ID   IFN21_HUMAN             Reviewed;         189 AA.
AC   P01568; Q14608; Q5VWD1; Q7M4Q4;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2002, sequence version 2.
DT   13-FEB-2019, entry version 179.
DE   RecName: Full=Interferon alpha-21;
DE            Short=IFN-alpha-21;
DE   AltName: Full=Interferon alpha-F;
DE            Short=LeIF F;
DE   Flags: Precursor;
GN   Name=IFNA21;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT MET-119.
RX   PubMed=6163083; DOI=10.1038/290020a0;
RA   Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M.,
RA   McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.;
RT   "The structure of eight distinct cloned human leukocyte interferon
RT   cDNAs.";
RL   Nature 290:20-26(1981).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gren E.Y., Berzin V.M., Tsimanis A.Y., Apsalon U.R., Vishnevskii Y.I.,
RA   Yansone I.V., Dishler A.V., Pudova N.V., Smorodintsev A.A.,
RA   Iovlev V.I., Stepanov A.N., Feldmane G.Y., Meldrais Y.A., Lozha V.P.,
RA   Kavsan V.M., Efimov V.A., Sverdlov E.D.;
RT   "A new type of leukocytic interferon.";
RL   Dokl. Biochem. 269:91-95(1983).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6548765; DOI=10.1089/jir.1984.4.609;
RA   Gren E., Berzin V.M., Jansone I., Tsimanis A., Vishnevsky Y.,
RA   Apsalons U.;
RT   "Novel human leukocyte interferon subtype and structural comparison of
RT   alpha interferon genes.";
RL   J. Interferon Res. 4:609-617(1984).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 24-189.
RC   TISSUE=Lymphoblast;
RX   PubMed=3803589; DOI=10.1016/0014-5793(87)81278-4;
RA   Ohara O., Teraoka H.;
RT   "Anomalous behavior of human leukocyte interferon subtypes on
RT   polyacrylamide gel electrophoresis in the presence of dodecyl
RT   sulfate.";
RL   FEBS Lett. 211:78-82(1987).
RN   [8]
RP   PROTEIN SEQUENCE OF 24-62, AND FUNCTION.
RX   PubMed=1634550;
RA   Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C.,
RA   Nguyen N.Y., Hu R.-Q.;
RT   "Purification and characterization of multiple components of human
RT   lymphoblastoid interferon-alpha.";
RL   J. Biol. Chem. 267:15210-15216(1992).
RN   [9]
RP   PROTEIN SEQUENCE OF 24-58.
RX   PubMed=9425112; DOI=10.1042/bj3290295;
RA   Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.;
RT   "Identification of nine interferon-alpha subtypes produced by Sendai
RT   virus-induced human peripheral blood leucocytes.";
RL   Biochem. J. 329:295-302(1998).
RN   [10]
RP   ABSENCE OF POLYMORPHISM.
RX   PubMed=8910771; DOI=10.1089/jir.1996.16.853;
RA   Hussain M., Gill D.S., Liao M.-J.;
RT   "Identification of interferon-alpha 7, -alpha 14, and -alpha 21
RT   variants in the genome of a large human population.";
RL   J. Interferon Cytokine Res. 16:853-859(1996).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral
CC       activities. Interferon stimulates the production of two enzymes: a
CC       protein kinase and an oligoadenylate synthetase.
CC       {ECO:0000269|PubMed:1634550}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA36041.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; V00540; CAA23801.1; -; mRNA.
DR   EMBL; M12350; AAA52718.1; -; mRNA.
DR   EMBL; X00145; CAA24980.1; -; mRNA.
DR   EMBL; M28586; AAA36041.1; ALT_INIT; mRNA.
DR   EMBL; AL390882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58623.1; -; Genomic_DNA.
DR   EMBL; BC069329; AAH69329.1; -; mRNA.
DR   EMBL; BC069372; AAH69372.1; -; mRNA.
DR   EMBL; BC069408; AAH69408.1; -; mRNA.
DR   EMBL; BC096699; AAH96699.1; -; mRNA.
DR   EMBL; BC101638; AAI01639.1; -; mRNA.
DR   EMBL; BC101640; AAI01641.1; -; mRNA.
DR   CCDS; CCDS6497.1; -.
DR   PIR; A01832; IVHUF.
DR   PIR; D42753; D42753.
DR   PIR; E25843; E25843.
DR   PIR; I56313; I56313.
DR   PIR; I84464; I84464.
DR   RefSeq; NP_002166.2; NM_002175.2.
DR   UniGene; Hs.113211; -.
DR   ProteinModelPortal; P01568; -.
DR   SMR; P01568; -.
DR   BioGrid; 109674; 29.
DR   STRING; 9606.ENSP00000369574; -.
DR   ChEMBL; CHEMBL3856161; -.
DR   iPTMnet; P01568; -.
DR   PhosphoSitePlus; P01568; -.
DR   BioMuta; IFNA21; -.
DR   DMDM; 20178289; -.
DR   PaxDb; P01568; -.
DR   PeptideAtlas; P01568; -.
DR   PRIDE; P01568; -.
DR   ProteomicsDB; 51384; -.
DR   DNASU; 3452; -.
DR   Ensembl; ENST00000380225; ENSP00000369574; ENSG00000137080.
DR   GeneID; 3452; -.
DR   KEGG; hsa:3452; -.
DR   UCSC; uc003zom.2; human.
DR   CTD; 3452; -.
DR   DisGeNET; 3452; -.
DR   EuPathDB; HostDB:ENSG00000137080.4; -.
DR   GeneCards; IFNA21; -.
DR   HGNC; HGNC:5424; IFNA21.
DR   HPA; HPA047557; -.
DR   MIM; 147584; gene.
DR   neXtProt; NX_P01568; -.
DR   OpenTargets; ENSG00000137080; -.
DR   PharmGKB; PA29663; -.
DR   eggNOG; ENOG410J735; Eukaryota.
DR   eggNOG; ENOG410ZH91; LUCA.
DR   GeneTree; ENSGT00940000153163; -.
DR   HOGENOM; HOG000230500; -.
DR   HOVERGEN; HBG052086; -.
DR   InParanoid; P01568; -.
DR   KO; K05414; -.
DR   OMA; ISIHHEM; -.
DR   OrthoDB; 1358010at2759; -.
DR   PhylomeDB; P01568; -.
DR   TreeFam; TF336177; -.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   Reactome; R-HSA-912694; Regulation of IFNA signaling.
DR   Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation.
DR   Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production.
DR   GeneWiki; IFNA21; -.
DR   GenomeRNAi; 3452; -.
DR   PRO; PR:P01568; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000137080; Expressed in 13 organ(s), highest expression level in caudate nucleus.
DR   Genevisible; P01568; HS.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005126; F:cytokine receptor binding; TAS:ProtInc.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0007596; P:blood coagulation; TAS:Reactome.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome.
DR   CDD; cd00095; IFab; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense; Complete proteome; Cytokine;
KW   Direct protein sequencing; Disulfide bond; Polymorphism;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     23       {ECO:0000269|PubMed:1634550,
FT                                ECO:0000269|PubMed:9425112}.
FT   CHAIN        24    189       Interferon alpha-21.
FT                                /FTId=PRO_0000016370.
FT   DISULFID     24    122       {ECO:0000250}.
FT   DISULFID     52    162       {ECO:0000250}.
FT   VARIANT     119    119       L -> M (in dbSNP:rs1053885).
FT                                {ECO:0000269|PubMed:6163083}.
FT                                /FTId=VAR_055325.
FT   VARIANT     179    179       K -> E (in dbSNP:rs3750478).
FT                                /FTId=VAR_049638.
FT   CONFLICT     60     60       G -> E (in Ref. 8; AA sequence).
FT                                {ECO:0000305}.
SQ   SEQUENCE   189 AA;  21741 MW;  F0B6C9C392905802 CRC64;
     MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF SCLKDRHDFG
     FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW EQSLLEKFST ELNQQLNDLE
     ACVIQEVGVE ETPLMNVDSI LAVKKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSLSKI
     FQERLRRKE
//