ID HV439_HUMAN Reviewed; 125 AA. AC P01824; A0A0A0MS13; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 05-OCT-2016, sequence version 2. DT 16-JAN-2019, entry version 105. DE RecName: Full=Immunoglobulin heavy variable 4-39 {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.4}; DE AltName: Full=Ig heavy chain V-II region WAH {ECO:0000305|PubMed:6806818}; DE Flags: Precursor; GN Name=IGHV4-39 {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.4}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (IMGT ALLELE RP IGHV4-39*01). RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., RA Quetier F., Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [2] RP PROTEIN SEQUENCE OF 27-125. RX PubMed=6806818; DOI=10.1073/pnas.79.9.2850; RA Takahashi N., Tetaert D., Debuire B., Lin L.-C., Putnam F.W.; RT "Complete amino acid sequence of the delta heavy chain of human RT immunoglobulin D."; RL Proc. Natl. Acad. Sci. U.S.A. 79:2850-2854(1982). RN [3] RP NOMENCLATURE. RX PubMed=11340299; RA Lefranc M.P.; RT "Nomenclature of the human immunoglobulin heavy (IGH) genes."; RL Exp. Clin. Immunogenet. 18:100-116(2001). RN [4] RP NOMENCLATURE. RA Lefranc M.P., Lefranc G.; RT "The Immunoglobulin FactsBook."; RL (In) Lefranc M.P., Lefranc G. (eds.); RL The Immunoglobulin FactsBook., pp.1-458, Academic Press, London. RL (2001). RN [5] RP REVIEW ON SOMATIC HYPERMUTATION. RX PubMed=17576170; DOI=10.1146/annurev.genet.41.110306.130340; RA Teng G., Papavasiliou F.N.; RT "Immunoglobulin somatic hypermutation."; RL Annu. Rev. Genet. 41:107-120(2007). RN [6] RP REVIEW ON IMMUNOGLOBULINS. RX PubMed=20176268; DOI=10.1016/j.jaci.2009.09.046; RA Schroeder H.W. Jr., Cavacini L.; RT "Structure and function of immunoglobulins."; RL J. Allergy Clin. Immunol. 125:S41-S52(2010). RN [7] RP REVIEW ON FUNCTION. RX PubMed=22158414; DOI=10.1038/nri3128; RA McHeyzer-Williams M., Okitsu S., Wang N., McHeyzer-Williams L.; RT "Molecular programming of B cell memory."; RL Nat. Rev. Immunol. 12:24-34(2012). RN [8] RP NOMENCLATURE. RX PubMed=24600447; DOI=10.3389/fimmu.2014.00022; RA Lefranc M.P.; RT "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and RT Rise of Immunoinformatics."; RL Front. Immunol. 5:22-22(2014). RN [9] RP STRUCTURE BY NMR OF 27-125. RX PubMed=16157351; DOI=10.1016/j.jmb.2005.07.072; RA Sun Z., Almogren A., Furtado P.B., Chowdhury B., Kerr M.A., RA Perkins S.J.; RT "Semi-extended solution structure of human myeloma immunoglobulin D RT determined by constrained X-ray scattering."; RL J. Mol. Biol. 353:155-173(2005). CC -!- FUNCTION: V region of the variable domain of immunoglobulin heavy CC chains that participates in the antigen recognition CC (PubMed:24600447). Immunoglobulins, also known as antibodies, are CC membrane-bound or secreted glycoproteins produced by B CC lymphocytes. In the recognition phase of humoral immunity, the CC membrane-bound immunoglobulins serve as receptors which, upon CC binding of a specific antigen, trigger the clonal expansion and CC differentiation of B lymphocytes into immunoglobulins-secreting CC plasma cells. Secreted immunoglobulins mediate the effector phase CC of humoral immunity, which results in the elimination of bound CC antigens (PubMed:22158414, PubMed:20176268). The antigen binding CC site is formed by the variable domain of one heavy chain, together CC with that of its associated light chain. Thus, each immunoglobulin CC has two antigen binding sites with remarkable affinity for a CC particular antigen. The variable domains are assembled by a CC process called V-(D)-J rearrangement and can then be subjected to CC somatic hypermutations which, after exposure to antigen and CC selection, allow affinity maturation for a particular antigen CC (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, CC ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, CC ECO:0000303|PubMed:24600447}. CC -!- SUBUNIT: Immunoglobulins are composed of two identical heavy CC chains and two identical light chains; disulfide-linked. CC {ECO:0000303|PubMed:20176268}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, CC ECO:0000303|PubMed:22158414}. Cell membrane CC {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. CC -!- POLYMORPHISM: There are several alleles. The sequence shown is CC that of IMGT allele IGHV4-39*01. {ECO:0000305}. CC -!- CAUTION: For examples of full-length immunoglobulin heavy chains CC (of different isotypes) see AC P0DOX2, AC P0DOX3, AC P0DOX4, AC CC P0DOX5 and AC P0DOX6. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC244452; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PIR; A02099; D2HUWA. DR PDB; 1ZVO; X-ray; -; C/D=27-125. DR PDBsum; 1ZVO; -. DR ProteinModelPortal; P01824; -. DR SMR; P01824; -. DR IMGT_GENE-DB; IGHV4-39; -. DR GlyConnect; 276; -. DR UniCarbKB; P01824; -. DR BioMuta; IGHV4-39; -. DR DMDM; 123827; -. DR jPOST; P01824; -. DR PeptideAtlas; P01824; -. DR PRIDE; P01824; -. DR ProteomicsDB; 51487; -. DR Ensembl; ENST00000390619; ENSP00000375028; ENSG00000211959. DR Ensembl; ENST00000633618; ENSP00000488798; ENSG00000282579. DR UCSC; uc059ggl.1; human. DR DisGeNET; 28394; -. DR EuPathDB; HostDB:ENSG00000211959.2; -. DR GeneCards; IGHV4-39; -. DR HGNC; HGNC:5651; IGHV4-39. DR neXtProt; NX_P01824; -. DR OpenTargets; ENSG00000211959; -. DR GeneTree; ENSGT00940000153119; -. DR HOVERGEN; HBG018013; -. DR OMA; ECEPREK; -. DR OrthoDB; 665362at2759; -. DR PhylomeDB; P01824; -. DR Reactome; R-HSA-166663; Initial triggering of complement. DR Reactome; R-HSA-173623; Classical antibody-mediated complement activation. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall. DR Reactome; R-HSA-2029481; FCGR activation. DR Reactome; R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation. DR Reactome; R-HSA-2029485; Role of phospholipids in phagocytosis. DR Reactome; R-HSA-2168880; Scavenging of heme from plasma. DR Reactome; R-HSA-2454202; Fc epsilon receptor (FCERI) signaling. DR Reactome; R-HSA-2730905; Role of LAT2/NTAL/LAB on calcium mobilization. DR Reactome; R-HSA-2871796; FCERI mediated MAPK activation. DR Reactome; R-HSA-2871809; FCERI mediated Ca+2 mobilization. DR Reactome; R-HSA-2871837; FCERI mediated NF-kB activation. DR Reactome; R-HSA-5690714; CD22 mediated BCR regulation. DR Reactome; R-HSA-977606; Regulation of Complement cascade. DR Reactome; R-HSA-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers. DR ChiTaRS; IGHV4-39; human. DR EvolutionaryTrace; P01824; -. DR PRO; PR:P01824; -. DR Proteomes; UP000005640; Chromosome 14. DR Bgee; ENSG00000211959; Expressed in 85 organ(s), highest expression level in lymph node. DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0003823; F:antigen binding; IBA:GO_Central. DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central. DR GO; GO:0004252; F:serine-type endopeptidase activity; TAS:Reactome. DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central. DR GO; GO:0006956; P:complement activation; TAS:Reactome. DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central. DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central. DR GO; GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome. DR GO; GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR GO; GO:0050900; P:leukocyte migration; TAS:Reactome. DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central. DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central. DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central. DR GO; GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome. DR GO; GO:0030449; P:regulation of complement activation; TAS:Reactome. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR Gene3D; 2.60.40.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013106; Ig_V-set. DR Pfam; PF07686; V-set; 1. DR SMART; SM00406; IGv; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW 3D-structure; Adaptive immunity; Cell membrane; Complete proteome; KW Direct protein sequencing; Disulfide bond; Immunity; KW Immunoglobulin domain; Immunoglobulin V region; Membrane; KW Polymorphism; Reference proteome; Secreted; Signal. FT SIGNAL 1 26 {ECO:0000269|PubMed:6806818}. FT CHAIN 27 125 Immunoglobulin heavy variable 4-39. FT {ECO:0000269|PubMed:6806818}. FT /FTId=PRO_0000059912. FT DOMAIN 27 >125 Ig-like. {ECO:0000255|PROSITE- FT ProRule:PRU00114}. FT DISULFID 48 123 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT CONFLICT 27 27 Q -> R (in Ref. 2; AA sequence). FT {ECO:0000305}. FT CONFLICT 49 49 T -> I (in Ref. 2; AA sequence). FT {ECO:0000305}. FT CONFLICT 54 59 SISSSS -> PIRRTG (in Ref. 2; AA FT sequence). {ECO:0000305}. FT CONFLICT 78 79 SI -> GV (in Ref. 2; AA sequence). FT {ECO:0000305}. FT CONFLICT 82 82 S -> T (in Ref. 2; AA sequence). FT {ECO:0000305}. FT CONFLICT 85 85 T -> I (in Ref. 2; AA sequence). FT {ECO:0000305}. FT CONFLICT 92 93 KS -> RG (in Ref. 2; AA sequence). FT {ECO:0000305}. FT CONFLICT 103 103 K -> R (in Ref. 2; AA sequence). FT {ECO:0000305}. FT CONFLICT 109 114 KLSSVT -> NLRSMS (in Ref. 2; AA FT sequence). {ECO:0000305}. FT CONFLICT 120 120 V -> M (in Ref. 2; AA sequence). FT {ECO:0000305}. FT NON_TER 125 125 SQ SEQUENCE 125 AA; 13917 MW; 287656E0D6905F1D CRC64; MDLMCKKMKH LWFFLLLVAA PRWVLSQLQL QESGPGLVKP SETLSLTCTV SGGSISSSSY YWGWIRQPPG KGLEWIGSIY YSGSTYYNPS LKSRVTISVD TSKNQFSLKL SSVTAADTAV YYCAR //