0.74467	benign, possibly damaging, probably damaging	0.53	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1220574404		7p11.2	7	55154135	G	T	C	F	291	291		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC	rs762649354		7p11.2	7	55154138	T	C	V	A	292	292		missense	0.909	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,NCI-TCGA,TOPMed,gnomAD	rs150549265		7p11.2	7	55154137	G	A	V	M	292	292		missense	0.9	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs751667358		7p11.2	7	55154152	C	T	R	C	297	297		missense	0.569	possibly damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs779094647		7p11.2	7	55155841	G	T	V	L	301	301		missense	0.66633	benign, possibly damaging, probably damaging	0.01333	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs182002674		7p11.2	7	55155852	C	A	H	Q	304	304	3.99E-4	missense	0.502	benign, possibly damaging, probably damaging	0.31333	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1277911361		7p11.2	7	55155851	A	G	H	R	304	304		missense	0.46467	benign, possibly damaging	0.16	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1278838499		7p11.2	7	55155853	G	T	G	C	305	305		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1321610304		7p11.2	7	55155859	T	C	C	R	307	307		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs749132706		7p11.2	7	55155862	G	A	V	I	308	308		missense	0.92033	possibly damaging, probably damaging	0.02333	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1444692842		7p11.2	7	55155865	C	G	R	G	309	309		missense	0.998	probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs770879879		7p11.2	7	55155875	G	C	G	A	312	312		missense	0.014	benign	0.02	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs149321481		7p11.2	7	55155878	C	T	A	V	313	313		missense	0.005	benign	0.16	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,NCI-TCGA	rs552062864		7p11.2	7	55155880	G	A	D	N	314	314	2.0E-4	missense	0.013	benign	0.71	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs745658347		7p11.2	7	55155884	G	A	S	N	315	315		missense	0.095	benign	0.255	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1484032303		7p11.2	7	55155887	A	G	Y	C	316	316		missense	0.791	possibly damaging	0.045	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs775800262		7p11.2	7	55155894	G	T	M	I	318	318		missense	0.0	benign	0.05	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1175454134		7p11.2	7	55155895	G	T	E	*	319	319		stop gained					0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs764038041		7p11.2	7	55155903	C	A	D	E	321	321		missense	0.096	benign	0.045	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs776791214		7p11.2	7	55155904	G	A	G	S	322	322		missense	0.95067	possibly damaging, probably damaging	0.04333	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs367680488		7p11.2	7	55155908	T	C	V	A	323	323		missense	0.2175	benign	0.045	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs761844164	COSM145361	7p11.2	7	55155907	G	A	V	I	323	323		missense	0.005	benign	0.96	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1343888047		7p11.2	7	55155910	C	T	R	C	324	324		missense	0.925	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs758748662	COSM3881813	7p11.2	7	55155911	G	A	R	H	324	324		missense	0.5916	benign, possibly damaging, probably damaging	0.048	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs766740458		7p11.2	7	55155913	A	C	K	Q	325	325		missense	0.4505	benign, possibly damaging	0.265	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,dbSNP	rs886037891		7p11.2	7	55155917	G	T	C	F	326	326		missense	1.0	probably damaging	0.0	deleterious	0	Cowden syndrome 1 (CWS1)	The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and Proteus-like syndrome.	MIM:158350		pubmed:15604628,pubmed:20301661,pubmed:24493721,pubmed:25394175,ClinVar:RCV000256393	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs144460286		7p11.2	7	55155922	A	C	K	Q	328	328		missense	0.527	benign, probably damaging	0.195	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs777342222		7p11.2	7	55155925	T	C	C	R	329	329		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs778901010		7p11.2	7	55155929	A	G	E	G	330	330		missense	0.106	benign	0.42	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs139429793		7p11.2	7	55155928	G	A	E	K	330	330		missense	0.176	benign	0.75	tolerated	0	Lung adenocarcinoma				pubmed:23562183,pubmed:24627688,pubmed:25311215,ClinVar:RCV000677876	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs778901010		7p11.2	7	55155929	A	T	E	V	330	330		missense	0.441	benign, possibly damaging	0.155	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs771929085		7p11.2	7	55155941	G	A	R	H	334	334		missense	0.123	benign	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1284204782		7p11.2	7	55156550	A	C	I	L	342	342		missense	0.014	benign	0.12	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1381010963		7p11.2	7	55156551	T	C	I	T	342	342		missense	0.005	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed	rs771398183		7p11.2	7	55156554	G	T	G	V	343	343		missense	0.8615	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,TOPMed	rs371234907		7p11.2	7	55156569	C	T	S	L	348	348		missense	0.001	benign	0.18	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs767790289	COSM3881815	7p11.2	7	55156577	A	G	I	V	351	351		missense	0.005	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs753466844		7p11.2	7	55156587	C	T	T	M	354	354		missense	0.69967	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1423110562		7p11.2	7	55156596	A	T	K	I	357	357		missense	0.329	benign	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl	rs1164954595	COSM2155594	7p11.2	7	55156614	C	T	T	I	363	363		missense	0.982	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs749927550		7p11.2	7	55156628	G	C	D	H	368	368		missense	0.68433	benign, possibly damaging, probably damaging	0.02333	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs758017949		7p11.2	7	55156629	A	T	D	V	368	368		missense	0.833	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780131926		7p11.2	7	55156631	C	A	L	I	369	369		missense	0.3535	benign, possibly damaging	0.15	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1405999227		7p11.2	7	55156637	A	G	I	V	371	371		missense	0.515	benign, possibly damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1341708803		7p11.2	7	55156652	T	C	F	L	376	376		missense	0.3245	benign, possibly damaging	0.37	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs755972013		7p11.2	7	55156772	C	A	H	N	383	383		missense	0.001	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1169461493		7p11.2	7	55156773	A	G	H	R	383	383		missense	0.0	benign	0.36	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1197499057		7p11.2	7	55156794	A	C	Q	P	390	390		missense	0.058	benign	0.02	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1389500636		7p11.2	7	55156796	G	A	E	K	391	391		missense	0.003	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	dbSNP,gnomAD	rs587778246		7p11.2	7	55156802	G	C	D	H	393	393		missense	0.78067	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1178642122		7p11.2	7	55156807	T	G	I	M	394	394		missense	0.804	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs757265130		7p11.2	7	55156817	G	A	V	I	398	398		missense	0.0305	benign	0.04	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC	rs777165081		7p11.2	7	55157665	T	A	F	I	404	404		missense	0.5964	benign, possibly damaging, probably damaging	0.074	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1230904747		7p11.2	7	55157672	T	A	L	Q	406	406		missense	0.728	possibly damaging, probably damaging	0.295	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1179620001		7p11.2	7	55157674	A	G	I	V	407	407		missense	0.845	possibly damaging, probably damaging	0.03333	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs770466526		7p11.2	7	55157693	A	G	N	S	413	413		missense	0.57	benign, probably damaging	0.235	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1424097500		7p11.2	7	55157696	G	T	R	M	414	414		missense	0.003	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1274543317		7p11.2	7	55157699	C	A	T	K	415	415		missense	0.76733	benign, probably damaging	0.12	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs758956103		7p11.2	7	55157703	C	G	D	E	416	416		missense	0.3465	benign, possibly damaging	0.02	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1456537863		7p11.2	7	55157705	T	G	L	R	417	417		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1390766480		7p11.2	7	55157707	C	T	H	Y	418	418		missense	0.02	benign	0.12	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs760639592		7p11.2	7	55157716	G	A	E	K	421	421		missense	0.728	benign, possibly damaging, probably damaging	0.03	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1230287644		7p11.2	7	55157727	A	T	E	D	424	424		missense	0.5455	benign, possibly damaging	0.16	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs558565565		7p11.2	7	55157728	A	G	I	V	425	425		missense	0.007	benign	0.94	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,dbSNP,gnomAD	rs606231253		7p11.2	7	55157738	G	A	G	D	428	428		missense	1.0	probably damaging	0.0	deleterious	0	Inflammatory skin and bowel disease, neonatal, 2 (NISBD2)		MIM:616069		ClinVar:RCV000144851	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs765369188		7p11.2	7	55157744	C	A	T	N	430	430		missense	0.773	benign, possibly damaging, probably damaging	0.02667	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1171743336		7p11.2	7	55160139	T	A	H	Q	433	433		missense	0.005	benign	0.46	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs750713244		7p11.2	7	55157753	A	G	H	R	433	433		missense	0.013	benign	0.33	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1345387967		7p11.2	7	55160146	T	A	F	I	436	436		missense	0.361	benign, possibly damaging	0.17	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1166858113	COSM1090876	7p11.2	7	55160161	G	A	V	I	441	441		missense	0.012	benign	0.5	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs765091640		7p11.2	7	55160165	G	A	S	N	442	442		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1032006770		7p11.2	7	55160171	A	G	N	S	444	444		missense	0.0	benign	0.54	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs372990493		7p11.2	7	55160173	A	G	I	V	445	445		missense	0.3465	benign, possibly damaging	0.2	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1310061365		7p11.2	7	55160177	C	T	T	I	446	446		missense	0.459	benign, possibly damaging	0.03667	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs763266323		7p11.2	7	55160184	G	C	L	F	448	448		missense	1.0	probably damaging	0.04	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs377567759		7p11.2	7	55160191	C	T	R	C	451	451		missense	0.996	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751667594		7p11.2	7	55160192	G	A	R	H	451	451		missense	0.997	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751667594		7p11.2	7	55160192	G	T	R	L	451	451		missense	0.925	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1226827460		7p11.2	7	55160195	C	T	S	F	452	452		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1177337471		7p11.2	7	55160207	T	C	I	T	456	456		missense	0.9005	possibly damaging, probably damaging	0.02	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1340811850		7p11.2	7	55160210	G	A	S	N	457	457		missense	0.8085	possibly damaging, probably damaging	0.0525	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs146711874		7p11.2	7	55160214	T	G	D	E	458	458	2.0E-4	missense	0.806	possibly damaging, probably damaging	0.115	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs753269876		7p11.2	7	55160218	G	A	D	N	460	460		missense	0.62733	benign, possibly damaging, probably damaging	0.59	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1197924233		7p11.2	7	55160226	A	G	I	M	462	462		missense	0.3895	benign, possibly damaging	0.155	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746763556		7p11.2	7	55160230	T	G	S	A	464	464		missense	0.051	benign	0.49	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746763556		7p11.2	7	55160230	T	A	S	T	464	464		missense	0.006	benign	0.88	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1389684767		7p11.2	7	55160257	A	G	N	D	473	473		missense	0.001	benign	0.51	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1221992080	COSM122790	7p11.2	7	55160263	A	G	I	V	475	475		missense	0.02	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746521110		7p11.2	7	55160267	A	G	N	S	476	476		missense	0.0035	benign	0.07	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs768208443		7p11.2	7	55160277	A	C	K	N	479	479		missense	0.005	benign	0.34	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs147732025		7p11.2	7	55160278	C	A	L	M	480	480	3.99E-4	missense	0.735	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs147732025		7p11.2	7	55160278	C	G	L	V	480	480	3.99E-4	missense	0.29833	benign, possibly damaging	0.04	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,dbSNP	rs587778247		7p11.2	7	55160283	T	G	F	L	481	481		missense	0.67	benign, possibly damaging, probably damaging	0.14	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs982033612		7p11.2	7	55160294	G	C	G	A	485	485		missense	0.001	benign	0.78	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769434273		7p11.2	7	55160293	G	T	G	C	485	485		missense	0.51133	benign, possibly damaging	0.04	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769434273		7p11.2	7	55160293	G	A	G	S	485	485		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1271375100		7p11.2	7	55160303	C	G	T	S	488	488		missense	0.018	benign	0.27	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519760		7p11.2	7	55160314	A	G	S	G	492	492		missense	0.013	benign	0.35	tolerated	1	Neoplasm of the large intestine				pubmed:23012255,ClinVar:RCV000429440	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519860		7p11.2	7	55160316	C	A	S	R	492	492		missense	0.001	benign	0.26	tolerated	1	Neoplasm of the large intestine				pubmed:23012255,ClinVar:RCV000423834	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs766676440		7p11.2	7	55160324	G	A	G	D	495	495		missense	0.005	benign	0.53	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs774773441		7p11.2	7	55160331	C	A	N	K	497	497		missense	0.0	benign	0.56	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs927866979		7p11.2	7	55160333	G	C	S	T	498	498		missense	0.0	benign	0.49	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1206537132		7p11.2	7	55160338	A	G	K	E	500	500		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs760711480		7p11.2	7	55161507	G	A	G	S	503	503		missense	0.048	benign	0.03	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1334180707		7p11.2	7	55161510	C	G	Q	E	504	504		missense	0.026	benign	0.23	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1188823834		7p11.2	7	55161512	G	C	Q	H	504	504		missense	0.0	benign	0.68	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1287531915		7p11.2	7	55161523	C	A	A	D	508	508		missense	0.015	benign	0.13	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1287531915		7p11.2	7	55161523	C	G	A	G	508	508		missense	5.0E-4	benign	0.08	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1407608935		7p11.2	7	55161522	G	A	A	T	508	508		missense	0.0	benign	0.14	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1240855741		7p11.2	7	55161526	T	C	L	S	509	509		missense	0.9435	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs371114444		7p11.2	7	55161532	C	A	S	Y	511	511		missense	0.996	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,dbSNP,gnomAD	rs587778248	COSM3639738	7p11.2	7	55161534	C	T	P	S	512	512		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754646330		7p11.2	7	55161537	G	T	E	*	513	513		stop gained					0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1339627647		7p11.2	7	55161538	A	C	E	A	513	513		missense	0.005	benign	0.51	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754646330		7p11.2	7	55161537	G	A	E	K	513	513		missense	0.309	benign	0.17	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs564398642		7p11.2	7	55161553	C	T	P	L	518	518	2.0E-4	missense	0.721	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed	rs368484180		7p11.2	7	55161552	C	T	P	S	518	518		missense	0.7678	benign, possibly damaging, probably damaging	0.056	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs116057045		7p11.2	7	55161557	G	T	E	D	519	519	2.0E-4	missense	0.0	benign	0.03	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs749186957		7p11.2	7	55161556	A	G	E	G	519	519		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,dbSNP,gnomAD	rs2227983		7p11.2	7	55161562	G	A	R	K	521	521		missense	0.0	benign	0.39	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs2227983		7p11.2	7	55161562	G	A	R	K	521	521	0.2921	missense	0.0	benign	0.44	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs2227983		7p11.2	7	55161562	G	T	R	M	521	521	0.2921	missense	0.0	benign	0.04	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs2227983		7p11.2	7	55161562	G	C	R	T	521	521	0.2921	missense	0.0	benign	0.62	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs587778249		7p11.2	7	55161570	G	A	V	I	524	524		missense	0.049	benign	0.06	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs587778249		7p11.2	7	55161570	G	C	V	L	524	524		missense	0.01	benign	0.84	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs768627073		7p11.2	7	55161579	C	G	R	G	527	527		missense	0.353	benign, possibly damaging	0.02	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs150477666		7p11.2	7	55161580	G	A	R	Q	527	527		missense	0.001	benign	0.2	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs768627073		7p11.2	7	55161579	C	T	R	W	527	527		missense	0.658	possibly damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs762336338		7p11.2	7	55161582	A	G	N	D	528	528		missense	0.043	benign	0.24	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1330512770		7p11.2	7	55161592	G	A	R	Q	531	531		missense	0.9485	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs752350337		7p11.2	7	55161607	T	C	V	A	536	536		missense	0.7485	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs767193132	COSM382936	7p11.2	7	55161606	G	A	V	M	536	536		missense	0.656	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1275660363		7p11.2	7	55161611	C	G	D	E	537	537		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1038997598		7p11.2	7	55161609	G	A	D	N	537	537		missense	0.001	benign	0.11	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1209490447		7p11.2	7	55161613	A	C	K	T	538	538		missense	0.001	benign	0.25	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1340266257		7p11.2	7	55161620	C	A	N	K	540	540		missense	0.926	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1208487495	COSM3639740	7p11.2	7	55161621	C	T	L	F	541	541		missense	0.0	benign	0.51	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs755584255		7p11.2	7	55161630	G	A	G	S	544	544		missense	0.917	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778985185		7p11.2	7	55163734	G	A	E	K	545	545		missense	0.46875	benign, possibly damaging, probably damaging	0.0725	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519830		7p11.2	7	55163737	C	T	P	S	546	546		missense	0.58633	benign, possibly damaging, probably damaging	0.28	tolerated	1	Head and Neck Neoplasms				ClinVar:RCV000443890	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1427028322		7p11.2	7	55163740	A	G	R	G	547	547		missense	0.817	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1419611893		7p11.2	7	55163747	T	C	F	S	549	549		missense	0.606	benign, possibly damaging	0.025	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs940873450		7p11.2	7	55163753	A	T	E	V	551	551		missense	0.0	benign	0.45	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1162236403		7p11.2	7	55163756	A	G	N	S	552	552		missense	0.015	benign	0.2	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs779741928		7p11.2	7	55163762	A	G	E	G	554	554		missense	0.155	benign	0.35	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs747203424		7p11.2	7	55163769	A	G	I	M	556	556		missense	0.003	benign	0.36	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1488695603		7p11.2	7	55163770	C	T	Q	*	557	557		stop gained					0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748219780		7p11.2	7	55163779	C	T	P	S	560	560		missense	0.042	benign	0.21	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748219780		7p11.2	7	55163779	C	A	P	T	560	560		missense	0.294	benign	0.02	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769918274		7p11.2	7	55163782	G	C	E	Q	561	561		missense	0.67367	benign, possibly damaging, probably damaging	0.33667	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs773651001		7p11.2	7	55163791	C	T	P	S	564	564		missense	0.011	benign	0.15	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs773651001		7p11.2	7	55163791	C	A	P	T	564	564		missense	0.079	benign	0.1	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1258211270		7p11.2	7	55163795	A	G	Q	R	565	565		missense	0.68733	benign, possibly damaging, probably damaging	0.20667	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs771278492		7p11.2	7	55163800	A	G	M	V	567	567		missense	0.018	benign	0.04	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1228970909		7p11.2	7	55163805	C	A	N	K	568	568		missense	0.21267	benign, possibly damaging	0.29667	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs774558548		7p11.2	7	55163810	C	G	T	S	570	570		missense	0.6505	benign, possibly damaging, probably damaging	0.15	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759987693		7p11.2	7	55163816	C	G	T	R	572	572		missense	0.5785	benign, possibly damaging	0.35	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1294381114		7p11.2	7	55163818	G	A	G	R	573	573		missense	0.988	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs370810719		7p11.2	7	55163822	G	A	R	Q	574	574		missense	0.112	benign	0.07	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs760471492		7p11.2	7	55163821	C	T	R	W	574	574		missense	0.829	possibly damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1249099747		7p11.2	7	55165281	G	A	G	E	575	575		missense	0.871	possibly damaging, probably damaging	0.1	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs556794990		7p11.2	7	55165290	A	G	N	S	578	578	2.0E-4	missense	0.0	benign	0.18	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs761585117		7p11.2	7	55165296	T	C	I	T	580	580		missense	0.009	benign	0.73	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs764787649		7p11.2	7	55165298	C	A	Q	K	581	581		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1376117521		7p11.2	7	55165299	A	C	Q	P	581	581		missense	0.22867	benign, possibly damaging	0.11667	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1306429085		7p11.2	7	55165301	T	C	C	R	582	582		missense	0.998	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1447966312		7p11.2	7	55165305	C	T	A	V	583	583		missense	0.5795	benign, possibly damaging, probably damaging	0.0575	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs956386356		7p11.2	7	55165309	C	G	H	Q	584	584		missense	0.9235	possibly damaging, probably damaging	0.03	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1281578598		7p11.2	7	55165315	T	G	I	M	586	586		missense	0.334	benign	0.06	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs542237406		7p11.2	7	55165314	T	A	I	N	586	586	2.0E-4	missense	0.204	benign	0.055	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs542237406		7p11.2	7	55165314	T	C	I	T	586	586	2.0E-4	missense	0.04	benign	0.05	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs953188147		7p11.2	7	55165313	A	G	I	V	586	586		missense	0.0	benign	0.055	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs989939484		7p11.2	7	55165319	G	A	G	S	588	588		missense	0.9405	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751570775		7p11.2	7	55165323	C	A	P	H	589	589		missense	0.989	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751570775	COSM747428	7p11.2	7	55165323	C	T	P	L	589	589		missense	0.51767	benign, possibly damaging, probably damaging	0.12667	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1235180640		7p11.2	7	55165322	C	T	P	S	589	589		missense	0.6406	benign, possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs144943614		7p11.2	7	55165331	G	A	V	I	592	592	3.99E-4	missense	0.48825	benign, possibly damaging	0.0475	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs756307243		7p11.2	7	55165336	G	C	K	N	593	593		missense	0.58033	benign, possibly damaging, probably damaging	0.19333	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778011429		7p11.2	7	55165338	C	T	T	I	594	594		missense	0.387	benign, possibly damaging	0.025	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778011429		7p11.2	7	55165338	C	A	T	N	594	594		missense	0.197	benign, possibly damaging	0.05	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1477025000		7p11.2	7	55165344	C	T	P	L	596	596		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs757419349		7p11.2	7	55165346	G	T	A	S	597	597		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,dbSNP,gnomAD	rs139236063	COSM3412197	7p11.2	7	55165350	G	C	G	A	598	598		missense	0.67533	benign, possibly damaging, probably damaging	0.01	deleterious	1	Neoplasm of brain				ClinVar:RCV000440786,ClinVar:RCV000423114	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,NCI-TCGA,dbSNP,gnomAD	rs139236063	COSM4967213	7p11.2	7	55165350	G	T	G	V	598	598		missense	0.94	possibly damaging, probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000436167,ClinVar:RCV000434448	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1206543227		7p11.2	7	55165353	T	A	V	D	599	599		missense	0.637	benign, possibly damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs746395542		7p11.2	7	55165355	A	T	M	L	600	600		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs149375515		7p11.2	7	55165356	T	C	M	T	600	600		missense	0.122	benign	0.24	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs746395542		7p11.2	7	55165355	A	G	M	V	600	600		missense	0.018	benign	0.22	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,TOPMed	rs201498575		7p11.2	7	55165359	G	A	G	E	601	601	2.0E-4	missense	0.7448	benign, possibly damaging, probably damaging	0.054	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769537072		7p11.2	7	55165366	C	A	N	K	603	603		missense	0.517	benign, probably damaging	0.655	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs913231421		7p11.2	7	55165368	A	G	N	S	604	604		missense	0.0	benign	1.0	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1436144358		7p11.2	7	55165370	A	G	T	A	605	605		missense	0.2715	benign, possibly damaging	0.395	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs143152775		7p11.2	7	55165373	C	G	L	V	606	606		missense	0.03	benign	0.08	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs201061916		7p11.2	7	55165388	G	A	A	T	611	611		missense	0.008	benign	0.08	deleterious, tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1214761095		7p11.2	7	55165391	G	A	D	N	612	612		missense	0.62567	benign, possibly damaging, probably damaging	0.18333	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs764290273		7p11.2	7	55165394	G	A	A	T	613	613		missense	0.056	benign	0.36	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs750850720		7p11.2	7	55165398	G	A	G	D	614	614		missense	0.0	benign	0.36	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs779076899		7p11.2	7	55165397	G	C	G	R	614	614		missense	0.024	benign	0.38	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs779076899		7p11.2	7	55165397	G	A	G	S	614	614		missense	0.0	benign	0.29	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC	rs756534868		7p11.2	7	55165404	T	C	V	A	616	616		missense	0.033	benign	0.72	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,NCI-TCGA	rs150899403	COSM35825	7p11.2	7	55165416	G	A	C	Y	620	620		missense	0.894	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs747376358		7p11.2	7	55165424	A	T	N	Y	623	623		missense	0.915	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	Ensembl,NCI-TCGA	rs28384376	COSM13560	7p11.2	7	55165428	G	T	C	F	624	624		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs753315940		7p11.2	7	55165436	G	A	G	R	627	627		missense	0.914	possibly damaging, probably damaging	0.02	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs990172397		7p11.2	7	55170308	C	T	P	S	628	628		missense	0.003	benign	0.08	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs371814116		7p11.2	7	55170312	G	A	G	E	629	629		missense	0.0	benign	0.02	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs371814116		7p11.2	7	55170312	G	T	G	V	629	629		missense	0.0	benign	0.03	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,dbSNP,gnomAD	rs909905659		7p11.2	7	55170317	G	T	E	*	631	631		stop gained					0	Cerebral arteriovenous malformation (BAVM)		MIM:108010		ClinVar:RCV000656335	
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs567073985		7p11.2	7	55170319	G	C	E	D	631	631	2.0E-4	missense	0.014	benign	0.16	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs909905659		7p11.2	7	55170317	G	A	E	K	631	631		missense	0.042	benign	0.06	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs750024622		7p11.2	7	55170320	A	G	S	G	632	632		missense	0.0	benign	0.37	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369826866		7p11.2	7	55170323	C	A	L	I	633	633		missense	0.701	possibly damaging	0.21	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs779726134		7p11.2	7	55170324	T	C	L	P	633	633		missense	0.302	benign	0.01	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1296564867		7p11.2	7	55170330	C	G	A	G	635	635		missense	0.111	benign	0.21	tolerated	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs147139524		7p11.2	7	55170329	G	T	A	S	635	635	3.99E-4	missense	0.081	benign	0.04	deleterious	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs754507771		7p11.2	7	55170332	A	G	M	V	636	636		missense	0.001	benign	0.26	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs781128508		7p11.2	7	55170342	G	C	C	S	639	639		missense	0.0	benign	0.43	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,dbSNP,gnomAD	rs140443314		7p11.2	7	55170344	C	A	L	I	640	640		missense	0.006	benign	0.02	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1336156477		7p11.2	7	55170345	T	C	L	P	640	640		missense	0.001	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1336156477		7p11.2	7	55170345	T	G	L	R	640	640		missense	0.172	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs769593091		7p11.2	7	55170349	T	A	F	L	641	641		missense	0.0	benign	0.28	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs777733466		7p11.2	7	55170357	C	T	S	L	644	644		missense	0.024	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs749145316		7p11.2	7	55170360	C	T	S	F	645	645		missense	0.0	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs749145316		7p11.2	7	55170360	C	A	S	Y	645	645		missense	0.06	benign	0.01	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs771274615		7p11.2	7	55170363	G	T	C	F	646	646		missense	0.01	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs771274615		7p11.2	7	55170363	G	A	C	Y	646	646		missense	0.0	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1312177375		7p11.2	7	55170367	T	A	N	K	647	647		missense	0.0	benign	0.14	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs774771530		7p11.2	7	55170366	A	C	N	T	647	647		missense	0.038	benign	0.14	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1416857014		7p11.2	7	55170372	G	A	S	N	649	649		missense	0.0	benign	0.01	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1167043439		7p11.2	7	55170378	A	G	D	G	651	651		missense	0.0	benign	0.12	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs371909721		7p11.2	7	55170381	G	A	G	D	652	652		missense	0.012	benign	0.14	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs371909721		7p11.2	7	55170381	G	T	G	V	652	652		missense	0.367	benign	0.21	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs761106266		7p11.2	7	55170386	G	A	V	M	654	654		missense	0.003	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1364432876		7p11.2	7	55170390	C	G	S	C	655	655		missense	0.263	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1364432876		7p11.2	7	55170390	C	T	S	F	655	655		missense	0.0	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs764631638		7p11.2	7	55170392	C	T	H	Y	656	656		missense	0.143	benign	0.1	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1235478360		7p11.2	7	55170397	G	C	Q	H	657	657		missense	0.007	benign	0.01	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs762236315		7p11.2	7	55170399	G	A	S	N	658	658		missense	0.0	benign	0.12	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs762236315		7p11.2	7	55170399	G	C	S	T	658	658		missense	0.027	benign	0.41	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs145830434		7p11.2	7	55170401	G	A	G	R	659	659		missense	0.0	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754446310		7p11.2	7	55170405	G	C	S	T	660	660		missense	0.0	benign	0.3	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1260801976		7p11.2	7	55170407	C	G	P	A	661	661		missense	0.001	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs930293960		7p11.2	7	55170408	C	G	P	R	661	661		missense	0.221	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780600637		7p11.2	7	55170413	G	T	A	S	663	663		missense	0.001	benign	0.03	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780600637		7p11.2	7	55170413	G	A	A	T	663	663		missense	0.031	benign	0.01	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1275228647		7p11.2	7	55170414	C	T	A	V	663	663		missense	0.0	benign	0.01	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1234957520		7p11.2	7	55170420	A	G	E	G	665	665		missense	0.0	benign	0.08	tolerated - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1475431691		7p11.2	7	55170428	T	G	L	V	668	668		missense	0.009	benign	0.0	deleterious - low confidence	0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs374459674		7p11.2	7	55170436	G	T	W	C	670	670		missense	0.263	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1405772617		7p11.2	7	55170438	T	A	I	N	671	671		missense	0.077	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs138963326		7p11.2	7	55170449	C	A	L	M	675	675	7.99E-4	missense	0.001	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1292664036		7p11.2	7	55170450	T	G	L	R	675	675		missense	0.021	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs138963326		7p11.2	7	55170449	C	G	L	V	675	675	7.99E-4	missense	0.0	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770861870		7p11.2	7	55170453	C	A	P	Q	676	676		missense	0.0	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770861870		7p11.2	7	55170453	C	G	P	R	676	676		missense	0.0	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs772139095		7p11.2	7	55170462	T	C	F	S	679	679		missense	0.001	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes	rs201419843		7p11.2	7	55170466	G	C	Q	H	680	680	2.0E-4	missense	0.281	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1429370247		7p11.2	7	55170468	T	G	L	R	681	681		missense	0.221	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs775407038		7p11.2	7	55170471	G	T	G	V	682	682		missense	0.006	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769151043		7p11.2	7	55170475	G	A	W	*	683	683		stop gained					0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs760845355		7p11.2	7	55170474	G	A	W	*	683	683		stop gained					0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769151043		7p11.2	7	55170475	G	C	W	C	683	683		missense	0.115	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs777184524		7p11.2	7	55170477	G	A	G	D	684	684		missense	0.015	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1208050900		7p11.2	7	55170482	T	C	C	R	686	686		missense	0.003	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs111275056		7p11.2	7	55170483	G	A	C	Y	686	686	2.0E-4	missense	0.003	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751185812		7p11.2	7	55170486	G	T	S	I	687	687		missense	0.282	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs759135866		7p11.2	7	55170494	C	T	H	Y	690	690		missense	0.044	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1230932173		7p11.2	7	55170498	C	A	A	D	691	691		missense	0.0	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	TOPMed	rs1478383579		7p11.2	7	55170507	C	G	S	C	694	694		missense	0.437	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs767248396		7p11.2	7	55170512	T	A	S	T	696	696		missense	0.146	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs755742111		7p11.2	7	55170519	T	A	I	N	698	698		missense	0.082	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs755742111		7p11.2	7	55170519	T	C	I	T	698	698		missense	0.04	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs368763603		7p11.2	7	55170525	C	T	T	M	700	700	2.0E-4	missense	0.0	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC	rs753828905		7p11.2	7	55170524	A	C	T	P	700	700		missense	0.044	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	gnomAD	rs1327319131		7p11.2	7	55170531	C	T	S	F	702	702		missense	0.0	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	ExAC,gnomAD	rs745721490		7p11.2	7	55170530	T	C	S	P	702	702		missense	0.013	benign			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs10258568		7p11.2	7	55170534	C	G	S	C	703	703	0.03714	missense	0.54	possibly damaging			0						
P00533-3	EGFR	Isoform 3 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,dbSNP,gnomAD	rs10258568		7p11.2	7	55170534	C	T	S	F	703	703		missense	0.127	benign			0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs749433287		7p11.2	7	55019285	C	T	P	L	3	3		missense	0.0015	benign	0.01	deleterious, deleterious - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773069229		7p11.2	7	55019284	C	T	P	S	3	3		missense	0.05633	benign	0.12	deleterious, tolerated, tolerated - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773069229		7p11.2	7	55019284	C	A	P	T	3	3		missense	0.0405	benign	0.035	deleterious, tolerated - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs771210838		7p11.2	7	55019288	C	T	S	F	4	4		missense	0.001	benign	0.03	deleterious, deleterious - low confidence, tolerated - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs771210838		7p11.2	7	55019288	C	A	S	Y	4	4		missense	0.0	benign	0.03	deleterious, deleterious - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759582787		7p11.2	7	55019291	G	C	G	A	5	5		missense	0.201	benign	0.295	tolerated, tolerated - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759582787		7p11.2	7	55019291	G	A	G	E	5	5		missense	0.01167	benign	0.04333	deleterious, deleterious - low confidence, tolerated - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs774487133		7p11.2	7	55019290	G	C	G	R	5	5		missense	0.021	benign	0.175	tolerated, tolerated - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs767651648		7p11.2	7	55019293	A	G	T	A	6	6		missense	0.0	benign	0.545	tolerated, tolerated - low confidence	0	Lung cancer		MIM:211980		pubmed:23562183,pubmed:23667368,pubmed:24627688,pubmed:24846033,pubmed:25311215,ClinVar:RCV000372969	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs761183109		7p11.2	7	55019296	G	C	A	P	7	7		missense	0.001	benign	0.07	deleterious, tolerated, tolerated - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs761183109		7p11.2	7	55019296	G	T	A	S	7	7		missense	0.001	benign	0.06333	deleterious, tolerated, tolerated - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754259847		7p11.2	7	55019299	G	C	G	R	8	8		missense	0.0015	benign	0.55	tolerated, tolerated - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754259847		7p11.2	7	55019299	G	A	G	R	8	8		missense	0.0	benign	0.235	tolerated, tolerated - low confidence	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1217714114		7p11.2	7	55019306	C	A	A	E	10	10		missense	0.045	benign	0.26	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs567894670		7p11.2	7	55019315	C	T	A	V	13	13	7.99E-4	missense	0.0	benign	0.52	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1180577495		7p11.2	7	55019327	C	T	A	V	17	17		missense	0.0	benign	0.65	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs754527029		7p11.2	7	55019329	C	T	L	F	18	18		missense	0.221	benign	0.12	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs780865931		7p11.2	7	55019333	G	C	C	S	19	19		missense	0.003	benign	0.46	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1028735720		7p11.2	7	55019336	C	A	P	Q	20	20		missense	0.0	benign	0.31	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1028735720		7p11.2	7	55019336	C	G	P	R	20	20		missense	0.0	benign	0.52	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1194702075		7p11.2	7	55019339	C	A	A	E	21	21		missense	0.062	benign	0.45	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373129709		7p11.2	7	55019338	G	T	A	S	21	21		missense	0.051	benign	0.59	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs373129709		7p11.2	7	55019338	G	A	A	T	21	21		missense	0.0	benign	0.48	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1194702075		7p11.2	7	55019339	C	T	A	V	21	21		missense	0.037	benign	0.44	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1257423707		7p11.2	7	55019342	G	A	S	N	22	22		missense	0.015	benign	0.49	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs987102148		7p11.2	7	55019344	C	T	R	W	23	23		missense	0.0	benign	0.19	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs911767401		7p11.2	7	55019347	G	A	A	T	24	24		missense	0.021	benign	0.19	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs749088691		7p11.2	7	55019359	A	G	K	E	28	28		missense	0.01	benign	0.37	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs774551548		7p11.2	7	55019363	A	C	K	T	29	29		missense	0.028	benign	0.28	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs746023542		7p11.2	7	55142292	A	G	Q	R	32	32		missense	0.4705	benign, probably damaging	0.58	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs772311777		7p11.2	7	55142294	G	A	G	S	33	33		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs144158123		7p11.2	7	55142298	C	T	T	M	34	34		missense	0.77633	possibly damaging, probably damaging	0.05667	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs144158123		7p11.2	7	55142298	C	G	T	R	34	34		missense	0.869	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1406387936		7p11.2	7	55142301	G	A	S	N	35	35		missense	0.0	benign	0.24	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs375919121		7p11.2	7	55142313	C	T	T	M	39	39		missense	0.8595	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1442908038		7p11.2	7	55142321	G	A	G	S	42	42		missense	0.53133	benign, possibly damaging, probably damaging	0.44	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1001476056		7p11.2	7	55142328	T	C	F	S	44	44		missense	0.0	benign	0.43	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1052582656		7p11.2	7	55142335	T	A	D	E	46	46		missense	0.026	benign	0.11	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1343024399		7p11.2	7	55142334	A	T	D	V	46	46		missense	0.45025	benign, possibly damaging, probably damaging	0.1025	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1263793183		7p11.2	7	55142340	T	C	F	S	48	48		missense	0.71	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs759219499		7p11.2	7	55142355	G	A	R	K	53	53		missense	0.003	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs767259994		7p11.2	7	55142364	A	G	N	S	56	56		missense	0.003	benign	0.84	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs763572530		7p11.2	7	55142373	A	C	E	A	59	59		missense	0.82	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs760228905		7p11.2	7	55142372	G	A	E	K	59	59		missense	0.67875	benign, possibly damaging, probably damaging	0.0275	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1470757416		7p11.2	7	55142408	C	T	Q	*	71	71		stop gained					0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369580836		7p11.2	7	55142409	A	C	Q	P	71	71		missense	0.006	benign	0.09	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs369580836		7p11.2	7	55142409	A	G	Q	R	71	71		missense	0.497	benign, possibly damaging	0.2	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1269583681		7p11.2	7	55142416	T	G	N	K	73	73		missense	0.06	benign	0.07	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs778638117		7p11.2	7	55142423	C	A	L	I	76	76		missense	0.9055	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs374986786		7p11.2	7	55143305	A	G	T	A	81	81		missense	0.038	benign	0.04	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1309796320		7p11.2	7	55143308	A	G	I	V	82	82		missense	0.85567	possibly damaging, probably damaging	0.03	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1282801317		7p11.2	7	55143316	G	C	E	D	84	84		missense	0.996	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs753319070		7p11.2	7	55143314	G	A	E	K	84	84		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs753319070		7p11.2	7	55143314	G	C	E	Q	84	84		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs765137528		7p11.2	7	55143327	A	G	Y	C	88	88		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs750399097		7p11.2	7	55143332	C	T	L	F	90	90		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs142061256		7p11.2	7	55143333	T	A	L	H	90	90		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs779879611		7p11.2	7	55143339	C	T	A	V	92	92		missense	0.961	probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1422504667		7p11.2	7	55143348	C	T	T	I	95	95		missense	0.134	benign	0.13	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1260357262		7p11.2	7	55143350	G	A	V	M	96	96		missense	0.889	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs755189573		7p11.2	7	55143353	G	C	E	Q	97	97		missense	0.35	benign	0.33	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17289589		7p11.2	7	55143357	G	T	R	L	98	98		missense	0.047	benign	0.28	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs17289589	COSM4680391	7p11.2	7	55143357	G	A	R	Q	98	98		missense	0.007	benign	0.32	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,NCI-TCGA	rs376963968	COSM6047689	7p11.2	7	55143363	C	A	P	H	100	100		missense	0.559	benign, possibly damaging	0.04667	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl	rs866460345	COSM4892885	7p11.2	7	55143362	C	T	P	S	100	100		missense	0.8665	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs141271101		7p11.2	7	55143379	G	C	Q	H	105	105		missense	0.9075	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs771366736		7p11.2	7	55143380	A	G	I	V	106	106		missense	0.031	benign	0.15	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519888	COSM1451537	7p11.2	7	55143386	A	G	R	G	108	108		missense	1.0	probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000424206,ClinVar:RCV000434481	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519828	COSM5576118	7p11.2	7	55143387	G	A	R	K	108	108		missense	1.0	probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000432019	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs145113601		7p11.2	7	55143390	G	C	G	A	109	109		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1488843432		7p11.2	7	55143397	G	A	M	I	111	111		missense	0.0	benign	0.13	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746631025		7p11.2	7	55143396	T	C	M	T	111	111		missense	0.0	benign	0.56	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1385682568		7p11.2	7	55143402	A	T	Y	F	113	113		missense	0.576	benign, possibly damaging	0.225	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1219568637	COSM5835422	7p11.2	7	55143404	G	A	E	K	114	114		missense	0.011	benign	0.05	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1332428616		7p11.2	7	55143407	A	C	N	H	115	115		missense	0.4832	benign, possibly damaging, probably damaging	0.046	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs773596817		7p11.2	7	55143409	T	A	N	K	115	115		missense	0.361	benign, possibly damaging	0.14	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1247204001		7p11.2	7	55143417	C	G	A	G	118	118		missense	0.573	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1249939049		7p11.2	7	55143416	G	T	A	S	118	118		missense	0.9285	possibly damaging, probably damaging	0.1	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1229095978		7p11.2	7	55143432	C	T	S	F	123	123		missense	0.592	benign, possibly damaging, probably damaging	0.30333	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1295285127		7p11.2	7	55143438	A	G	Y	C	125	125		missense	0.968	probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs377444977		7p11.2	7	55143443	G	A	A	T	127	127		missense	0.001	benign	0.58	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1485906237		7p11.2	7	55143444	C	T	A	V	127	127		missense	0.0	benign	0.09	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs762889647		7p11.2	7	55143450	A	C	K	T	129	129		missense	0.007	benign	0.37	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1485016142		7p11.2	7	55143455	G	A	G	R	131	131		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs751337426		7p11.2	7	55143464	G	A	E	K	134	134		missense	0.3735	benign, possibly damaging	0.03	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754854319		7p11.2	7	55143473	A	G	M	V	137	137		missense	0.084	benign	0.03	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1437762652		7p11.2	7	55143477	G	A	R	K	138	138		missense	0.018	benign	0.74	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs767608234		7p11.2	7	55143487	G	T	Q	H	141	141		missense	0.303	benign, possibly damaging	0.02333	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1198703773		7p11.2	7	55146614	C	A	H	N	145	145		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780476417		7p11.2	7	55146615	A	G	H	R	145	145		missense	0.0	benign	0.32	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs532655845		7p11.2	7	55146620	G	C	A	P	147	147	2.0E-4	missense	0.403	benign, possibly damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,NCI-TCGA,TOPMed,gnomAD	rs532655845		7p11.2	7	55146620	G	A	A	T	147	147	2.0E-4	missense	0.026	benign	0.03	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759532524		7p11.2	7	55146627	G	A	R	Q	149	149		missense	0.2575	benign, possibly damaging	0.375	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs774146556	COSM3412169	7p11.2	7	55146626	C	T	R	W	149	149		missense	0.34	benign, probably damaging	0.08333	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1398462122		7p11.2	7	55146629	T	C	F	L	150	150		missense	0.0805	benign	0.045	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs551591429		7p11.2	7	55146636	A	G	N	S	152	152	2.0E-4	missense	0.054	benign	0.38	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs919891568		7p11.2	7	55146644	G	T	A	S	155	155		missense	0.007	benign	0.42	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs937907395		7p11.2	7	55146653	A	G	N	D	158	158		missense	0.2725	benign, possibly damaging	0.225	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs761795138		7p11.2	7	55146675	G	A	R	Q	165	165		missense	0.007	benign	0.68	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs587778252		7p11.2	7	55146674	C	T	R	W	165	165		missense	0.4455	benign, possibly damaging	0.26	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs765416003		7p11.2	7	55146681	T	C	I	T	167	167		missense	0.988	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs530692924		7p11.2	7	55146683	G	C	V	L	168	168	2.0E-4	missense	0.056	benign	0.23	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs758945260		7p11.2	7	55146690	G	T	S	I	170	170		missense	0.017	benign	0.04	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs758945260		7p11.2	7	55146690	G	A	S	N	170	170		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs17289686		7p11.2	7	55146694	C	A	D	E	171	171	3.99E-4	missense	0.001	benign	0.72	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770290445		7p11.2	7	55146711	C	T	S	L	177	177		missense	0.003	benign	0.18	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770290445		7p11.2	7	55146711	C	G	S	W	177	177		missense	0.9005	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs745755245		7p11.2	7	55146715	G	A	M	I	178	178		missense	0.001	benign	0.82	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1219334377		7p11.2	7	55146713	A	G	M	V	178	178		missense	0.0	benign	0.22	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs772071414		7p11.2	7	55146728	C	G	H	D	183	183		missense	0.007	benign	0.42	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs772071414		7p11.2	7	55146728	C	A	H	N	183	183		missense	0.0	benign	0.98	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs921852102		7p11.2	7	55146732	T	C	L	P	184	184		missense	0.0	benign	0.4	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs921852102		7p11.2	7	55146732	T	A	L	Q	184	184		missense	0.003	benign	0.6	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1224862076		7p11.2	7	55146731	C	G	L	V	184	184		missense	0.003	benign	0.31	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs770074413		7p11.2	7	55151308	C	A	P	T	192	192		missense	0.146	benign	0.045	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs766507267		7p11.2	7	55151321	A	G	N	S	196	196		missense	0.021	benign	0.27	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1335854310		7p11.2	7	55151327	G	A	S	N	198	198		missense	0.2725	benign, possibly damaging	0.33	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs767829342		7p11.2	7	55151344	G	A	E	K	204	204		missense	0.001	benign	0.46	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs779156097		7p11.2	7	55152549	C	G	T	S	211	211		missense	0.878	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs750423932		7p11.2	7	55152551	A	C	K	Q	212	212		missense	0.625	benign, possibly damaging, probably damaging	0.00667	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1372330611		7p11.2	7	55152564	C	G	A	G	216	216		missense	0.992	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1190573231		7p11.2	7	55152563	G	A	A	T	216	216		missense	0.9455	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs776050604		7p11.2	7	55152571	G	T	Q	H	218	218		missense	0.7655	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs761098433		7p11.2	7	55152575	T	C	S	P	220	220		missense	0.56675	benign, probably damaging	0.0825	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs776886714		7p11.2	7	55152578	G	A	G	R	221	221		missense	0.067	benign	0.2	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs776886714		7p11.2	7	55152578	G	T	G	W	221	221		missense	0.666	benign, probably damaging	0.035	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751295137		7p11.2	7	55152582	G	A	R	H	222	222		missense	0.965	possibly damaging, probably damaging	0.06333	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs759106015		7p11.2	7	55152588	G	A	R	H	224	224		missense	0.913	possibly damaging, probably damaging	0.33	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1046438724	COSM3639726	7p11.2	7	55152597	C	T	S	F	227	227		missense	0.2485	benign, possibly damaging	0.625	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs766952405		7p11.2	7	55152596	T	C	S	P	227	227		missense	0.267	benign, possibly damaging	0.185	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs752616839		7p11.2	7	55152600	C	A	P	H	228	228		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1247276424		7p11.2	7	55152602	A	G	S	G	229	229		missense	0.47933	benign, possibly damaging	0.03333	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1291943679		7p11.2	7	55152603	G	A	S	N	229	229		missense	0.3905	benign, possibly damaging	0.255	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1357816760		7p11.2	7	55152604	T	A	S	R	229	229		missense	0.6474	benign, possibly damaging, probably damaging	0.072	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1203062307		7p11.2	7	55152606	A	C	D	A	230	230		missense	0.981	probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC	rs756040606		7p11.2	7	55152608	T	G	C	G	231	231		missense	0.998	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs777575581		7p11.2	7	55152609	G	C	C	S	231	231		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1447176163		7p11.2	7	55152633	G	C	G	A	239	239		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs370744986		7p11.2	7	55152639	C	T	T	I	241	241		missense	0.9335	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs554981236		7p11.2	7	55152647	C	G	R	G	244	244	2.0E-4	missense	0.40425	benign, possibly damaging	0.0475	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs200664836		7p11.2	7	55152648	G	A	R	Q	244	244	2.0E-4	missense	0.031	benign	0.2	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs554981236		7p11.2	7	55152647	C	T	R	W	244	244	2.0E-4	missense	0.918	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780001754		7p11.2	7	55152656	G	C	D	H	247	247		missense	0.878	possibly damaging, probably damaging	0.02	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780001754		7p11.2	7	55152656	G	A	D	N	247	247		missense	0.38567	benign, possibly damaging	0.03667	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs765893589		7p11.2	7	55152663	T	C	L	P	249	249		missense	0.996	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs775252718		7p11.2	7	55154017	C	G	R	G	252	252		missense	0.65075	benign, possibly damaging, probably damaging	0.025	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs760101437	COSM1176674	7p11.2	7	55154018	G	A	R	H	252	252		missense	0.0305	benign	0.07	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs374084791		7p11.2	7	55154021	A	G	K	R	253	253	5.99E-4	missense	0.003	benign	0.36	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs776490661		7p11.2	7	55154026	C	T	R	*	255	255		stop gained					0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs372202099		7p11.2	7	55154027	G	A	R	Q	255	255		missense	0.003	benign	0.17	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs138847501		7p11.2	7	55154032	G	A	E	K	257	257		missense	0.247	benign	0.04	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs766478921		7p11.2	7	55154039	C	T	T	M	259	259		missense	0.888	possibly damaging, probably damaging	0.105	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1396651256		7p11.2	7	55154038	A	C	T	P	259	259		missense	0.999	probably damaging	0.04	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1057519829		7p11.2	7	55154050	A	G	T	A	263	263		missense	0.003	benign	0.85	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	dbSNP,gnomAD	rs1057519829	COSM21684	7p11.2	7	55154050	A	C	T	P	263	263		missense	0.422	benign, possibly damaging	0.205	tolerated	1	Neoplasm of brain				ClinVar:RCV000444169	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748627278		7p11.2	7	55154057	C	A	P	H	265	265		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17336639		7p11.2	7	55154060	C	A	P	Q	266	266		missense	0.021	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs17336639		7p11.2	7	55154060	C	G	P	R	266	266		missense	0.38	benign, possibly damaging	0.295	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1483973439		7p11.2	7	55154066	T	C	M	T	268	268		missense	0.3645	benign, possibly damaging	0.31	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1220356597		7p11.2	7	55154068	C	T	L	F	269	269		missense	0.4345	benign, possibly damaging	0.15	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1268199326		7p11.2	7	55154078	C	A	P	H	272	272		missense	0.8905	possibly damaging, probably damaging	0.025	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1412517681		7p11.2	7	55154083	A	G	T	A	274	274		missense	0.0295	benign	0.04	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs966001143		7p11.2	7	55154084	C	T	T	M	274	274		missense	0.8685	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs771396903		7p11.2	7	55154090	A	G	Q	R	276	276		missense	0.25767	benign, possibly damaging	0.07333	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1215369904		7p11.2	7	55154093	T	C	M	T	277	277		missense	0.38767	benign, possibly damaging	0.02667	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs918710688		7p11.2	7	55154105	C	G	P	R	281	281		missense	0.8725	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,NCI-TCGA,TOPMed,gnomAD	rs199796955		7p11.2	7	55154107	G	A	E	K	282	282		missense	0.011	benign	0.17	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs776146284		7p11.2	7	55154116	T	C	Y	H	285	285		missense	0.998	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,dbSNP	rs149840192	COSM21685	7p11.2	7	55154129	C	A	A	D	289	289		missense	0.595	benign, possibly damaging, probably damaging	0.01667	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000434840,ClinVar:RCV000427425,ClinVar:RCV000443311	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,dbSNP,gnomAD	rs769696078	COSM21686	7p11.2	7	55154128	G	A	A	T	289	289		missense	0.9275	possibly damaging, probably damaging	0.01	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000443246,ClinVar:RCV000433672,ClinVar:RCV000422848	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,NCI-TCGA,dbSNP	rs149840192	COSM4966963	7p11.2	7	55154129	C	T	A	V	289	289		missense	0.953	probably damaging	0.03	deleterious	1	Squamous cell carcinoma of the head and neck (HNSCC)	Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells.	MIM:275355		ClinVar:RCV000423404,ClinVar:RCV000423749,ClinVar:RCV000439402	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1020654485		7p11.2	7	55154132	C	T	T	I	290	290		missense	0.74467	benign, possibly damaging, probably damaging	0.53	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1220574404		7p11.2	7	55154135	G	T	C	F	291	291		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC	rs762649354		7p11.2	7	55154138	T	C	V	A	292	292		missense	0.909	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,NCI-TCGA,TOPMed,gnomAD	rs150549265		7p11.2	7	55154137	G	A	V	M	292	292		missense	0.9	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs751667358		7p11.2	7	55154152	C	T	R	C	297	297		missense	0.569	possibly damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs779094647		7p11.2	7	55155841	G	T	V	L	301	301		missense	0.66633	benign, possibly damaging, probably damaging	0.01333	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs182002674		7p11.2	7	55155852	C	A	H	Q	304	304	3.99E-4	missense	0.502	benign, possibly damaging, probably damaging	0.31333	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1277911361		7p11.2	7	55155851	A	G	H	R	304	304		missense	0.46467	benign, possibly damaging	0.16	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1278838499		7p11.2	7	55155853	G	T	G	C	305	305		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1321610304		7p11.2	7	55155859	T	C	C	R	307	307		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs749132706		7p11.2	7	55155862	G	A	V	I	308	308		missense	0.92033	possibly damaging, probably damaging	0.02333	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1444692842		7p11.2	7	55155865	C	G	R	G	309	309		missense	0.998	probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs770879879		7p11.2	7	55155875	G	C	G	A	312	312		missense	0.014	benign	0.02	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs149321481		7p11.2	7	55155878	C	T	A	V	313	313		missense	0.005	benign	0.16	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,NCI-TCGA	rs552062864		7p11.2	7	55155880	G	A	D	N	314	314	2.0E-4	missense	0.013	benign	0.71	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs745658347		7p11.2	7	55155884	G	A	S	N	315	315		missense	0.095	benign	0.255	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1484032303		7p11.2	7	55155887	A	G	Y	C	316	316		missense	0.791	possibly damaging	0.045	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs775800262		7p11.2	7	55155894	G	T	M	I	318	318		missense	0.0	benign	0.05	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1175454134		7p11.2	7	55155895	G	T	E	*	319	319		stop gained					0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs764038041		7p11.2	7	55155903	C	A	D	E	321	321		missense	0.096	benign	0.045	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs776791214		7p11.2	7	55155904	G	A	G	S	322	322		missense	0.95067	possibly damaging, probably damaging	0.04333	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs367680488		7p11.2	7	55155908	T	C	V	A	323	323		missense	0.2175	benign	0.045	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs761844164	COSM145361	7p11.2	7	55155907	G	A	V	I	323	323		missense	0.005	benign	0.96	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1343888047		7p11.2	7	55155910	C	T	R	C	324	324		missense	0.925	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,gnomAD	rs758748662	COSM3881813	7p11.2	7	55155911	G	A	R	H	324	324		missense	0.5916	benign, possibly damaging, probably damaging	0.048	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs766740458		7p11.2	7	55155913	A	C	K	Q	325	325		missense	0.4505	benign, possibly damaging	0.265	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,dbSNP	rs886037891		7p11.2	7	55155917	G	T	C	F	326	326		missense	1.0	probably damaging	0.0	deleterious	0	Cowden syndrome 1 (CWS1)	The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and Proteus-like syndrome.	MIM:158350		pubmed:15604628,pubmed:20301661,pubmed:24493721,pubmed:25394175,ClinVar:RCV000256393	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs144460286		7p11.2	7	55155922	A	C	K	Q	328	328		missense	0.527	benign, probably damaging	0.195	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs777342222		7p11.2	7	55155925	T	C	C	R	329	329		missense	0.999	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs778901010		7p11.2	7	55155929	A	G	E	G	330	330		missense	0.106	benign	0.42	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs139429793		7p11.2	7	55155928	G	A	E	K	330	330		missense	0.176	benign	0.75	tolerated	0	Lung adenocarcinoma				pubmed:23562183,pubmed:24627688,pubmed:25311215,ClinVar:RCV000677876	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs778901010		7p11.2	7	55155929	A	T	E	V	330	330		missense	0.441	benign, possibly damaging	0.155	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs771929085		7p11.2	7	55155941	G	A	R	H	334	334		missense	0.123	benign	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1284204782		7p11.2	7	55156550	A	C	I	L	342	342		missense	0.014	benign	0.12	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1381010963		7p11.2	7	55156551	T	C	I	T	342	342		missense	0.005	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed	rs771398183		7p11.2	7	55156554	G	T	G	V	343	343		missense	0.8615	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,TOPMed	rs371234907		7p11.2	7	55156569	C	T	S	L	348	348		missense	0.001	benign	0.18	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs767790289	COSM3881815	7p11.2	7	55156577	A	G	I	V	351	351		missense	0.005	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs753466844		7p11.2	7	55156587	C	T	T	M	354	354		missense	0.69967	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1423110562		7p11.2	7	55156596	A	T	K	I	357	357		missense	0.329	benign	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl	rs1164954595	COSM2155594	7p11.2	7	55156614	C	T	T	I	363	363		missense	0.982	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs749927550		7p11.2	7	55156628	G	C	D	H	368	368		missense	0.68433	benign, possibly damaging, probably damaging	0.02333	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs758017949		7p11.2	7	55156629	A	T	D	V	368	368		missense	0.833	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs780131926		7p11.2	7	55156631	C	A	L	I	369	369		missense	0.3535	benign, possibly damaging	0.15	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1405999227		7p11.2	7	55156637	A	G	I	V	371	371		missense	0.515	benign, possibly damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1341708803		7p11.2	7	55156652	T	C	F	L	376	376		missense	0.3245	benign, possibly damaging	0.37	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs755972013		7p11.2	7	55156772	C	A	H	N	383	383		missense	0.001	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1169461493		7p11.2	7	55156773	A	G	H	R	383	383		missense	0.0	benign	0.36	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1197499057		7p11.2	7	55156794	A	C	Q	P	390	390		missense	0.058	benign	0.02	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1389500636		7p11.2	7	55156796	G	A	E	K	391	391		missense	0.003	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	dbSNP,gnomAD	rs587778246		7p11.2	7	55156802	G	C	D	H	393	393		missense	0.78067	possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1178642122		7p11.2	7	55156807	T	G	I	M	394	394		missense	0.804	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs757265130		7p11.2	7	55156817	G	A	V	I	398	398		missense	0.0305	benign	0.04	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC	rs777165081		7p11.2	7	55157665	T	A	F	I	404	404		missense	0.5964	benign, possibly damaging, probably damaging	0.074	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1230904747		7p11.2	7	55157672	T	A	L	Q	406	406		missense	0.728	possibly damaging, probably damaging	0.295	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1179620001		7p11.2	7	55157674	A	G	I	V	407	407		missense	0.845	possibly damaging, probably damaging	0.03333	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs770466526		7p11.2	7	55157693	A	G	N	S	413	413		missense	0.57	benign, probably damaging	0.235	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1424097500		7p11.2	7	55157696	G	T	R	M	414	414		missense	0.003	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1274543317		7p11.2	7	55157699	C	A	T	K	415	415		missense	0.76733	benign, probably damaging	0.12	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs758956103		7p11.2	7	55157703	C	G	D	E	416	416		missense	0.3465	benign, possibly damaging	0.02	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1456537863		7p11.2	7	55157705	T	G	L	R	417	417		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1390766480		7p11.2	7	55157707	C	T	H	Y	418	418		missense	0.02	benign	0.12	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs760639592		7p11.2	7	55157716	G	A	E	K	421	421		missense	0.728	benign, possibly damaging, probably damaging	0.03	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1230287644		7p11.2	7	55157727	A	T	E	D	424	424		missense	0.5455	benign, possibly damaging	0.16	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs558565565		7p11.2	7	55157728	A	G	I	V	425	425		missense	0.007	benign	0.94	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,dbSNP,gnomAD	rs606231253		7p11.2	7	55157738	G	A	G	D	428	428		missense	1.0	probably damaging	0.0	deleterious	0	Inflammatory skin and bowel disease, neonatal, 2 (NISBD2)		MIM:616069		ClinVar:RCV000144851	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs765369188		7p11.2	7	55157744	C	A	T	N	430	430		missense	0.773	benign, possibly damaging, probably damaging	0.02667	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1171743336		7p11.2	7	55160139	T	A	H	Q	433	433		missense	0.005	benign	0.46	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs750713244		7p11.2	7	55157753	A	G	H	R	433	433		missense	0.013	benign	0.33	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1345387967		7p11.2	7	55160146	T	A	F	I	436	436		missense	0.361	benign, possibly damaging	0.17	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1166858113	COSM1090876	7p11.2	7	55160161	G	A	V	I	441	441		missense	0.012	benign	0.5	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs765091640		7p11.2	7	55160165	G	A	S	N	442	442		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1032006770		7p11.2	7	55160171	A	G	N	S	444	444		missense	0.0	benign	0.54	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs372990493		7p11.2	7	55160173	A	G	I	V	445	445		missense	0.3465	benign, possibly damaging	0.2	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1310061365		7p11.2	7	55160177	C	T	T	I	446	446		missense	0.459	benign, possibly damaging	0.03667	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs763266323		7p11.2	7	55160184	G	C	L	F	448	448		missense	1.0	probably damaging	0.04	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,TOPMed,gnomAD	rs377567759		7p11.2	7	55160191	C	T	R	C	451	451		missense	0.996	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751667594		7p11.2	7	55160192	G	A	R	H	451	451		missense	0.997	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751667594		7p11.2	7	55160192	G	T	R	L	451	451		missense	0.925	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1226827460		7p11.2	7	55160195	C	T	S	F	452	452		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1177337471		7p11.2	7	55160207	T	C	I	T	456	456		missense	0.9005	possibly damaging, probably damaging	0.02	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1340811850		7p11.2	7	55160210	G	A	S	N	457	457		missense	0.8085	possibly damaging, probably damaging	0.0525	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs146711874		7p11.2	7	55160214	T	G	D	E	458	458	2.0E-4	missense	0.806	possibly damaging, probably damaging	0.115	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs753269876		7p11.2	7	55160218	G	A	D	N	460	460		missense	0.62733	benign, possibly damaging, probably damaging	0.59	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1197924233		7p11.2	7	55160226	A	G	I	M	462	462		missense	0.3895	benign, possibly damaging	0.155	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746763556		7p11.2	7	55160230	T	G	S	A	464	464		missense	0.051	benign	0.49	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746763556		7p11.2	7	55160230	T	A	S	T	464	464		missense	0.006	benign	0.88	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1389684767		7p11.2	7	55160257	A	G	N	D	473	473		missense	0.001	benign	0.51	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1221992080	COSM122790	7p11.2	7	55160263	A	G	I	V	475	475		missense	0.02	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs746521110		7p11.2	7	55160267	A	G	N	S	476	476		missense	0.0035	benign	0.07	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs768208443		7p11.2	7	55160277	A	C	K	N	479	479		missense	0.005	benign	0.34	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs147732025		7p11.2	7	55160278	C	A	L	M	480	480	3.99E-4	missense	0.735	benign, possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs147732025		7p11.2	7	55160278	C	G	L	V	480	480	3.99E-4	missense	0.29833	benign, possibly damaging	0.04	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,dbSNP	rs587778247		7p11.2	7	55160283	T	G	F	L	481	481		missense	0.67	benign, possibly damaging, probably damaging	0.14	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs982033612		7p11.2	7	55160294	G	C	G	A	485	485		missense	0.001	benign	0.78	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769434273		7p11.2	7	55160293	G	T	G	C	485	485		missense	0.51133	benign, possibly damaging	0.04	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769434273		7p11.2	7	55160293	G	A	G	S	485	485		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1271375100		7p11.2	7	55160303	C	G	T	S	488	488		missense	0.018	benign	0.27	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519760		7p11.2	7	55160314	A	G	S	G	492	492		missense	0.013	benign	0.35	tolerated	1	Neoplasm of the large intestine				pubmed:23012255,ClinVar:RCV000429440	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519860		7p11.2	7	55160316	C	A	S	R	492	492		missense	0.001	benign	0.26	tolerated	1	Neoplasm of the large intestine				pubmed:23012255,ClinVar:RCV000423834	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs766676440		7p11.2	7	55160324	G	A	G	D	495	495		missense	0.005	benign	0.53	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs774773441		7p11.2	7	55160331	C	A	N	K	497	497		missense	0.0	benign	0.56	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs927866979		7p11.2	7	55160333	G	C	S	T	498	498		missense	0.0	benign	0.49	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1206537132		7p11.2	7	55160338	A	G	K	E	500	500		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs760711480		7p11.2	7	55161507	G	A	G	S	503	503		missense	0.048	benign	0.03	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1334180707		7p11.2	7	55161510	C	G	Q	E	504	504		missense	0.026	benign	0.23	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1188823834		7p11.2	7	55161512	G	C	Q	H	504	504		missense	0.0	benign	0.68	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1287531915		7p11.2	7	55161523	C	A	A	D	508	508		missense	0.015	benign	0.13	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1287531915		7p11.2	7	55161523	C	G	A	G	508	508		missense	5.0E-4	benign	0.08	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1407608935		7p11.2	7	55161522	G	A	A	T	508	508		missense	0.0	benign	0.14	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1240855741		7p11.2	7	55161526	T	C	L	S	509	509		missense	0.9435	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs371114444		7p11.2	7	55161532	C	A	S	Y	511	511		missense	0.996	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,dbSNP,gnomAD	rs587778248	COSM3639738	7p11.2	7	55161534	C	T	P	S	512	512		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754646330		7p11.2	7	55161537	G	T	E	*	513	513		stop gained					0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1339627647		7p11.2	7	55161538	A	C	E	A	513	513		missense	0.005	benign	0.51	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs754646330		7p11.2	7	55161537	G	A	E	K	513	513		missense	0.309	benign	0.17	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,TOPMed,gnomAD	rs564398642		7p11.2	7	55161553	C	T	P	L	518	518	2.0E-4	missense	0.721	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed	rs368484180		7p11.2	7	55161552	C	T	P	S	518	518		missense	0.7678	benign, possibly damaging, probably damaging	0.056	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs116057045		7p11.2	7	55161557	G	T	E	D	519	519	2.0E-4	missense	0.0	benign	0.03	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs749186957		7p11.2	7	55161556	A	G	E	G	519	519		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,dbSNP,gnomAD	rs2227983		7p11.2	7	55161562	G	A	R	K	521	521		missense	0.0	benign	0.39	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs2227983		7p11.2	7	55161562	G	T	R	M	521	521	0.2921	missense	0.047	benign	0.03	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs2227983		7p11.2	7	55161562	G	C	R	T	521	521	0.2921	missense	0.0	benign	0.4	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,dbSNP,gnomAD	rs587778249		7p11.2	7	55161570	G	A	V	I	524	524		missense	0.049	benign	0.06	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs587778249		7p11.2	7	55161570	G	C	V	L	524	524		missense	0.01	benign	0.84	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs768627073		7p11.2	7	55161579	C	G	R	G	527	527		missense	0.353	benign, possibly damaging	0.02	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,dbSNP,gnomAD	rs150477666		7p11.2	7	55161580	G	A	R	Q	527	527		missense	0.001	benign	0.2	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs768627073		7p11.2	7	55161579	C	T	R	W	527	527		missense	0.658	possibly damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs762336338		7p11.2	7	55161582	A	G	N	D	528	528		missense	0.043	benign	0.24	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1330512770		7p11.2	7	55161592	G	A	R	Q	531	531		missense	0.9485	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs752350337		7p11.2	7	55161607	T	C	V	A	536	536		missense	0.7485	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs767193132	COSM382936	7p11.2	7	55161606	G	A	V	M	536	536		missense	0.656	benign, possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1275660363		7p11.2	7	55161611	C	G	D	E	537	537		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1038997598		7p11.2	7	55161609	G	A	D	N	537	537		missense	0.001	benign	0.11	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1209490447		7p11.2	7	55161613	A	C	K	T	538	538		missense	0.001	benign	0.25	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1340266257		7p11.2	7	55161620	C	A	N	K	540	540		missense	0.926	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1208487495	COSM3639740	7p11.2	7	55161621	C	T	L	F	541	541		missense	0.0	benign	0.51	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs755584255		7p11.2	7	55161630	G	A	G	S	544	544		missense	0.917	possibly damaging, probably damaging	0.015	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778985185		7p11.2	7	55163734	G	A	E	K	545	545		missense	0.46875	benign, possibly damaging, probably damaging	0.0725	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,dbSNP	rs1057519830		7p11.2	7	55163737	C	T	P	S	546	546		missense	0.58633	benign, possibly damaging, probably damaging	0.28	tolerated	1	Head and Neck Neoplasms				ClinVar:RCV000443890	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1427028322		7p11.2	7	55163740	A	G	R	G	547	547		missense	0.817	possibly damaging, probably damaging	0.005	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1419611893		7p11.2	7	55163747	T	C	F	S	549	549		missense	0.606	benign, possibly damaging	0.025	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs940873450		7p11.2	7	55163753	A	T	E	V	551	551		missense	0.0	benign	0.45	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1162236403		7p11.2	7	55163756	A	G	N	S	552	552		missense	0.015	benign	0.2	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs779741928		7p11.2	7	55163762	A	G	E	G	554	554		missense	0.155	benign	0.35	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs747203424		7p11.2	7	55163769	A	G	I	M	556	556		missense	0.003	benign	0.36	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1488695603		7p11.2	7	55163770	C	T	Q	*	557	557		stop gained					0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748219780		7p11.2	7	55163779	C	T	P	S	560	560		missense	0.042	benign	0.21	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs748219780		7p11.2	7	55163779	C	A	P	T	560	560		missense	0.294	benign	0.02	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769918274		7p11.2	7	55163782	G	C	E	Q	561	561		missense	0.67367	benign, possibly damaging, probably damaging	0.33667	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs773651001		7p11.2	7	55163791	C	T	P	S	564	564		missense	0.011	benign	0.15	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs773651001		7p11.2	7	55163791	C	A	P	T	564	564		missense	0.079	benign	0.1	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1258211270		7p11.2	7	55163795	A	G	Q	R	565	565		missense	0.68733	benign, possibly damaging, probably damaging	0.20667	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs771278492		7p11.2	7	55163800	A	G	M	V	567	567		missense	0.018	benign	0.04	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1228970909		7p11.2	7	55163805	C	A	N	K	568	568		missense	0.21267	benign, possibly damaging	0.29667	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs774558548		7p11.2	7	55163810	C	G	T	S	570	570		missense	0.6505	benign, possibly damaging, probably damaging	0.15	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs759987693		7p11.2	7	55163816	C	G	T	R	572	572		missense	0.5785	benign, possibly damaging	0.35	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1294381114		7p11.2	7	55163818	G	A	G	R	573	573		missense	0.988	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,gnomAD	rs370810719		7p11.2	7	55163822	G	A	R	Q	574	574		missense	0.112	benign	0.07	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,TOPMed,gnomAD	rs760471492		7p11.2	7	55163821	C	T	R	W	574	574		missense	0.829	possibly damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1249099747		7p11.2	7	55165281	G	A	G	E	575	575		missense	0.871	possibly damaging, probably damaging	0.1	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs556794990		7p11.2	7	55165290	A	G	N	S	578	578	2.0E-4	missense	0.0	benign	0.18	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs761585117		7p11.2	7	55165296	T	C	I	T	580	580		missense	0.009	benign	0.73	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs764787649		7p11.2	7	55165298	C	A	Q	K	581	581		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1376117521		7p11.2	7	55165299	A	C	Q	P	581	581		missense	0.22867	benign, possibly damaging	0.11667	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1306429085		7p11.2	7	55165301	T	C	C	R	582	582		missense	0.998	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1447966312		7p11.2	7	55165305	C	T	A	V	583	583		missense	0.5795	benign, possibly damaging, probably damaging	0.0575	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs956386356		7p11.2	7	55165309	C	G	H	Q	584	584		missense	0.9235	possibly damaging, probably damaging	0.03	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1281578598		7p11.2	7	55165315	T	G	I	M	586	586		missense	0.334	benign	0.06	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs542237406		7p11.2	7	55165314	T	A	I	N	586	586	2.0E-4	missense	0.204	benign	0.055	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ExAC,gnomAD	rs542237406		7p11.2	7	55165314	T	C	I	T	586	586	2.0E-4	missense	0.04	benign	0.05	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs953188147		7p11.2	7	55165313	A	G	I	V	586	586		missense	0.0	benign	0.055	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs989939484		7p11.2	7	55165319	G	A	G	S	588	588		missense	0.9405	possibly damaging, probably damaging	0.01	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751570775		7p11.2	7	55165323	C	A	P	H	589	589		missense	0.989	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs751570775	COSM747428	7p11.2	7	55165323	C	T	P	L	589	589		missense	0.51767	benign, possibly damaging, probably damaging	0.12667	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs1235180640		7p11.2	7	55165322	C	T	P	S	589	589		missense	0.6406	benign, possibly damaging, probably damaging	0.05	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,ESP,ExAC,TOPMed,gnomAD	rs144943614		7p11.2	7	55165331	G	A	V	I	592	592	3.99E-4	missense	0.48825	benign, possibly damaging	0.0475	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs756307243		7p11.2	7	55165336	G	C	K	N	593	593		missense	0.58033	benign, possibly damaging, probably damaging	0.19333	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778011429		7p11.2	7	55165338	C	T	T	I	594	594		missense	0.387	benign, possibly damaging	0.025	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs778011429		7p11.2	7	55165338	C	A	T	N	594	594		missense	0.197	benign, possibly damaging	0.05	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed,gnomAD	rs1477025000		7p11.2	7	55165344	C	T	P	L	596	596		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs757419349		7p11.2	7	55165346	G	T	A	S	597	597		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,dbSNP,gnomAD	rs139236063	COSM3412197	7p11.2	7	55165350	G	C	G	A	598	598		missense	0.67533	benign, possibly damaging, probably damaging	0.01	deleterious	1	Neoplasm of brain				ClinVar:RCV000440786,ClinVar:RCV000423114	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,NCI-TCGA,dbSNP,gnomAD	rs139236063	COSM4967213	7p11.2	7	55165350	G	T	G	V	598	598		missense	0.94	possibly damaging, probably damaging	0.0	deleterious	1	Neoplasm of brain				ClinVar:RCV000436167,ClinVar:RCV000434448	
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1206543227		7p11.2	7	55165353	T	A	V	D	599	599		missense	0.637	benign, possibly damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs746395542		7p11.2	7	55165355	A	T	M	L	600	600		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs149375515		7p11.2	7	55165356	T	C	M	T	600	600		missense	0.122	benign	0.24	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs746395542		7p11.2	7	55165355	A	G	M	V	600	600		missense	0.018	benign	0.22	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	1000Genomes,TOPMed	rs201498575		7p11.2	7	55165359	G	A	G	E	601	601	2.0E-4	missense	0.7448	benign, possibly damaging, probably damaging	0.054	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs769537072		7p11.2	7	55165366	C	A	N	K	603	603		missense	0.517	benign, probably damaging	0.655	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	TOPMed	rs913231421		7p11.2	7	55165368	A	G	N	S	604	604		missense	0.0	benign	1.0	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1436144358		7p11.2	7	55165370	A	G	T	A	605	605		missense	0.2715	benign, possibly damaging	0.395	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ESP,ExAC,TOPMed,gnomAD	rs143152775		7p11.2	7	55165373	C	G	L	V	606	606		missense	0.03	benign	0.08	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs201061916		7p11.2	7	55165388	G	A	A	T	611	611		missense	0.008	benign	0.08	deleterious, tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	gnomAD	rs1214761095		7p11.2	7	55165391	G	A	D	N	612	612		missense	0.62567	benign, possibly damaging, probably damaging	0.18333	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs764290273		7p11.2	7	55165394	G	A	A	T	613	613		missense	0.056	benign	0.36	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs750850720		7p11.2	7	55165398	G	A	G	D	614	614		missense	0.0	benign	0.36	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs779076899		7p11.2	7	55165397	G	C	G	R	614	614		missense	0.024	benign	0.38	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,TOPMed,gnomAD	rs779076899		7p11.2	7	55165397	G	A	G	S	614	614		missense	0.0	benign	0.29	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC	rs756534868		7p11.2	7	55165404	T	C	V	A	616	616		missense	0.033	benign	0.72	tolerated	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,NCI-TCGA	rs150899403	COSM35825	7p11.2	7	55165416	G	A	C	Y	620	620		missense	0.894	possibly damaging, probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs747376358		7p11.2	7	55165424	A	T	N	Y	623	623		missense	0.915	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	Ensembl,NCI-TCGA	rs28384376	COSM13560	7p11.2	7	55165428	G	T	C	F	624	624		missense	1.0	probably damaging	0.0	deleterious	0						
P00533-4	EGFR	Isoform 4 of Epidermal growth factor receptor	ExAC,gnomAD	rs753315940		7p11.2	7	55165436	G	A	G	R	627	627		missense	0.914	possibly damaging, probably damaging	0.02	deleterious	0