ID   IFNA5_HUMAN             Reviewed;         189 AA.
AC   P01569; Q52LX3;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   13-FEB-2019, entry version 166.
DE   RecName: Full=Interferon alpha-5;
DE            Short=IFN-alpha-5;
DE   AltName: Full=Interferon alpha-61;
DE   AltName: Full=Interferon alpha-G;
DE            Short=LeIF G;
DE   Flags: Precursor;
GN   Name=IFNA5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=4057246; DOI=10.1016/0022-2836(85)90401-2;
RA   Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R.,
RA   Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J.,
RA   Todokoro K., Waelchli M., Nagata S., Weissmann C.;
RT   "Structural relationship of human interferon alpha genes and
RT   pseudogenes.";
RL   J. Mol. Biol. 185:227-260(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 57-189.
RC   TISSUE=Spleen;
RX   PubMed=6163083; DOI=10.1038/290020a0;
RA   Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M.,
RA   McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.;
RT   "The structure of eight distinct cloned human leukocyte interferon
RT   cDNAs.";
RL   Nature 290:20-26(1981).
RN   [5]
RP   PROTEIN SEQUENCE OF 22-36.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral
CC       activities. Interferon stimulates the production of two enzymes: a
CC       protein kinase and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC       {ECO:0000305}.
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DR   EMBL; X02956; CAA26702.1; -; Genomic_DNA.
DR   EMBL; AL162420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC093755; AAH93755.1; -; mRNA.
DR   EMBL; BC093757; AAH93757.1; -; mRNA.
DR   EMBL; V00541; CAA23802.1; -; mRNA.
DR   CCDS; CCDS6502.1; -.
DR   PIR; D25843; D25843.
DR   PIR; S43716; IVHUA7.
DR   RefSeq; NP_002160.1; NM_002169.2.
DR   UniGene; Hs.37113; -.
DR   ProteinModelPortal; P01569; -.
DR   SMR; P01569; -.
DR   BioGrid; 109665; 15.
DR   DIP; DIP-6019N; -.
DR   STRING; 9606.ENSP00000259555; -.
DR   ChEMBL; CHEMBL3856161; -.
DR   iPTMnet; P01569; -.
DR   PhosphoSitePlus; P01569; -.
DR   BioMuta; IFNA5; -.
DR   DMDM; 124457; -.
DR   PaxDb; P01569; -.
DR   PeptideAtlas; P01569; -.
DR   PRIDE; P01569; -.
DR   ProteomicsDB; 51385; -.
DR   Ensembl; ENST00000610521; ENSP00000484479; ENSG00000147873.
DR   GeneID; 3442; -.
DR   KEGG; hsa:3442; -.
DR   UCSC; uc011lnh.3; human.
DR   CTD; 3442; -.
DR   DisGeNET; 3442; -.
DR   EuPathDB; HostDB:ENSG00000147873.5; -.
DR   GeneCards; IFNA5; -.
DR   HGNC; HGNC:5426; IFNA5.
DR   HPA; HPA047557; -.
DR   MIM; 147565; gene.
DR   neXtProt; NX_P01569; -.
DR   OpenTargets; ENSG00000147873; -.
DR   PharmGKB; PA29665; -.
DR   eggNOG; ENOG410J735; Eukaryota.
DR   eggNOG; ENOG410ZH91; LUCA.
DR   GeneTree; ENSGT00940000153163; -.
DR   HOGENOM; HOG000230500; -.
DR   HOVERGEN; HBG052086; -.
DR   InParanoid; P01569; -.
DR   KO; K05414; -.
DR   OMA; EACMMQE; -.
DR   OrthoDB; 1358010at2759; -.
DR   PhylomeDB; P01569; -.
DR   TreeFam; TF336177; -.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   Reactome; R-HSA-912694; Regulation of IFNA signaling.
DR   Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation.
DR   Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production.
DR   GeneWiki; IFNA5; -.
DR   GenomeRNAi; 3442; -.
DR   PRO; PR:P01569; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000147873; Expressed in 17 organ(s), highest expression level in lower esophagus muscularis layer.
DR   Genevisible; P01569; HS.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005126; F:cytokine receptor binding; TAS:ProtInc.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0007596; P:blood coagulation; TAS:Reactome.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome.
DR   CDD; cd00095; IFab; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense; Complete proteome; Cytokine;
KW   Direct protein sequencing; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     21       {ECO:0000269|PubMed:15340161}.
FT   CHAIN        22    189       Interferon alpha-5.
FT                                /FTId=PRO_0000016362.
FT   DISULFID     24    122       {ECO:0000250}.
FT   DISULFID     52    162       {ECO:0000250}.
SQ   SEQUENCE   189 AA;  21942 MW;  C605992FE2E78043 CRC64;
     MALPFVLLMA LVVLNCKSIC SLGCDLPQTH SLSNRRTLMI MAQMGRISPF SCLKDRHDFG
     FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW DETLLDKFYT ELYQQLNDLE
     ACMMQEVGVE DTPLMNVDSI LTVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSLSAN
     LQERLRRKE
//